NO964735L - Adenosine derivatives - Google Patents

Adenosine derivatives

Info

Publication number
NO964735L
NO964735L NO964735A NO964735A NO964735L NO 964735 L NO964735 L NO 964735L NO 964735 A NO964735 A NO 964735A NO 964735 A NO964735 A NO 964735A NO 964735 L NO964735 L NO 964735L
Authority
NO
Norway
Prior art keywords
compounds
formula
alkyl
adenosine derivatives
cycloalkyl
Prior art date
Application number
NO964735A
Other languages
Norwegian (no)
Other versions
NO964735D0 (en
Inventor
Fulvio Gadient
Bonnie L K Mangold
John R Fozard
Mahavir Prashad
Prasad Koteswara Kapa
Original Assignee
Sandoz Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB9409324A external-priority patent/GB9409324D0/en
Priority claimed from GB9416693A external-priority patent/GB9416693D0/en
Application filed by Sandoz Ltd filed Critical Sandoz Ltd
Publication of NO964735D0 publication Critical patent/NO964735D0/en
Publication of NO964735L publication Critical patent/NO964735L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurosurgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

Forbindelser med formel I hvori R! har en rekke betydninger, inkluderende cykloalkyl og hydroksycykloalkyl, R2 er hydrogen, (C1.4)alkyl, amino, (C3_5)cykloalkyl eller halogen med et atomtall 9 til 35, og R3 er (C1.4)alkyl, og som kan anvendes som analgetiske midler. Forbindelser med formel I hvori Rx er hydroksyalkyl er nye forbindelser. Forbindelsene med formel I kan fremstilles ved alkylering i 2'-stillingen i nærvær av tetrabutylammonium- hydrogensulfat og et ikke-polart løsningsmiddel.Compounds of Formula I wherein R has a variety of meanings, including cycloalkyl and hydroxycycloalkyl, R2 is hydrogen, (C1.4) alkyl, amino, (C3-5) cycloalkyl or halogen having an atomic number 9 to 35, and R3 is (C1.4) alkyl as analgesic agents. Compounds of formula I wherein Rx is hydroxyalkyl are novel compounds. The compounds of formula I can be prepared by alkylation at the 2 'position in the presence of tetrabutylammonium hydrogen sulfate and a non-polar solvent.

NO964735A 1994-05-10 1996-11-08 Adenosine derivatives NO964735L (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB9409324A GB9409324D0 (en) 1994-05-10 1994-05-10 New organic compounds, their preparation and use
US24991494A 1994-05-26 1994-05-26
GB9416693A GB9416693D0 (en) 1994-08-18 1994-08-18 Improvements in or relating to organic compounds
PCT/US1995/005802 WO1995030683A1 (en) 1994-05-10 1995-05-09 Adenosine derivatives

Publications (2)

Publication Number Publication Date
NO964735D0 NO964735D0 (en) 1996-11-08
NO964735L true NO964735L (en) 1997-01-10

Family

ID=27267177

Family Applications (1)

Application Number Title Priority Date Filing Date
NO964735A NO964735L (en) 1994-05-10 1996-11-08 Adenosine derivatives

Country Status (13)

Country Link
EP (1) EP0759925A1 (en)
JP (1) JPH09512823A (en)
CN (1) CN1147815A (en)
AU (1) AU2546195A (en)
BR (1) BR9507683A (en)
CA (1) CA2186847A1 (en)
CZ (1) CZ327896A3 (en)
FI (1) FI964468A (en)
HU (1) HUT75338A (en)
NO (1) NO964735L (en)
PL (1) PL316985A1 (en)
SK (1) SK146096A3 (en)
WO (1) WO1995030683A1 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6110902A (en) * 1997-06-23 2000-08-29 Moehler; Hanns Method for the inhibition of neuronal activity leading to a focal epileptic seizure by local delivery of adenosine
GB0228723D0 (en) 2002-12-09 2003-01-15 Cambridge Biotechnology Ltd Treatment of pain
GB0305149D0 (en) * 2003-03-07 2003-04-09 Cambridge Biotechnology Ltd Compounds for the treatment of pain
US20100048501A1 (en) 2006-03-21 2010-02-25 Heinrich-Heine-Universitat Dusseldorf Phosphorylated A2A Receptor Agonists
CN108822174A (en) * 2018-08-29 2018-11-16 上海兆维科技发展有限公司 2 '-EOE- guanosine of novel nucleoside modifier and preparation method thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8729994D0 (en) * 1987-12-23 1988-02-03 Glaxo Group Ltd Chemical compounds
GB2226027B (en) * 1988-12-13 1992-05-20 Sandoz Ltd Adenosine derivatives,their production and use
US5017578A (en) * 1989-06-09 1991-05-21 Hoechst-Roussel Pharmaceuticals Inc. N-heteroaryl-purin-6-amines useful as analgesic and anticonvulsant agents
HUT61567A (en) * 1990-12-07 1993-01-28 Sandoz Ag Process for producing new pharmaceutical compositions comprising 2'-o-alkyladenosine derivatives and for producing 6-cyclohexyl-2'-o-methyladenosinehydrate
DK62692D0 (en) * 1992-05-14 1992-05-14 Novo Nordisk As

Also Published As

Publication number Publication date
AU2546195A (en) 1995-11-29
NO964735D0 (en) 1996-11-08
HU9603105D0 (en) 1997-01-28
WO1995030683A1 (en) 1995-11-16
PL316985A1 (en) 1997-03-03
FI964468A0 (en) 1996-11-06
JPH09512823A (en) 1997-12-22
CN1147815A (en) 1997-04-16
FI964468A (en) 1996-11-06
CZ327896A3 (en) 1997-03-12
CA2186847A1 (en) 1995-11-16
SK146096A3 (en) 1997-07-09
BR9507683A (en) 1997-09-23
EP0759925A1 (en) 1997-03-05
HUT75338A (en) 1997-05-28

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