HUP0302405A2 - Új benzofuránszármazékok - Google Patents
Új benzofuránszármazékokInfo
- Publication number
- HUP0302405A2 HUP0302405A2 HU0302405A HUP0302405A HUP0302405A2 HU P0302405 A2 HUP0302405 A2 HU P0302405A2 HU 0302405 A HU0302405 A HU 0302405A HU P0302405 A HUP0302405 A HU P0302405A HU P0302405 A2 HUP0302405 A2 HU P0302405A2
- Authority
- HU
- Hungary
- Prior art keywords
- cancer
- salts
- substituted
- benzofuran derivatives
- steroid
- Prior art date
Links
- 150000001907 coumarones Chemical class 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 150000003431 steroids Chemical class 0.000 abstract 2
- 125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 abstract 1
- 125000003349 3-pyridyl group Chemical group N1=C([H])C([*])=C([H])C([H])=C1[H] 0.000 abstract 1
- 125000000339 4-pyridyl group Chemical group N1=C([H])C([H])=C([*])C([H])=C1[H] 0.000 abstract 1
- 201000004384 Alopecia Diseases 0.000 abstract 1
- 206010004446 Benign prostatic hyperplasia Diseases 0.000 abstract 1
- 206010006187 Breast cancer Diseases 0.000 abstract 1
- 208000026310 Breast neoplasm Diseases 0.000 abstract 1
- 201000009273 Endometriosis Diseases 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 206010033128 Ovarian cancer Diseases 0.000 abstract 1
- 206010061535 Ovarian neoplasm Diseases 0.000 abstract 1
- 208000004403 Prostatic Hyperplasia Diseases 0.000 abstract 1
- 208000002495 Uterine Neoplasms Diseases 0.000 abstract 1
- 239000003098 androgen Substances 0.000 abstract 1
- 230000001548 androgenic effect Effects 0.000 abstract 1
- 125000006615 aromatic heterocyclic group Chemical group 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 230000001419 dependent effect Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940011871 estrogen Drugs 0.000 abstract 1
- 239000000262 estrogen Substances 0.000 abstract 1
- 230000003676 hair loss Effects 0.000 abstract 1
- 239000005556 hormone Substances 0.000 abstract 1
- 229940088597 hormone Drugs 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 230000003449 preventive effect Effects 0.000 abstract 1
- 201000004240 prostatic hypertrophy Diseases 0.000 abstract 1
- 208000011580 syndromic disease Diseases 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
- 206010046766 uterine cancer Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/28—Antiandrogens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/32—Antioestrogens
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Endocrinology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
A találmány szerint megvalósíthatók az (I) általános képletűvegyületek, és sóik ahol Py jelentése 2-, 3- vagy 4-piridilcsoport, ésR jelentése szubsztituált vagy szubsztituálatlan fenilcsoport, vagyszubsztituált vagy szubsztituálatlan aromás heterociklusos csoport. Atalálmány továbbá a szteroid 17a-hidroxilázzal és/vagy szteroid C17-20-liázzal szemben gátló hatású szerekre, valamint a fenti (I) képletűbenzofuránszármazékokat, vagy azok sóit tartalmazó gyógyászatikészítményekre is kiterjed. A találmány szerinti vegyületek megelőzőés/vagy terápiás szerekként alkalmazhatók az androgén hormonoktól ésösztrogénektől függő betegségek eseteiben, amilyenek például: aprosztatarák, prosztatahipertrófia, androgén tünetcsoport, kopaszság,emlőrák, méhrák, endometriózis és petefészekrák. Ó
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2000146583 | 2000-05-18 | ||
PCT/JP2001/004190 WO2001087875A1 (fr) | 2000-05-18 | 2001-05-18 | Nouveaux derives de benzofurane |
Publications (1)
Publication Number | Publication Date |
---|---|
HUP0302405A2 true HUP0302405A2 (hu) | 2003-10-28 |
Family
ID=18652915
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU0302405A HUP0302405A2 (hu) | 2000-05-18 | 2001-05-18 | Új benzofuránszármazékok |
Country Status (12)
Country | Link |
---|---|
US (1) | US6689798B2 (hu) |
EP (1) | EP1283208A4 (hu) |
KR (1) | KR20020094041A (hu) |
CN (1) | CN1429223A (hu) |
AU (1) | AU5878101A (hu) |
CA (1) | CA2409096A1 (hu) |
HU (1) | HUP0302405A2 (hu) |
IL (1) | IL152893A0 (hu) |
MX (1) | MXPA02011352A (hu) |
NO (1) | NO20025474L (hu) |
WO (1) | WO2001087875A1 (hu) |
ZA (1) | ZA200210201B (hu) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0124933D0 (en) | 2001-10-17 | 2001-12-05 | Glaxo Group Ltd | Chemical compounds |
US6815408B2 (en) * | 2002-02-11 | 2004-11-09 | Paul C. Wegner | Hydrogen peroxide stabilizer and resulting product and applications |
DK1474395T3 (da) | 2002-02-12 | 2008-02-11 | Smithkline Beecham Corp | Nicotinamidderivater, der er nyttige som p38-inhibitorer |
GB0308186D0 (en) | 2003-04-09 | 2003-05-14 | Smithkline Beecham Corp | Novel compounds |
GB0308201D0 (en) | 2003-04-09 | 2003-05-14 | Smithkline Beecham Corp | Novel compounds |
GB0318814D0 (en) | 2003-08-11 | 2003-09-10 | Smithkline Beecham Corp | Novel compounds |
CN102471738B (zh) * | 2009-07-09 | 2015-11-25 | 宝洁公司 | 包含苯二甲酰亚氨基过氧己酸的轻度碱性低复配固体织物处理洗涤剂组合物 |
EP2388255A1 (en) * | 2010-05-11 | 2011-11-23 | Ikerchem, S.L. | Polysubstituted benzofurans and medicinal applications thereof |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3678062A (en) * | 1970-09-08 | 1972-07-18 | American Cyanamid Co | Certain 4-/(indazol-3-yl)-pyridinium/compounds |
JPH01213276A (ja) * | 1988-02-19 | 1989-08-28 | Takeda Chem Ind Ltd | ベンゾフラン透導体 |
AU7124691A (en) * | 1990-02-27 | 1991-08-29 | Ciba-Geigy Ag | Benzofurans |
GB9408577D0 (en) * | 1994-04-29 | 1994-06-22 | Fujisawa Pharmaceutical Co | New compound |
-
2001
- 2001-05-18 IL IL15289301A patent/IL152893A0/xx unknown
- 2001-05-18 MX MXPA02011352A patent/MXPA02011352A/es unknown
- 2001-05-18 AU AU58781/01A patent/AU5878101A/en not_active Abandoned
- 2001-05-18 CA CA002409096A patent/CA2409096A1/en not_active Abandoned
- 2001-05-18 WO PCT/JP2001/004190 patent/WO2001087875A1/ja not_active Application Discontinuation
- 2001-05-18 EP EP01932148A patent/EP1283208A4/en not_active Withdrawn
- 2001-05-18 CN CN01809659A patent/CN1429223A/zh active Pending
- 2001-05-18 KR KR1020027015122A patent/KR20020094041A/ko not_active Application Discontinuation
- 2001-05-18 HU HU0302405A patent/HUP0302405A2/hu unknown
-
2002
- 2002-11-15 NO NO20025474A patent/NO20025474L/no not_active Application Discontinuation
- 2002-11-18 US US10/298,771 patent/US6689798B2/en not_active Expired - Fee Related
- 2002-12-17 ZA ZA200210201A patent/ZA200210201B/en unknown
Also Published As
Publication number | Publication date |
---|---|
ZA200210201B (en) | 2003-12-17 |
NO20025474L (no) | 2003-01-07 |
CN1429223A (zh) | 2003-07-09 |
NO20025474D0 (no) | 2002-11-15 |
KR20020094041A (ko) | 2002-12-16 |
AU5878101A (en) | 2001-11-26 |
EP1283208A4 (en) | 2003-08-13 |
US20030149079A1 (en) | 2003-08-07 |
WO2001087875A1 (fr) | 2001-11-22 |
MXPA02011352A (es) | 2005-07-01 |
CA2409096A1 (en) | 2002-11-15 |
US6689798B2 (en) | 2004-02-10 |
IL152893A0 (en) | 2003-06-24 |
EP1283208A1 (en) | 2003-02-12 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD9A | Lapse of provisional protection due to non-payment of fees |