PA8802101A1 - Compuestos de 1,2,4-3,5-diona adecuados para el tratamiento de trastornos que responden a la modulación del receptor de dopamina d3 - Google Patents
Compuestos de 1,2,4-3,5-diona adecuados para el tratamiento de trastornos que responden a la modulación del receptor de dopamina d3Info
- Publication number
- PA8802101A1 PA8802101A1 PA20088802101A PA8802101A PA8802101A1 PA 8802101 A1 PA8802101 A1 PA 8802101A1 PA 20088802101 A PA20088802101 A PA 20088802101A PA 8802101 A PA8802101 A PA 8802101A PA 8802101 A1 PA8802101 A1 PA 8802101A1
- Authority
- PA
- Panama
- Prior art keywords
- dopamine
- fluorated
- rented
- compounds
- rent
- Prior art date
Links
- VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 title abstract 6
- 229960003638 dopamine Drugs 0.000 title abstract 3
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 239000002131 composite material Substances 0.000 abstract 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical class [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 2
- 150000002430 hydrocarbons Chemical group 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- XFXPMWWXUTWYJX-UHFFFAOYSA-N Cyanide Chemical group N#[C-] XFXPMWWXUTWYJX-UHFFFAOYSA-N 0.000 abstract 1
- 239000000556 agonist Substances 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical group 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- 229930195734 saturated hydrocarbon Natural products 0.000 abstract 1
- 229930195735 unsaturated hydrocarbon Natural products 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Abstract
COMPUESTO DE LA FÓRMULA I: EN DONDE A ES UNA CADENA HIDROCARBONADA SATURADA O INSATURADA QUE TIENE UNA LONGITUD DE CADENA DE 4 A 6 ÁTOMOS DE CARBONO, DONDE LA CADENA HIDROCARBONADA NO ESTÁ SUSTITUIDA O ESTÁ SUSTITUIDA POR 1, 2 Ó 3 GRUPOS METILO; R1 SE SELECCIONA DEL GRUPO FORMADO POR HIDRÓGENO, C1-C3 ALQUILO Y ALQUILO C1-C3 FLUORADO; R2 ES HIDRÓGENO, HALÓGENO, CIANO, C1-C3 ALCOXI, ALQUILO C1-C3 FLUORADO O ALCOXI C1-C3 FLUORADO; R3 SE SELECCIONA DEL GRUPO FORMADO POR ALQUILO C4-C6 ALQUILO RAMIFICADO Y CICLOALQUILO C3-C6, Y R4 ES ALQUILO C1-C6, CICLOALQUILO C3-C6, ALQUILO C1-C3 FLUORADO Y CICLOALQUILO C3-C6 FLUORADO. Y LAS SALES TOLERABLES PARA USO FISIOLÓGICO DE ESTOS COMPUESTOS Y SUS N-ÓXIDOS. LA INVENCIÓN TAMBIÉN SE RELACIONA CON UNA COMPOSICIÓN FARMACÉUTICA QUE COMPRENDE AL MENOS UN COMPUESTO DE LA FÓRMULA I Y/O AL MENOS UNA SAL DE ADICIÓN ÁCIDA TOLERABLE PARA USO FISIOLÓGICO DEL MISMO, Y ADEMÁS CON UN MÉTODO PARA TRATAR TRASTORNOS QUE RESPONDEN BENEFICIOSAMENTE A ANTAGONISTAS DEL RECEPTOR DE DOPAMINA D3 O AGONISTAS DE DOPAMINA D3, DONDE DICHO MÉTODO COMPRENDE ADMINISTRAR UNA CANTIDAD EFICAZ DE AL MENOS UN COMPUESTO O UNA SAL DE ADICIÓN ÁCIDA TOLERABLE PARA USO FISIOLÓGICO DE LA FÓRMULA I A UN SUJETO QUE LO NECESITA.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07119927 | 2007-11-02 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PA8802101A1 true PA8802101A1 (es) | 2009-08-26 |
Family
ID=40210491
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PA20088802101A PA8802101A1 (es) | 2007-11-02 | 2008-10-29 | Compuestos de 1,2,4-3,5-diona adecuados para el tratamiento de trastornos que responden a la modulación del receptor de dopamina d3 |
Country Status (29)
| Country | Link |
|---|---|
| US (1) | US8492540B2 (es) |
| EP (1) | EP2217593B1 (es) |
| JP (1) | JP5559694B2 (es) |
| KR (1) | KR20100094491A (es) |
| CN (1) | CN101932574B (es) |
| AR (1) | AR069150A1 (es) |
| AT (1) | ATE556069T1 (es) |
| AU (1) | AU2008320814B2 (es) |
| BR (1) | BRPI0818726A2 (es) |
| CA (1) | CA2704533C (es) |
| CL (1) | CL2008003253A1 (es) |
| CO (1) | CO6280473A2 (es) |
| CR (1) | CR11410A (es) |
| DO (1) | DOP2010000126A (es) |
| EC (1) | ECSP10010227A (es) |
| ES (1) | ES2386691T3 (es) |
| HK (1) | HK1146628A1 (es) |
| IL (1) | IL205468A0 (es) |
| MX (1) | MX2010004830A (es) |
| MY (1) | MY154066A (es) |
| NZ (1) | NZ585051A (es) |
| PA (1) | PA8802101A1 (es) |
| PE (1) | PE20090950A1 (es) |
| RU (1) | RU2478633C2 (es) |
| TW (1) | TWI463984B (es) |
| UA (1) | UA99634C2 (es) |
| UY (1) | UY31448A1 (es) |
| WO (1) | WO2009056625A1 (es) |
| ZA (1) | ZA201003593B (es) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014025993A1 (en) * | 2012-08-08 | 2014-02-13 | The Johns Hopkins University | Inhibitors of d-amino acid oxidase |
| US9376396B2 (en) | 2012-10-22 | 2016-06-28 | AbbVie Deutschland GmbH & Co. KG | Acylaminocycloalkyl compounds suitable for treating disorders that respond to modulation of dopamine D3 receptor |
| AR095264A1 (es) | 2013-03-15 | 2015-09-30 | Abbvie Deutschland | Compuestos de acilaminocicloalquilo apropiados para tratar trastornos que responden a la modulación del receptor de dopamina d3 |
| UY35420A (es) | 2013-03-15 | 2014-10-31 | Abbvie Inc | Compuestos de acilaminocicloalquilo apropiados para tratar trastornos que responden a la modulación del receptor de dopamina d3 |
| KR102643833B1 (ko) | 2022-06-30 | 2024-03-06 | 현대제철 주식회사 | 이강종 연연주시 강종 예측 정합성 증대 방법 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4425143A1 (de) | 1994-07-15 | 1996-01-18 | Basf Ag | Substituierte Pyrimidinverbindungen und deren Verwendung |
| DE4425144A1 (de) | 1994-07-15 | 1996-01-18 | Basf Ag | Triazolverbindungen und deren Verwendung |
| DE4425146A1 (de) | 1994-07-15 | 1996-01-18 | Basf Ag | Verwendung heterocyclischer Verbindungen |
| FR2727682A1 (fr) * | 1994-12-02 | 1996-06-07 | Pf Medicament | Nouveaux derives de 3,5-dioxo-(2h,4h)-1,2,4-triazines, leur preparation et leur application a titre de medicament |
| DE19728996A1 (de) | 1997-07-07 | 1999-01-14 | Basf Ag | Triazolverbindungen und deren Verwendung |
| FR2769913B1 (fr) * | 1997-10-16 | 2000-03-10 | Pf Medicament | Nouveaux derives cyclohexaniques difonctionnalises en 1, 4, leur preparation et leur application therapeutique humaine |
| DE10311065A1 (de) | 2003-03-13 | 2004-09-23 | Abbott Gmbh & Co. Kg | Pyrimidin-2-on-Verbindungen und ihre therapeutische Verwendung |
| TW200510395A (en) | 2003-06-05 | 2005-03-16 | Abbott Gmbh & Co Kg | Triazole compounds suitable for treating disorders that respond to modulation of the dopamine D3 receptor |
| DE102004027358A1 (de) | 2004-06-04 | 2005-12-29 | Abbott Gmbh & Co. Kg | Pyrimidinverbindungen und ihre Verwendung |
| DE102004027359A1 (de) | 2004-06-04 | 2005-12-29 | Abbott Gmbh & Co. Kg | Pyridin-2-onverbindungen und deren Verwendung |
| JP4904267B2 (ja) * | 2004-08-09 | 2012-03-28 | アボット ゲーエムベーハー ウント カンパニー カーゲー | ドーパミンｄ３受容体の調節に応答する障害の治療に好適な４−ピペラジニル−ピリミジン化合物 |
| CN101384263A (zh) | 2004-12-02 | 2009-03-11 | 艾博特股份有限两合公司 | 适合治疗对多巴胺d3受体调节产生反应的疾病的***化合物 |
| DE102004061593A1 (de) | 2004-12-21 | 2006-06-22 | Abbott Gmbh & Co. Kg | Substituierte N-heterocyclische Verbindungen und ihre therapeutische Verwendung |
| NZ582249A (en) * | 2007-06-28 | 2012-06-29 | Intervet Int Bv | Substituted piperazines as cb1 antagonists |
-
2008
- 2008-10-29 PA PA20088802101A patent/PA8802101A1/es unknown
- 2008-10-30 CL CL2008003253A patent/CL2008003253A1/es unknown
- 2008-10-30 TW TW097141858A patent/TWI463984B/zh not_active IP Right Cessation
- 2008-10-31 BR BRPI0818726 patent/BRPI0818726A2/pt not_active IP Right Cessation
- 2008-10-31 KR KR1020107011975A patent/KR20100094491A/ko not_active Application Discontinuation
- 2008-10-31 UY UY31448A patent/UY31448A1/es not_active Application Discontinuation
- 2008-10-31 ES ES08844723T patent/ES2386691T3/es active Active
- 2008-10-31 RU RU2010122337/04A patent/RU2478633C2/ru not_active IP Right Cessation
- 2008-10-31 MX MX2010004830A patent/MX2010004830A/es active IP Right Grant
- 2008-10-31 AT AT08844723T patent/ATE556069T1/de active
- 2008-10-31 PE PE2008001865A patent/PE20090950A1/es not_active Application Discontinuation
- 2008-10-31 EP EP08844723A patent/EP2217593B1/en active Active
- 2008-10-31 NZ NZ585051A patent/NZ585051A/en not_active IP Right Cessation
- 2008-10-31 AU AU2008320814A patent/AU2008320814B2/en not_active Ceased
- 2008-10-31 UA UAA201006793A patent/UA99634C2/ru unknown
- 2008-10-31 AR ARP080104789A patent/AR069150A1/es unknown
- 2008-10-31 US US12/740,714 patent/US8492540B2/en active Active
- 2008-10-31 JP JP2010531532A patent/JP5559694B2/ja not_active Expired - Fee Related
- 2008-10-31 WO PCT/EP2008/064795 patent/WO2009056625A1/en active Application Filing
- 2008-10-31 CN CN200880124247.7A patent/CN101932574B/zh not_active Expired - Fee Related
- 2008-10-31 CA CA2704533A patent/CA2704533C/en not_active Expired - Fee Related
- 2008-10-31 MY MYPI2010001969A patent/MY154066A/en unknown
-
2010
- 2010-04-29 DO DO2010000126A patent/DOP2010000126A/es unknown
- 2010-04-29 IL IL205468A patent/IL205468A0/en unknown
- 2010-05-03 CR CR11410A patent/CR11410A/es unknown
- 2010-05-20 ZA ZA2010/03593A patent/ZA201003593B/en unknown
- 2010-06-01 EC EC2010010227A patent/ECSP10010227A/es unknown
- 2010-06-01 CO CO10065792A patent/CO6280473A2/es active IP Right Grant
-
2011
- 2011-01-25 HK HK11100717.9A patent/HK1146628A1/xx not_active IP Right Cessation
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