OA12316A - 3-Aminoquinazolin-2,4-dione antibacterial agents. - Google Patents

3-Aminoquinazolin-2,4-dione antibacterial agents. Download PDF

Info

Publication number: OA12316A
Authority: OA; OAPI
Prior art keywords: amino; dione; cyclopropyl; fluoro; quinazoline
Prior art date: 2000-01-24

Application number

OA1200200210A

Other languages

English (en)

Inventor

Paul Bird

Edmund Lee Ellsworth

Dai Quoc Nguyen

Joseph Peter Sanchez

Howard Daniel Hollis Showalter

Rajeshwar Singh

Michael Andrew Stier

Tuan Phong Tran

Brian Morgan Watson

Judy Yip

Original Assignee

Warner Lambert Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-01-24

Filing date

2000-12-12

Publication date

2006-05-15

2000-12-12 Application filed by Warner Lambert Co filed Critical Warner Lambert Co

2006-05-15 Publication of OA12316A publication Critical patent/OA12316A/en

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
- C07D239/96—Two oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Oncology (AREA)
Pharmacology & Pharmacy (AREA)
Communicable Diseases (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Veterinary Medicine (AREA)
Virology (AREA)
Molecular Biology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Paper (AREA)

OA1200200210A 2000-01-24 2000-12-12 3-Aminoquinazolin-2,4-dione antibacterial agents. OA12316A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US17825200P	2000-01-24	2000-01-24
US24126700P	2000-10-18	2000-10-18

Publications (1)

Publication Number	Publication Date
OA12316A true OA12316A (en)	2006-05-15

Family

ID=26874138

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
OA1200200210A OA12316A (en)	2000-01-24	2000-12-12	3-Aminoquinazolin-2,4-dione antibacterial agents.

Country Status (38)

Country	Link
US (2)	US7094780B1 (no)
EP (1)	EP1255739B1 (no)
JP (1)	JP4811978B2 (no)
KR (1)	KR20020067701A (no)
CN (1)	CN1425008A (no)
AP (1)	AP2002002603A0 (no)
AR (1)	AR030186A1 (no)
AT (1)	ATE398110T1 (no)
AU (1)	AU783078B2 (no)
BG (1)	BG107023A (no)
BR (1)	BR0017010A (no)
CA (1)	CA2393802C (no)
CO (1)	CO5320600A1 (no)
CR (1)	CR6709A (no)
DE (1)	DE60039194D1 (no)
EA (1)	EA005585B1 (no)
EE (1)	EE200200412A (no)
ES (1)	ES2304992T3 (no)
GE (1)	GEP20053429B (no)
HK (1)	HK1054237A1 (no)
HN (1)	HN2001000009A (no)
HR (1)	HRP20020696A2 (no)
HU (1)	HUP0204101A3 (no)
IL (1)	IL150393A0 (no)
IS (1)	IS6448A (no)
MA (1)	MA26866A1 (no)
MX (1)	MXPA02005989A (no)
NO (1)	NO20023516D0 (no)
OA (1)	OA12316A (no)
PA (1)	PA8510101A1 (no)
PE (1)	PE20011060A1 (no)
PL (1)	PL356837A1 (no)
SK (1)	SK10572002A3 (no)
SV (1)	SV2001000288A (no)
TN (1)	TNSN01011A1 (no)
UY (1)	UY26551A1 (no)
WO (1)	WO2001053273A1 (no)
YU (1)	YU55902A (no)

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SK286420B6 (sk)	1997-09-15	2008-09-05	The Procter & Gamble Company	Zlúčenina so štruktúrou chinolónu, farmaceutický prostriedok s jej obsahom a jej použitie
MXPA03010799A (es)	2001-05-30	2005-07-25	Warner Lambert Co	Agentes antibacterianos.
EP1401830A2 (en) *	2001-06-19	2004-03-31	Warner-Lambert Company LLC	Quinazolinediones as antibacterial agents
US6900224B2 (en) *	2002-07-31	2005-05-31	The Procter & Gamble Company	Antimicrobial quinolones, their compositions and uses
WO2005026154A1 (en) *	2003-09-12	2005-03-24	Warner-Lambert Company Llc	Quinolone antibacterial agents
WO2005026153A1 (en) *	2003-09-12	2005-03-24	Warner-Lambert Company Llc	Quinazoline-2, 4-diones as antibacterial agents
MXPA06005550A (es) *	2003-11-18	2006-08-17	Warner Lambert Co	Agentes antibacterianos.
WO2006019965A2 (en) *	2004-07-16	2006-02-23	Takeda San Diego, Inc.	Dipeptidyl peptidase inhibitors
GB0416730D0 (en)	2004-07-27	2004-09-01	Novartis Ag	Organic compounds
RU2007126951A (ru) *	2005-01-26	2009-03-10	Ф.Хоффманн-Ля Рош Аг (Ch)	Производные фенилметанона и их применение в качестве ингибиторов переносчика глицина 1
GB0507298D0 (en) *	2005-04-11	2005-05-18	Novartis Ag	Organic compounds
US7977346B2 (en)	2006-01-17	2011-07-12	Guoqing Paul Chen	Spiro compounds and methods of use
CA2647454A1 (en)	2006-03-28	2007-10-04	The Procter & Gamble Company	A coupling process for preparing quinolone intermediates
BRPI0709772B8 (pt)	2006-03-28	2021-05-25	The Protecter & Gamble Company	sais de malato e polimorfos do ácido (3s,5s)-7-[3-amino-5-metil-piperidinil]-1-ciclopropil-1,4-diidro-8-metóxi-4-oxo-3-quinolinocarboxílico
US20080139574A1 (en)	2006-11-30	2008-06-12	Cadila Healthcare Limited	Novel quinoline derivatives
MY153733A (en) *	2008-01-30	2015-03-13	Shin Poong Pharmaceutical Co	Novel quinazoline-2,4-dione derivative, and medical compositions for the prophylaxis and treatment of cranial nerve disease containing the same
WO2011031745A1 (en)	2009-09-09	2011-03-17	Achaogen, Inc.	Antibacterial fluoroquinolone analogs
US8754114B2 (en)	2010-12-22	2014-06-17	Incyte Corporation	Substituted imidazopyridazines and benzimidazoles as inhibitors of FGFR3
CN103562208B (zh)	2011-03-15	2016-08-31	默沙东公司	三环促旋酶抑制剂
JP6075736B2 (ja) *	2011-12-21	2017-02-08	ジエンスヘンルイメデイシンカンパニーリミテッドＪｉａｎｇｓｕＨｅｎｇｒｕｉＭｅｄｉｃｉｎｅＣｏ．，Ｌｔｄ．	ピロール−６員ヘテロアリール環誘導体、その合成法およびその医薬用途
PT3176170T (pt)	2012-06-13	2019-02-05	Incyte Holdings Corp	Compostos tricíclicos substituídos como inibidores de fgfr
WO2014026125A1 (en)	2012-08-10	2014-02-13	Incyte Corporation	Pyrazine derivatives as fgfr inhibitors
EP2895488A1 (en)	2012-09-12	2015-07-22	Trius Therapeutics, Inc.	Tricyclic gyrase inhibitors for use as antibacterial agents
US9266892B2 (en)	2012-12-19	2016-02-23	Incyte Holdings Corporation	Fused pyrazoles as FGFR inhibitors
SG10201708520YA (en)	2013-04-19	2017-12-28	Incyte Corp	Bicyclic heterocycles as fgfr inhibitors
US10851105B2 (en)	2014-10-22	2020-12-01	Incyte Corporation	Bicyclic heterocycles as FGFR4 inhibitors
WO2016134294A1 (en)	2015-02-20	2016-08-25	Incyte Corporation	Bicyclic heterocycles as fgfr4 inhibitors
TWI712601B (zh)	2015-02-20	2020-12-11	美商英塞特公司	作為fgfr抑制劑之雙環雜環
MA41551A (fr)	2015-02-20	2017-12-26	Incyte Corp	Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4
CN108530448A (zh) *	2017-03-02	2018-09-14	浙江司太立制药股份有限公司	含有碱性氮杂螺环片段的苯并噻嗪-4-酮类化合物及其制备方法
AR111960A1 (es)	2017-05-26	2019-09-04	Incyte Corp	Formas cristalinas de un inhibidor de fgfr y procesos para su preparación
US11466004B2 (en)	2018-05-04	2022-10-11	Incyte Corporation	Solid forms of an FGFR inhibitor and processes for preparing the same
MA52493A (fr)	2018-05-04	2021-03-10	Incyte Corp	Sels d'un inhibiteur de fgfr
CN111620866A (zh) *	2019-02-27	2020-09-04	南京药石科技股份有限公司	一种顺式-7,7-二氟-六氢-1H 吡咯并[3,4-c]吡啶衍生物及其制备方法
US11628162B2 (en)	2019-03-08	2023-04-18	Incyte Corporation	Methods of treating cancer with an FGFR inhibitor
US11591329B2 (en)	2019-07-09	2023-02-28	Incyte Corporation	Bicyclic heterocycles as FGFR inhibitors
CA3157361A1 (en)	2019-10-14	2021-04-22	Incyte Corporation	Bicyclic heterocycles as fgfr inhibitors
US11566028B2 (en)	2019-10-16	2023-01-31	Incyte Corporation	Bicyclic heterocycles as FGFR inhibitors
BR112022010664A2 (pt)	2019-12-04	2022-08-16	Incyte Corp	Derivados de um inibidor de fgfr
JP2023505258A (ja)	2019-12-04	2023-02-08	インサイト・コーポレイション	Ｆｇｆｒ阻害剤としての三環式複素環
CN111499513B (zh) *	2020-04-24	2023-03-14	上海毕得医药科技股份有限公司	一种2,3,4,5-四溴苯甲酸酯的合成方法
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DE1068263B (no) *		1959-11-05
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EP0035619B1 (fr) *	1980-03-10	1984-07-25	BERRI-BALZAC Société dite:	Dérivés d'amino-3 (1H,3H) quinazolinedione-2,4
GB2097784A (en) *	1981-04-28	1982-11-10	Davidson Dr John Stirton	Dihydrobenzotriazepine diones; aminoquinazoline diones
AU5813394A (en)	1992-12-23	1994-07-19	Byk Gulden Lomberg Chemische Fabrik Gmbh	Anellated uracil derivates
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CN1138778C (zh) *	1998-05-26	2004-02-18	沃尼尔·朗伯公司	用作细胞增殖抑制剂的二环嘧啶及二环3,4-二氢嘧啶化合物及用途
EP1137640B1 (en) *	1998-12-11	2005-09-21	F. Hoffmann-La Roche Ag	Cyclic hydrazine derivatives as tnf-alpha inhibitors

2000
- 2000-12-12 MX MXPA02005989A patent/MXPA02005989A/es active IP Right Grant
- 2000-12-12 BR BR0017010-0A patent/BR0017010A/pt not_active Application Discontinuation
- 2000-12-12 EA EA200200661A patent/EA005585B1/ru not_active IP Right Cessation
- 2000-12-12 CA CA2393802A patent/CA2393802C/en not_active Expired - Fee Related
- 2000-12-12 AP APAP/P/2002/002603A patent/AP2002002603A0/en unknown
- 2000-12-12 SK SK1057-2002A patent/SK10572002A3/sk unknown
- 2000-12-12 JP JP2001553275A patent/JP4811978B2/ja not_active Expired - Fee Related
- 2000-12-12 AU AU20899/01A patent/AU783078B2/en not_active Ceased
- 2000-12-12 HU HU0204101A patent/HUP0204101A3/hu unknown
- 2000-12-12 US US10/182,221 patent/US7094780B1/en not_active Expired - Fee Related
- 2000-12-12 EP EP00984246A patent/EP1255739B1/en not_active Expired - Lifetime
- 2000-12-12 WO PCT/US2000/033656 patent/WO2001053273A1/en active Search and Examination
- 2000-12-12 DE DE60039194T patent/DE60039194D1/de not_active Expired - Lifetime
- 2000-12-12 KR KR1020027009515A patent/KR20020067701A/ko not_active Application Discontinuation
- 2000-12-12 PL PL00356837A patent/PL356837A1/xx not_active Application Discontinuation
- 2000-12-12 AT AT00984246T patent/ATE398110T1/de not_active IP Right Cessation
- 2000-12-12 YU YU55902A patent/YU55902A/sh unknown
- 2000-12-12 GE GE4912A patent/GEP20053429B/en unknown
- 2000-12-12 OA OA1200200210A patent/OA12316A/en unknown
- 2000-12-12 ES ES00984246T patent/ES2304992T3/es not_active Expired - Lifetime
- 2000-12-12 CN CN00818578A patent/CN1425008A/zh active Pending
- 2000-12-12 EE EEP200200412A patent/EE200200412A/xx unknown
- 2000-12-12 IL IL15039300A patent/IL150393A0/xx unknown
2001
- 2001-01-19 PA PA20018510101A patent/PA8510101A1/es unknown
- 2001-01-22 UY UY26551A patent/UY26551A1/es not_active Application Discontinuation
- 2001-01-22 PE PE2001000066A patent/PE20011060A1/es not_active Application Discontinuation
- 2001-01-22 TN TNTNSN01011A patent/TNSN01011A1/en unknown
- 2001-01-22 HN HN2001000009A patent/HN2001000009A/es unknown
- 2001-01-22 SV SV2001000288A patent/SV2001000288A/es not_active Application Discontinuation
- 2001-01-22 CO CO01004183A patent/CO5320600A1/es not_active Application Discontinuation
- 2001-01-23 AR ARP010100278A patent/AR030186A1/es unknown
2002
- 2002-06-27 IS IS6448A patent/IS6448A/is unknown
- 2002-07-19 CR CR6709A patent/CR6709A/es not_active Application Discontinuation
- 2002-07-22 MA MA26734A patent/MA26866A1/fr unknown
- 2002-07-23 NO NO20023516A patent/NO20023516D0/no not_active Application Discontinuation
- 2002-08-22 BG BG107023A patent/BG107023A/xx unknown
- 2002-08-23 HR HR20020696A patent/HRP20020696A2/hr not_active Application Discontinuation
2003
- 2003-09-11 HK HK03106519.6A patent/HK1054237A1/zh unknown
2006
- 2006-06-13 US US11/452,121 patent/US7582627B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
EA200200661A1 (ru)	2003-02-27
MA26866A1 (fr)	2004-12-20
US20060183762A1 (en)	2006-08-17
JP2003520277A (ja)	2003-07-02
UY26551A1 (es)	2001-04-30
KR20020067701A (ko)	2002-08-23
AP2002002603A0 (en)	2002-09-30
PE20011060A1 (es)	2001-10-12
CO5320600A1 (es)	2003-09-30
CA2393802A1 (en)	2001-07-26
US20060287308A1 (en)	2006-12-21
EP1255739A1 (en)	2002-11-13
PA8510101A1 (es)	2003-06-30
HN2001000009A (es)	2001-06-13
CR6709A (es)	2003-11-25
EA005585B1 (ru)	2005-04-28
BR0017010A (pt)	2002-11-05
GEP20053429B (en)	2005-01-25
CA2393802C (en)	2011-04-19
CN1425008A (zh)	2003-06-18
SV2001000288A (es)	2001-11-30
YU55902A (sh)	2006-01-16
AU783078B2 (en)	2005-09-22
TNSN01011A1 (en)	2005-11-10
BG107023A (en)	2003-04-30
NO20023516L (no)	2002-07-23
NO20023516D0 (no)	2002-07-23
EP1255739B1 (en)	2008-06-11
MXPA02005989A (es)	2002-10-23
HRP20020696A2 (en)	2003-12-31
PL356837A1 (en)	2004-07-12
DE60039194D1 (de)	2008-07-24
IS6448A (is)	2002-06-27
AR030186A1 (es)	2003-08-13
US7094780B1 (en)	2006-08-22
EE200200412A (et)	2003-10-15
ATE398110T1 (de)	2008-07-15
AU2089901A (en)	2001-07-31
HUP0204101A3 (en)	2004-05-28
IL150393A0 (en)	2002-12-01
HK1054237A1 (zh)	2003-11-21
SK10572002A3 (sk)	2003-10-07
HUP0204101A2 (hu)	2003-04-28
US7582627B2 (en)	2009-09-01
JP4811978B2 (ja)	2011-11-09
ES2304992T3 (es)	2008-11-01
WO2001053273A1 (en)	2001-07-26

Publication	Publication Date	Title
OA12316A (en)	2006-05-15	3-Aminoquinazolin-2,4-dione antibacterial agents.
JPH0819099B2 (ja)	1996-02-28	アザビシクロキノロンカルボン酸化合物製造用中間体
EP1028950B1 (en)	2003-05-02	7-substituted quinazolin-2,4-diones useful as antibacterial agents
WO2015089143A1 (en)	2015-06-18	Imidazopyridazine compounds useful as modulators of il-12, il-23 and/or ifn alpha responses
JP2003026574A (ja)	2003-01-29	抗バクテリア剤
NZ205529A (en)	1986-05-09	Heterocyclic derivatives as antibacterial agents and intermediates
AU748749B2 (en)	2002-06-13	Isoquinolones
CA2446963A1 (en)	2002-12-27	Quinazolinediones as antibacterial agents
NZ243214A (en)	1995-07-26	7-isoindolino-quinolone and naphthyridonecarboxylic acid derivatives and pharmaceutical compositions
CZ190393A3 (en)	1994-04-13	Derivatives of 7-isoindolinylquinoline and 7-isoindolinylnaphthhydridone
JPS61243077A (ja)	1986-10-29	抗菌剤
HU219581B (hu)	2001-05-28	Új piridon-karbonsav-származékok, eljárás előállításukra, ezeket tartalmazó gyógyszerkészítmények, valamint intermedierek
EP0362759A1 (en)	1990-04-11	Pyridonecarboxylic acids
US20030114666A1 (en)	2003-06-19	Antibacterial agents
WO1995021163A1 (fr)	1995-08-10	Derive d'acide pyridonecarboxylique substitue par un groupe amino bicyclique, ester et sel de celui-ci, et amine bicyclique utilisee en tant qu'intermediaire pour celui-ci
US5605910A (en)	1997-02-25	Quinolone-and naphthyridonecarboxylic acid derivatives
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