PE20001093A1 - 3-amino-4-aril-maleimidas como inhibidores de gsk-3 - Google Patents
3-amino-4-aril-maleimidas como inhibidores de gsk-3Info
- Publication number
- PE20001093A1 PE20001093A1 PE1999001014A PE00101499A PE20001093A1 PE 20001093 A1 PE20001093 A1 PE 20001093A1 PE 1999001014 A PE1999001014 A PE 1999001014A PE 00101499 A PE00101499 A PE 00101499A PE 20001093 A1 PE20001093 A1 PE 20001093A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- phenyl
- heterocycle
- alcoxialkyl
- arylalkyl
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/44—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members
- C07D207/444—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members having two doubly-bound oxygen atoms directly attached in positions 2 and 5
- C07D207/456—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members having two doubly-bound oxygen atoms directly attached in positions 2 and 5 with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Abstract
SE REFIERE A 3-AMINO-4-ARIL-MALEIMIDA DE FORMULA I, DONDE R ES H, ALQUILO, ARILO, ARILALQUILO; R1 ES H, ALQUILO, ARILALQUILO, HIDROXIALQUILO, ALCOXIALQUILO; R2 ES ARILO, HETEROCICLO; R3 ES H, ALQUILO, CICLOALQUILO, ALCOXIALQUILO, ARILO, HETEROCICLO, ARILALQUILO; R1 Y R3 JUNTO CON N FORMAN UN HETEROCICLO SATURADO O INSATURADO. TAMBIEN SE REFIERE A UN COMPUESTO DE FORMULA IC, DONDE R10 ES H, ALCOXICARBONILO, ALCOXIALQUILO, PERFLUOROALQUILO, ENTRE OTROS; R11 ES H, ALQUILO C1-C6, FENILO, BENCILO, ALQUIL C1-C6-S-, HALO, HIDROXI, ENTRE OTROS; COMPUESTOS IC EXCEPTO 3-FENILAMINO-4-FENIL-1H-PIRROL-2,5-DIONA, ENTRE OTROS; LOS COMPUESTOS I EXCEPTO CUANDO R2 ES FENILO, INDOLILO; R3 ES H, ALQUILO, CICLOALQUILO, FENILO, ALQUIL C1-C6, FENILO, ALCOXIALQUILO, HETEROCICLO. EL COMPUESTO I (PIRROL 2,5-DIONAS) INHIBE A LA GLUCOGENO QUINASA SINTASA 3 (GSK-3) Y PUEDE SER UTIL PARA EL TRATAMIENTO DE DIABETES, CONDICIONES NEURODEGENERATIVAS, ENFERMEDADES NEUROTRAUMATICAS, PERDIDA DEL CABELLO, CANCER
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9821974.4A GB9821974D0 (en) | 1998-10-08 | 1998-10-08 | Novel method and compounds |
GBGB9827521.7A GB9827521D0 (en) | 1998-12-14 | 1998-12-14 | Novel method and compounds |
GBGB9827883.1A GB9827883D0 (en) | 1998-12-17 | 1998-12-17 | Novel compounds |
GBGB9905518.8A GB9905518D0 (en) | 1999-03-10 | 1999-03-10 | Novel method and compound |
GBGB9907086.4A GB9907086D0 (en) | 1999-03-26 | 1999-03-26 | Novel compounds |
GBGB9919362.5A GB9919362D0 (en) | 1999-08-16 | 1999-08-16 | Novel method and compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20001093A1 true PE20001093A1 (es) | 2000-12-22 |
Family
ID=27547324
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE1999001014A PE20001093A1 (es) | 1998-10-08 | 1999-10-06 | 3-amino-4-aril-maleimidas como inhibidores de gsk-3 |
Country Status (11)
Country | Link |
---|---|
EP (1) | EP1119548B1 (es) |
JP (1) | JP2002527419A (es) |
AR (1) | AR020727A1 (es) |
AT (1) | ATE284387T1 (es) |
AU (1) | AU6111699A (es) |
DE (1) | DE69922526T2 (es) |
ES (1) | ES2234300T3 (es) |
HK (1) | HK1038564A1 (es) |
MA (1) | MA26697A1 (es) |
PE (1) | PE20001093A1 (es) |
WO (1) | WO2000021927A2 (es) |
Families Citing this family (79)
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TWI263636B (en) * | 1999-09-16 | 2006-10-11 | Ciba Sc Holding Ag | Fluorescent maleimides and use thereof |
ES2436610T3 (es) | 2000-01-21 | 2014-01-03 | Novartis Ag | Combinaciones que contienen inhibidores de la dipeptidilpeptidasa-IV y agentes antidiabéticos |
GB0008264D0 (en) * | 2000-04-04 | 2000-05-24 | Smithkline Beecham Plc | Novel method and compounds |
CZ296087B6 (cs) * | 2000-05-11 | 2006-01-11 | Consejo Superior Investigaciones Cientificas | Farmaceutický prostredek pro lécbu nemoci, na nízse podílí heterocyklické inhibitory glykogensyntázakinázy GSK-3 |
ES2166328B1 (es) * | 2000-05-11 | 2003-09-16 | Consejo Superior Investigacion | Inhibidores heterociclicos del enzima gsk 3 utiles en el tratamiento de procesos neurodegenerativos e hiperproliferativos |
IL153851A0 (en) * | 2000-07-27 | 2003-07-31 | Hoffmann La Roche | 3-indolyl-4-phenyl-1h-pyrrole-2,5-dione derivatives as inhibitors of glycogen synthase kinase-3beta |
KR20080014934A (ko) * | 2000-11-07 | 2008-02-14 | 노파르티스 아게 | 단백질 키나제 c 억제제로서의 인돌릴말레이미드 유도체 |
PT1362047E (pt) | 2000-12-08 | 2006-09-29 | Ortho Mcneil Pharm Inc | Compostos de pirrolina substituidos com indazolilo como inibidores de cinase |
AUPR213700A0 (en) * | 2000-12-18 | 2001-01-25 | Biota Scientific Management Pty Ltd | Antiviral agents |
GB0103031D0 (en) * | 2001-02-07 | 2001-03-21 | Smithkline Beecham Plc | Novel treatment |
AU2002249103A1 (en) * | 2001-03-29 | 2002-10-15 | Topo Target Aps | Succinimide and maleimide derivatives and their use as topoisomerase ii catalytic inhibitors |
US7132445B2 (en) | 2001-04-16 | 2006-11-07 | Schering Corporation | 3,4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands |
US20040106794A1 (en) | 2001-04-16 | 2004-06-03 | Schering Corporation | 3,4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands |
CA2455753A1 (en) * | 2001-08-03 | 2003-02-13 | Novo Nordisk A/S | Novel 2,4-diaminothiazole derivatives |
TWI335221B (en) | 2001-09-27 | 2011-01-01 | Alcon Inc | Inhibtors of glycogen synthase kinase-3 (gsk-3) for treating glaucoma |
CA2462862A1 (en) | 2001-10-12 | 2003-04-17 | Schering Corporation | 3,4-di-substituted maleimide compounds as cxc-chemokine receptor antagonists |
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EP1465610B1 (en) * | 2002-01-10 | 2008-12-31 | F. Hoffmann-La Roche Ag | Use of a gsk-3beta inhibitor in the manufacture of a medicament for increasing bone formation |
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WO2003074046A1 (fr) | 2002-03-01 | 2003-09-12 | Takeda Chemical Industries, Ltd. | Antidepresseur |
NZ535314A (en) | 2002-03-18 | 2007-08-31 | Schering Corp | Combination treatments for chemokine-mediated diseases |
DE60329910D1 (de) * | 2002-03-29 | 2009-12-17 | Novartis Vaccines & Diagnostic | Substituierte benzazole und ihre verwendung als raf-kinase-hemmer |
WO2003095452A1 (en) | 2002-05-08 | 2003-11-20 | Janssen Pharmaceutica N.V. | Substituted pyrroline kinase inhibitors |
ES2312785T3 (es) | 2002-06-05 | 2009-03-01 | Janssen Pharmaceutica Nv | Pirrolinas sustituidas utiles como inhibidores de quinasa. |
KR20050008787A (ko) | 2002-06-05 | 2005-01-21 | 얀센 파마슈티카 엔.브이. | 키나제 저해제로서의 비스인돌릴-말레이미드 유도체 |
BR0313176A (pt) * | 2002-08-02 | 2005-06-14 | Vertex Pharma | Composições de pirazol úteis como inibidores de gsk-3 |
ES2321186T3 (es) | 2002-10-09 | 2009-06-03 | Schering Corporation | Dioxidos de tiadiazol y monoxidos de tiadiazol como ligandos de los receptores de quimioquinas cxc y cc. |
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CA2592771A1 (en) * | 2005-01-10 | 2006-07-13 | Astrazeneca Ab | Derivatives of isothiazol-3(2h)-one 1,1-dioxides as liver x receptor modulators |
SE0500056D0 (sv) * | 2005-01-10 | 2005-01-10 | Astrazeneca Ab | Therapeutic agents 4 |
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SE0500058D0 (sv) * | 2005-01-10 | 2005-01-10 | Astrazeneca Ab | Therapeutic agents 5 |
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WO2016207366A1 (en) | 2015-06-26 | 2016-12-29 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for the treatment of viral infections |
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EP3187495A1 (en) | 2015-12-30 | 2017-07-05 | Johannes Gutenberg-Universität Mainz | 3-(5-fluoroindolyl)-4-arylmaleimide compounds and their use in tumor treatment |
KR101702897B1 (ko) * | 2016-04-15 | 2017-02-06 | 가톨릭대학교 산학협력단 | 바이오틴이 결합된 카페인산 화합물을 유효성분으로 함유하는 통풍 예방 또는 치료용 조성물 |
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CA2330756C (en) * | 1998-05-04 | 2007-10-02 | Asta Medica Aktiengesellschaft | Indole derivatives and their use for the treatment of malignant and other diseases based on pathological cell proliferation |
WO2000006564A1 (fr) * | 1998-07-30 | 2000-02-10 | Japan Tobacco Inc. | Composes de maleimide disubstitues et utilisation en medecine de ces derniers |
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1999
- 1999-10-05 EP EP99947744A patent/EP1119548B1/en not_active Expired - Lifetime
- 1999-10-05 WO PCT/GB1999/003280 patent/WO2000021927A2/en active IP Right Grant
- 1999-10-05 DE DE69922526T patent/DE69922526T2/de not_active Expired - Fee Related
- 1999-10-05 JP JP2000575836A patent/JP2002527419A/ja active Pending
- 1999-10-05 AT AT99947744T patent/ATE284387T1/de not_active IP Right Cessation
- 1999-10-05 AU AU61116/99A patent/AU6111699A/en not_active Abandoned
- 1999-10-05 ES ES99947744T patent/ES2234300T3/es not_active Expired - Lifetime
- 1999-10-06 PE PE1999001014A patent/PE20001093A1/es not_active Application Discontinuation
- 1999-10-06 AR ARP990105056A patent/AR020727A1/es unknown
- 1999-10-06 MA MA25810A patent/MA26697A1/fr unknown
-
2002
- 2002-01-11 HK HK02100210.2A patent/HK1038564A1/zh unknown
Also Published As
Publication number | Publication date |
---|---|
EP1119548B1 (en) | 2004-12-08 |
WO2000021927A2 (en) | 2000-04-20 |
AU6111699A (en) | 2000-05-01 |
EP1119548A1 (en) | 2001-08-01 |
DE69922526D1 (de) | 2005-01-13 |
WO2000021927A3 (en) | 2000-07-13 |
AR020727A1 (es) | 2002-05-29 |
DE69922526T2 (de) | 2005-06-02 |
ES2234300T3 (es) | 2005-06-16 |
MA26697A1 (fr) | 2004-12-20 |
JP2002527419A (ja) | 2002-08-27 |
ATE284387T1 (de) | 2004-12-15 |
HK1038564A1 (zh) | 2002-03-22 |
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