OA09468A - Nouveaux dérivés du 1,2-benzisoxazole, leurs procédés de préparation et les compositions pharmaceutiques qui les contiennent. - Google Patents

Nouveaux dérivés du 1,2-benzisoxazole, leurs procédés de préparation et les compositions pharmaceutiques qui les contiennent.

Info

Publication number
OA09468A
OA09468A OA59885A OA59885A OA09468A OA 09468 A OA09468 A OA 09468A OA 59885 A OA59885 A OA 59885A OA 59885 A OA59885 A OA 59885A OA 09468 A OA09468 A OA 09468A
Authority
OA
OAPI
Prior art keywords
radical
formula
image
hydrogen atom
represent
Prior art date
Application number
OA59885A
Other languages
English (en)
French (fr)
Inventor
Peglion Jean-Louis
Colpaert Francis
Original Assignee
Adir
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Adir filed Critical Adir
Publication of OA09468A publication Critical patent/OA09468A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, ***e
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
OA59885A 1989-11-07 1990-11-07 Nouveaux dérivés du 1,2-benzisoxazole, leurs procédés de préparation et les compositions pharmaceutiques qui les contiennent. OA09468A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8914571A FR2654104B1 (fr) 1989-11-07 1989-11-07 Nouveaux derives du 1,2-benzisoxazole, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent.

Publications (1)

Publication Number Publication Date
OA09468A true OA09468A (fr) 1992-11-15

Family

ID=9387148

Family Applications (1)

Application Number Title Priority Date Filing Date
OA59885A OA09468A (fr) 1989-11-07 1990-11-07 Nouveaux dérivés du 1,2-benzisoxazole, leurs procédés de préparation et les compositions pharmaceutiques qui les contiennent.

Country Status (15)

Country Link
US (2) US5100902A (pt)
EP (1) EP0428437B1 (pt)
JP (1) JPH0692403B2 (pt)
AT (1) ATE110075T1 (pt)
AU (1) AU631466B2 (pt)
CA (1) CA2029372C (pt)
DE (1) DE69011628T2 (pt)
DK (1) DK0428437T3 (pt)
ES (1) ES2062458T3 (pt)
FR (1) FR2654104B1 (pt)
IE (1) IE65004B1 (pt)
NZ (1) NZ235892A (pt)
OA (1) OA09468A (pt)
PT (1) PT95808B (pt)
ZA (1) ZA908884B (pt)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5776963A (en) * 1989-05-19 1998-07-07 Hoechst Marion Roussel, Inc. 3-(heteroaryl)-1- (2,3-dihydro-1h-isoindol-2-yl)alkyl!pyrrolidines and 3-(heteroaryl)-1- (2,3-dihydro-1h-indol-1-yl)alkyl!pyrrolidines and related compounds and their therapeutic untility
US5750542A (en) 1993-09-28 1998-05-12 Pfizer Benzisoxazole and benzisothizole derivatives as cholinesterase inhibitors
CZ289756B6 (cs) * 1991-03-28 2002-04-17 Eisai Co., Ltd. Heterocyklicko-cyklické aminové deriváty, meziprodukty postupu přípravy těchto sloučenin, farmaceutický prostředek a pouľití uvedených derivátů
CA2116117A1 (en) * 1991-08-22 1993-03-04 Hiroyuki Sueoka Benzisoxazole compound and use thereof
WO1993010742A2 (en) * 1991-11-27 1993-06-10 Novo Nordisk A/S Chemical compounds, their preparation and use
US5378714A (en) * 1991-11-27 1995-01-03 Novo Nordisk A/S Antipsychotic piperidine derivatives
FR2694005B1 (fr) * 1992-07-21 1994-08-26 Adir Nouvelles aminoalkylchromones, leurs procédés de préparation et les compositions pharmaceutiques qui les contiennent.
US5494908A (en) * 1992-11-23 1996-02-27 Hoechst-Roussel Pharmaceutical Incorporated Substituted 3-(aminoalkylamino)-1,2-benzisoxazoles and related compounds
DK0669920T3 (da) * 1992-11-23 2003-05-26 Aventis Pharma Inc Substituerede 3-(aminoalkylamino)-1,2-benzisoxazoler og beslægtede forbindelser
DK60793D0 (da) * 1993-05-26 1993-05-26 Novo Nordisk As Kemiske forbindelser, deres fremstilling og anvendelse
DK60593D0 (da) * 1993-05-26 1993-05-26 Novo Nordisk As Kemiske forbindelser, deres fremstilling og anvendelse
AU1867095A (en) * 1994-01-10 1995-08-01 Technion Research & Development Foundation Ltd. 1-aminoindan derivatives and compositions thereof
US5914349A (en) 1994-01-10 1999-06-22 Teva Pharmaceutical Industries, Ltd. Compositions containing and methods of using 1-aminoindan and derivatives thereof and process for preparing optically active 1-aminoindan derivatives
US6743808B1 (en) 1994-06-08 2004-06-01 H. Lundbeck A/S 4-aryl-1-(indanmethyl, dihydrobenzofuranmethyl or dihydrobenzothiophenemethyl) tetrahydropyridines or piperazines
ZA954689B (en) * 1994-06-08 1996-01-29 Lundbeck & Co As H 4-Aryl-1-(indanmethyl dihydrobenzofuranmethyl or dihydrobenzothiophenemethyl) piperidines tetrahydropyridines or piperazines
ES2101646B1 (es) * 1995-04-12 1998-04-01 Ferrer Int Nuevo compuesto derivado del cromeno.
IL117646A (en) * 1995-04-12 2000-06-01 Ferrer Int 7-¬3-¬4-(6-fluoro-1,2-benzisoxazole-3-YL)piperidin-1-YL¾propoxy¾3-alkyl-chromen-4-ones their preparation their uses and pharmaceutical compositions comprising them
FR2735129B1 (fr) * 1995-06-07 1997-07-11 Adir Nouveaux derives de l'indole, de l'indazole et du benzisoxazole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
JP4222632B2 (ja) 1996-12-18 2009-02-12 テバ・ファーマシューティカル・インダストリーズ・リミテッド アミノインダン誘導体
ZA9711376B (en) 1996-12-20 1998-07-21 Lundbeck & Co As H Indole or dihydroindole derivatives
ES2144355B1 (es) * 1997-12-30 2001-01-01 Ferrer Int Compuestos derivados del cromeno.
US6737547B1 (en) 1998-12-31 2004-05-18 Teva Pharmaceutical Industries, Ltd. Compositions containing and methods of using N-acyl-1H-aminoindenes
ATE261445T1 (de) * 1999-12-08 2004-03-15 Grelan Pharmaceutical Co Neue 1,8-naphtyridin-2(1h)-on-derivate
US6916822B2 (en) * 2000-02-18 2005-07-12 Meiji Seika Kaisha, Ltd. Phenoxyalkylamine derivatives useful as opioid δ receptor agonists
JP3772204B2 (ja) * 2000-06-05 2006-05-10 独立行政法人産業技術総合研究所 糖鎖誘導体及びその製造方法
GB0102841D0 (en) * 2001-02-05 2001-03-21 Novartis Ag Organic compounds
US7355042B2 (en) * 2001-10-16 2008-04-08 Hypnion, Inc. Treatment of CNS disorders using CNS target modulators
US20040010038A1 (en) * 2002-02-27 2004-01-15 Eran Blaugrund Propargylamino indan derivatives and propargylamino tetralin derivatives as brain-selective MAO inhibitors
WO2004009591A1 (en) * 2002-07-22 2004-01-29 Aurobindo Pharma Ltd. A process for the preparation of antipsychotic risperidone
JP2007513197A (ja) * 2003-12-08 2007-05-24 ワーナー−ランバート カンパニー リミテッド ライアビリティー カンパニー 統合失調症の治療のための複素環式置換インダン誘導体および関連化合物
US8816090B2 (en) * 2005-02-25 2014-08-26 Pfizer Inc. Benzisoxazole derivatives
DE602006012650D1 (de) 2005-04-26 2010-04-15 Hypnion Inc Benzisoxazolpiperidinverbindungen und verfahren zu deren anwendung
DE102005026194A1 (de) * 2005-06-06 2006-12-07 Grünenthal GmbH Substituierte N-Benzo[d]isoxazol-3-yl-amin-Derivate und deren Verwendung zur Herstellung von Arzneimitteln
CA2634166C (en) * 2005-12-09 2016-03-29 Marta Weinstock-Rosin Use of low-dose ladostigil for neuroprotection
TW200744576A (en) * 2006-02-24 2007-12-16 Teva Pharma Propargylated aminoindans, processes for preparation, and uses thereof
US20090318690A1 (en) 2006-04-28 2009-12-24 Eisai R&D Management Co., Ltd. Benzisoxazole Compound
ATE544766T1 (de) 2009-07-13 2012-02-15 Krka Verfahren zur synthese von paliperidon
WO2012063269A2 (en) 2010-11-12 2012-05-18 Cadila Healthcare Limited Process for preparing iloperidone
JP2016000697A (ja) * 2012-10-02 2016-01-07 大日本住友製薬株式会社 ピリミジン誘導体
EP3497075B1 (de) * 2016-08-12 2020-08-05 Bayer CropScience Aktiengesellschaft Verfahren zur herstellung von substituierten styrol-derivaten
CN115057809B (zh) * 2022-07-15 2024-02-13 扬州市普林斯医药科技有限公司 一种4-(2,4-二氟苯甲酰基)-哌啶的制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4355037A (en) * 1981-11-12 1982-10-19 Hoechst-Roussel Pharmaceuticals 3-(4-Piperidyl)-1,2-benzisoxales
US4352811A (en) * 1981-11-12 1982-10-05 Hoechst-Roussel Pharmaceuticals Inc. 3-(1-Substituted-4-piperidyl)-1,2-benzisoxazoles
US4472193A (en) * 1982-07-06 1984-09-18 The Dow Chemical Company Naphthyridinyloxy(or thio)phenoxy propanoic acids, derivatives thereof and methods of herbicidal use
US4528376A (en) * 1982-08-11 1985-07-09 Hoechst-Roussel Pharmaceuticals Inc. 3-(4-Piperidyl)-1,2-benzisoxazoles
AU5529286A (en) * 1985-03-26 1986-10-02 Hayes, B.L. Shock absorbent moving platform
US4804663A (en) * 1985-03-27 1989-02-14 Janssen Pharmaceutica N.V. 3-piperidinyl-substituted 1,2-benzisoxazoles and 1,2-benzisothiazoles
JPH01199967A (ja) * 1987-10-26 1989-08-11 Sumitomo Pharmaceut Co Ltd 新規なイミド誘導体
WO1991008208A1 (en) * 1989-12-04 1991-06-13 Schering Corporation Heterocyclic substituted naphthyridinones and methods and compositions employing them

Also Published As

Publication number Publication date
DE69011628T2 (de) 1995-03-30
FR2654104A1 (fr) 1991-05-10
ATE110075T1 (de) 1994-09-15
IE903992A1 (en) 1991-05-08
AU6581990A (en) 1991-05-16
AU631466B2 (en) 1992-11-26
DK0428437T3 (da) 1995-01-02
NZ235892A (en) 1992-08-26
EP0428437B1 (fr) 1994-08-17
JPH03188077A (ja) 1991-08-16
CA2029372C (fr) 1998-01-06
CA2029372A1 (fr) 1991-05-08
IE65004B1 (en) 1995-10-04
EP0428437A1 (fr) 1991-05-22
ZA908884B (en) 1991-08-28
US5134147A (en) 1992-07-28
PT95808A (pt) 1991-09-13
US5100902A (en) 1992-03-31
JPH0692403B2 (ja) 1994-11-16
ES2062458T3 (es) 1994-12-16
DE69011628D1 (de) 1994-09-22
FR2654104B1 (fr) 1992-01-03
PT95808B (pt) 1997-11-28

Similar Documents

Publication Publication Date Title
OA09468A (fr) Nouveaux dérivés du 1,2-benzisoxazole, leurs procédés de préparation et les compositions pharmaceutiques qui les contiennent.
DE122009000040I2 (de) Naphthalin-Derivate, Verfahren zu ihrer Herstellung und sie enthaltende pharmazeutische Zusammensetzungen.
IE902182L (en) Tricyclic compounds; pharmaceutical compositions
ATE96772T1 (de) Substituierte 2-alkinylphenole mit entzuendungshemmender wirkung, verfahren zu deren herstellung und pharmazeutische zusammensetzungen.
DE60010596D1 (de) Pyridinderivate, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zubereitungen
ATE88468T1 (de) Arylalkoxycumarine, verfahren zu ihrer herstellung und diese enthaltende therapeutische mittel.
YU47002B (sh) N-imidazolini i n-imidazolilmetilni derivati supstituisanih bicikličnih jedinjenja i postupak za njihovo dobijanje
DE3850603D1 (de) Arylaralkylether, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Zusammensetzung.
ATE103921T1 (de) 1-oxa-2-oxo-8-azaspiro(4,5>decan-derivate, verfahren zu ihrer herstellung und pharmazeutische zusammensetzungen daraus.
DK435583D0 (da) Fremgangsmade til fremstilling af heterocykliske derivater af cyklobutan
DE69104416D1 (de) Acylbenzoxazolinone, Verfahren zu ihrer Herstellung und pharmazeutische Zusammensetzungen die sie enthalten.
HUT58269A (en) Process for producing aralkyl-amine derivatives and pharmaceutical compositions containing them as active components
DK0411736T3 (da) 11beta-substituerede 16alfa,17alfa-methylen-østra-4,9-dien-3-oner
ES2063157T3 (es) Nuevos derivados del indol, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen.
WO2000024389A3 (en) Benzoquinoline derivatives useful as antibacterial agents
ATE103920T1 (de) 1-oxa-2-oxo-8-azaspiro(4,5>decan-derivate, verfahren zu ihrer herstellung und pharmazeutische zusammensetzungen daraus.
DE69702955D1 (de) Bis-Imide Derivate, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zubereitung
ATE29133T1 (de) Troponon-derivate, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammensetzung.
ATE18223T1 (de) Ergolinderivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zusammensetzungen.
ES2060979T3 (es) Nuevos derivados de n-(23-vincristoil) y n-(5'-noranhidro-23-vinblastinoil) de acido 1-amino-metil-fosforico, su procedimiento de preparacion y composiciones farmaceuticas que los contienen.
ATE49207T1 (de) 3-iminopyridazinderivate, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammensetzungen.
DK1264836T3 (da) Fremgangsmåde til fremstilling af indolopyrrolocarbaxolderivater
ATE4384T1 (de) Benzothiopyrano(2,3-c)pyridine und ihre saeureadditions-salze, ihre herstellung, ihre verwendung als arzneimittel und diese verbindungen enthaltende zusammensetzungen.