NO992725D0 - 6-Fenylpyridyl-2-amin-derivater anvendelige som NOS-inhibitorer - Google Patents

6-Fenylpyridyl-2-amin-derivater anvendelige som NOS-inhibitorer

Info

Publication number
NO992725D0
NO992725D0 NO992725A NO992725A NO992725D0 NO 992725 D0 NO992725 D0 NO 992725D0 NO 992725 A NO992725 A NO 992725A NO 992725 A NO992725 A NO 992725A NO 992725 D0 NO992725 D0 NO 992725D0
Authority
NO
Norway
Prior art keywords
phenylpyridyl
amine derivatives
derivatives useful
nos inhibitors
inhibitors
Prior art date
Application number
NO992725A
Other languages
English (en)
Other versions
NO313517B1 (no
NO992725L (no
Inventor
Iii John Adams Lowe
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of NO992725D0 publication Critical patent/NO992725D0/no
Publication of NO992725L publication Critical patent/NO992725L/no
Publication of NO313517B1 publication Critical patent/NO313517B1/no

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    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72Nitrogen atoms
    • C07D213/73Unsubstituted amino or imino radicals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
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    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/06Antimigraine agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/08Antiepileptics; Anticonvulsants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
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    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • A61P27/06Antiglaucoma agents or miotics
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P35/00Antineoplastic agents
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    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/08Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P9/00Drugs for disorders of the cardiovascular system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
NO19992725A 1996-12-06 1999-06-04 6-Fenylpyridyl-2-aminderivater, anvendelse av disse og farmasöytiske preparater inneholdende dem NO313517B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3279396P 1996-12-06 1996-12-06
PCT/IB1997/001446 WO1998024766A1 (en) 1996-12-06 1997-11-17 6-phenylpyridyl-2-amine derivatives useful as nos inhibitors

Publications (3)

Publication Number Publication Date
NO992725D0 true NO992725D0 (no) 1999-06-04
NO992725L NO992725L (no) 1999-06-04
NO313517B1 NO313517B1 (no) 2002-10-14

Family

ID=21866837

Family Applications (1)

Application Number Title Priority Date Filing Date
NO19992725A NO313517B1 (no) 1996-12-06 1999-06-04 6-Fenylpyridyl-2-aminderivater, anvendelse av disse og farmasöytiske preparater inneholdende dem

Country Status (42)

Country Link
US (3) US6235750B1 (no)
EP (1) EP0946512B1 (no)
JP (2) JP3604399B2 (no)
KR (1) KR100360633B1 (no)
CN (1) CN1117077C (no)
AP (1) AP848A (no)
AR (1) AR010331A1 (no)
AT (1) ATE251612T1 (no)
AU (2) AU4791797A (no)
BG (1) BG103540A (no)
BR (1) BR9714381A (no)
CA (1) CA2273479C (no)
CZ (1) CZ293863B6 (no)
DE (1) DE69725465T2 (no)
DK (1) DK0946512T3 (no)
DZ (1) DZ2361A1 (no)
EA (1) EA002907B1 (no)
ES (1) ES2206691T3 (no)
HN (2) HN1997000027A (no)
HR (1) HRP970664A2 (no)
HU (1) HUP0001848A3 (no)
ID (1) ID19056A (no)
IL (1) IL130111A0 (no)
IS (1) IS5053A (no)
MA (1) MA26453A1 (no)
NO (1) NO313517B1 (no)
NZ (1) NZ335733A (no)
OA (1) OA11123A (no)
PA (1) PA8442201A1 (no)
PE (1) PE46499A1 (no)
PL (1) PL333918A1 (no)
PT (1) PT946512E (no)
SI (1) SI0946512T1 (no)
SK (1) SK70899A3 (no)
TN (1) TNSN97198A1 (no)
TR (1) TR199901259T2 (no)
TW (1) TW491840B (no)
UA (1) UA59379C2 (no)
UY (1) UY24799A1 (no)
WO (1) WO1998024766A1 (no)
YU (1) YU25399A (no)
ZA (1) ZA9710906B (no)

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US20010049379A1 (en) 1997-08-27 2001-12-06 Lowe John Adams 2-aminopyridines containing fused ring substituents
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HN1998000125A (es) 1997-08-28 1999-02-09 Pfizer Prod Inc 2-aminopiridinas con sustituyentes alcoxi ramificados
AR019190A1 (es) * 1998-07-08 2001-12-26 Sod Conseils Rech Applic Derivados de 2-aminopiridinas, productos intermedios para su preparacion, medicamentos y composiciones farmaceuticas que los contienen y su uso para preparar medicamentos
FR2791674A1 (fr) * 1999-04-02 2000-10-06 Sod Conseils Rech Applic Nouveaux derives de 2-aminopyridines, leur utilisation en tant que medicaments et compositions pharmaceutiques les contenant
FR2780971B1 (fr) * 1998-07-08 2001-09-28 Sod Conseils Rech Applic Nouveaux derives de 2-aminopyridines, leur application en tant que medicaments et compositions pharmaceutiques les contenant
EE200100084A (xx) * 1998-08-11 2002-08-15 Pfizer Products Inc. NOS inhibiitorite uued farmatseutilised kasutusv�imalused
US7115557B2 (en) 1998-09-25 2006-10-03 Sciaticon Ab Use of certain drugs for treating nerve root injury
SE9803710L (sv) 1998-09-25 2000-03-26 A & Science Invest Ab Användning av vissa substanser för behandling av nervrotsskador
KR20010114213A (ko) 1999-02-25 2001-12-31 실버스타인 아써 에이. 접합 고리 치환기를 함유한 2-아미노피리딘
AU763976B2 (en) * 1999-07-23 2003-08-07 Shionogi & Co., Ltd. Th2 differentiation inhibitors
FR2804429B1 (fr) * 2000-01-31 2003-05-09 Adir Nouveaux derives de 4-sulfonamides piperidine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
WO2002080853A2 (en) * 2001-04-09 2002-10-17 Bristol-Myers Squibb Company Fused heterocyclic inhibitors of factor xa
US20030045449A1 (en) * 2001-08-15 2003-03-06 Pfizer, Inc. Pharmaceutical combinations for the treatment of neurodegenerative diseases
BRPI0409307A (pt) * 2003-04-14 2006-04-25 Pfizer Prod Inc derivados de 3-azabiciclo[3.2.1]octano
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WO2006105795A1 (en) * 2005-04-08 2006-10-12 Leo Pharma A/S Novel indolinone derivatives
CN103980151A (zh) 2006-08-09 2014-08-13 史密丝克莱恩比彻姆公司 作为阿片样物质受体的拮抗剂或反向激动剂的新型化合物
JO2972B1 (en) 2007-06-08 2016-03-15 جانسين فارماسوتيكا ان. في Piperidine / piperazine derivatives
WO2008148851A1 (en) 2007-06-08 2008-12-11 Janssen Pharmaceutica N.V. Piperidine/piperazine derivatives
CA2687754C (en) 2007-06-08 2015-12-08 Janssen Pharmaceutica N.V. Piperidine, piperazine derivatives for use as dgat inhibitors
AU2008258549B2 (en) 2007-06-08 2013-11-14 Janssen Pharmaceutica N.V. Piperidine/piperazine derivatives
WO2009147170A2 (en) 2008-06-05 2009-12-10 Janssen Pharmaceutica Nv Drug combinations comprising a dgat inhibitor and a ppar-agonist
UA105182C2 (ru) 2008-07-03 2014-04-25 Ньюрексон, Інк. Бензоксазины, бензотиазины и родственные соединения, которые имеют ингибирующую nos активность
JP5642661B2 (ja) * 2009-03-05 2014-12-17 塩野義製薬株式会社 Npyy5受容体拮抗作用を有するピペリジンおよびピロリジン誘導体
US11013844B2 (en) * 2014-11-20 2021-05-25 City Of Hope Treatment device for plasma virus inactivation
DK3497099T3 (da) 2016-08-12 2022-05-23 Athenex Inc Biarylsammensætninger og fremgangsmåder til modulering af en kinasekaskade
NZ762985A (en) 2017-09-22 2024-03-22 Jubilant Epipad LLC Heterocyclic compounds as pad inhibitors
HUE061607T2 (hu) 2017-10-18 2023-07-28 Jubilant Epipad LLC Imidazopiridin vegyületek mint PAD inhibitorok
CN111386265A (zh) 2017-11-06 2020-07-07 朱比连特普罗德尔有限责任公司 作为pd1/pd-l1活化的抑制剂的嘧啶衍生物
EP3704120B1 (en) 2017-11-24 2024-03-06 Jubilant Episcribe LLC Heterocyclic compounds as prmt5 inhibitors
BR112020018610A2 (pt) 2018-03-13 2020-12-29 Jubilant Prodel LLC Compostos de fórmula i, fórmula ii, fórmula iii, fórmula iv, fórmula v, fórmula vi, ou seus polimorfos, estereoisômeros, tautômeros, profármacos, solvatos e sais farmaceuticamente aceitáveis dos mesmos e uso dos mesmos; processo de preparação; composição farmacêutica; e método para o tratamento e/ou prevenção de várias doenças, que incluem câncer e doenças infecciosas
JP2022537140A (ja) * 2019-06-14 2022-08-24 エスアールエックス カーディオ,エル エル シー プロタンパク質転換酵素サブチリシン/ケキシン9型(pcsk9)の調節のための化合物
US20220193058A1 (en) * 2020-12-16 2022-06-23 Srx Cardio, Llc Compounds for the modulation of proprotein convertase subtilisin/kexin type 9 (pcsk9)

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PT891332E (pt) * 1996-03-29 2004-07-30 Pfizer Derivados de 6-fenilpiridil-2-amina
US6093743A (en) 1998-06-23 2000-07-25 Medinox Inc. Therapeutic methods employing disulfide derivatives of dithiocarbamates and compositions useful therefor

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HRP970664A2 (en) 1998-10-31
CN1117077C (zh) 2003-08-06
EA199900448A1 (ru) 2000-02-28
NO313517B1 (no) 2002-10-14
DZ2361A1 (fr) 2002-12-28
EP0946512A1 (en) 1999-10-06
ID19056A (id) 1998-06-11
BR9714381A (pt) 2000-05-02
BG103540A (bg) 2000-12-29
EP0946512B1 (en) 2003-10-08
ATE251612T1 (de) 2003-10-15
DE69725465D1 (de) 2003-11-13
HUP0001848A2 (hu) 2001-04-28
NZ335733A (en) 2001-01-26
TNSN97198A1 (fr) 2005-03-15
NO992725L (no) 1999-06-04
HN1997000027A (es) 1997-06-05
AR010331A1 (es) 2000-06-07
AP9701156A0 (en) 1998-01-31
CA2273479C (en) 2006-02-07
US6235750B1 (en) 2001-05-22
TW491840B (en) 2002-06-21
DK0946512T3 (da) 2004-01-12
DE69725465T2 (de) 2004-05-06
PT946512E (pt) 2004-01-30
PE46499A1 (es) 1999-05-12
PA8442201A1 (es) 2000-05-24
IL130111A0 (en) 2000-06-01
CZ293863B6 (cs) 2004-08-18
JP2005170924A (ja) 2005-06-30
HUP0001848A3 (en) 2002-03-28
UY24799A1 (es) 2001-08-27
CZ201799A3 (cs) 2000-07-12
CN1239952A (zh) 1999-12-29
KR20000057413A (ko) 2000-09-15
AU4791797A (en) 1998-06-29
OA11123A (en) 2003-04-07
US20020103227A1 (en) 2002-08-01
WO1998024766A1 (en) 1998-06-11
SI0946512T1 (en) 2004-04-30
HN1997000149A (es) 1997-12-26
YU25399A (sh) 2001-07-10
IS5053A (is) 1999-05-18
AU7205001A (en) 2001-11-15
MA26453A1 (fr) 2004-12-20
AP848A (en) 2000-06-09
JP2000505814A (ja) 2000-05-16
ZA9710906B (en) 1999-06-09
KR100360633B1 (ko) 2002-11-13
SK70899A3 (en) 2002-04-04
EA002907B1 (ru) 2002-10-31
PL333918A1 (en) 2000-01-31
TR199901259T2 (xx) 1999-08-23
US20020032191A1 (en) 2002-03-14
AU766080B2 (en) 2003-10-09
CA2273479A1 (en) 1998-06-11
UA59379C2 (uk) 2003-09-15
ES2206691T3 (es) 2004-05-16
JP3604399B2 (ja) 2004-12-22

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