ATE398110T1 - 3-aminochinazolin-2,4-dione als antibakterielle mittel - Google Patents

3-aminochinazolin-2,4-dione als antibakterielle mittel

Info

Publication number
ATE398110T1
ATE398110T1 AT00984246T AT00984246T ATE398110T1 AT E398110 T1 ATE398110 T1 AT E398110T1 AT 00984246 T AT00984246 T AT 00984246T AT 00984246 T AT00984246 T AT 00984246T AT E398110 T1 ATE398110 T1 AT E398110T1
Authority
AT
Austria
Prior art keywords
aminoquinazoline
dione
antibacterial agent
antibacterial
agent
Prior art date
Application number
AT00984246T
Other languages
English (en)
Inventor
Paul Bird
Edmund Ellsworth
Dai Nguyen
Joseph SANCHEZ
Howard Showalter
Rajeshwar Singh
Michael STIER
Tuan Tran
Brian Watson
Judy Yip
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Application granted granted Critical
Publication of ATE398110T1 publication Critical patent/ATE398110T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
    • C07D239/96—Two oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Paper (AREA)
AT00984246T 2000-01-24 2000-12-12 3-aminochinazolin-2,4-dione als antibakterielle mittel ATE398110T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US17825200P 2000-01-24 2000-01-24
US24126700P 2000-10-18 2000-10-18

Publications (1)

Publication Number Publication Date
ATE398110T1 true ATE398110T1 (de) 2008-07-15

Family

ID=26874138

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00984246T ATE398110T1 (de) 2000-01-24 2000-12-12 3-aminochinazolin-2,4-dione als antibakterielle mittel

Country Status (38)

Country Link
US (2) US7094780B1 (de)
EP (1) EP1255739B1 (de)
JP (1) JP4811978B2 (de)
KR (1) KR20020067701A (de)
CN (1) CN1425008A (de)
AP (1) AP2002002603A0 (de)
AR (1) AR030186A1 (de)
AT (1) ATE398110T1 (de)
AU (1) AU783078B2 (de)
BG (1) BG107023A (de)
BR (1) BR0017010A (de)
CA (1) CA2393802C (de)
CO (1) CO5320600A1 (de)
CR (1) CR6709A (de)
DE (1) DE60039194D1 (de)
EA (1) EA005585B1 (de)
EE (1) EE200200412A (de)
ES (1) ES2304992T3 (de)
GE (1) GEP20053429B (de)
HK (1) HK1054237A1 (de)
HN (1) HN2001000009A (de)
HR (1) HRP20020696A2 (de)
HU (1) HUP0204101A3 (de)
IL (1) IL150393A0 (de)
IS (1) IS6448A (de)
MA (1) MA26866A1 (de)
MX (1) MXPA02005989A (de)
NO (1) NO20023516D0 (de)
OA (1) OA12316A (de)
PA (1) PA8510101A1 (de)
PE (1) PE20011060A1 (de)
PL (1) PL356837A1 (de)
SK (1) SK10572002A3 (de)
SV (1) SV2001000288A (de)
TN (1) TNSN01011A1 (de)
UY (1) UY26551A1 (de)
WO (1) WO2001053273A1 (de)
YU (1) YU55902A (de)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SK286420B6 (sk) 1997-09-15 2008-09-05 The Procter & Gamble Company Zlúčenina so štruktúrou chinolónu, farmaceutický prostriedok s jej obsahom a jej použitie
MXPA03010799A (es) 2001-05-30 2005-07-25 Warner Lambert Co Agentes antibacterianos.
EP1401830A2 (de) * 2001-06-19 2004-03-31 Warner-Lambert Company LLC Chinazolindione als antibakterielle mittel
US6900224B2 (en) * 2002-07-31 2005-05-31 The Procter & Gamble Company Antimicrobial quinolones, their compositions and uses
WO2005026154A1 (en) * 2003-09-12 2005-03-24 Warner-Lambert Company Llc Quinolone antibacterial agents
WO2005026153A1 (en) * 2003-09-12 2005-03-24 Warner-Lambert Company Llc Quinazoline-2, 4-diones as antibacterial agents
MXPA06005550A (es) * 2003-11-18 2006-08-17 Warner Lambert Co Agentes antibacterianos.
WO2006019965A2 (en) * 2004-07-16 2006-02-23 Takeda San Diego, Inc. Dipeptidyl peptidase inhibitors
GB0416730D0 (en) 2004-07-27 2004-09-01 Novartis Ag Organic compounds
RU2007126951A (ru) * 2005-01-26 2009-03-10 Ф.Хоффманн-Ля Рош Аг (Ch) Производные фенилметанона и их применение в качестве ингибиторов переносчика глицина 1
GB0507298D0 (en) * 2005-04-11 2005-05-18 Novartis Ag Organic compounds
US7977346B2 (en) 2006-01-17 2011-07-12 Guoqing Paul Chen Spiro compounds and methods of use
CA2647454A1 (en) 2006-03-28 2007-10-04 The Procter & Gamble Company A coupling process for preparing quinolone intermediates
BRPI0709772B8 (pt) 2006-03-28 2021-05-25 The Protecter & Gamble Company sais de malato e polimorfos do ácido (3s,5s)-7-[3-amino-5-metil-piperidinil]-1-ciclopropil-1,4-diidro-8-metóxi-4-oxo-3-quinolinocarboxílico
US20080139574A1 (en) 2006-11-30 2008-06-12 Cadila Healthcare Limited Novel quinoline derivatives
MY153733A (en) * 2008-01-30 2015-03-13 Shin Poong Pharmaceutical Co Novel quinazoline-2,4-dione derivative, and medical compositions for the prophylaxis and treatment of cranial nerve disease containing the same
WO2011031745A1 (en) 2009-09-09 2011-03-17 Achaogen, Inc. Antibacterial fluoroquinolone analogs
US8754114B2 (en) 2010-12-22 2014-06-17 Incyte Corporation Substituted imidazopyridazines and benzimidazoles as inhibitors of FGFR3
CN103562208B (zh) 2011-03-15 2016-08-31 默沙东公司 三环促旋酶抑制剂
JP6075736B2 (ja) * 2011-12-21 2017-02-08 ジエンス ヘンルイ メデイシンカンパニー リミテッドＪｉａｎｇｓｕ Ｈｅｎｇｒｕｉ Ｍｅｄｉｃｉｎｅ Ｃｏ．，Ｌｔｄ． ピロール−６員ヘテロアリール環誘導体、その合成法およびその医薬用途
PT3176170T (pt) 2012-06-13 2019-02-05 Incyte Holdings Corp Compostos tricíclicos substituídos como inibidores de fgfr
WO2014026125A1 (en) 2012-08-10 2014-02-13 Incyte Corporation Pyrazine derivatives as fgfr inhibitors
EP2895488A1 (de) 2012-09-12 2015-07-22 Trius Therapeutics, Inc. Tricyclische gyrase-inhibitoren zur verwendung als antibakterielle wirkstoffe
US9266892B2 (en) 2012-12-19 2016-02-23 Incyte Holdings Corporation Fused pyrazoles as FGFR inhibitors
SG10201708520YA (en) 2013-04-19 2017-12-28 Incyte Corp Bicyclic heterocycles as fgfr inhibitors
US10851105B2 (en) 2014-10-22 2020-12-01 Incyte Corporation Bicyclic heterocycles as FGFR4 inhibitors
WO2016134294A1 (en) 2015-02-20 2016-08-25 Incyte Corporation Bicyclic heterocycles as fgfr4 inhibitors
TWI712601B (zh) 2015-02-20 2020-12-11 美商英塞特公司 作為fgfr抑制劑之雙環雜環
MA41551A (fr) 2015-02-20 2017-12-26 Incyte Corp Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4
CN108530448A (zh) * 2017-03-02 2018-09-14 浙江司太立制药股份有限公司 含有碱性氮杂螺环片段的苯并噻嗪-4-酮类化合物及其制备方法
AR111960A1 (es) 2017-05-26 2019-09-04 Incyte Corp Formas cristalinas de un inhibidor de fgfr y procesos para su preparación
US11466004B2 (en) 2018-05-04 2022-10-11 Incyte Corporation Solid forms of an FGFR inhibitor and processes for preparing the same
MA52493A (fr) 2018-05-04 2021-03-10 Incyte Corp Sels d'un inhibiteur de fgfr
CN111620866A (zh) * 2019-02-27 2020-09-04 南京药石科技股份有限公司 一种顺式-7,7-二氟-六氢-1H 吡咯并[3,4-c]吡啶衍生物及其制备方法
US11628162B2 (en) 2019-03-08 2023-04-18 Incyte Corporation Methods of treating cancer with an FGFR inhibitor
US11591329B2 (en) 2019-07-09 2023-02-28 Incyte Corporation Bicyclic heterocycles as FGFR inhibitors
CA3157361A1 (en) 2019-10-14 2021-04-22 Incyte Corporation Bicyclic heterocycles as fgfr inhibitors
US11566028B2 (en) 2019-10-16 2023-01-31 Incyte Corporation Bicyclic heterocycles as FGFR inhibitors
BR112022010664A2 (pt) 2019-12-04 2022-08-16 Incyte Corp Derivados de um inibidor de fgfr
JP2023505258A (ja) 2019-12-04 2023-02-08 インサイト・コーポレイション Ｆｇｆｒ阻害剤としての三環式複素環
CN111499513B (zh) * 2020-04-24 2023-03-14 上海毕得医药科技股份有限公司 一种2,3,4,5-四溴苯甲酸酯的合成方法
EP4352059A1 (de) 2021-06-09 2024-04-17 Incyte Corporation Tricyclische heterocyclen als fgfr-inhibitoren

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1068263B (de) * 1959-11-05
NL80851C (de) * 1958-02-25 1956-03-15
EP0035619B1 (de) * 1980-03-10 1984-07-25 BERRI-BALZAC Société dite: 3-Amino-(1H,3H)-2,4-chinazolindionderivate
GB2097784A (en) * 1981-04-28 1982-11-10 Davidson Dr John Stirton Dihydrobenzotriazepine diones; aminoquinazoline diones
AU5813394A (en) 1992-12-23 1994-07-19 Byk Gulden Lomberg Chemische Fabrik Gmbh Anellated uracil derivates
WO1998018781A2 (en) 1996-10-28 1998-05-07 Versicor, Inc. Fused 2,4-pyrimidinedione combinatorial libraries, their preparation and the use of fused 2,4-pyrimidinediones derivatives as antimicrobial agents
US6331538B1 (en) 1997-10-28 2001-12-18 Warner-Lambert Company 7-substituted quinazolin-2,4-diones useful as antibacterial agents
CN1138778C (zh) * 1998-05-26 2004-02-18 沃尼尔·朗伯公司 用作细胞增殖抑制剂的二环嘧啶及二环3,4-二氢嘧啶化合物及用途
EP1137640B1 (de) * 1998-12-11 2005-09-21 F. Hoffmann-La Roche Ag Zyklische hydrazinderivate als tnf-alpha inhibitoren

Also Published As

Publication number Publication date
EA200200661A1 (ru) 2003-02-27
MA26866A1 (fr) 2004-12-20
US20060183762A1 (en) 2006-08-17
JP2003520277A (ja) 2003-07-02
UY26551A1 (es) 2001-04-30
KR20020067701A (ko) 2002-08-23
AP2002002603A0 (en) 2002-09-30
PE20011060A1 (es) 2001-10-12
CO5320600A1 (es) 2003-09-30
CA2393802A1 (en) 2001-07-26
US20060287308A1 (en) 2006-12-21
EP1255739A1 (de) 2002-11-13
PA8510101A1 (es) 2003-06-30
HN2001000009A (es) 2001-06-13
CR6709A (es) 2003-11-25
EA005585B1 (ru) 2005-04-28
BR0017010A (pt) 2002-11-05
GEP20053429B (en) 2005-01-25
CA2393802C (en) 2011-04-19
CN1425008A (zh) 2003-06-18
SV2001000288A (es) 2001-11-30
YU55902A (sh) 2006-01-16
AU783078B2 (en) 2005-09-22
TNSN01011A1 (en) 2005-11-10
BG107023A (en) 2003-04-30
NO20023516L (no) 2002-07-23
NO20023516D0 (no) 2002-07-23
EP1255739B1 (de) 2008-06-11
MXPA02005989A (es) 2002-10-23
HRP20020696A2 (en) 2003-12-31
PL356837A1 (en) 2004-07-12
DE60039194D1 (de) 2008-07-24
IS6448A (is) 2002-06-27
AR030186A1 (es) 2003-08-13
US7094780B1 (en) 2006-08-22
EE200200412A (et) 2003-10-15
AU2089901A (en) 2001-07-31
HUP0204101A3 (en) 2004-05-28
IL150393A0 (en) 2002-12-01
HK1054237A1 (zh) 2003-11-21
SK10572002A3 (sk) 2003-10-07
HUP0204101A2 (hu) 2003-04-28
OA12316A (en) 2006-05-15
US7582627B2 (en) 2009-09-01
JP4811978B2 (ja) 2011-11-09
ES2304992T3 (es) 2008-11-01
WO2001053273A1 (en) 2001-07-26

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