HUP0302405A2 - Új benzofuránszármazékok - Google Patents

Új benzofuránszármazékok

Info

Publication number
HUP0302405A2
HUP0302405A2 HU0302405A HUP0302405A HUP0302405A2 HU P0302405 A2 HUP0302405 A2 HU P0302405A2 HU 0302405 A HU0302405 A HU 0302405A HU P0302405 A HUP0302405 A HU P0302405A HU P0302405 A2 HUP0302405 A2 HU P0302405A2
Authority
HU
Hungary
Prior art keywords
cancer
salts
substituted
benzofuran derivatives
steroid
Prior art date
Application number
HU0302405A
Other languages
English (en)
Inventor
Yoshikazu Ikeda
Ken'ichi Kimura
Junji Nakamura
Shin Nomoto
Masayuki Okue
Shin'ichi Shimada
Takeko Takada
Original Assignee
Daiichi Pharmaceutical Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Daiichi Pharmaceutical Co., Ltd. filed Critical Daiichi Pharmaceutical Co., Ltd.
Publication of HUP0302405A2 publication Critical patent/HUP0302405A2/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/28—Antiandrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/32—Antioestrogens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Endocrinology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

A találmány szerint megvalósíthatók az (I) általános képletűvegyületek, és sóik ahol Py jelentése 2-, 3- vagy 4-piridilcsoport, ésR jelentése szubsztituált vagy szubsztituálatlan fenilcsoport, vagyszubsztituált vagy szubsztituálatlan aromás heterociklusos csoport. Atalálmány továbbá a szteroid 17a-hidroxilázzal és/vagy szteroid C17-20-liázzal szemben gátló hatású szerekre, valamint a fenti (I) képletűbenzofuránszármazékokat, vagy azok sóit tartalmazó gyógyászatikészítményekre is kiterjed. A találmány szerinti vegyületek megelőzőés/vagy terápiás szerekként alkalmazhatók az androgén hormonoktól ésösztrogénektől függő betegségek eseteiben, amilyenek például: aprosztatarák, prosztatahipertrófia, androgén tünetcsoport, kopaszság,emlőrák, méhrák, endometriózis és petefészekrák. Ó
HU0302405A 2000-05-18 2001-05-18 Új benzofuránszármazékok HUP0302405A2 (hu)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2000146583 2000-05-18
PCT/JP2001/004190 WO2001087875A1 (fr) 2000-05-18 2001-05-18 Nouveaux derives de benzofurane

Publications (1)

Publication Number Publication Date
HUP0302405A2 true HUP0302405A2 (hu) 2003-10-28

Family

ID=18652915

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0302405A HUP0302405A2 (hu) 2000-05-18 2001-05-18 Új benzofuránszármazékok

Country Status (12)

Country Link
US (1) US6689798B2 (hu)
EP (1) EP1283208A4 (hu)
KR (1) KR20020094041A (hu)
CN (1) CN1429223A (hu)
AU (1) AU5878101A (hu)
CA (1) CA2409096A1 (hu)
HU (1) HUP0302405A2 (hu)
IL (1) IL152893A0 (hu)
MX (1) MXPA02011352A (hu)
NO (1) NO20025474L (hu)
WO (1) WO2001087875A1 (hu)
ZA (1) ZA200210201B (hu)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0124933D0 (en) 2001-10-17 2001-12-05 Glaxo Group Ltd Chemical compounds
US6815408B2 (en) * 2002-02-11 2004-11-09 Paul C. Wegner Hydrogen peroxide stabilizer and resulting product and applications
DK1474395T3 (da) 2002-02-12 2008-02-11 Smithkline Beecham Corp Nicotinamidderivater, der er nyttige som p38-inhibitorer
GB0308186D0 (en) 2003-04-09 2003-05-14 Smithkline Beecham Corp Novel compounds
GB0308201D0 (en) 2003-04-09 2003-05-14 Smithkline Beecham Corp Novel compounds
GB0318814D0 (en) 2003-08-11 2003-09-10 Smithkline Beecham Corp Novel compounds
CN102471738B (zh) * 2009-07-09 2015-11-25 宝洁公司 包含苯二甲酰亚氨基过氧己酸的轻度碱性低复配固体织物处理洗涤剂组合物
EP2388255A1 (en) * 2010-05-11 2011-11-23 Ikerchem, S.L. Polysubstituted benzofurans and medicinal applications thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3678062A (en) * 1970-09-08 1972-07-18 American Cyanamid Co Certain 4-/(indazol-3-yl)-pyridinium/compounds
JPH01213276A (ja) * 1988-02-19 1989-08-28 Takeda Chem Ind Ltd ベンゾフラン透導体
AU7124691A (en) * 1990-02-27 1991-08-29 Ciba-Geigy Ag Benzofurans
GB9408577D0 (en) * 1994-04-29 1994-06-22 Fujisawa Pharmaceutical Co New compound

Also Published As

Publication number Publication date
ZA200210201B (en) 2003-12-17
NO20025474L (no) 2003-01-07
CN1429223A (zh) 2003-07-09
NO20025474D0 (no) 2002-11-15
KR20020094041A (ko) 2002-12-16
AU5878101A (en) 2001-11-26
EP1283208A4 (en) 2003-08-13
US20030149079A1 (en) 2003-08-07
WO2001087875A1 (fr) 2001-11-22
MXPA02011352A (es) 2005-07-01
CA2409096A1 (en) 2002-11-15
US6689798B2 (en) 2004-02-10
IL152893A0 (en) 2003-06-24
EP1283208A1 (en) 2003-02-12

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Legal Events

Date Code Title Description
FD9A Lapse of provisional protection due to non-payment of fees