DE69922526D1 - 3-(3-chloro-4-hydroxyphenylamino)-4-(2-nitrophenyl)-1h-pyrrol-2,5-dion als glykogen synthase kinase-3 inhibitor (gsk-3) - Google Patents
3-(3-chloro-4-hydroxyphenylamino)-4-(2-nitrophenyl)-1h-pyrrol-2,5-dion als glykogen synthase kinase-3 inhibitor (gsk-3)Info
- Publication number
- DE69922526D1 DE69922526D1 DE1999622526 DE69922526T DE69922526D1 DE 69922526 D1 DE69922526 D1 DE 69922526D1 DE 1999622526 DE1999622526 DE 1999622526 DE 69922526 T DE69922526 T DE 69922526T DE 69922526 D1 DE69922526 D1 DE 69922526D1
- Authority
- DE
- Germany
- Prior art keywords
- glycogenic
- hydroxyphenylamino
- dion
- gsk
- pyrrol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/44—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members
- C07D207/444—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members having two doubly-bound oxygen atoms directly attached in positions 2 and 5
- C07D207/456—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members having two doubly-bound oxygen atoms directly attached in positions 2 and 5 with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Emergency Medicine (AREA)
- Communicable Diseases (AREA)
- Endocrinology (AREA)
- Hospice & Palliative Care (AREA)
- Dermatology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Hydrogenated Pyridines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyrrole Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (13)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9821974 | 1998-10-08 | ||
GBGB9821974.4A GB9821974D0 (en) | 1998-10-08 | 1998-10-08 | Novel method and compounds |
GB9827521 | 1998-12-14 | ||
GBGB9827521.7A GB9827521D0 (en) | 1998-12-14 | 1998-12-14 | Novel method and compounds |
GB9827883 | 1998-12-17 | ||
GBGB9827883.1A GB9827883D0 (en) | 1998-12-17 | 1998-12-17 | Novel compounds |
GBGB9905518.8A GB9905518D0 (en) | 1999-03-10 | 1999-03-10 | Novel method and compound |
GB9905518 | 1999-03-10 | ||
GBGB9907086.4A GB9907086D0 (en) | 1999-03-26 | 1999-03-26 | Novel compounds |
GB9907086 | 1999-03-26 | ||
GB9919362 | 1999-08-16 | ||
GBGB9919362.5A GB9919362D0 (en) | 1999-08-16 | 1999-08-16 | Novel method and compounds |
PCT/GB1999/003280 WO2000021927A2 (en) | 1998-10-08 | 1999-10-05 | Pyrrole-2,5-diones as gsk-3 inhibitors |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69922526D1 true DE69922526D1 (de) | 2005-01-13 |
DE69922526T2 DE69922526T2 (de) | 2005-06-02 |
Family
ID=27547324
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69922526T Expired - Fee Related DE69922526T2 (de) | 1998-10-08 | 1999-10-05 | 3-(3-chloro-4-hydroxyphenylamino)-4-(2-nitrophenyl)-1h-pyrrol-2,5-dion als glykogen synthase kinase-3 inhibitor (gsk-3) |
Country Status (11)
Country | Link |
---|---|
EP (1) | EP1119548B1 (de) |
JP (1) | JP2002527419A (de) |
AR (1) | AR020727A1 (de) |
AT (1) | ATE284387T1 (de) |
AU (1) | AU6111699A (de) |
DE (1) | DE69922526T2 (de) |
ES (1) | ES2234300T3 (de) |
HK (1) | HK1038564A1 (de) |
MA (1) | MA26697A1 (de) |
PE (1) | PE20001093A1 (de) |
WO (1) | WO2000021927A2 (de) |
Families Citing this family (80)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TWI263636B (en) * | 1999-09-16 | 2006-10-11 | Ciba Sc Holding Ag | Fluorescent maleimides and use thereof |
DK1741445T3 (da) | 2000-01-21 | 2013-11-04 | Novartis Ag | Kombinationer omfattende dipeptidylpeptidase-IV-inhibitorer og antidiabetiske midler |
GB0008264D0 (en) * | 2000-04-04 | 2000-05-24 | Smithkline Beecham Plc | Novel method and compounds |
IL152721A0 (en) * | 2000-05-11 | 2003-06-24 | Consejo Superior Investigacion | Heterocyclic compounds and pharmaceutical compositions for inhibition of glycogen synthase kinase containing the same |
ES2166328B1 (es) * | 2000-05-11 | 2003-09-16 | Consejo Superior Investigacion | Inhibidores heterociclicos del enzima gsk 3 utiles en el tratamiento de procesos neurodegenerativos e hiperproliferativos |
CZ2003555A3 (en) * | 2000-07-27 | 2004-03-17 | F. Hoffmann-La Roche Ag | 3-indolyl-4-phenyl-1h-pyrrole-2,5-dione derivatives as inhibitors of glycogen synthase kinase-3beta |
PE20020544A1 (es) * | 2000-11-07 | 2002-07-30 | Novartis Ag | Derivados de indolilmaleimida |
YU46603A (sh) | 2000-12-08 | 2006-05-25 | Ortho-Mcneil Pharmaceutical Inc. | Indazolil-supstituisana jedinjenja pirolina, kao inhibitori kinaze |
AUPR213700A0 (en) | 2000-12-18 | 2001-01-25 | Biota Scientific Management Pty Ltd | Antiviral agents |
GB0103031D0 (en) * | 2001-02-07 | 2001-03-21 | Smithkline Beecham Plc | Novel treatment |
ATE318596T1 (de) * | 2001-03-29 | 2006-03-15 | Topotarget As | Succinimid- und maleimidderivate und ihre verwendung als katalytische inhibitoren der topoisomerase ii |
US7132445B2 (en) | 2001-04-16 | 2006-11-07 | Schering Corporation | 3,4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands |
US20040106794A1 (en) | 2001-04-16 | 2004-06-03 | Schering Corporation | 3,4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands |
WO2003011843A1 (en) * | 2001-08-03 | 2003-02-13 | Novo Nordisk A/S | Novel 2,4-diaminothiazole derivatives |
TW201041580A (en) | 2001-09-27 | 2010-12-01 | Alcon Inc | Inhibitors of glycogen synthase kinase-3 (GSK-3) for treating glaucoma |
EP1434775A1 (de) | 2001-10-12 | 2004-07-07 | Schering Corporation | 3,4-disubstituierte maleimid-derivate als cxc-chemokin-rezeptor antagonisten |
US6878709B2 (en) | 2002-01-04 | 2005-04-12 | Schering Corporation | 3,4-di-substituted pyridazinediones as CXC chemokine receptor antagonists |
CN100409840C (zh) * | 2002-01-10 | 2008-08-13 | 霍夫曼-拉罗奇有限公司 | GSK-3β抑制剂在制备增加骨生成的药物中的应用 |
KR101011657B1 (ko) | 2002-03-01 | 2011-01-28 | 다케다 야쿠힌 고교 가부시키가이샤 | 항우울제 |
WO2003074072A1 (en) * | 2002-03-01 | 2003-09-12 | Chiron Corporation | Methods and compositions for the treatment of ischemia |
WO2003080053A1 (en) | 2002-03-18 | 2003-10-02 | Schering Corporation | Combination treatments for chemokine-mediated diseases |
US7071216B2 (en) * | 2002-03-29 | 2006-07-04 | Chiron Corporation | Substituted benz-azoles and methods of their use as inhibitors of Raf kinase |
ATE387444T1 (de) | 2002-05-08 | 2008-03-15 | Janssen Pharmaceutica Nv | Substituierte pyrroline als kinase inhibitoren |
MXPA04012188A (es) | 2002-06-05 | 2005-07-25 | Johnson & Johnson | Derivados de bisindolil-maleimida como inhibidores de cinasa. |
EP1513520B1 (de) | 2002-06-05 | 2008-09-24 | Janssen Pharmaceutica N.V. | Substituierte pyrroline als kinase inhibitoren |
MXPA05001367A (es) * | 2002-08-02 | 2005-04-28 | Vertex Pharma | Composiciones de pirazol utiles como inhibidores de gsk-3. |
CN1720240B (zh) | 2002-10-09 | 2010-10-27 | 先灵公司 | 作为cxc-和cc-趋化因子受体配体的噻二唑二氧化物和噻二唑氧化物 |
GB0224830D0 (en) | 2002-10-24 | 2002-12-04 | Sterix Ltd | Compound |
EP1556040A1 (de) * | 2002-10-24 | 2005-07-27 | Sterix Limited | Inhibitoren der 11-beta-hydroxy-steroid-dehydrogenase des typs 1 und des typ 2 |
WO2005024755A2 (en) * | 2002-12-31 | 2005-03-17 | Deciphera Pharmaceuticals, Llc. | Medicaments for the treatment of neurodegenerative disorders or diabetes |
US7202257B2 (en) | 2003-12-24 | 2007-04-10 | Deciphera Pharmaceuticals, Llc | Anti-inflammatory medicaments |
US7279576B2 (en) | 2002-12-31 | 2007-10-09 | Deciphera Pharmaceuticals, Llc | Anti-cancer medicaments |
US7144911B2 (en) | 2002-12-31 | 2006-12-05 | Deciphera Pharmaceuticals Llc | Anti-inflammatory medicaments |
GB0303319D0 (en) | 2003-02-13 | 2003-03-19 | Novartis Ag | Organic compounds |
WO2004094422A1 (en) | 2003-03-27 | 2004-11-04 | Janssen Pharmaceutica N.V. | Substituted pyrroline kinase inhibitors |
KR20060021890A (ko) | 2003-06-13 | 2006-03-08 | 얀센 파마슈티카 엔.브이. | 키나제 저해제로서의 치환된 인다졸릴(인돌릴)말레이미드유도체 |
GB0316232D0 (en) | 2003-07-11 | 2003-08-13 | Astrazeneca Ab | Therapeutic agents |
GB0316237D0 (en) * | 2003-07-11 | 2003-08-13 | Astrazeneca Ab | Therapeutic agents |
CN1918138B (zh) | 2003-12-19 | 2011-05-04 | 先灵公司 | 作为cxc-和cc-趋化因子受体配体的噻二唑化合物 |
MXPA06007205A (es) | 2003-12-22 | 2006-08-31 | Schering Corp | Dioxidos de isotiazol como ligandos del receptor cxc y cc-quimiocina. |
JP4875978B2 (ja) * | 2004-03-15 | 2012-02-15 | 武田薬品工業株式会社 | アミノフェニルプロパン酸誘導体 |
WO2005102997A1 (en) * | 2004-04-26 | 2005-11-03 | Astrazeneca Ab | 3,4-disubstituted maleimides for use as vascular damaging agents |
AU2005239812B2 (en) * | 2004-05-12 | 2011-04-14 | Bayer Cropscience Ag | Plant growth regulation |
EP1819697B1 (de) | 2004-12-08 | 2012-08-01 | Johannes Gutenberg-Universität Mainz | 3-(indolyl)-4-arylmaleimidderivate und ihre verwendung als angiogenese inhibitoren |
JP2008526842A (ja) * | 2005-01-10 | 2008-07-24 | アストラゼネカ アクチボラグ | 肝x受容体モジュレーターとしてのイソチアゾール−3(2h)−チオン1,1−ジオキシドのアニリン誘導体 |
SE0500058D0 (sv) * | 2005-01-10 | 2005-01-10 | Astrazeneca Ab | Therapeutic agents 5 |
CA2592771A1 (en) * | 2005-01-10 | 2006-07-13 | Astrazeneca Ab | Derivatives of isothiazol-3(2h)-one 1,1-dioxides as liver x receptor modulators |
SE0500055D0 (sv) | 2005-01-10 | 2005-01-10 | Astrazeneca Ab | Therapeutic agents 3 |
SE0500056D0 (sv) * | 2005-01-10 | 2005-01-10 | Astrazeneca Ab | Therapeutic agents 4 |
JP2009500334A (ja) | 2005-06-29 | 2009-01-08 | シェーリング コーポレイション | Cxc−ケモカインレセプターリガンドとしてのジ置換オキサジアゾール |
EP1907399B1 (de) | 2005-06-29 | 2010-10-27 | Schering Corporation | 5,6-disubstituierte oxadiazolopyrazine und thiadiazolopyrazine als liganden des cxc-chemokinrezeptors |
EP2258359A3 (de) | 2005-08-26 | 2011-04-06 | Braincells, Inc. | Neurogenese durch Modulation des Muscarinrezeptors mit Sabcomelin |
JP2009506069A (ja) | 2005-08-26 | 2009-02-12 | ブレインセルス,インコーポレイティド | ムスカリン性受容体調節による神経発生 |
KR101352588B1 (ko) | 2005-09-14 | 2014-01-17 | 다케다 야쿠힌 고교 가부시키가이샤 | 당뇨병 치료용 디펩티딜 펩티다아제 억제제 |
CA2625153A1 (en) | 2005-10-21 | 2007-04-26 | Braincells, Inc. | Modulation of neurogenesis by pde inhibition |
US20070112017A1 (en) | 2005-10-31 | 2007-05-17 | Braincells, Inc. | Gaba receptor mediated modulation of neurogenesis |
US20100216734A1 (en) | 2006-03-08 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
EP2377531A2 (de) | 2006-05-09 | 2011-10-19 | Braincells, Inc. | Neurogenese mittels Angiotensin-Modulation |
US20100184806A1 (en) | 2006-09-19 | 2010-07-22 | Braincells, Inc. | Modulation of neurogenesis by ppar agents |
US20100216805A1 (en) | 2009-02-25 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis using d-cycloserine combinations |
WO2011041293A1 (en) | 2009-09-30 | 2011-04-07 | Takeda Pharmaceutical Company Limited | Pyrazolo [1, 5-a] pyrimidine derivatives as apoptosis signal-regulating kinase 1 inhibitors |
EP2343291A1 (de) | 2009-12-18 | 2011-07-13 | Johannes Gutenberg-Universität Mainz | 3-(Indolyl)- oder 3-(Azaindolyl)-4-Arylmaleimid-Verbindungen und ihre Verwendung bei der Behandlung von Tumoren |
PL2531501T3 (pl) | 2010-02-03 | 2014-05-30 | Takeda Pharmaceuticals Co | Inhibitory kinazy 1 regulującej sygnał apoptotyczny |
SG190784A1 (en) * | 2010-11-09 | 2013-07-31 | Fujian Haixi Pharmaceuticals Inc | Compound for increasing kinase active and application thereof |
EP2474541A1 (de) | 2010-12-23 | 2012-07-11 | Johannes- Gutenberg-Universität Mainz | Konjugierte 3-(Indolyl)- und 3-(Azaindolyl)-4-arylmaleinimid-Verbindungen und deren Verwendung bei der Behandlung von Tumoren |
US8461179B1 (en) | 2012-06-07 | 2013-06-11 | Deciphera Pharmaceuticals, Llc | Dihydronaphthyridines and related compounds useful as kinase inhibitors for the treatment of proliferative diseases |
US20160051514A1 (en) * | 2013-05-03 | 2016-02-25 | The Brigham And Women's Hospital, Inc. | Methods for treatment of cardiomyopathy |
EP3169337A1 (de) | 2014-07-17 | 2017-05-24 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Verfahren zur behandlung von erkrankungen in zusammenhang mit neuromuskulären verbindungen |
WO2016207366A1 (en) | 2015-06-26 | 2016-12-29 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for the treatment of viral infections |
WO2017049194A1 (en) * | 2015-09-16 | 2017-03-23 | Harris Thurl E Jr | Compositions and method for regulating adipose tissue lipolysis, insulin-resistance, and hyperglycemia |
EP3353151A1 (de) | 2015-09-24 | 2018-08-01 | Glaxosmithkline Intellectual Property (No. 2) Limited | Modulatoren der indolamin-2,3-dioxygenase |
EP3187495A1 (de) | 2015-12-30 | 2017-07-05 | Johannes Gutenberg-Universität Mainz | 3-(5-fluorindolyl)-4-arylmaleimid-verbindungen und deren verwendung bei der tumorbehandlung |
KR101702897B1 (ko) * | 2016-04-15 | 2017-02-06 | 가톨릭대학교 산학협력단 | 바이오틴이 결합된 카페인산 화합물을 유효성분으로 함유하는 통풍 예방 또는 치료용 조성물 |
CN106188007B (zh) * | 2016-06-29 | 2018-08-14 | 东华大学 | 一种3-哌啶基-4-吲哚马来酰亚胺类化合物及其制备和应用 |
CN111818915B (zh) | 2018-01-31 | 2024-05-24 | 德西费拉制药有限责任公司 | 治疗胃肠道间质瘤的组合疗法 |
KR20220045189A (ko) | 2019-08-12 | 2022-04-12 | 데시페라 파마슈티칼스, 엘엘씨. | 위장관 기질 종양을 치료하는 방법 |
TW202122082A (zh) | 2019-08-12 | 2021-06-16 | 美商迪賽孚爾製藥有限公司 | 治療胃腸道基質瘤方法 |
JP2023509628A (ja) | 2019-12-30 | 2023-03-09 | デシフェラ・ファーマシューティカルズ,エルエルシー | 1-(4-ブロモ-5-(1-エチル-7-(メチルアミノ)-2-オキソ-1,2-ジヒドロ-1,6-ナフチリジン-3-イル)-2-フルオロフェニル)-3-フェニル尿素の組成物 |
EP4327827A3 (de) | 2019-12-30 | 2024-05-29 | Deciphera Pharmaceuticals, LLC | Amorphe kinasehemmerformulierungen und verfahren zur verwendung davon |
US11779572B1 (en) | 2022-09-02 | 2023-10-10 | Deciphera Pharmaceuticals, Llc | Methods of treating gastrointestinal stromal tumors |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3335147A (en) * | 1965-04-29 | 1967-08-08 | Us Vitamin Pharm Corp | Anilino-pyridinium-maleimides |
NZ227850A (en) * | 1988-02-10 | 1991-11-26 | Hoffmann La Roche | Indole substituted pyrrole derivatives; preparatory process and medicaments for use against inflammatory immunological, bronchopulmonary or vascular disorders |
DE4005969A1 (de) * | 1990-02-26 | 1991-08-29 | Boehringer Mannheim Gmbh | Neue trisubstituierte pyrrole, verfahren zu ihrer herstellung sowie arzneimittel, die diese verbindungen enthalten |
DE4005970A1 (de) * | 1990-02-26 | 1991-08-29 | Boehringer Mannheim Gmbh | Neue trisubstituierte maleinimide, verfahren zu ihrer herstellung sowie arzneimittel, die diese verbindungen enthalten |
EP1019043A4 (de) * | 1996-05-07 | 2003-07-30 | Univ Pennsylvania | Inhibitoren der glykogensynthese-kinase 3 und verfahren zu ihrer identifizierung und verwendung |
DE19637042A1 (de) * | 1996-09-12 | 1998-03-19 | Boehringer Mannheim Gmbh | Heterocyclische Verbindungen und deren Verwendung in der Detektion von Nucleinsäuren |
WO1998016528A1 (en) * | 1996-10-11 | 1998-04-23 | Chiron Corporation | Purine inhibitors of glycogen synthase kinase 3 (gsk3) |
BR9911017A (pt) * | 1998-05-04 | 2001-02-06 | Asta Medica Ag | Derivados de indol e seu emprego para o tratamento de doenças malignas e outras, que se baseiam na proliferação de células patológicas |
CA2338866A1 (en) * | 1998-07-30 | 2000-02-10 | Japan Tobacco Inc. | Disubstituted maleimide compound and pharmaceutical use thereof |
-
1999
- 1999-10-05 ES ES99947744T patent/ES2234300T3/es not_active Expired - Lifetime
- 1999-10-05 DE DE69922526T patent/DE69922526T2/de not_active Expired - Fee Related
- 1999-10-05 EP EP99947744A patent/EP1119548B1/de not_active Expired - Lifetime
- 1999-10-05 JP JP2000575836A patent/JP2002527419A/ja active Pending
- 1999-10-05 AU AU61116/99A patent/AU6111699A/en not_active Abandoned
- 1999-10-05 AT AT99947744T patent/ATE284387T1/de not_active IP Right Cessation
- 1999-10-05 WO PCT/GB1999/003280 patent/WO2000021927A2/en active IP Right Grant
- 1999-10-06 PE PE1999001014A patent/PE20001093A1/es not_active Application Discontinuation
- 1999-10-06 MA MA25810A patent/MA26697A1/fr unknown
- 1999-10-06 AR ARP990105056A patent/AR020727A1/es unknown
-
2002
- 2002-01-11 HK HK02100210.2A patent/HK1038564A1/zh unknown
Also Published As
Publication number | Publication date |
---|---|
ATE284387T1 (de) | 2004-12-15 |
AU6111699A (en) | 2000-05-01 |
DE69922526T2 (de) | 2005-06-02 |
WO2000021927A3 (en) | 2000-07-13 |
WO2000021927A2 (en) | 2000-04-20 |
EP1119548B1 (de) | 2004-12-08 |
ES2234300T3 (es) | 2005-06-16 |
EP1119548A1 (de) | 2001-08-01 |
HK1038564A1 (zh) | 2002-03-22 |
JP2002527419A (ja) | 2002-08-27 |
PE20001093A1 (es) | 2000-12-22 |
MA26697A1 (fr) | 2004-12-20 |
AR020727A1 (es) | 2002-05-29 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE69922526D1 (de) | 3-(3-chloro-4-hydroxyphenylamino)-4-(2-nitrophenyl)-1h-pyrrol-2,5-dion als glykogen synthase kinase-3 inhibitor (gsk-3) | |
EE04834B1 (et) | Tselekoksiibiühendid | |
AU6895801A (en) | Heterocyclic compounds, which are inhibitors of the enzyme dpp-iv | |
DE60003709D1 (de) | Substituierte azole | |
NL300242I1 (nl) | Mega-carboxyaryl gesubstitueerde difenylureums alsraf kinaseremmers. | |
ATE294805T1 (de) | Triazoloverbindungen als mmp-inhibitoren | |
NO20014593L (no) | Kjemokinreseptor bindende heterocykliske forbindelser | |
DK2020408T3 (da) | Pyrrol-substitueret 2-indolinon som proteinkinaseinhibitor | |
EE200100268A (et) | Asendatud pürasoolid p38 kinaasi inhibiitoritena | |
FI20002822A (fi) | Osoitteen jakaminen | |
NO20025719L (no) | Nye triazolpyrimidinforbindelser | |
DE122010000004I1 (de) | Pyrrol substituierte indolin-2-on protein kinase inhibitoren | |
DE60106252D1 (de) | Substituierte pyprolopyridinonderivate als phosphodiesterase-inhibitoren | |
MA25996A1 (fr) | Inhibiteurs de phosphodiesterase 4. | |
DK1228073T3 (da) | Imidazolforbindelser som phosphodiesterase VII-inhibitorer | |
NO20025659L (no) | Heterocykliske forbindelser | |
AU2001258841A1 (en) | Heterocyclic compounds | |
DE50100739D1 (de) | Drehmaschine | |
DE60122948D1 (de) | Fungizide Zusammensetzungen enthaltend Fludioxonil | |
NO20013713D0 (no) | Anordning ved borekrone | |
DE50107596D1 (de) | Bohrfutter | |
DE60000472D1 (de) | Verdübelungs-Bohrlehre | |
DE50011110D1 (de) | Hebelfutter | |
DE50004496D1 (de) | Spannfutter | |
DE50115282D1 (de) | Schraubwerkzeugeinsatz |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |