OA09482A - "Nouveaux dérivés à structure naphtalénique, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent". - Google Patents
"Nouveaux dérivés à structure naphtalénique, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent".Info
- Publication number
- OA09482A OA09482A OA59957A OA59957A OA09482A OA 09482 A OA09482 A OA 09482A OA 59957 A OA59957 A OA 59957A OA 59957 A OA59957 A OA 59957A OA 09482 A OA09482 A OA 09482A
- Authority
- OA
- OAPI
- Prior art keywords
- lower alkyl
- contain
- pharmaceutical compositions
- preparation process
- aryl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/15—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C217/56—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms
- C07C217/60—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms linked by carbon chains having two carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
- C07C233/17—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/22—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to an acyclic carbon atom of a carbon skeleton containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/57—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings
- C07C233/60—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
- C07C233/67—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
- C07C233/68—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/73—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom of a carbon skeleton containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
- C07C237/08—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/12—Oxygen or sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Dermatology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Pyridine Compounds (AREA)
- Pyrrole Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9002393A FR2658818B1 (fr) | 1990-02-27 | 1990-02-27 | Nouveaux derives a structure naphtalenique, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
Publications (1)
Publication Number | Publication Date |
---|---|
OA09482A true OA09482A (fr) | 1992-11-15 |
Family
ID=9394160
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
OA59957A OA09482A (fr) | 1990-02-27 | 1991-02-27 | "Nouveaux dérivés à structure naphtalénique, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent". |
Country Status (17)
Country | Link |
---|---|
US (3) | US5194614A (xx) |
EP (1) | EP0447285B1 (xx) |
JP (1) | JP2624901B2 (xx) |
AT (1) | ATE89263T1 (xx) |
AU (1) | AU634350B2 (xx) |
CA (1) | CA2036876C (xx) |
DE (2) | DE69100079T2 (xx) |
DK (1) | DK0447285T3 (xx) |
ES (1) | ES2059069T4 (xx) |
FR (1) | FR2658818B1 (xx) |
HK (1) | HK57197A (xx) |
IE (1) | IE66011B1 (xx) |
LU (1) | LU91587I2 (xx) |
NL (1) | NL300396I1 (xx) |
OA (1) | OA09482A (xx) |
PT (1) | PT96890B (xx) |
ZA (1) | ZA911403B (xx) |
Families Citing this family (170)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2689124A1 (fr) * | 1992-03-27 | 1993-10-01 | Adir | Nouvelles naphtylalkylamines, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent. |
FR2696453B1 (fr) * | 1992-10-02 | 1994-12-23 | Adir | Nouveaux arylalkyl(thio)amides, leur procédé de préparation, et les compositions pharmaceutiques qui les contiennent. |
FR2713636B1 (fr) * | 1993-12-07 | 1996-01-05 | Adir | Nouveaux dérivés naphtaléniques, leur procédé de préparation, et les compositions pharmaceutiques qui les contiennent. |
CA2182700A1 (en) * | 1994-03-30 | 1995-10-12 | Irmgard Wiesenberg | Screening method using the rzr receptor family |
US7081349B1 (en) | 1994-06-17 | 2006-07-25 | The General Hospital Corporation | High-affinity melatonin receptor and uses thereof |
US5856124A (en) | 1994-06-17 | 1999-01-05 | The General Hospital Corporation | DNA encoding high-affinity melatonin receptors |
US5496826A (en) * | 1994-09-02 | 1996-03-05 | Bristol-Myers Squibb Company | Pharmaceutical methods of using heterocyclic derivatives of N-phenylamides |
WO1996008466A1 (en) * | 1994-09-12 | 1996-03-21 | Takeda Chemical Industries, Ltd. | Benzocycloalkene compounds, their production and use |
US5541228A (en) * | 1994-10-14 | 1996-07-30 | Bristol-Myers Squibb Co. | Melatonergic agents |
US6071946A (en) * | 1994-10-21 | 2000-06-06 | Adir Et Compagnie | Tricyclic urea compounds |
US5998461A (en) * | 1994-10-21 | 1999-12-07 | Adir Et Compagnie | Tricyclic amide compounds |
FR2725985B1 (fr) * | 1994-10-21 | 1996-11-15 | Adir | Nouveaux composes tricycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
FR2726268B1 (fr) * | 1994-10-26 | 1996-12-06 | Adir | Nouvelles o-arylmethyl n-(thio)acyl hydroxylamines, leur procede de preparation, et les compositions pharmaceutiques qui les contiennent |
US5530012A (en) | 1994-12-22 | 1996-06-25 | Bristol-Myers Squibb Co. | 3-alkoxybenzylpiperidine derivatives as melatonergic agents |
FR2729147A1 (fr) * | 1995-01-11 | 1996-07-12 | Adir | Nouveaux composes (hetero) cycliques alkyles, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
US5661186A (en) * | 1995-02-24 | 1997-08-26 | Bristol-Myers Squibb Co. | Tetralinyl-and indanyl-ethylamides |
FR2734816B1 (fr) * | 1995-05-31 | 1997-07-04 | Adir | Nouveaux aryl (alkyl) propylamides, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
FR2734815B1 (fr) * | 1995-05-31 | 1997-07-04 | Adir | Nouveaux composes arylalkyl (thio) carboxamides, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent |
FR2734814B1 (fr) * | 1995-05-31 | 1997-07-04 | Adir | Nouveaux composes alkoxy-aryles, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
US5708005A (en) * | 1995-06-27 | 1998-01-13 | Takeda Chemical Industries, Ltd. | Quinolines, their production and use |
CA2224260A1 (en) * | 1995-07-26 | 1997-02-13 | Kohji Fukatsu | Benzocycloalkene compounds with melatonine receptor binding affinity, their production and use |
FR2737725B1 (fr) * | 1995-08-08 | 1997-10-31 | Valentonine | Nouveaux derives acyles de la melatonine et d'analogues melatoninergiques, leur procede de preparation et leur utilisation en tant que medicament |
FR2741799B1 (fr) * | 1995-12-04 | 1998-01-02 | Oreal | Utilisation de melatonine dans une composition pour traiter les signes cutanes des etats de fatigue |
ATE203744T1 (de) * | 1995-12-13 | 2001-08-15 | Lilly Co Eli | Naphthyl-acetamide als spla2-inhibitoren |
EP0779273B1 (en) * | 1995-12-13 | 2002-03-20 | Eli Lilly And Company | Naphthyl glyoxamides as sPLA2 inhibitors |
US6090850A (en) * | 1996-02-05 | 2000-07-18 | Eli Lilly And Company | Naphthyl glyoxamides as SPLA2 inhibitors |
AUPO274596A0 (en) * | 1996-10-04 | 1996-10-31 | Armstrong, Stuart Maxwell | Method for the treatment of neurological or neuropsychiatric disorders |
US6369080B2 (en) | 1996-10-11 | 2002-04-09 | Cor Therapeutics, Inc. | Selective factor Xa inhibitors |
US6262047B1 (en) | 1996-10-11 | 2001-07-17 | Cor Therapeutics, Inc. | Selective factor Xa inhibitors |
US6194435B1 (en) | 1996-10-11 | 2001-02-27 | Cor Therapeutics, Inc. | Lactams as selective factor Xa inhibitors |
US6063794A (en) * | 1996-10-11 | 2000-05-16 | Cor Therapeutics Inc. | Selective factor Xa inhibitors |
PT1027043E (pt) * | 1996-12-10 | 2005-02-28 | Bristol Myers Squibb Co | Benzodioxole benzofurano di-hidrobenzofurano e benzodioxano como agentes melatonergicos |
CA2285659A1 (en) | 1997-04-14 | 1998-10-22 | Cor Therapeutics, Inc. | Selective factor xa inhibitors |
EP0975625A1 (en) * | 1997-04-14 | 2000-02-02 | Cor Therapeutics, Inc. | SELECTIVE FACTOR Xa INHIBITORS |
JP2001521524A (ja) * | 1997-04-14 | 2001-11-06 | シーオーアール セラピューティクス インコーポレイテッド | 選択的Xa因子阻害剤 |
WO1998046626A1 (en) | 1997-04-14 | 1998-10-22 | Cor Therapeutics, Inc. | SELECTIVE FACTOR Xa INHIBITORS |
FR2763335B1 (fr) * | 1997-05-16 | 2000-11-24 | Adir | Nouveaux composes heterocycliques substitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
US6028112A (en) * | 1997-05-23 | 2000-02-22 | Bristol-Myers Squibb Company | Spirocyclopropyl fluorenes as melatonergic agents |
US6333321B1 (en) | 1997-08-11 | 2001-12-25 | Cor Therapeutics, Inc. | Selective factor Xa inhibitors |
US6218382B1 (en) | 1997-08-11 | 2001-04-17 | Cor Therapeutics, Inc | Selective factor Xa inhibitors |
US6228854B1 (en) | 1997-08-11 | 2001-05-08 | Cor Therapeutics, Inc. | Selective factor Xa inhibitors |
FR2771739B1 (fr) * | 1997-11-28 | 2001-04-20 | Adir | Nouveaux composes naphtaleniques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
FR2793793B1 (fr) * | 1999-05-19 | 2004-02-27 | Adir | Nouveaux derives dimeriques substitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
WO2001007654A1 (en) | 1999-07-22 | 2001-02-01 | The General Hospital Corporation | Method for identifying compounds which modulate circadian rhythm |
CA2381860C (en) | 1999-08-26 | 2009-11-24 | Takeda Chemical Industries, Ltd. | Matrix adhering to nasal mucosa |
JP2001288138A (ja) * | 2000-04-04 | 2001-10-16 | Kanto Denka Kogyo Co Ltd | 含フッ素α,β−不飽和カルボン酸の製造方法 |
IL144900A (en) | 2001-08-14 | 2013-12-31 | Neurim Pharma 1991 | Melatonin and drugs containing it for use in the treatment of primary insomnia, and the manufacture of those drugs |
FR2834890B1 (fr) * | 2002-01-23 | 2004-02-27 | Servier Lab | Composition pharmaceutique orodispersible d'agomelatine |
FR2853649B1 (fr) * | 2003-04-09 | 2006-07-14 | Servier Lab | Nouveaux derives d'isoquinoleine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
AR047553A1 (es) | 2003-07-04 | 2006-01-25 | Lundbeck & Co As H | La combinacion de un inhibidor de reabsorcion de serotonina y agomelatina |
FR2857593B1 (fr) * | 2003-07-18 | 2005-10-14 | Servier Lab | Composition pharmaceutique orodispersible d'un compose antithrombotique |
FR2866337B1 (fr) * | 2004-02-13 | 2006-05-26 | Servier Lab | Nouveau procede de synthese du (7-methoxy-1-naphtyl) acetonitrile et application a la synthese de l'aglomelatine |
FR2866336B1 (fr) * | 2004-02-13 | 2006-03-24 | Servier Lab | Nouveau procede de synthese du (7-methoxy-3,4-dihydro-1-naphtalenyl) acetonitrile et application a la synthese de l'agomelatine |
FR2866335B1 (fr) * | 2004-02-13 | 2006-05-26 | Servier Lab | Nouveau procede de synthese de l'agomelatine |
FR2866334B1 (fr) * | 2004-02-13 | 2006-05-26 | Servier Lab | Nouveau procede de synthese du (7-methoxy-1-naphtyl) acetonitrile et application a la synthese de l'agomelatine |
US7498465B2 (en) | 2004-02-13 | 2009-03-03 | Les Laboratoires Servier | Process for the synthesis and crystalline form of agomelatine |
CA2556914A1 (en) * | 2004-02-25 | 2005-09-09 | La Jolla Pharmaceutical Company | Amines and amides for the treatment of diseases |
FR2884714B1 (fr) * | 2005-04-20 | 2011-05-06 | Servier Lab | Utilisation de l'agomelatine pour l'obtention de medicaments destines au traitement des troubles bipolaires |
US7645905B2 (en) | 2005-08-03 | 2010-01-12 | Les Laboratoires Servier | Crystalline form IV of agomelatine, a process for its preparation and pharmaceutical compositions containing it |
FR2889523B1 (fr) * | 2005-08-03 | 2007-12-28 | Servier Lab | Nouvelle forme cristalline v de l'agomelatine, son procede de preparation et les compositions pharmaceutiques qui la contiennent |
FR2889522B1 (fr) * | 2005-08-03 | 2007-12-28 | Servier Lab | Nouvelle forme cristalline iv de l'agomelatine, son procede de preparation et les compositions pharmaceutiques qui la contiennent |
KR100904116B1 (ko) * | 2005-08-03 | 2009-06-24 | 르 라보레또레 쎄르비에르 | 아고멜라틴의 ⅴ 결정형, 이의 제조 방법 및 이를 함유하는 약제 조성물 |
FR2889521B1 (fr) | 2005-08-03 | 2007-12-28 | Servier Lab | Nouvelle forme cristalline iii de l'agomelatine, son procede de preparation et les compositions pharmaceutiques qui la contiennent |
US7358395B2 (en) * | 2005-08-03 | 2008-04-15 | Les Laboratories Servier | Crystalline form V of agomelatine, a process for its preparation and pharmaceutical compositions containing it |
US7635721B2 (en) | 2005-08-03 | 2009-12-22 | Les Laboratoires Servier | Crystalline form III of agomelatine, a process for its preparation and pharmaceutical compositions containing it |
FR2890564B1 (fr) | 2005-09-09 | 2007-10-19 | Servier Lab | Nouvelle association entre l'agomelatine et un inhibiteur de la recapture de la noradrenaline et les compositions pharmaceutiques qui la contiennent |
FR2890562B1 (fr) * | 2005-09-09 | 2012-10-12 | Servier Lab | Utilisation de l'agomelatine pour l'obtention de medicaments destines au traitement des troubles du sommeil chez le patient deprime |
FR2890563B1 (fr) | 2005-09-09 | 2007-10-19 | Servier Lab | Nouvelle association entre l'agomelatine et un agent thymoregulateur et les compositions pharmaceutiques qui la contiennent |
FR2899472B1 (fr) * | 2006-04-07 | 2008-09-12 | Servier Lab | Utilisation de l'agomelatine pour l'obtention de medicaments destines au traitement du trouble anxiete generalisee |
CN101161638B (zh) * | 2006-10-13 | 2010-09-29 | 北京德众万全药物技术开发有限公司 | 一种新的阿戈美拉汀重要中间体的制备方法 |
FR2908995B1 (fr) | 2006-11-24 | 2009-02-06 | Servier Lab | Utilisation de l'agomelatine pour l'obtention de medicaments destines au traitement du syndrome de smith magenis |
FR2908994B1 (fr) * | 2006-11-24 | 2009-04-03 | Servier Lab | Utilisation de l'agomelatine pour l'obtention de medicaments destines au traitement de la leucomalacie periventriculaire |
AU2008247805A1 (en) * | 2007-05-01 | 2008-11-13 | Concert Pharmaceuticals Inc. | Naphthyl(ethyl) acetamides |
US20080280991A1 (en) * | 2007-05-08 | 2008-11-13 | Auspex Pharmaceuticals, Inc. | Substituted naphthalenes |
JP2009013074A (ja) * | 2007-06-30 | 2009-01-22 | Lab Servier | 全般性不安障害の処置を目的とする医薬を得るためのアゴメラチンの使用 |
FR2919606B1 (fr) | 2007-08-03 | 2010-09-17 | Servier Lab | Nouveau procede de synthese du (7-methoxy-1-naphtyl) acetonitrile et application a la synthese de l'agomelatine. |
DE102007039745A1 (de) * | 2007-08-22 | 2009-02-26 | Henkel Ag & Co. Kgaa | Haarbehandlungsmittel mit Pflegestoff(en) und Melatonin/Agomelatin |
DE102007039741A1 (de) * | 2007-08-22 | 2009-02-26 | Henkel Ag & Co. Kgaa | Haarbehandlungsmittel mit Tensid(en) und Melatonin/Agomelatin |
DE102007039743A1 (de) * | 2007-08-22 | 2009-02-26 | Henkel Ag & Co. Kgaa | Haarbehandlungsmittel mit Alkohol(en) und Melatonin/Agomelatin |
FR2923482B1 (fr) * | 2007-11-09 | 2010-01-29 | Servier Lab | Nouvelle forme cristalline vi de l'agomelatine, son procede de preparation et les compositions pharmaceutiques qui la contiennent |
CN101429124B (zh) * | 2007-11-09 | 2011-10-26 | 上海医药工业研究院 | 一种(7-甲氧基-1-萘基)乙酸乙酯的合成方法 |
WO2009097144A1 (en) * | 2008-01-30 | 2009-08-06 | The Trustees Of Columbia University In The City Of New York | Molecular probes for pet-imaging of dopamine neurotransmission and neuroendocrine processes in vivo |
WO2009128057A2 (en) | 2008-04-18 | 2009-10-22 | UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN et al | Psycho-pharmaceuticals |
CN101638376B (zh) | 2008-07-29 | 2011-04-27 | 江苏恩华药业股份有限公司 | 阿戈美拉汀的制备方法及其中间体 |
FR2934859B1 (fr) * | 2008-08-05 | 2010-08-13 | Servier Lab | Nouveau procede de synthese de l'agomelatine |
FR2934855B1 (fr) * | 2008-08-05 | 2010-08-13 | Servier Lab | Nouveau procede de synthese de l'agomelatine |
FR2934856B1 (fr) * | 2008-08-05 | 2010-08-13 | Servier Lab | Nouveau procede d'obtention de la forme cristalline v de l'agomelatine |
CN101481321B (zh) * | 2009-02-27 | 2012-04-18 | 上海医药工业研究院 | 阿戈美拉汀卤化氢复合物及其制备方法 |
CN101585779B (zh) * | 2009-03-10 | 2014-04-02 | 上海医药工业研究院 | 阿戈美拉汀的晶型vi及其制备方法和应用 |
WO2011006387A1 (zh) * | 2009-07-11 | 2011-01-20 | 浙江华海药业股份有限公司 | 阿戈美拉汀的制备方法、阿戈美拉汀晶形及其制备方法 |
CN101955440B (zh) * | 2009-07-17 | 2014-04-09 | 江苏万特制药有限公司 | 一种阿戈美拉汀新晶型及其制备方法 |
CN102001959B (zh) * | 2009-09-01 | 2014-07-02 | 北京本草天源药物研究院 | 一种药物晶体及其制备方法和用途 |
EP2319827A1 (en) * | 2009-11-09 | 2011-05-11 | Ratiopharm GmbH | Process for the production of polymorph form I of agomelatine |
CN101781226B (zh) * | 2009-12-23 | 2012-03-28 | 天津泰普药品科技发展有限公司 | 阿戈美拉汀及其药物组合物 |
CN102146046B (zh) * | 2010-02-05 | 2013-07-03 | 天津市汉康医药生物技术有限公司 | 一种n-[2-(7-甲氧基-1-萘基)乙基]乙酰胺新的制备方法 |
FR2956031B1 (fr) | 2010-02-11 | 2012-03-02 | Servier Lab | Utilisation de l'agomelatine pour l'obtention de medicaments destines au traitement du trouble obsessionnel compulsif (toc) |
CN102190595A (zh) * | 2010-03-17 | 2011-09-21 | 上海医药工业研究院 | 阿戈美拉汀溴化氢水合物及其制备方法 |
CN102190594A (zh) * | 2010-03-17 | 2011-09-21 | 上海医药工业研究院 | 阿戈美拉汀氯化氢水合物及其制备方法 |
WO2011128413A1 (en) | 2010-04-15 | 2011-10-20 | Ratiopharm Gmbh | Process for the production of polymorph form i of agomelatine |
MX351368B (es) | 2010-05-26 | 2017-10-12 | Sunovion Pharmaceuticals Inc | Compuestos heteroarilo y metodos para utilizarlos. |
CN102276492B (zh) * | 2010-06-08 | 2013-04-10 | 上海医药工业研究院 | 阿戈美拉汀中间体及其制备方法 |
EP2580183B1 (en) | 2010-06-10 | 2014-07-23 | Gador S.A. | New process for the preparation of n-[2-(7-methoxy-1-naphthyl)-ethyl]acetamide |
CN102229541A (zh) * | 2010-09-17 | 2011-11-02 | 福建广生堂药业有限公司 | 阿戈美拉汀n-[2-(7-甲氧基萘-1-基)乙基]乙酰胺的制备方法 |
CN102452951B (zh) * | 2010-10-25 | 2014-02-19 | 天津泰普药品科技发展有限公司 | 阿戈美拉汀及其药物组合物 |
CN102452952A (zh) * | 2010-11-03 | 2012-05-16 | 天津药物研究院 | 一种高纯度的i型阿戈美拉汀晶体制备方法 |
WO2012070025A1 (en) | 2010-11-26 | 2012-05-31 | Cadila Pharmaceuticals Ltd | Process for the preparation of agomelatine |
CN102531956B (zh) * | 2010-12-21 | 2014-07-09 | 浙江九洲药业股份有限公司 | 用于制备阿戈美拉汀的中间体及相关制备方法 |
WO2012093402A1 (en) * | 2011-01-04 | 2012-07-12 | Symed Labs Limited | Processes for the preparation of n-[2-(7-methoxy-1-naphthyl)ethyl]acetamide |
FR2970000B1 (fr) * | 2011-01-05 | 2013-01-04 | Servier Lab | Nouveau procede de synthese de l'agomelatine |
FR2970001B1 (fr) * | 2011-01-05 | 2013-01-04 | Servier Lab | Nouveau procede de synthese de l'agomelatine |
CZ303788B6 (cs) * | 2011-01-21 | 2013-05-02 | Zentiva, K.S. | Zpusob prípravy krystalové formy agomelatinu |
CZ303789B6 (cs) * | 2011-01-21 | 2013-05-02 | Zentiva, K.S. | Zpusob prípravy krystalové formy agomelatinu a jeho pouzití |
CZ303787B6 (cs) | 2011-01-21 | 2013-05-02 | Zentiva, K.S. | Metastabilní krystalové formy agomelatinu a jejich farmaceutické kompozice |
CN102690209A (zh) * | 2011-03-23 | 2012-09-26 | 上海医药工业研究院 | 阿戈美拉汀的混晶(形式-ⅷ)、其制备方法、应用和包含其的药物组合物 |
CN102690210A (zh) * | 2011-03-23 | 2012-09-26 | 上海医药工业研究院 | 阿戈美拉汀的新晶型ⅶ、其制备方法、应用和包含其的药物组合物 |
WO2012130837A1 (en) | 2011-03-28 | 2012-10-04 | Ratiopharm Gmbh | Solid agomelatine in non-crystalline form |
CN102206864B (zh) * | 2011-04-13 | 2012-10-03 | 吉林省博大伟业制药有限公司 | 阿戈美拉汀的ⅵ晶型单晶及混合晶型和制备方法 |
PH12012000132B1 (en) | 2011-06-09 | 2014-10-20 | Servier Lab | New co-crystals of agomelatine, a process for their preparation and pharmaceutical compositions containing them |
ITMI20111078A1 (it) * | 2011-06-15 | 2012-12-16 | Laboratorio Chimico Int Spa | Procedimento per la preparazione di forme cristalline dell?agomelatina e nuovo polimorfo |
WO2013013060A1 (en) * | 2011-07-19 | 2013-01-24 | Lycus, Llc | Agomelatine derivatives |
US20150291508A1 (en) | 2011-08-03 | 2015-10-15 | Laboratorio Chimico Internazionale S.P.A. | Process for the preparation of crystalline form of agomelatine |
FR2978916B1 (fr) | 2011-08-10 | 2013-07-26 | Servier Lab | Composition pharmaceutique solide pour administration buccale d'agomelatine |
EP2562151A1 (en) | 2011-08-25 | 2013-02-27 | Dr. Reddy's Laboratories Ltd. | Processes for the preparation of agomelatine and its intermediates |
WO2013054273A2 (en) | 2011-10-11 | 2013-04-18 | Ranbaxy Laboratories Limited | Process for the preparation of agomelatine |
WO2013063289A1 (en) * | 2011-10-25 | 2013-05-02 | Lycus Llc | Pharmaceutical compositions for treating pain |
CN102432490A (zh) * | 2011-11-02 | 2012-05-02 | 江西施美制药有限公司 | 一种阿戈美拉汀晶型d及其制备方法 |
WO2013082302A1 (en) | 2011-11-30 | 2013-06-06 | Ratiopharm Gmbh | Agomelatine-urea complex and crystalline forms thereof |
WO2013080095A1 (en) | 2011-12-01 | 2013-06-06 | Ranbaxy Laboratories Limited | Process for the preparation of agomelatine |
US11918557B2 (en) | 2012-01-26 | 2024-03-05 | Vanda Pharmaceuticals Inc. | Treatment of circadian rhythm disorders |
KR20180100450A (ko) | 2012-01-26 | 2018-09-10 | 반다 파마슈티칼즈, 인코퍼레이티드. | 일주기 리듬 장애의 치료 |
CZ2012108A3 (en) | 2012-02-15 | 2013-02-27 | Zentiva Ks | A method for the manufacture of a polymorphously stable pharmaceutical composition containing agomelatine |
EP2851363B1 (en) | 2012-05-14 | 2018-01-03 | Shanghai Righthand Pharmtech. Co., Ltd. | Agomelatine acid radical composite, and preparation method and application thereof |
WO2014001939A1 (en) * | 2012-06-30 | 2014-01-03 | Alembic Pharmaceuticals Limited | Process for preparation of agomelatine and crystalline form i thereof |
WO2014010603A1 (ja) | 2012-07-10 | 2014-01-16 | アステラス製薬株式会社 | 腹圧性尿失禁又は混合型尿失禁の治療又は予防用医薬組成物、及び該医薬組成物に含有される化合物のスクリーニング方法 |
AR091699A1 (es) | 2012-07-10 | 2015-02-25 | Astellas Pharma Inc | Derivado de indol carboxamida |
CA2877410A1 (en) | 2012-07-16 | 2014-01-23 | Ratiopharm Gmbh | Complex of agomelatine and cyclodextrin |
ITMI20121444A1 (it) | 2012-08-27 | 2014-02-28 | Procos Spa | Processo per la produzione di agomelatine |
CN102911075A (zh) * | 2012-09-29 | 2013-02-06 | 福建广生堂药业股份有限公司 | 一种阿戈美拉汀硫酸盐新晶型ⅰ及其制备方法 |
WO2014056421A1 (zh) * | 2012-10-09 | 2014-04-17 | 江西同和药业有限责任公司 | 1-氰基-1-(7-甲氧基-1-萘基)甲醇酯类化合物及其制备方法和应用 |
WO2014064706A1 (en) * | 2012-10-22 | 2014-05-01 | Symed Labs Limited | Processes for the preparation of agomelatine using novel intermediates |
WO2014072998A1 (en) | 2012-11-07 | 2014-05-15 | Cadila Healthcare Limited | An improved process for preparation of agomelatine |
EP2743255B1 (en) | 2012-12-17 | 2016-06-22 | Dr. Reddy's Laboratories Ltd. | Cocrystal of agomelatine with phosphoric acid |
KR102148990B1 (ko) | 2012-12-18 | 2020-08-27 | 반다 파마슈티칼즈, 인코퍼레이티드. | 일주기 리듬 장애의 치료 |
CN103073445A (zh) * | 2012-12-21 | 2013-05-01 | 北京万全德众医药生物技术有限公司 | 阿戈美拉汀工艺杂质的制备方法 |
WO2014096373A1 (en) | 2012-12-21 | 2014-06-26 | Laboratorios Lesvi, S. L. | Process for prepararing n-(2-(7-methoxy-1-naphthalenyl)ethyl) acetamide and solid forms thereof |
CN103073441A (zh) * | 2012-12-27 | 2013-05-01 | 上海右手医药科技开发有限公司 | 合成(7-甲氧基-1-萘基)乙胺的新方法及其在合成阿戈美拉汀中的应用 |
FR3001894A1 (fr) | 2013-02-08 | 2014-08-15 | Servier Lab | Composition pharmaceutique solide pour administration buccale d'agomelatine |
EP2810647A1 (en) | 2013-06-06 | 2014-12-10 | Zentiva, a.s. | Pharmaceutical formulations comprising agomelatine in the form of agomelatine co-crystal with an organic acid |
PL2810656T3 (pl) | 2013-06-06 | 2018-01-31 | Zentiva Ks | Preparaty agomelatyny zawierające agomelatynę w postaci kokryształów |
CZ2013621A3 (cs) | 2013-08-13 | 2015-02-25 | Zentiva, K.S. | Termodynamicky stabilní tuhý roztok agomelatinu pro použití ve farmaceutické formulaci |
US10376487B2 (en) | 2013-11-12 | 2019-08-13 | Vanda Pharmaceuticals Inc. | Method of treatment |
US11090285B2 (en) | 2013-11-12 | 2021-08-17 | Vanda Pharmaceuticals Inc | Treatment of circadian rhythm disorders |
FR3014433B1 (fr) | 2013-12-05 | 2015-12-25 | Servier Lab | Nouveau procede de synthese du 7-methoxy-naphtalene-1-carbaldehyde et application a la synthese de l'agomelatine |
US11479766B2 (en) * | 2013-12-05 | 2022-10-25 | New England Biolabs, Inc. | Methods for labeling a population of RNA molecules |
FR3014437B1 (fr) * | 2013-12-05 | 2016-12-23 | Servier Lab | Nouveau procede de synthese de l'agomelatine |
FR3014434B1 (fr) * | 2013-12-05 | 2015-12-25 | Servier Lab | Nouveau procede de synthese du 7-methoxy-naphtalene-1-carbaldehyde et application a la synthese de l'agomelatine |
CN103690499B (zh) * | 2013-12-23 | 2015-05-06 | 天津泰普药品科技发展有限公司 | 一种稳定的晶i型阿戈美拉汀片剂及其制备方法 |
CN103804232B (zh) * | 2014-01-26 | 2015-08-19 | 江西同和药业股份有限公司 | 一种1-氰基-1-(7-甲氧基-3,4-二氢-1-萘基)甲醇酯类化合物及其制备方法和应用 |
KR101606395B1 (ko) | 2014-02-05 | 2016-03-25 | (주)국전약품 | 아고멜라틴의 제조방법 |
WO2015124496A1 (en) | 2014-02-19 | 2015-08-27 | Synthon B.V. | Pharmaceutical composition comprising amorphous agomelatine |
CN105193764A (zh) * | 2014-05-30 | 2015-12-30 | 北大方正集团有限公司 | 一种阿戈美拉汀固体分散体及其制备方法 |
EP3075724B1 (en) | 2015-03-31 | 2023-07-12 | F.I.S.- Fabbrica Italiana Sintetici S.p.A. | Solid form of agomelatine |
FR3056211B1 (fr) | 2016-09-19 | 2018-09-07 | Servier Lab | Nouveau procede de synthese de l'agomelatine |
BR102016024814A2 (pt) | 2016-10-24 | 2018-05-08 | Aché Laboratórios Farmacêuticos S.A. | composto, processo de obtenção do composto, composição farmacêutica, uso do composto e método de tratamento de desordens psiquiátricas e/ou distúrbios do sono |
CN107353229B (zh) * | 2017-08-08 | 2019-04-30 | 许昌恒生制药有限公司 | 一种阿戈美拉汀中间体的制备方法 |
EP3466413A1 (en) | 2017-10-09 | 2019-04-10 | KRKA, d.d., Novo mesto | Pharmaceutical composition containing agomelatine and process for the preparation thereof |
EP3466923A1 (en) | 2017-10-09 | 2019-04-10 | KRKA, d.d., Novo mesto | Process for the preparation of agomelatine in crystalline form |
TW202214558A (zh) * | 2020-07-28 | 2022-04-16 | 大陸商上海翰森生物醫藥科技有限公司 | 雙環類衍生物調節劑、其製備方法和應用 |
US11840731B2 (en) | 2021-05-11 | 2023-12-12 | Neurim Pharmaceuticals (1991) Ltd. | Method for diagnosing and treating subjects having single nucleotide polymorphisms in chromosome 2, 2:107,510,000-107,540,000 locus |
CN115872887B (zh) * | 2022-12-30 | 2023-07-07 | 上海国创医药股份有限公司 | 一种阿戈美拉汀的制备方法 |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US1188544A (en) * | 1914-07-09 | 1916-06-27 | Basf Ag | Derivatives of 1-amino-7-naphthol. |
US2516130A (en) * | 1949-03-26 | 1950-07-25 | Parke Davis & Co | Naphthalene compounds |
US3057919A (en) * | 1961-02-17 | 1962-10-09 | Dow Chemical Co | N-(salicyl)-benzamide derivatives |
US3259622A (en) * | 1962-09-07 | 1966-07-05 | Merck & Co Inc | 1-benzyl-3-indolyl-alpha-haloalkyl and alkylidenyl acetic acids |
US3308157A (en) * | 1964-08-07 | 1967-03-07 | Colgate Palmolive Co | N-(benzocyclobutene-1-loweralkyl)-carboxylic acid amides |
US3625972A (en) * | 1968-07-03 | 1971-12-07 | Sterling Drug Inc | N-phenylbenzanilides |
US3689557A (en) * | 1969-06-09 | 1972-09-05 | American Home Prod | Phenethylamides |
US3871865A (en) * | 1970-11-18 | 1975-03-18 | Eugene G Teach | Ether and sulfide meta-substituted anilides and their utility as herbicides |
US3706796A (en) * | 1970-11-25 | 1972-12-19 | Monsanto Co | Substituted amides |
BE787381A (fr) * | 1971-08-12 | 1973-02-09 | Basf Ag | Amides substitues de l'acide benzoique |
DE2235597A1 (de) * | 1972-07-20 | 1974-01-31 | Boehringer Mannheim Gmbh | 1-eckige klammer auf 3-(5,6,7,8tetrahydronaphth-1-yl-oxy) -propyl eckige klammer zu -piperazin-derivate und verfahren zu ihrer herstellung |
US4169108A (en) * | 1973-08-16 | 1979-09-25 | Sterling Drug Inc. | 5(OR 6)-[(Substituted-amino)alkyl]-2,3-naphthalenediols |
JPS53113033A (en) * | 1977-03-14 | 1978-10-03 | Tanabe Seiyaku Co Ltd | Antihyperlipemics |
GB2093837B (en) * | 1981-03-02 | 1985-04-24 | Abbott Lab | Aminoalkyl subsituted 1,2,3,4-tetrahydronaphtalenes |
GB8400964D0 (en) * | 1984-01-13 | 1984-02-15 | Sandoz Ltd | Organic compounds |
JPS6461447A (en) * | 1987-08-28 | 1989-03-08 | Nihon Iyakuhin Kogyo Co Ltd | (+-)-or (+)-1-(2-n-substituted aminoethyl)-1-methyl-7-methoxy-1,2,3,4-tetrahydronaphthalene and production thereof |
ES2063324T3 (es) * | 1989-08-18 | 1995-01-01 | Ciba Geigy Ag | Derivados del acido butirico. |
AU6659090A (en) * | 1989-11-16 | 1991-06-13 | Warner-Lambert Company | Acat inhibitors |
FR2655988B1 (fr) * | 1989-12-20 | 1994-05-20 | Adir Cie | Nouveaux derives de la napht-1-yl piperazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
-
1990
- 1990-02-27 FR FR9002393A patent/FR2658818B1/fr not_active Expired - Lifetime
-
1991
- 1991-02-22 CA CA002036876A patent/CA2036876C/fr not_active Expired - Lifetime
- 1991-02-26 IE IE64091A patent/IE66011B1/en not_active IP Right Cessation
- 1991-02-26 AU AU71375/91A patent/AU634350B2/en not_active Expired
- 1991-02-26 US US07/661,425 patent/US5194614A/en not_active Expired - Lifetime
- 1991-02-26 PT PT96890A patent/PT96890B/pt not_active IP Right Cessation
- 1991-02-26 ZA ZA911403A patent/ZA911403B/xx unknown
- 1991-02-27 ES ES91400526T patent/ES2059069T4/es not_active Expired - Lifetime
- 1991-02-27 DE DE91400526T patent/DE69100079T2/de not_active Expired - Lifetime
- 1991-02-27 JP JP3033192A patent/JP2624901B2/ja not_active Expired - Lifetime
- 1991-02-27 DK DK91400526.9T patent/DK0447285T3/da active
- 1991-02-27 DE DE122009000040C patent/DE122009000040I2/de active Active
- 1991-02-27 AT AT91400526T patent/ATE89263T1/de active
- 1991-02-27 OA OA59957A patent/OA09482A/xx unknown
- 1991-02-27 EP EP91400526A patent/EP0447285B1/fr not_active Expired - Lifetime
-
1992
- 1992-01-03 US US07/816,466 patent/US5225442A/en not_active Expired - Lifetime
- 1992-11-03 US US07/970,578 patent/US5318994A/en not_active Expired - Lifetime
-
1997
- 1997-05-01 HK HK57197A patent/HK57197A/xx not_active IP Right Cessation
-
2009
- 2009-07-22 LU LU91587C patent/LU91587I2/fr unknown
- 2009-07-24 NL NL300396C patent/NL300396I1/nl unknown
Also Published As
Publication number | Publication date |
---|---|
EP0447285A1 (fr) | 1991-09-18 |
JP2624901B2 (ja) | 1997-06-25 |
FR2658818A1 (fr) | 1991-08-30 |
IE66011B1 (en) | 1995-11-29 |
FR2658818B1 (fr) | 1993-12-31 |
US5318994A (en) | 1994-06-07 |
HK57197A (en) | 1997-05-09 |
PT96890A (pt) | 1991-10-31 |
DE69100079T2 (de) | 1993-12-09 |
ATE89263T1 (de) | 1993-05-15 |
AU634350B2 (en) | 1993-02-18 |
ZA911403B (en) | 1991-11-27 |
LU91587I2 (fr) | 2009-09-22 |
JPH0748331A (ja) | 1995-02-21 |
CA2036876C (fr) | 1998-08-18 |
IE910640A1 (en) | 1991-08-28 |
DK0447285T3 (da) | 1993-08-16 |
NL300396I1 (nl) | 2009-10-01 |
DE122009000040I2 (de) | 2011-01-13 |
DE69100079D1 (de) | 1993-06-17 |
AU7137591A (en) | 1991-08-29 |
CA2036876A1 (fr) | 1991-08-28 |
US5194614A (en) | 1993-03-16 |
EP0447285B1 (fr) | 1993-05-12 |
ES2059069T3 (es) | 1994-11-01 |
PT96890B (pt) | 1998-07-31 |
US5225442A (en) | 1993-07-06 |
DE122009000040I1 (de) | 2009-11-05 |
ES2059069T4 (es) | 2012-03-13 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
OA09482A (fr) | "Nouveaux dérivés à structure naphtalénique, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent". | |
FR2430412A1 (fr) | Derives substitues de propanolamine utiles comme medicaments et procede de leur preparation | |
ATE19878T1 (de) | Benzimidazol-derivate, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammensetzungen. | |
ATE10192T1 (de) | Substituierte imidazol-derivate, deren herstellung und verwendung. | |
FR2403989A1 (fr) | Nouveaux derives a-halogenomethyles d'amines utiles comme medicaments et procedes de leur preparation | |
ES478605A1 (es) | Un procedimiento para preparar derivados de flavano. | |
KR900016098A (ko) | 카페인산의 유도체 및 이를 함유하는 약제학적 조성물 | |
DE3850603D1 (de) | Arylaralkylether, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Zusammensetzung. | |
KR900016178A (ko) | 2-치환 n,n'-디트리메톡시벤조일 피페라진, 그의 제조 방법 및 그를 함유하는 치료 조성물 | |
FI104071B (fi) | Analogiamenetelmä terapeuttisesti käyttökelpoisten 2,5-dihydro-2,5-diokso-1H-bents£b|atsepiinijohdannaisten valmistamiseksi | |
PT77666B (fr) | Procede de preparation de nouveaux derives de la nitrosouree | |
FR2669030B1 (fr) | Nouveaux derives d'imidazole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. | |
FR2709489B1 (fr) | Nouveaux dérivés de 2-(1H)-quinoléinone, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent. | |
FR2572074B1 (fr) | Derives du thiadiazole actifs sur le systeme nerveux central, procede d'obtention et compositions pharmaceutiques les contenant | |
ATE34739T1 (de) | Neue 2-pyridin-thiol-derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate. | |
NO180475C (no) | Fremgangsmåte for fremstilling av et farmasöytisk preparat | |
OA09147A (fr) | Nouveaux dérivés de l'indole, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent. | |
FR2355839A1 (fr) | Derives optiquement actifs d'acide benzoxazolyl-propionique, procede pour leur preparation et compositions therapeutiques les contenant | |
BE905432A (fr) | Nouveaux derives du catechol, un procede pour leur preparation, et compositions therapeutiques a base de ces derives. | |
FR2566407B1 (fr) | Nouveaux derives de l'isoxazoloquinoleine, procede de preparation, application a titre de medicaments, et compositions les renfermant | |
SE8204791L (sv) | Sett att framstella alkoxivinkaminsyraestrar och alkoxiapovinkaminsyraestrar | |
OA09299A (fr) | Nouveaux dérivés N- (vincristinoyl-23) et N- (noranhydro-5' vinblastinoyl-23) d'acide animo-1 méthylphosphonique, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent. | |
ATE29133T1 (de) | Troponon-derivate, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammensetzung. | |
FR2572404B2 (fr) | Nouveaux derives de l'acide 4-oh-3-quinoleine carboxylique substitues en 2, leur procede de preparation, leur application comme medicaments et les compositions les renfermant | |
KR950704322A (ko) | 스피로푸라논 유도체 및 그의 신경변성 질환 치료 용도(Spirofuranone Derivatives and Their Use in the Treatment of Neurodegenerative Disorders) |