BR9916807A - Antagonistas de 5ht1 para terapia antidepressiva - Google Patents

Antagonistas de 5ht1 para terapia antidepressiva

Info

Publication number
BR9916807A
BR9916807A BR9916807-3A BR9916807A BR9916807A BR 9916807 A BR9916807 A BR 9916807A BR 9916807 A BR9916807 A BR 9916807A BR 9916807 A BR9916807 A BR 9916807A
Authority
BR
Brazil
Prior art keywords
antagonists
antidepressant therapy
compounds
therapy
antidepressant
Prior art date
Application number
BR9916807-3A
Other languages
English (en)
Inventor
Gene Michael Bright
Kishor Amratlal Desai
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of BR9916807A publication Critical patent/BR9916807A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Abstract

Patente de Invenção: "ANTAGONISTAS DE 5HT1 PARA TERAPIA ANTIDEPRESSIVA". A presente invenção refere-se a compostos da fórmula I em que R^ 1^, R^ 2^, R^ 3^ e R^ 4^ são definidos como no relatório descritivo. Estes compostos são úteis como agentes psicoterapêuticos.
BR9916807-3A 1998-12-28 1999-11-03 Antagonistas de 5ht1 para terapia antidepressiva BR9916807A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11395798P 1998-12-28 1998-12-28
PCT/IB1999/001772 WO2000039128A1 (en) 1998-12-28 1999-11-03 5ht1 antagonists for antidepressant therapy

Publications (1)

Publication Number Publication Date
BR9916807A true BR9916807A (pt) 2001-10-23

Family

ID=22352526

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9916807-3A BR9916807A (pt) 1998-12-28 1999-11-03 Antagonistas de 5ht1 para terapia antidepressiva

Country Status (43)

Country Link
US (1) US6525196B1 (pt)
EP (1) EP1140931B1 (pt)
JP (1) JP2002533463A (pt)
KR (1) KR100417506B1 (pt)
CN (1) CN1332740A (pt)
AP (1) AP2001002188A0 (pt)
AR (1) AR024840A1 (pt)
AT (1) ATE260278T1 (pt)
AU (1) AU761711B2 (pt)
BG (1) BG105710A (pt)
BR (1) BR9916807A (pt)
CA (1) CA2356985C (pt)
CO (1) CO5150179A1 (pt)
CR (1) CR6398A (pt)
CZ (1) CZ291163B6 (pt)
DE (1) DE69915113T2 (pt)
DK (1) DK1140931T3 (pt)
DZ (1) DZ2933A1 (pt)
EA (1) EA003099B1 (pt)
EE (1) EE04439B1 (pt)
ES (1) ES2214892T3 (pt)
GE (1) GEP20043227B (pt)
GT (1) GT199900224A (pt)
HR (1) HRP20010488A2 (pt)
HU (1) HUP0104852A3 (pt)
ID (1) ID30117A (pt)
IL (1) IL143385A0 (pt)
IS (1) IS5951A (pt)
MA (1) MA26706A1 (pt)
NO (1) NO20013215L (pt)
NZ (1) NZ511964A (pt)
OA (1) OA11742A (pt)
PA (1) PA8486701A1 (pt)
PE (1) PE20001234A1 (pt)
PT (1) PT1140931E (pt)
SK (1) SK9002001A3 (pt)
TN (1) TNSN99218A1 (pt)
TR (1) TR200101979T2 (pt)
TW (1) TW523514B (pt)
UA (1) UA62015C2 (pt)
WO (1) WO2000039128A1 (pt)
YU (1) YU44301A (pt)
ZA (1) ZA200105041B (pt)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003065970A2 (en) * 2001-02-20 2003-08-14 Royal College Of Surgeons Ie Treatment of fibromyalgia and related fatigue syndromes using pindolol
GB0203778D0 (en) * 2002-02-18 2002-04-03 Glaxo Group Ltd Compounds
OA13038A (en) * 2003-03-12 2006-11-10 Pfizer Prod Inc Pryridyloxymethyl and benzisoxazole azabicyclic derivatives.
GB0316915D0 (en) * 2003-07-18 2003-08-20 Glaxo Group Ltd Compounds
MXPA06008647A (es) * 2004-01-29 2006-09-04 Pfizer Prod Inc Combinaciones de un antipsicotico atipico y derivados azabiciclicos aminometilpiridiloximetil/bencisoxazol para tratar trastornos del sistema nervioso central.
AR048112A1 (es) * 2004-03-25 2006-03-29 Solvay Pharm Bv Derivados de 1-(2h-1-benzopiran-2-on-8-il)-piperazina para el tratamiento de dolor
AR049478A1 (es) 2004-03-25 2006-08-09 Solvay Pharm Bv Un procedimiento para la preparacion de 3-amino-8-(1-piperazinil)-2h-1-benzopiran-2-ona. sales e hidratos y composiciones farmaceuticas.
CA2580042A1 (en) * 2004-09-10 2006-03-16 Pfizer Products Inc. Methods of treating cognitive disorders using pyridyloxymethyl and benzisoxazole azabicyclic derivatives
US20080318926A1 (en) * 2004-09-10 2008-12-25 Pfizer Inc Methods of Treating Mood Disorders Using Pyridyloxymethyl and Benzisoxazole Azabicyclic Derivatives
DE102005026194A1 (de) * 2005-06-06 2006-12-07 Grünenthal GmbH Substituierte N-Benzo[d]isoxazol-3-yl-amin-Derivate und deren Verwendung zur Herstellung von Arzneimitteln
WO2008019431A1 (en) * 2006-08-14 2008-02-21 Brc Operations Pty Limited Method and compositions for simultaneously regulating memory and mood
EP3610890A1 (en) 2012-11-14 2020-02-19 The Johns Hopkins University Methods and compositions for treating schizophrenia
WO2020183011A1 (en) 2019-03-14 2020-09-17 Institut Curie Htr1d inhibitors and uses thereof in the treatment of cancer
AU2020407614A1 (en) * 2019-12-20 2022-08-18 The Jackson Laboratory Molecular targets for addiction

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5157034A (en) * 1991-02-27 1992-10-20 Pfizer Inc. Neuroleptic perhydro-1H-pyrido[1,2-a]pyrazines
GB9410512D0 (en) * 1994-05-25 1994-07-13 Smithkline Beecham Plc Novel treatment
EP0763034A1 (en) * 1994-05-28 1997-03-19 Smithkline Beecham Plc Amide derivatives having 5ht1d-antagonist activity
NZ500252A (en) * 1997-04-18 2001-07-27 Smithkline Beecham P 6-(4-Methyl-piperazin-1-yl)-1H-indole derivatives useful as 5HT1A, 5HT1B and 5HT1D receptor antagonists
IT1293807B1 (it) * 1997-08-01 1999-03-10 Recordati Chem Pharm Derivati 1- (n-fenilaminoalchil) piperazinici sostituiti alla posizione 2 dell'anello fenilico
PA8469101A1 (es) * 1998-04-09 2000-09-29 Pfizer Prod Inc Ligandos azabiciclicos de receptores 5ht1

Also Published As

Publication number Publication date
HUP0104852A2 (hu) 2002-05-29
NO20013215D0 (no) 2001-06-27
ATE260278T1 (de) 2004-03-15
DK1140931T3 (da) 2004-04-19
CA2356985A1 (en) 2000-07-06
MA26706A1 (fr) 2004-12-20
SK9002001A3 (en) 2002-04-04
GT199900224A (es) 2001-06-15
AU6361499A (en) 2000-07-31
TW523514B (en) 2003-03-11
PT1140931E (pt) 2004-05-31
OA11742A (en) 2005-05-13
ID30117A (id) 2001-11-08
DE69915113T2 (de) 2004-08-26
EP1140931A1 (en) 2001-10-10
HUP0104852A3 (en) 2002-12-28
AR024840A1 (es) 2002-10-30
PA8486701A1 (es) 2000-09-29
YU44301A (sh) 2004-07-15
BG105710A (en) 2002-02-28
EA200100517A1 (ru) 2001-12-24
CA2356985C (en) 2006-08-08
TNSN99218A1 (fr) 2005-11-10
GEP20043227B (en) 2004-04-26
US6525196B1 (en) 2003-02-25
PE20001234A1 (es) 2000-11-07
DZ2933A1 (fr) 2004-03-15
KR20010092455A (ko) 2001-10-25
ES2214892T3 (es) 2004-09-16
EE200100346A (et) 2002-12-16
TR200101979T2 (tr) 2001-12-21
IS5951A (is) 2001-05-22
EA003099B1 (ru) 2002-12-26
EP1140931B1 (en) 2004-02-25
EE04439B1 (et) 2005-02-15
AP2001002188A0 (en) 2001-06-30
NO20013215L (no) 2001-08-27
CN1332740A (zh) 2002-01-23
WO2000039128A1 (en) 2000-07-06
ZA200105041B (en) 2002-06-20
JP2002533463A (ja) 2002-10-08
DE69915113D1 (de) 2004-04-01
CZ20012386A3 (cs) 2002-02-13
CZ291163B6 (cs) 2003-01-15
HRP20010488A2 (en) 2002-08-31
CO5150179A1 (es) 2002-04-29
KR100417506B1 (ko) 2004-02-05
AU761711B2 (en) 2003-06-05
IL143385A0 (en) 2002-04-21
UA62015C2 (en) 2003-12-15
NZ511964A (en) 2003-08-29
CR6398A (es) 2004-03-24

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B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: INDEFIRO O PRESENTE PEDIDO DE PATENTE DE ACORDO COM ART. 8O DA LPI.

B09B Patent application refused [chapter 9.2 patent gazette]

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