NO980209D0 - Ny fremgangsmåte for fremstilling av amorft £R-(R*,R*)|-2-(4-fluorfenyl)-<beta>,<delta>-dihydroksy-5-(1-metyletyl)-3-fenyl-4-£(fenylamino)karbonyl|-1H-pyrrol-1-heptansyre-kalsiumsalt (2:1) - Google Patents

Ny fremgangsmåte for fremstilling av amorft £R-(R*,R*)|-2-(4-fluorfenyl)-<beta>,<delta>-dihydroksy-5-(1-metyletyl)-3-fenyl-4-£(fenylamino)karbonyl|-1H-pyrrol-1-heptansyre-kalsiumsalt (2:1)

Info

Publication number
NO980209D0
NO980209D0 NO980209A NO980209A NO980209D0 NO 980209 D0 NO980209 D0 NO 980209D0 NO 980209 A NO980209 A NO 980209A NO 980209 A NO980209 A NO 980209A NO 980209 D0 NO980209 D0 NO 980209D0
Authority
NO
Norway
Prior art keywords
phenylamino
fluorophenyl
pyrrole
carbonyl
amorphous
Prior art date
Application number
NO980209A
Other languages
English (en)
Other versions
NO309322B1 (no
NO980209L (no
Inventor
Dieter Schweiss
Min Lin
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21696097&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO980209(D0) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Publication of NO980209L publication Critical patent/NO980209L/no
Publication of NO980209D0 publication Critical patent/NO980209D0/no
Publication of NO309322B1 publication Critical patent/NO309322B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pyrrole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
NO980209A 1995-07-17 1998-01-16 Fremgangsmåte for fremstilling av amorft [R-(R*,R*)]-2-(4- fluorfenyl)-<beta>,<delta>-dihydroksy-5-(1-metyletyl)-3-fenyl-4- [(fenylamino)karbonyl]-1H-pyrrol-1-heptansyre-kalsiumsalt (2:1) NO309322B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US145395P 1995-07-17 1995-07-17
PCT/US1996/011807 WO1997003960A1 (en) 1995-07-17 1996-07-16 NOVEL PROCESS FOR THE PRODUCTION OF AMORPHOUS [R-(R*,R*)]-2-(4-FLUOROPHENYL)-β,δ-DIHYDROXY-5-(1-METHYLETHYL)-3-PHENYL-4-[(PHENYLAMINO)CARBONYL]-1H-PYRROLE-1-HEPTANOIC ACID CALCIUM SALT (2:1)

Publications (3)

Publication Number Publication Date
NO980209L NO980209L (no) 1998-01-16
NO980209D0 true NO980209D0 (no) 1998-01-16
NO309322B1 NO309322B1 (no) 2001-01-15

Family

ID=21696097

Family Applications (1)

Application Number Title Priority Date Filing Date
NO980209A NO309322B1 (no) 1995-07-17 1998-01-16 Fremgangsmåte for fremstilling av amorft [R-(R*,R*)]-2-(4- fluorfenyl)-<beta>,<delta>-dihydroksy-5-(1-metyletyl)-3-fenyl-4- [(fenylamino)karbonyl]-1H-pyrrol-1-heptansyre-kalsiumsalt (2:1)

Country Status (38)

Country Link
US (1) US6274740B1 (no)
EP (1) EP0839132B1 (no)
JP (1) JP4064459B2 (no)
KR (1) KR100400805B1 (no)
CN (1) CN1087289C (no)
AR (1) AR002849A1 (no)
AT (1) ATE199542T1 (no)
AU (1) AU700794B2 (no)
BG (1) BG63631B1 (no)
BR (1) BR9609714A (no)
CA (1) CA2220455C (no)
CO (1) CO4700441A1 (no)
CZ (1) CZ289421B6 (no)
DE (1) DE69611999T2 (no)
DK (1) DK0839132T5 (no)
EA (1) EA000625B1 (no)
EE (1) EE03605B1 (no)
ES (1) ES2156997T3 (no)
GE (1) GEP20002027B (no)
GR (1) GR3035859T3 (no)
HK (1) HK1018054A1 (no)
HR (1) HRP960312B1 (no)
HU (1) HU220343B (no)
IL (1) IL122161A (no)
IN (1) IN185276B (no)
MX (1) MX9708959A (no)
NO (1) NO309322B1 (no)
NZ (1) NZ313008A (no)
PE (1) PE1698A1 (no)
PL (1) PL191017B1 (no)
PT (1) PT839132E (no)
RO (1) RO120069B1 (no)
SI (1) SI0839132T1 (no)
SK (1) SK283204B6 (no)
UA (1) UA50743C2 (no)
UY (1) UY24286A1 (no)
WO (1) WO1997003960A1 (no)
ZA (1) ZA966043B (no)

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FI94339C (fi) 1989-07-21 1995-08-25 Warner Lambert Co Menetelmä farmaseuttisesti käyttökelpoisen /R-(R*,R*)/-2-(4-fluorifenyyli)- , -dihydroksi-5-(1-metyylietyyli)-3-fenyyli-4-/(fenyyliamino)karbonyyli/-1H-pyrroli-1-heptaanihapon ja sen farmaseuttisesti hyväksyttävien suolojen valmistamiseksi
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SI20425A (sl) 1999-12-10 2001-06-30 LEK tovarna farmacevtskih in kemi�nih izdelkov d.d. Priprava amorfnega atorvastatina
CA2427255A1 (en) 2000-11-16 2002-06-06 Teva Pharmaceutical Industries Ltd. Hydrolysis of [r(r*,r*)]-2-(4-fluorophenyl)-.beta.,.delta. -dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoic acid esters with calcium hydroxide
IL156055A0 (en) 2000-11-30 2003-12-23 Teva Pharma Novel crystal forms of atorvastatin hemi calcium and processes for their preparation as well as novel processes for preparing other forms
US7501450B2 (en) * 2000-11-30 2009-03-10 Teva Pharaceutical Industries Ltd. Crystal forms of atorvastatin hemi-calcium and processes for their preparation as well as novel processes for preparing other forms
CA2626317A1 (en) 2000-12-27 2002-07-04 Teva Pharmaceutical Industries Ltd. Crystalline forms of atorvastatin
WO2002057228A1 (en) * 2001-01-17 2002-07-25 Biocon India Limited Atorvastatin calcium
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CZ296967B6 (cs) 2002-02-01 2006-08-16 Zentiva, A.S. Zpusob výroby amorfní formy hemivápenaté soli (3R,5R) 7-[3-fenyl-4-fenylkarbamoyl-2-(4-fluorfenyl)-5-isopropylpyrrol-1-yl]-3,5-dihydroxyheptanové kyseliny (atorvastatinu)
EP1485343B1 (en) 2002-03-18 2009-12-23 Biocon Limited Amorphous hmg-coa reductase inhibitors of desired particle size
ITMI20020907A1 (it) * 2002-04-29 2003-10-29 Chemi Spa Processo di preparazione della forma amorfa del sale di calcio della atorvastatina
WO2003099785A1 (en) * 2002-05-28 2003-12-04 Cadila Healthcare Limited Process for the preparation of amorphous atorvastatin calcium
US7179942B2 (en) 2002-07-05 2007-02-20 Bicon Limited Halo-substituted active methylene compounds
AU2002330735A1 (en) * 2002-09-03 2004-03-29 Morepen Laboratories Limited Atorvastatin calcium form vi or hydrates thereof
CA2520740C (en) 2003-04-11 2012-06-05 Lek Pharmaceuticals D.D. Process for the preparation of amorphous calcium salt of atorvastatin
AU2003231926A1 (en) 2003-04-22 2004-11-19 Biocon Limited NOVEL PROCESS FOR STEREOSELECTIVE REDUCTION OF ss-KETOESTERS
US7790197B2 (en) * 2003-06-09 2010-09-07 Warner-Lambert Company Llc Pharmaceutical compositions of atorvastatin
US7655692B2 (en) * 2003-06-12 2010-02-02 Pfizer Inc. Process for forming amorphous atorvastatin
US20040253305A1 (en) * 2003-06-12 2004-12-16 Luner Paul E. Pharmaceutical compositions of atorvastatin
US20050271717A1 (en) * 2003-06-12 2005-12-08 Alfred Berchielli Pharmaceutical compositions of atorvastatin
US7557238B2 (en) 2003-09-18 2009-07-07 Biocon Limited Process for the preparation of tert-butyl 6-cyano-5-hydroxy-3-oxohexanoate
CA2456430A1 (en) * 2004-01-28 2005-07-28 Brantford Chemicals Inc. Improved process for the preparation of amorphous atorvastatin calcium
CZ298382B6 (cs) * 2004-03-10 2007-09-12 Zentiva, A. S. Zpusob prípravy amorfní formy hemivápenaté soli atorvastatinu a její stabilizace
PT1727795E (pt) * 2004-03-17 2012-04-11 Ranbaxy Lab Ltd Processo para a produção de atorvastatina cálcica na forma amorfa
JP2007536373A (ja) * 2004-05-05 2007-12-13 ファイザー・プロダクツ・インク アトルバスタチンの塩形態
RU2412191C2 (ru) * 2004-07-16 2011-02-20 Лек Фармасьютиклз Д.Д. Продукты окислительной деструкции кальций аторвастатина
CA2578722C (en) 2004-08-27 2010-02-02 Biocon Limited Process for atorvastatin calcium amorphous
KR20070106680A (ko) * 2004-09-30 2007-11-05 닥터 레디스 레보러터리즈 리미티드 비정질 아토르바스타틴 칼슘
US20060106230A1 (en) * 2004-10-18 2006-05-18 Michael Pinchasov Processes for preparing amorphous atorvastatin hemi-calcium
JP2008517992A (ja) * 2004-10-28 2008-05-29 ワーナー−ランバート カンパニー リミテッド ライアビリティー カンパニー アモルファスのアトルバスタチンを形成する方法
US20090208539A1 (en) * 2004-11-22 2009-08-20 Adel Penhasi Stable atorvastatin formulations
JP2008521878A (ja) * 2004-12-02 2008-06-26 ワーナー−ランバート カンパニー リミテッド ライアビリティー カンパニー 非晶質アトルバスタチンの医薬組成物及びその製造のための方法
US20080108664A1 (en) * 2005-12-23 2008-05-08 Liu Belle B Solid-state form of AMG 706 and pharmaceutical compositions thereof
EP1810667A1 (en) 2006-01-20 2007-07-25 KRKA, tovarna zdravil, d.d., Novo mesto Pharmaceutical composition comprising amorphous atorvastatin
JP2007231018A (ja) * 2006-03-01 2007-09-13 Teva Pharmaceutical Industries Ltd アトルバスタチンヘミカルシウムの結晶形の調製方法
WO2008053312A2 (en) * 2006-11-02 2008-05-08 Cadila Pharmaceuticals Limited Process for preparing amorphous atorvastatin hemi calcium salt and its intermediate
US7834195B2 (en) 2007-01-24 2010-11-16 Apotex Pharmachem Inc. Atorvastatin calcium propylene glycol solvates
EP2185527A2 (en) * 2007-07-11 2010-05-19 Actavis Group PTC EHF Novel polymorph of atorvastatin calcium and use thereof for the preparation of amorphous atorvastatin calcium
US20090124817A1 (en) * 2007-11-09 2009-05-14 The Industry & Academic Cooperation In Chungnam National University Process for Preparing Amorphous Atorvastatin Calcium Nanoparticles
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SI2373609T1 (sl) 2008-12-19 2013-12-31 Krka, D.D., Novo Mesto Uporaba amfifilnih spojin za kontrolirano kristalizacijo statinov in intermediatov statinov
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Also Published As

Publication number Publication date
AU700794B2 (en) 1999-01-14
GEP20002027B (en) 2000-04-10
JPH11510486A (ja) 1999-09-14
KR100400805B1 (ko) 2003-12-24
CN1190956A (zh) 1998-08-19
DE69611999D1 (de) 2001-04-12
UA50743C2 (uk) 2002-11-15
DE69611999T2 (de) 2001-07-26
SK5898A3 (en) 1998-08-05
NZ313008A (en) 2000-01-28
JP4064459B2 (ja) 2008-03-19
PE1698A1 (es) 1998-02-19
EP0839132B1 (en) 2001-03-07
IL122161A0 (en) 1998-04-05
GR3035859T3 (en) 2001-08-31
HK1018054A1 (en) 1999-12-10
BG63631B1 (bg) 2002-07-31
CO4700441A1 (es) 1998-12-29
PL324463A1 (en) 1998-05-25
DK0839132T3 (da) 2001-04-09
EA000625B1 (ru) 1999-12-29
IL122161A (en) 1999-07-14
ZA966043B (en) 1997-02-03
HUP9903017A3 (en) 2001-01-29
CZ289421B6 (cs) 2002-01-16
PT839132E (pt) 2001-06-29
SK283204B6 (sk) 2003-03-04
NO309322B1 (no) 2001-01-15
ATE199542T1 (de) 2001-03-15
CA2220455A1 (en) 1997-02-06
PL191017B1 (pl) 2006-03-31
CN1087289C (zh) 2002-07-10
BG102188A (en) 1998-08-31
EE9700369A (et) 1998-06-15
SI0839132T1 (no) 2001-06-30
EA199800128A1 (ru) 1998-08-27
DK0839132T5 (da) 2006-03-20
UY24286A1 (es) 1997-01-17
NO980209L (no) 1998-01-16
HRP960312B1 (en) 2001-10-31
WO1997003960A1 (en) 1997-02-06
CZ12298A3 (cs) 1998-12-16
EP0839132A1 (en) 1998-05-06
AR002849A1 (es) 1998-04-29
AU6497896A (en) 1997-02-18
IN185276B (no) 2000-12-16
HU220343B (hu) 2001-12-28
MX9708959A (es) 1998-03-31
BR9609714A (pt) 1999-02-23
HRP960312A2 (en) 1998-02-28
CA2220455C (en) 2002-09-24
EE03605B1 (et) 2002-02-15
RO120069B1 (ro) 2005-08-30
KR19990029045A (ko) 1999-04-15
ES2156997T3 (es) 2001-08-01
US6274740B1 (en) 2001-08-14

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