NO971261L - Kinoksalin-derivater nyttige innen terapi - Google Patents

Kinoksalin-derivater nyttige innen terapi

Info

Publication number
NO971261L
NO971261L NO971261A NO971261A NO971261L NO 971261 L NO971261 L NO 971261L NO 971261 A NO971261 A NO 971261A NO 971261 A NO971261 A NO 971261A NO 971261 L NO971261 L NO 971261L
Authority
NO
Norway
Prior art keywords
pct
alkyl
therapy
derivatives useful
quinoxaline derivatives
Prior art date
Application number
NO971261A
Other languages
English (en)
Other versions
NO971261D0 (no
Inventor
Michael Jonathan Fray
Charles Eric Mowbray
Alan Stobie
Original Assignee
Pfizer Res & Dev
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Res & Dev filed Critical Pfizer Res & Dev
Publication of NO971261D0 publication Critical patent/NO971261D0/no
Publication of NO971261L publication Critical patent/NO971261L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
    • C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
    • C07D241/40—Benzopyrazines
    • C07D241/44—Benzopyrazines with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

Forbindelser med formel (I) ,. hvor A betyr N eller CH; Rog Rhver uavhengig betyr--alkyl, halogen eller CFR3 betyr c ± (valgfritt substituert), C.-cykloalkyl, CFeller -ryi; og R betyr H, C.-cykloal*yl eller C-alkyl (valgfrxtt substituert); og deres far^tis* aksepta-ble derivater; er nyttige ved behandling av bl a neurodegenerative lidelser.
NO971261A 1994-09-24 1997-03-19 Kinoksalin-derivater nyttige innen terapi NO971261L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9419318A GB9419318D0 (en) 1994-09-24 1994-09-24 Therapeutic agents
PCT/EP1995/003559 WO1996009295A1 (en) 1994-09-24 1995-09-08 Quinoxaline derivatives useful in therapy

Publications (2)

Publication Number Publication Date
NO971261D0 NO971261D0 (no) 1997-03-19
NO971261L true NO971261L (no) 1997-05-05

Family

ID=10761869

Family Applications (1)

Application Number Title Priority Date Filing Date
NO971261A NO971261L (no) 1994-09-24 1997-03-19 Kinoksalin-derivater nyttige innen terapi

Country Status (28)

Country Link
US (1) US5852016A (no)
EP (1) EP0783495B1 (no)
JP (1) JP2986920B2 (no)
KR (1) KR970706261A (no)
CN (1) CN1158610A (no)
AT (1) ATE213731T1 (no)
AU (1) AU688591B2 (no)
BR (1) BR9504132A (no)
CA (1) CA2200742C (no)
CO (1) CO4410336A1 (no)
CZ (1) CZ85797A3 (no)
DE (1) DE69525633T2 (no)
DK (1) DK0783495T3 (no)
ES (1) ES2171553T3 (no)
FI (1) FI971193A (no)
GB (1) GB9419318D0 (no)
HU (1) HUT77734A (no)
IL (2) IL115334A0 (no)
MX (1) MX9702259A (no)
NO (1) NO971261L (no)
NZ (1) NZ292922A (no)
PE (1) PE47596A1 (no)
PL (1) PL319405A1 (no)
PT (1) PT783495E (no)
RU (1) RU2135484C1 (no)
TR (1) TR199501158A2 (no)
WO (1) WO1996009295A1 (no)
ZA (1) ZA958023B (no)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY132385A (en) * 1995-08-31 2007-10-31 Novartis Ag 2,3-dioxo-1,2,3,4-tetrahydro-quinoxalinyl derivatives
DK0784973T3 (da) * 1995-10-10 2002-03-18 Pfizer Quinoxalinderivater til behandling af tinnitus
GB9604400D0 (en) * 1996-03-01 1996-05-01 Pfizer Ltd Compounds useful in therapy
AU3133697A (en) 1996-06-05 1998-01-05 Warner-Lambert Company Amide derivatives of substituted quinoxaline 2,3-diones as glutamate receptor antagonists
US5721256A (en) * 1997-02-12 1998-02-24 Gpi Nil Holdings, Inc. Method of using neurotrophic sulfonamide compounds
AU722616B2 (en) * 1997-02-18 2000-08-10 American Home Products Corporation 5-aminoalkoxy-1,4-dihydroquinoxaline-2,3-diones being dopamine agonists
US5922715A (en) * 1997-02-18 1999-07-13 American Home Products Corporation 5-aminoalkoxy-1, 4-dihydroquinoxaline-2, 3-diones
TW526195B (en) 1997-06-10 2003-04-01 Novartis Ag Crystal modifications of 1-(2,6-difluorobenzyl)-1H-1,2,3-triazole-4-carboxamide and their use
GB0310881D0 (en) * 2003-05-12 2003-06-18 Merck Sharp & Dohme Pharmaceutical formulation
US10208000B2 (en) 2015-12-16 2019-02-19 University Of Kentucky Research Foundation Eis inhibitors

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE572852C (de) * 1931-03-08 1933-03-24 Willy Messerschmitt Dipl Ing Verfahren zur Herstellung von Flugzeugtragfluegeln mit trapezfoermigem Grundriss
DK146787A (da) * 1987-03-23 1988-09-24 Ferrosan Heterocykliske forbindelser, deres fremstilling og anvendelse
DK715888D0 (da) * 1988-12-22 1988-12-22 Ferrosan As Quinoxalinforbindelser, deres fremstilling og anvendelse
DE69132340T2 (de) * 1990-11-06 2001-02-08 Yamanouchi Pharma Co Ltd Kondensiertes pyrazinderivat
DE4123106A1 (de) * 1991-07-09 1993-01-14 Schering Ag Arzneimittel zur behandlung von entzugssymptomen
PT101004B (pt) * 1991-10-26 1999-10-29 Schering Ag Derivados da quinoxalina, processo para a sua preparacao e composicoes farmaceuticas que os contem
DE4217952A1 (de) * 1992-05-30 1993-12-02 Basf Ag Chinoxalin-2,3(1H,4H)-dione
DE69334237D1 (de) * 1992-06-22 2008-09-25 State Of Oregon Through Oregon Glycinrezeptorantagonisten und ihre verwendung
IL109397A0 (en) * 1993-04-28 1994-07-31 Schering Ag Quinoxalinedione derivatives, processes for the preparation thereof and pharmaceutical compositions containing the same
DE4439493A1 (de) * 1994-10-25 1996-05-02 Schering Ag Neue Chinoxalindionderivate, deren Herstellung und Verwendung in Arzneimitteln
DE4439492A1 (de) * 1994-10-25 1996-05-02 Schering Ag Neue Chinoxalindionderivate, deren Herstellung und Verwendung in Arzneimitteln
US5614508A (en) * 1995-06-07 1997-03-25 Warner-Lambert Company Amino acid derivatives of substituted quinoxaline 2,3-dione derivatives as glutamate receptor antagonists

Also Published As

Publication number Publication date
AU688591B2 (en) 1998-03-12
NO971261D0 (no) 1997-03-19
CA2200742C (en) 2001-09-11
MX9702259A (es) 1997-06-28
ES2171553T3 (es) 2002-09-16
ZA958023B (en) 1997-03-24
JPH09511526A (ja) 1997-11-18
CA2200742A1 (en) 1996-03-28
EP0783495A1 (en) 1997-07-16
CN1158610A (zh) 1997-09-03
ATE213731T1 (de) 2002-03-15
TR199501158A2 (tr) 1997-02-21
RU2135484C1 (ru) 1999-08-27
PT783495E (pt) 2002-07-31
DE69525633D1 (de) 2002-04-04
IL126104A0 (en) 1999-05-09
EP0783495B1 (en) 2002-02-27
BR9504132A (pt) 1996-08-06
WO1996009295A1 (en) 1996-03-28
KR970706261A (ko) 1997-11-03
JP2986920B2 (ja) 1999-12-06
CZ85797A3 (cs) 1998-09-16
PE47596A1 (es) 1996-11-12
DK0783495T3 (da) 2002-04-22
IL115334A0 (en) 1995-12-31
NZ292922A (en) 1998-07-28
US5852016A (en) 1998-12-22
AU3523295A (en) 1996-04-09
FI971193A0 (fi) 1997-03-21
GB9419318D0 (en) 1994-11-09
HUT77734A (hu) 1998-07-28
DE69525633T2 (de) 2002-08-08
FI971193A (fi) 1997-05-21
PL319405A1 (en) 1997-08-04
CO4410336A1 (es) 1997-01-09

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