DK279790A - Aromatiske steroid-5-alfa-reduktaseinhibitorer - Google Patents

Aromatiske steroid-5-alfa-reduktaseinhibitorer Download PDF

Info

Publication number: DK279790A
Authority: DK; Denmark
Prior art keywords: compounds; alfa; reductase inhibitors; aromatic steroid; steroid
Prior art date: 1988-05-25

Application number

DK279790A

Other languages

English (en)

Other versions

DK279790D0 (da

DK168295B1 (da

Inventor

Dennis Alan Holt

Mark Alan Levy

Brian Walter Metcalf

Original Assignee

Smithkline Beckman Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-05-25

Filing date

1990-11-23

Publication date

1990-11-23

1990-11-23 Application filed by Smithkline Beckman Corp filed Critical Smithkline Beckman Corp

1990-11-23 Publication of DK279790D0 publication Critical patent/DK279790D0/da

1990-11-23 Publication of DK279790A publication Critical patent/DK279790A/da

1994-03-07 Application granted granted Critical

1994-03-07 Publication of DK168295B1 publication Critical patent/DK168295B1/da

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J13/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17
- C07J13/005—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17 with double bond in position 16 (17)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0051—Estrane derivatives
- C07J1/0059—Estrane derivatives substituted in position 17 by a keto group
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J13/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17
- C07J13/007—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17 with double bond in position 17 (20)
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
- C07J3/005—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom the carbon atom being part of a carboxylic function
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
- C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0072—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the A ring of the steroid being aromatic
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0094—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing nitrile radicals, including thiocyanide radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
- C07J7/008—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21
- C07J7/0095—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21 carbon in position 21 is part of carboxylic group
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Endocrinology (AREA)
Diabetes (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Toxicology (AREA)
Steroid Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Plural Heterocyclic Compounds (AREA)

DK279790A 1988-05-25 1990-11-23 Østrananalog forbindelse, farmaceutisk middel indeholdende forbindelsen samt anvendelse af forbindelsen ved fremstilling af et lægemiddel til inhibering af steroid-5-alfa-reduktaseaktivitet DK168295B1 (da)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
US19853488A	1988-05-25	1988-05-25
US19853488		1988-05-25
US8902269		1989-05-23
PCT/US1989/002269 WO1989011282A1 (en)	1988-05-25	1989-05-23	AROMATIC STEROID 5-alpha-REDUCTASE INHIBITORS

Publications (3)

Publication Number	Publication Date
DK279790D0 DK279790D0 (da)	1990-11-23
DK279790A true DK279790A (da)	1990-11-23
DK168295B1 DK168295B1 (da)	1994-03-07

Family

ID=22733779

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DK279790A DK168295B1 (da)	1988-05-25	1990-11-23	Østrananalog forbindelse, farmaceutisk middel indeholdende forbindelsen samt anvendelse af forbindelsen ved fremstilling af et lægemiddel til inhibering af steroid-5-alfa-reduktaseaktivitet
DK130393A DK169787B1 (da)	1988-05-25	1993-11-19	3-trifluormethylsulfonatsteroidderivater

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
DK130393A DK169787B1 (da)	1988-05-25	1993-11-19	3-trifluormethylsulfonatsteroidderivater

Country Status (16)

Country	Link
EP (1)	EP0343954B1 (da)
JP (1)	JP2675418B2 (da)
AT (1)	ATE114665T1 (da)
AU (1)	AU627466B2 (da)
CA (1)	CA1331457C (da)
DE (1)	DE68919537T2 (da)
DK (2)	DK168295B1 (da)
ES (1)	ES2065378T3 (da)
GR (1)	GR3015135T3 (da)
HK (1)	HK1006461A1 (da)
IE (1)	IE68858B1 (da)
IL (1)	IL91968A (da)
NO (1)	NO174964C (da)
PT (1)	PT90656B (da)
WO (1)	WO1989011282A1 (da)
ZA (1)	ZA893971B (da)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5138063A (en) *	1984-02-27	1992-08-11	Merck & Co., Inc.	17β-methoxycarbonyl-4-aza-androsten-1-en-3-ones
US5571817A (en) *	1984-02-27	1996-11-05	Merck & Co., Inc.	Methods of treating androgenic alopecia with finasteride [17β-N-mono-substituted-carbamoyl-4-aza-5-α-androst-1-en-ones]
US5151430A (en) *	1990-06-20	1992-09-29	Merck & Co., Inc.	Specific 17β-thiobenzoyl-4-aza-5α-androst-1-en-3-ones as antiandrogen agents
US5162332A (en) *	1990-06-20	1992-11-10	Merck & Co., Inc.	Selected 17 β-polyaroyl-4-aza-5 α-androst-1-en-3-ones as steroidal reductase inhibitors
US5061802A (en) *	1990-06-20	1991-10-29	Merck & Co. Inc.	17β-aminobenzoyl-4-aza-5α-androst-1-en-3-ones as benign prostatic hypertrophy agents
US5098908A (en) *	1990-06-20	1992-03-24	Merck & Co., Inc.	17β-hydroxybenzoyl-4-aza-5α-androst-1-en-3-ones as testosterone reductase inhibitors
US5091380A (en) *	1990-06-28	1992-02-25	Merck & Co., Inc.	N-monosubstituted adamantyl/norbornanyl 17β-carbamides of 3-carboxy-androst-3,5-dienes as testosterone 5α-reductase inhibitors
NZ241979A (en) *	1991-03-20	1996-01-26	Merck & Co Inc	Treatment of benign prostatic hyperplasia using 5alpha-reductase inhibitor and an alpha1-adrenergic recepter blocker
SK129294A3 (en) *	1992-04-30	1995-07-11	Smithkline Beecham Corp	17-alpha and 17-beta-substituted estra-1,3,5(10)-triene-3- -carboxylic acid
AU668180B2 (en) *	1992-05-20	1996-04-26	Merck & Co., Inc.	17-ethers and thioethers of 4-aza-steroids
US5237064A (en) *	1992-05-20	1993-08-17	Merck & Co., Inc.	Process for producing 7β-substituted-aza-5αandrostan-3-ones
AU675225B2 (en) *	1992-05-20	1997-01-30	Merck & Co., Inc.	17-amino substituted 4-azasteroid 5alpha-reductase inhibitors
US5610162A (en) *	1992-05-20	1997-03-11	Merck & Co., Inc.	Ester derivatives of 4-aza-steroids
AU672978B2 (en) *	1992-05-20	1996-10-24	Merck & Co., Inc.	4-azasteroid 5-alpha-reductase inhibitors
HUT71484A (en) *	1992-05-20	1995-11-28	Merck & Co Inc	Process for producing of 7beta-substituted-4-aza-5alpha-cholestan-ones as 5-alpha-reductase inhibitors and pharmaceuticals compositions containing them
US5324734A (en) *	1992-09-15	1994-06-28	Merck & Co., Inc.	Oxidization metabolites of 5-α-23-methyl-4-aza-21-nor-chol-1-ene-3, 20-dione
US5278159A (en) *	1992-10-06	1994-01-11	Merck & Co., Inc.	Aryl ester derivatives of 3-oxo-4-aza-androstane 17-β-carboxylates as 5-α-reductase inhibitors
US5641765A (en) *	1992-11-18	1997-06-24	Smithkline Beecham Corporation	17-αand 17-βsubstituted acyl-3-carboxy-3,5-dienes and use in inhibiting 5-α-reductase
US5683995A (en) *	1992-11-18	1997-11-04	Smithkline Beecham Corporation	17 substituted acyl-3-carboxy 3,5-diene steroidals as α-reductase inhibitors
US5359071A (en) *	1993-03-12	1994-10-25	Merck & Co., Inc.	15-substituted 4-azasteroids
AU6413594A (en) *	1993-03-24	1994-10-11	Merck & Co., Inc.	Substituted 3-phenanthridinone derivatives as 5alpha-reductase inhibitors
CA2165077A1 (en) *	1993-06-28	1995-01-05	Philippe L. Durette	4-aza-pregnane 5.alpha.-reductase isozyme 1 inhibitors
TW369521B (en) *	1993-09-17	1999-09-11	Smithkline Beecham Corp	Androstenone derivative
US5430157A (en) *	1993-12-13	1995-07-04	Eli Lilly And Company	Reduced phenanthrenes
US5541322A (en) *	1994-10-14	1996-07-30	Glaxo Wellcome Inc.	Synthesis of 6-azaandrostenones
US5595996A (en) *	1994-10-25	1997-01-21	Merck & Co., Inc.	7-substituted 4-aza cholanic acid derivatives and their use
GB201102913D0 (en)	2011-02-18	2011-04-06	Univ Birmingham	Novel therapeutic

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE1107664B (de) *	1959-11-05	1961-05-31	Schering Ag	Verfahren zur Herstellung neuer in 3-Stellung substituierter OEstratriene
US3622670A (en) *	1969-08-22	1971-11-23	American Home Prod	Method of inducing ovulation
US4185101A (en) *	1977-08-11	1980-01-22	Schering Corporation	1,3,5(10),6,8-19-Nor-pregnapentaenes, their use as anti-psoriatic agents, and pharmaceutical formulations useful therefor
US4191759A (en) *	1978-04-13	1980-03-04	Merck & Co., Inc.	N-substituted-17β-carbamoylandrost-4-en-3-one 5α reductase inhibitors
US4340602A (en) *	1978-10-18	1982-07-20	Wayne State University	Compositions inhibiting estrogen sulfotransferase activity
US4910226A (en) *	1987-04-29	1990-03-20	Smithkline Beckman Corporation	Steroid 5-alpha-reductase inhibitors

1989
- 1989-05-23 WO PCT/US1989/002269 patent/WO1989011282A1/en unknown
- 1989-05-23 AU AU37487/89A patent/AU627466B2/en not_active Ceased
- 1989-05-23 CA CA000600335A patent/CA1331457C/en not_active Expired - Fee Related
- 1989-05-23 JP JP1506391A patent/JP2675418B2/ja not_active Expired - Lifetime
- 1989-05-24 AT AT89305246T patent/ATE114665T1/de not_active IP Right Cessation
- 1989-05-24 ES ES89305246T patent/ES2065378T3/es not_active Expired - Lifetime
- 1989-05-24 DE DE68919537T patent/DE68919537T2/de not_active Expired - Fee Related
- 1989-05-24 EP EP89305246A patent/EP0343954B1/en not_active Expired - Lifetime
- 1989-05-24 PT PT90656A patent/PT90656B/pt not_active IP Right Cessation
- 1989-05-25 ZA ZA893971A patent/ZA893971B/xx unknown
- 1989-06-12 IE IE173289A patent/IE68858B1/en not_active IP Right Cessation
- 1989-10-11 NO NO894065A patent/NO174964C/no unknown
- 1989-10-12 IL IL9196889A patent/IL91968A/en not_active IP Right Cessation
1990
- 1990-11-23 DK DK279790A patent/DK168295B1/da not_active IP Right Cessation
1993
- 1993-11-19 DK DK130393A patent/DK169787B1/da active
1995
- 1995-02-22 GR GR950400355T patent/GR3015135T3/el unknown
1998
- 1998-06-18 HK HK98105689A patent/HK1006461A1/xx not_active IP Right Cessation

Also Published As

Publication number	Publication date
WO1989011282A1 (en)	1989-11-30
NO894065D0 (no)	1989-10-11
HK1006461A1 (en)	1999-02-26
AU627466B2 (en)	1992-08-27
DK130393D0 (da)	1993-11-19
NO174964B (no)	1994-05-02
IE891732L (en)	1989-11-25
ATE114665T1 (de)	1994-12-15
CA1331457C (en)	1994-08-16
ES2065378T3 (es)	1995-02-16
NO894065L (no)	1991-04-12
DK279790D0 (da)	1990-11-23
DK130393A (da)	1993-11-19
DE68919537T2 (de)	1995-05-11
ZA893971B (en)	1990-05-30
JP2675418B2 (ja)	1997-11-12
DK169787B1 (da)	1995-02-27
DE68919537D1 (de)	1995-01-12
IE68858B1 (en)	1996-07-24
EP0343954A3 (en)	1990-05-16
EP0343954A2 (en)	1989-11-29
DK168295B1 (da)	1994-03-07
PT90656A (pt)	1989-11-30
PT90656B (pt)	1994-10-31
IL91968A (en)	1994-10-21
AU3748789A (en)	1989-12-12
JPH03504498A (ja)	1991-10-03
EP0343954B1 (en)	1994-11-30
GR3015135T3 (en)	1995-05-31
NO174964C (no)	1994-08-10

Legal Events

Date	Code	Title	Description
1994-03-07	B1	Patent granted (law 1993)
1999-03-29	PBP	Patent lapsed

Publication	Publication Date	Title
DK279790A (da)	1990-11-23	Aromatiske steroid-5-alfa-reduktaseinhibitorer
ATE192649T1 (de)	2000-05-15	Stereochemische wortmanninderivate
MY103518A (en)	1993-07-31	Steroid 5- -reductase inhibitors
ECSP045520A (es)	2005-03-10	Metodos de tratamiento con inhibidores de la ptec y agentes antihipertensivos
BG99261A (en)	1995-06-30	Steroid glycosides for the treatment of hyperchlesterolemia
BR0113670A (pt)	2004-11-09	Composição farmacêutica e método para tratar hipogonadismo
AP9901478A0 (en)	1999-03-31	Compounds for the treatment of ischemia.
GT199700009AA (es)	1999-01-23	Terapia combinada para la osteoporosis
BR9401183A (pt)	1994-11-01	Composto e formulação farmacêutica
ES2170252T3 (es)	2002-08-01	Tetrahidroimidazopiridoindoldionas como inhibidores de cgmp especifico pde.
DE69329240D1 (de)	2000-09-21	17-ether und thioether von 4-aza-steroiden
HN1998000157A (es)	1999-06-02	Agonistas de prostaglandinas
NO20065784L (no)	2001-12-13	Steroidforbindelser og anvendelse av slike
PT748190E (pt)	2003-12-31	Metodos e formulacoes para uso no tratamento de disturbios ginecologicos benignos
ES2055745T3 (es)	1994-09-01	Compuestos antigestagenicos y antiestrogenos para el tratamiento de tumores hormono-dependientes.
ES2148178T3 (es)	2000-10-16	Uso de derivados de sulfamato como inhibidores de esteroide-sulfatasa.
BR9805544A (pt)	2000-03-28	Uso de um composto.
BG99177A (en)	1995-07-28	New 7 -substituted-4-aza-5 - cholestanones as inhibitors of 5 - reductase
DE69720996D1 (de)	2003-05-22	Neue pharmazeutische zusammensetzungen von steroid-nitratester zur verwendung als enzündungshemmer
DK0719276T3 (da)	1998-08-10	Ïstradiolestre med stærk oral virkning samt farmaceutiske præparater med indhold deraf
MX9301939A (es)	1994-08-31	Composicion farmaceutica que comprende un compuesto inhibidor de 5-ó-reductasa esteroidal.
ES2175661T3 (es)	2002-11-16	Derivados de la isoflavona, procedimientos para la preparacion de los mismos y composiciones farmaceuticas que los contienen.
ID26703A (id)	2001-02-01	Penggunaan anestesi lokal untuk sakit kepala vaskular
MX9303970A (es)	1994-04-29	COMPUESTOS ESTEROIDALES DE ANILLO A DE 17Ó Y 17ß-ALQUILCETONA-3-CARBOXIAROMATICO.
BR9203266A (pt)	1993-04-06	Composto,formulacao farmaceutica,processo para inibir 5alfa-reductase,processos para tratar hiperplasia benigna da prostata,seborreia e alopecia androgenica