DK0839132T3 - Fremgangsmåde til fremstilling af amorft [R-(R*,R*)]-2-(4-fluorphenyl)-beta, delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[ - Google Patents

Fremgangsmåde til fremstilling af amorft [R-(R*,R*)]-2-(4-fluorphenyl)-beta, delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[

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Publication number
DK0839132T3
DK0839132T3 DK96924553T DK96924553T DK0839132T3 DK 0839132 T3 DK0839132 T3 DK 0839132T3 DK 96924553 T DK96924553 T DK 96924553T DK 96924553 T DK96924553 T DK 96924553T DK 0839132 T3 DK0839132 T3 DK 0839132T3
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DK
Denmark
Prior art keywords
methylethyl
fluorophenyl
dihydroxy
delta
amorphous
Prior art date
Application number
DK96924553T
Other languages
English (en)
Other versions
DK0839132T5 (da
Inventor
Min Lin
Dieter Schweiss
Original Assignee
Warner Lambert Co
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Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21696097&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK0839132(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Publication of DK0839132T3 publication Critical patent/DK0839132T3/da
Application granted granted Critical
Publication of DK0839132T5 publication Critical patent/DK0839132T5/da

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pyrrole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
DK96924553T 1995-07-17 1996-07-16 Fremgangsmåde til fremstilling af amorft [R-(R*,R*)]-2-(4-fluorphenyl)-beta, delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrol-1-heptansyrecalciumsalt (2:1) DK0839132T5 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US145395P 1995-07-17 1995-07-17
PCT/US1996/011807 WO1997003960A1 (en) 1995-07-17 1996-07-16 NOVEL PROCESS FOR THE PRODUCTION OF AMORPHOUS [R-(R*,R*)]-2-(4-FLUOROPHENYL)-β,δ-DIHYDROXY-5-(1-METHYLETHYL)-3-PHENYL-4-[(PHENYLAMINO)CARBONYL]-1H-PYRROLE-1-HEPTANOIC ACID CALCIUM SALT (2:1)

Publications (2)

Publication Number Publication Date
DK0839132T3 true DK0839132T3 (da) 2001-04-09
DK0839132T5 DK0839132T5 (da) 2006-03-20

Family

ID=21696097

Family Applications (1)

Application Number Title Priority Date Filing Date
DK96924553T DK0839132T5 (da) 1995-07-17 1996-07-16 Fremgangsmåde til fremstilling af amorft [R-(R*,R*)]-2-(4-fluorphenyl)-beta, delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrol-1-heptansyrecalciumsalt (2:1)

Country Status (38)

Country Link
US (1) US6274740B1 (da)
EP (1) EP0839132B1 (da)
JP (1) JP4064459B2 (da)
KR (1) KR100400805B1 (da)
CN (1) CN1087289C (da)
AR (1) AR002849A1 (da)
AT (1) ATE199542T1 (da)
AU (1) AU700794B2 (da)
BG (1) BG63631B1 (da)
BR (1) BR9609714A (da)
CA (1) CA2220455C (da)
CO (1) CO4700441A1 (da)
CZ (1) CZ289421B6 (da)
DE (1) DE69611999T2 (da)
DK (1) DK0839132T5 (da)
EA (1) EA000625B1 (da)
EE (1) EE03605B1 (da)
ES (1) ES2156997T3 (da)
GE (1) GEP20002027B (da)
GR (1) GR3035859T3 (da)
HK (1) HK1018054A1 (da)
HR (1) HRP960312B1 (da)
HU (1) HU220343B (da)
IL (1) IL122161A (da)
IN (1) IN185276B (da)
MX (1) MX9708959A (da)
NO (1) NO309322B1 (da)
NZ (1) NZ313008A (da)
PE (1) PE1698A1 (da)
PL (1) PL191017B1 (da)
PT (1) PT839132E (da)
RO (1) RO120069B1 (da)
SI (1) SI0839132T1 (da)
SK (1) SK283204B6 (da)
UA (1) UA50743C2 (da)
UY (1) UY24286A1 (da)
WO (1) WO1997003960A1 (da)
ZA (1) ZA966043B (da)

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HU226640B1 (en) * 1999-10-18 2009-05-28 Egis Gyogyszergyar Nyilvanosan Process for producing amorphous atorvastatin calcium salt
US7411075B1 (en) 2000-11-16 2008-08-12 Teva Pharmaceutical Industries Ltd. Polymorphic form of atorvastatin calcium
SI20425A (sl) 1999-12-10 2001-06-30 LEK tovarna farmacevtskih in kemi�nih izdelkov d.d. Priprava amorfnega atorvastatina
DE60136095D1 (de) * 2000-11-16 2008-11-20 Teva Pharma Hydrolyse von är(r*,r*)ü-2-(4-fluorphenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-ä(phenylamino)carbonylü-1h-pyrrol-heptansäureestern mit calciumhydroxid
US7501450B2 (en) * 2000-11-30 2009-03-10 Teva Pharaceutical Industries Ltd. Crystal forms of atorvastatin hemi-calcium and processes for their preparation as well as novel processes for preparing other forms
IL156055A0 (en) 2000-11-30 2003-12-23 Teva Pharma Novel crystal forms of atorvastatin hemi calcium and processes for their preparation as well as novel processes for preparing other forms
CA2622477A1 (en) 2000-12-27 2002-07-04 Teva Pharmaceutical Industries Ltd. Crystalline forms of atorvastatin
WO2002057228A1 (en) * 2001-01-17 2002-07-25 Biocon India Limited Atorvastatin calcium
WO2002057229A1 (en) 2001-01-19 2002-07-25 Biocon India Limited FORM V CRYSTALLINE [R-(R*,R*)]-2-(4-FLUOROPHENYL)-ß,$G(D)-DIHYDROXY-5-(1-METHYLETHYL)-3-PHENYL-4-[(PHENYLAMINO)CARBONYL]-1H-PYRROLE-1- HEPTANOIC ACID HEMI CALCIUM SALT. (ATORVASTATIN)
SI20814A (sl) * 2001-01-23 2002-08-31 LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. Priprava amorfnega atorvastatina
SI20848A (sl) 2001-03-14 2002-10-31 Lek, Tovarna Farmacevtskih In Kemijskih Izdelkov, D.D. Farmacevtska formulacija, ki vsebuje atorvastatin kalcij
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CA2456095C (en) 2001-08-31 2010-05-11 Morepen Laboratories Ltd. An improved process for the preparation of amorphous atorvastatin calcium salt (2:1)
UA77990C2 (en) * 2001-12-12 2007-02-15 Crystalline calcium salt of (2:1) [r-(r*,r*)]-2-(4-fluorophenyl)-?,?-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrroleheptanic acid
CZ296967B6 (cs) 2002-02-01 2006-08-16 Zentiva, A.S. Zpusob výroby amorfní formy hemivápenaté soli (3R,5R) 7-[3-fenyl-4-fenylkarbamoyl-2-(4-fluorfenyl)-5-isopropylpyrrol-1-yl]-3,5-dihydroxyheptanové kyseliny (atorvastatinu)
HUP0500074A3 (en) 2002-03-18 2005-07-28 Biocon Ltd Bangalore Amorphous hmg-coa reductase inhibitors of desired particle size and process for producing them
ITMI20020907A1 (it) * 2002-04-29 2003-10-29 Chemi Spa Processo di preparazione della forma amorfa del sale di calcio della atorvastatina
AU2002356423A1 (en) * 2002-05-28 2003-12-12 Cadila Healthcare Limited Process for the preparation of amorphous atorvastatin calcium
US7179942B2 (en) 2002-07-05 2007-02-20 Bicon Limited Halo-substituted active methylene compounds
JP2006503024A (ja) * 2002-09-03 2006-01-26 モレペン、ラボラトリーズ、リミテッド Ｖｉ型アトルバスタチンカルシウムまたはその水和物
EP1615884B1 (en) * 2003-04-11 2016-06-29 LEK Pharmaceuticals d.d. Process for the preparation of amorphous calcium salt of atorvastatin
SI1631533T1 (sl) 2003-04-22 2009-08-31 Bicon Ltd Nov postopek za stereoselektivno redukcijo beta - ketoestrov
US7790197B2 (en) * 2003-06-09 2010-09-07 Warner-Lambert Company Llc Pharmaceutical compositions of atorvastatin
US7655692B2 (en) 2003-06-12 2010-02-02 Pfizer Inc. Process for forming amorphous atorvastatin
US20040253305A1 (en) * 2003-06-12 2004-12-16 Luner Paul E. Pharmaceutical compositions of atorvastatin
US20050271717A1 (en) * 2003-06-12 2005-12-08 Alfred Berchielli Pharmaceutical compositions of atorvastatin
AU2003272080A1 (en) 2003-09-18 2005-04-06 Biocon Limited Novel process for the preparation of tert-butyl 6-cyano-5-hydroxy-3-oxohexanoate
CA2456430A1 (en) * 2004-01-28 2005-07-28 Brantford Chemicals Inc. Improved process for the preparation of amorphous atorvastatin calcium
CZ298382B6 (cs) * 2004-03-10 2007-09-12 Zentiva, A. S. Zpusob prípravy amorfní formy hemivápenaté soli atorvastatinu a její stabilizace
CN1942439B (zh) 2004-03-17 2011-12-21 兰贝克赛实验室有限公司 无定形形式的阿托伐他汀钙的制备方法
JP2007536373A (ja) 2004-05-05 2007-12-13 ファイザー・プロダクツ・インク アトルバスタチンの塩形態
WO2006008091A2 (en) * 2004-07-16 2006-01-26 Lek Pharmaceuticals D.D. Oxidative degradation products of atorvastatin calcium
EP1784389A4 (en) 2004-08-27 2009-03-25 Biocon Ltd PROCESS FOR THE PREPARATION OF AMORPHIC ATORVASTATIN CALCIUM
WO2006039441A2 (en) * 2004-09-30 2006-04-13 Dr. Reddy's Laboratories Ltd. Amorphous atorvastatin calcium
KR20090033405A (ko) * 2004-10-18 2009-04-02 테바 파마슈티컬 인더스트리즈 리미티드 알콜 및 케톤 및/또는 에스테르의 혼합물인 유기 용매에 아토르바스타틴 헤미-칼슘 염을 용해시키고 용매를 제거하여 비결정형 아토르바스타틴 헤미-칼슘을 제조하는 방법
EP1807055A1 (en) * 2004-10-28 2007-07-18 Warner-Lambert Company LLC Process for forming amorphous atorvastatin
AU2005305460B2 (en) * 2004-11-22 2011-04-21 Dexcel Pharma Technologies Ltd. Stable atorvastatin formulations
JP2008521878A (ja) * 2004-12-02 2008-06-26 ワーナー−ランバート カンパニー リミテッド ライアビリティー カンパニー 非晶質アトルバスタチンの医薬組成物及びその製造のための方法
US20080108664A1 (en) * 2005-12-23 2008-05-08 Liu Belle B Solid-state form of AMG 706 and pharmaceutical compositions thereof
EP1810667A1 (en) 2006-01-20 2007-07-25 KRKA, tovarna zdravil, d.d., Novo mesto Pharmaceutical composition comprising amorphous atorvastatin
CA2640573A1 (en) * 2006-03-01 2007-09-13 Michael Pinchasov Process for preparing a crystalline form of atorvastatin hemi-calcium
US20100113802A1 (en) * 2006-11-02 2010-05-06 Cadila Pharmaceuticals Limited Process for preparing amorphous atorvastatin hemi calcium salt and its itermediate
US7834195B2 (en) 2007-01-24 2010-11-16 Apotex Pharmachem Inc. Atorvastatin calcium propylene glycol solvates
US20100260851A1 (en) * 2007-07-11 2010-10-14 Actavis Group Ptc Ehf Novel Polymorph of Atorvastatin Calcium and Use Thereof for the Preparation of Amorphous Atorvastatin Calcium
US20090124817A1 (en) * 2007-11-09 2009-05-14 The Industry & Academic Cooperation In Chungnam National University Process for Preparing Amorphous Atorvastatin Calcium Nanoparticles
EP2075246A1 (en) 2007-12-27 2009-07-01 M. J. Institute of Research A process for preparation of amorphous form of atorvastatin hemi-calcium salt
WO2010066846A2 (en) * 2008-12-11 2010-06-17 Dsm Ip Assets B.V. Method for the isolation of atorvastatin
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Also Published As

Publication number Publication date
BG63631B1 (bg) 2002-07-31
BG102188A (en) 1998-08-31
CN1190956A (zh) 1998-08-19
AU700794B2 (en) 1999-01-14
HRP960312A2 (en) 1998-02-28
HK1018054A1 (en) 1999-12-10
EA199800128A1 (ru) 1998-08-27
NO309322B1 (no) 2001-01-15
IN185276B (da) 2000-12-16
ATE199542T1 (de) 2001-03-15
NZ313008A (en) 2000-01-28
ZA966043B (en) 1997-02-03
NO980209D0 (no) 1998-01-16
AU6497896A (en) 1997-02-18
SK5898A3 (en) 1998-08-05
AR002849A1 (es) 1998-04-29
CZ12298A3 (cs) 1998-12-16
UY24286A1 (es) 1997-01-17
CA2220455A1 (en) 1997-02-06
CO4700441A1 (es) 1998-12-29
PL324463A1 (en) 1998-05-25
PT839132E (pt) 2001-06-29
UA50743C2 (uk) 2002-11-15
EP0839132B1 (en) 2001-03-07
PE1698A1 (es) 1998-02-19
GR3035859T3 (en) 2001-08-31
KR100400805B1 (ko) 2003-12-24
RO120069B1 (ro) 2005-08-30
GEP20002027B (en) 2000-04-10
SI0839132T1 (da) 2001-06-30
US6274740B1 (en) 2001-08-14
ES2156997T3 (es) 2001-08-01
KR19990029045A (ko) 1999-04-15
HUP9903017A3 (en) 2001-01-29
HRP960312B1 (en) 2001-10-31
WO1997003960A1 (en) 1997-02-06
BR9609714A (pt) 1999-02-23
PL191017B1 (pl) 2006-03-31
CA2220455C (en) 2002-09-24
JPH11510486A (ja) 1999-09-14
CZ289421B6 (cs) 2002-01-16
SK283204B6 (sk) 2003-03-04
NO980209L (no) 1998-01-16
EE03605B1 (et) 2002-02-15
EP0839132A1 (en) 1998-05-06
DK0839132T5 (da) 2006-03-20
DE69611999D1 (de) 2001-04-12
CN1087289C (zh) 2002-07-10
EA000625B1 (ru) 1999-12-29
IL122161A0 (en) 1998-04-05
IL122161A (en) 1999-07-14
DE69611999T2 (de) 2001-07-26
HU220343B (hu) 2001-12-28
MX9708959A (es) 1998-03-31
EE9700369A (et) 1998-06-15
JP4064459B2 (ja) 2008-03-19

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