NO983724D0 - 17-<beta>-syklopropyl (amino/oksi)-4-aza-steroider som aktive inhibitorer av testosteron-5-<alfa>-reduktase og C17-20-lylase - Google Patents

17-<beta>-syklopropyl (amino/oksi)-4-aza-steroider som aktive inhibitorer av testosteron-5-<alfa>-reduktase og C17-20-lylase

Info

Publication number
NO983724D0
NO983724D0 NO983724A NO983724A NO983724D0 NO 983724 D0 NO983724 D0 NO 983724D0 NO 983724 A NO983724 A NO 983724A NO 983724 A NO983724 A NO 983724A NO 983724 D0 NO983724 D0 NO 983724D0
Authority
NO
Norway
Prior art keywords
alpha
beta
androgen
compounds
reductase
Prior art date
Application number
NO983724A
Other languages
English (en)
Other versions
NO983724L (no
Inventor
James R Pribish
Cynthia A Gates
Philip M Weintraub
Original Assignee
Hoechst Marion Roussel Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Marion Roussel Inc filed Critical Hoechst Marion Roussel Inc
Publication of NO983724D0 publication Critical patent/NO983724D0/no
Publication of NO983724L publication Critical patent/NO983724L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J73/00—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J73/00—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms
    • C07J73/001—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom
    • C07J73/005—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom by nitrogen as hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steroid Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
NO983724A 1996-02-14 1998-08-13 17-<beta>-syklopropyl (amino/oksi)-4-aza-steroider som aktive inhibitorer av testosteron-5-<alfa>-reduktase og C17-20-lylase NO983724L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US60127896A 1996-02-14 1996-02-14
PCT/US1997/000469 WO1997030069A1 (en) 1996-02-14 1997-01-09 17-beta-cyclopropyl(amino/oxy) 4-aza steroids as active inhibitors of testosterone 5-alpha-reductase and c17-20-lyase

Publications (2)

Publication Number Publication Date
NO983724D0 true NO983724D0 (no) 1998-08-13
NO983724L NO983724L (no) 1998-10-13

Family

ID=24406899

Family Applications (1)

Application Number Title Priority Date Filing Date
NO983724A NO983724L (no) 1996-02-14 1998-08-13 17-<beta>-syklopropyl (amino/oksi)-4-aza-steroider som aktive inhibitorer av testosteron-5-<alfa>-reduktase og C17-20-lylase

Country Status (17)

Country Link
EP (1) EP0880540B1 (no)
JP (1) JP2000505444A (no)
KR (1) KR19990082543A (no)
CN (1) CN1211256A (no)
AT (1) ATE219100T1 (no)
AU (1) AU710208B2 (no)
BR (1) BR9708301A (no)
CA (1) CA2244823A1 (no)
DE (1) DE69713285T2 (no)
DK (1) DK0880540T3 (no)
ES (1) ES2178750T3 (no)
HU (1) HUP9900955A3 (no)
IL (1) IL125575A0 (no)
NO (1) NO983724L (no)
NZ (1) NZ327041A (no)
PT (1) PT880540E (no)
WO (1) WO1997030069A1 (no)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6187925B1 (en) * 1997-12-23 2001-02-13 Merck & Co., Inc. Intermediates and process for the synthesis of azasteroids
US7005428B1 (en) 1998-06-11 2006-02-28 Endorecherche, Inc. Medical uses of a selective estrogen receptor modulator in combination with sex steroid precursors
US6465445B1 (en) 1998-06-11 2002-10-15 Endorecherche, Inc. Medical uses of a selective estrogen receptor modulator in combination with sex steroid precursors
DE60139639D1 (de) * 2000-12-08 2009-10-01 Takeda Pharmaceutical Substituierte thiazolderivate mit 3-pyridylgruppen, verfahren zu deren herstellung und deren verwendung
WO2004100874A2 (en) 2003-05-07 2004-11-25 Merck & Co., Inc. Androgen receptor modulators and methods of use thereof
AR069079A1 (es) * 2007-10-29 2009-12-30 Takeda Pharmaceutical Farmaco para la prevencion o el tratamiento de cancer
BRPI0920681A2 (pt) * 2008-10-28 2015-12-29 Biomarin Pharm Inc inibidores de decahidro-1h-indenoquinolinona e decahidro-3h-ciclopentafenantridinona de cyp17
WO2011088160A2 (en) * 2010-01-15 2011-07-21 Biomarin Pharmaceutical Inc. Novel cyp17 inhibitors
GB201102913D0 (en) 2011-02-18 2011-04-06 Univ Birmingham Novel therapeutic
CN109438549B (zh) * 2018-12-13 2022-01-04 湖北葛店人福药业有限责任公司 一种制备N-叔丁基-3-氧代-4-氮杂-5α-雄甾-17β-甲酰胺的方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5264427A (en) * 1992-01-29 1993-11-23 Research Corporation Technologies, Inc. 20-substituted pregnene derivatives and their use as androgen synthesis inhibitors
WO1993023053A1 (en) * 1992-05-21 1993-11-25 Endorecherche Inc. INHIBITORS OF TESTOSTERONE 5α-REDUCTASE ACTIVITY
US5486511A (en) * 1993-05-25 1996-01-23 Merrell Dow Pharmaceuticals Inc. 4-amino-17β-(cyclopropyloxy)androst-4-en-3-one, 4-amino-17β-(cyclopropylamino)androst-4-en-3-one and related compounds as C17-20 lyase and 5α-reductase

Also Published As

Publication number Publication date
CN1211256A (zh) 1999-03-17
DK0880540T3 (da) 2002-10-07
EP0880540A1 (en) 1998-12-02
HUP9900955A3 (en) 2000-06-28
JP2000505444A (ja) 2000-05-09
KR19990082543A (ko) 1999-11-25
PT880540E (pt) 2002-10-31
AU710208B2 (en) 1999-09-16
BR9708301A (pt) 1999-08-03
EP0880540B1 (en) 2002-06-12
DE69713285D1 (en) 2002-07-18
ES2178750T3 (es) 2003-01-01
IL125575A0 (en) 1999-03-12
NZ327041A (en) 1999-11-29
CA2244823A1 (en) 1997-08-21
ATE219100T1 (de) 2002-06-15
DE69713285T2 (de) 2003-01-02
NO983724L (no) 1998-10-13
WO1997030069A1 (en) 1997-08-21
HUP9900955A2 (hu) 1999-07-28
AU1576797A (en) 1997-09-02

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