NO962637D0 - 2,4-disulfonylfenylbutylnitron, salter derav og anveldelse som farmasöytiske midler - Google Patents
2,4-disulfonylfenylbutylnitron, salter derav og anveldelse som farmasöytiske midlerInfo
- Publication number
- NO962637D0 NO962637D0 NO962637A NO962637A NO962637D0 NO 962637 D0 NO962637 D0 NO 962637D0 NO 962637 A NO962637 A NO 962637A NO 962637 A NO962637 A NO 962637A NO 962637 D0 NO962637 D0 NO 962637D0
- Authority
- NO
- Norway
- Prior art keywords
- nervous system
- central nervous
- pharmaceutical agents
- salts
- disulfonylphenylbutylnitrone
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/01—Sulfonic acids
- C07C309/28—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C309/45—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing nitrogen atoms, not being part of nitro or nitroso groups, bound to the carbon skeleton
- C07C309/46—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing nitrogen atoms, not being part of nitro or nitroso groups, bound to the carbon skeleton having the sulfo groups bound to carbon atoms of non-condensed six-membered aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Epidemiology (AREA)
- Psychiatry (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Hydrogenated Pyridines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/173,579 US5488145A (en) | 1993-12-23 | 1993-12-23 | 2,4-disulfonyl phenyl butyl nitrone, its salts, and their use as pharmaceutical free radical traps |
PCT/US1994/014545 WO1995017876A2 (en) | 1993-12-23 | 1994-12-22 | 2,4-disulphophenyl butylnitrone, its salts, and their use as pharmaceutical spintraps |
Publications (3)
Publication Number | Publication Date |
---|---|
NO962637D0 true NO962637D0 (no) | 1996-06-20 |
NO962637L NO962637L (no) | 1996-08-13 |
NO306457B1 NO306457B1 (no) | 1999-11-08 |
Family
ID=22632663
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO962637A NO306457B1 (no) | 1993-12-23 | 1996-06-20 | 2,4-disulfonylfenylbutylnitron, salter derav, farmasöytisk sammensetning, samt anvendelse av denne forbindelse til fremstilling av et medikament |
Country Status (29)
Country | Link |
---|---|
US (4) | US5488145A (no) |
EP (1) | EP0736004B1 (no) |
JP (3) | JP3412821B2 (no) |
KR (1) | KR100370522B1 (no) |
CN (1) | CN1070176C (no) |
AT (1) | ATE192736T1 (no) |
AU (1) | AU679835B2 (no) |
BR (2) | BR9408378A (no) |
CA (1) | CA2179521C (no) |
CZ (1) | CZ289629B6 (no) |
DE (1) | DE69424441T2 (no) |
DK (1) | DK0736004T3 (no) |
ES (1) | ES2145264T3 (no) |
FI (1) | FI111718B (no) |
GR (1) | GR3034134T3 (no) |
HK (2) | HK1001768A1 (no) |
HR (1) | HRP950358B1 (no) |
HU (1) | HU221167B1 (no) |
MY (1) | MY114178A (no) |
NO (1) | NO306457B1 (no) |
NZ (1) | NZ279025A (no) |
PL (1) | PL185189B1 (no) |
PT (1) | PT736004E (no) |
RU (1) | RU2159231C2 (no) |
SG (1) | SG64903A1 (no) |
SK (1) | SK282403B6 (no) |
TW (1) | TW299315B (no) |
UA (1) | UA45964C2 (no) |
WO (1) | WO1995017876A2 (no) |
Families Citing this family (64)
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US5723502A (en) * | 1985-07-18 | 1998-03-03 | Proctor; Peter H. | Topical spin trap composition and method |
US5622994A (en) * | 1989-10-17 | 1997-04-22 | Oklahoma Medical Research Foundation | Spin trapping pharmaceutical compositions and methods for use thereof |
DK0496796T3 (da) * | 1989-10-17 | 1994-10-03 | Oklahoma Med Res Found | Fremgangsmåde og præparater til inhibering af sygdomme i forbindelse med oxidativ beskadigelse |
US20050107366A1 (en) * | 1991-06-18 | 2005-05-19 | Carney John M. | Spin trapping pharmaceutical compositions and methods for use thereof |
US6002001A (en) * | 1991-06-18 | 1999-12-14 | Oklahoma Medical Research Foundation | Spin trapping pharmaceutical compositions and methods for use thereof |
US20040208875A1 (en) * | 1995-03-15 | 2004-10-21 | Queen's University At Kingston | Method for treating amyloidosis |
US5488145A (en) * | 1993-12-23 | 1996-01-30 | Oklahoma Medical Research Foundation | 2,4-disulfonyl phenyl butyl nitrone, its salts, and their use as pharmaceutical free radical traps |
CA2231812C (en) * | 1995-09-11 | 2002-08-06 | Hoechst Marion Roussel, Inc. | Cyclic nitrones and pharmaceutical compositions containing them |
AU7739796A (en) | 1995-11-17 | 1997-06-11 | Florida International University | Azulenyl nitrone spin trapping agents, methods of making and using same |
WO1997038683A1 (en) * | 1996-04-17 | 1997-10-23 | Oklahoma Medical Research Foundation | Nitrone free radical trap treatment of dementia associated with aids virus (hiv-1) infection |
NZ333705A (en) * | 1996-07-19 | 2000-09-29 | Centaur Pharmaceuticals Inc | Furan nitrone derivatives and medicaments thereof |
TW429241B (en) * | 1996-09-26 | 2001-04-11 | Sumitomo Pharma | Nitrone derivatives |
MA26553A1 (fr) | 1997-10-17 | 2004-12-20 | Centaur Pharmaceuticals Inc | Alpha-aryl-n-alkylnitrones et compositions pharmaceutiques contenant ceux-la |
ATE228123T1 (de) * | 1998-01-16 | 2002-12-15 | Centaur Pharmaceuticals Inc | Thiophennitronderivate |
US5998469A (en) * | 1998-01-16 | 1999-12-07 | Centaur Pharmaceuticals, Inc. | Thioether furan nitrone compounds |
CA2323490A1 (en) * | 1998-03-13 | 1999-09-16 | Lowell D. Waterbury | Inhibition of angiogenesis |
EP1077696A1 (en) * | 1998-05-19 | 2001-02-28 | Centaur Pharmaceuticals, Inc. | Furan nitrone therapeutics for the treatment of inflammatory bowel disease |
US6083989A (en) * | 1999-05-18 | 2000-07-04 | Centaur Pharmaceuticals, Inc. | Aryl nitrone therapeutics for the treatment of inflammatory bowel disease |
UA66401C2 (en) | 1998-12-02 | 2004-05-17 | Sentor Pharmaceuticals Inc | 3,4,5-trisubstituted aryl nitrone compounds and pharmaceutical composition containing the same |
US6730700B2 (en) * | 1998-12-02 | 2004-05-04 | Renovis, Inc. | 3,4,5,-trisubstituted aryl nitrone compounds and pharmaceutical compositions containing the same |
ATE312103T1 (de) | 1999-01-25 | 2005-12-15 | Nat Jewish Med & Res Center | Substituierte porphyrine und deren therapeutische verwendungen |
CA2369997C (en) * | 1999-04-28 | 2009-11-17 | Queen's University At Kingston | Compositions and methods for treating amyloidosis |
BR9904931A (pt) * | 1999-10-18 | 2001-06-12 | Sergio Teixeira Ferreira | Inibição de amiloidoses |
US6815425B1 (en) | 1999-10-22 | 2004-11-09 | The United States Of America As Represented By The Secretary Of The Army | Pharmaceutical composition containing pGLU-GLU-PRO-NH2 and method for treating diseases and injuries to the brain, spinal cord and retina using same |
WO2001028578A2 (en) * | 1999-10-22 | 2001-04-26 | Wrair | A PHARMACEUTICAL COMPOSITION CONTAINING pGLU-GLU-PRO-NH2 AND METHOD FOR TREATING DISEASES AND INJURIES TO THE BRAIN, SPINAL CORD AND RETINA USING SAME |
SE0000056D0 (sv) * | 2000-01-10 | 2000-01-10 | Astrazeneca Ab | Novel process |
SE0000055D0 (sv) * | 2000-01-10 | 2000-01-10 | Centaur Pharmaceuticals Inc | Novel process |
US20020022743A1 (en) * | 2000-01-10 | 2002-02-21 | Sergei Pouhov | Method for the purification of aryl sulfonic acids and salts |
SE0001916D0 (sv) * | 2000-05-23 | 2000-05-23 | Astrazeneca Ab | Novel formulation |
US6664297B1 (en) | 2000-10-18 | 2003-12-16 | Universidade Federal Do Rio De Janeiro | Methods for inhibition and dissolution of amyloidoses by administration of compositions comprising 2,4-dinitrophenol |
AU2002253857A1 (en) | 2001-01-08 | 2002-09-04 | Centaur Pharmaceuticals, Inc. | Use of aryl nitrone compounds in methods for treating neuropathic pain |
WO2003010154A1 (en) * | 2001-07-26 | 2003-02-06 | Samsung Electronics Co. Ltd. | Seleno compounds containing nitrone moiety, their preparation and their therapeutic uses |
US20030045461A1 (en) * | 2001-09-06 | 2003-03-06 | Jen-Chang Hsia | Composition and methods of esterified nitroxides gated with carboxylic acids |
FR2846968B1 (fr) * | 2002-11-08 | 2005-02-04 | Salles Jean Pierre | Nouveaux derives amphiphiles de l'alpha-c-phenyl-n-tert- butyl nitrone |
US7414076B2 (en) * | 2003-06-23 | 2008-08-19 | Neurochem (International) Limited | Methods and compositions for treating amyloid-related diseases |
US7244764B2 (en) * | 2003-06-23 | 2007-07-17 | Neurochem (International) Limited | Methods and compositions for treating amyloid-related diseases |
US20070010573A1 (en) * | 2003-06-23 | 2007-01-11 | Xianqi Kong | Methods and compositions for treating amyloid-related diseases |
US20050059638A1 (en) * | 2003-08-04 | 2005-03-17 | Kelly Michael G. | Aryl, heteroaromatic and bicyclic aryl nitrone compounds, prodrugs and pharmaceutical compositions of the same to treat human disorders |
US20050182060A1 (en) * | 2004-02-13 | 2005-08-18 | Kelly Michael G. | 2-Substituted and 4-substituted aryl nitrone compounds |
WO2006059252A2 (en) * | 2004-11-12 | 2006-06-08 | Neurochem (International) Limited | Methods and fluorinated compositions for treating amyloid-related diseases |
JP2008520647A (ja) * | 2004-11-16 | 2008-06-19 | ニューロケム (インターナショナル) リミテッド | Cnsおよびアミロイド関連疾患治療のための化合物 |
CN101128421A (zh) | 2004-12-22 | 2008-02-20 | 神经化学(国际)有限公司 | 治疗淀粉样相关疾病用的方法与组合物 |
US20060235370A1 (en) * | 2005-04-04 | 2006-10-19 | Oblong John E | Method of regulating mammalian keratinous tissue |
TW200716088A (en) * | 2005-04-15 | 2007-05-01 | Neurochem Int Ltd | Formulations and methods for treating amyloidosis |
WO2007013843A1 (en) * | 2005-07-26 | 2007-02-01 | Astrazeneca Ab | Use of 4-[(tert-butylimino)methyl]benzene-1,3-disulfonate n-oxide against myocardial ischaemia |
WO2007013841A1 (en) * | 2005-07-26 | 2007-02-01 | Astrazeneca Ab | Use of 4-((tert-butylimine)methyl) benzene-1,3-disulfonate n-oxide against cerebral oedema |
WO2007013844A1 (en) * | 2005-07-26 | 2007-02-01 | Astrazeneca Ab | Use of 4-[(tert-butylimino)benzene-1,3-disulfonate n-oxide against nausea |
WO2007013842A1 (en) * | 2005-07-26 | 2007-02-01 | Astrazeneca Ab | Use of 4-((tert-butylimino)methyl) benzene-1,3-disulfonate n-oxide against maemorrhagic changes in the brain |
CA2634871A1 (en) * | 2005-12-22 | 2007-11-08 | Neurochem (International) Limited | Treatment of renal disorders, diabetic nephopathy and dyslipidemias |
JP5236641B2 (ja) * | 2006-07-25 | 2013-07-17 | ハフ イヤ インスティテュート | 急性音響外傷の治療方法 |
JP5607930B2 (ja) | 2006-10-12 | 2014-10-15 | ビーエイチアイ リミテッド パートナーシップ | 3−アミノ−1−プロパンスルホン酸を送達するための方法、化合物、組成物および媒体 |
JP2010529947A (ja) * | 2006-12-22 | 2010-09-02 | ベラス ヘルス(インターナショナル)リミテッド | 代謝性疾患および糖尿病を治療するための方法、化合物、および組成物 |
US20090082454A1 (en) * | 2007-09-25 | 2009-03-26 | Protia, Llc | Deuterium-enriched disufenton |
EP4309627A3 (en) | 2007-09-26 | 2024-07-17 | St. Jude Medical, LLC | Collapsible prosthetic heart valves |
US8227517B2 (en) * | 2008-02-12 | 2012-07-24 | Tosk, Incorporated | Doxorubicin adjuvants to reduce toxicity and methods for using the same |
RU2506083C2 (ru) * | 2008-05-23 | 2014-02-10 | Нэшнл Джуиш Хелт | Способ лечения поражений, ассоциированных с воздействием алкилирующих веществ |
US8633249B2 (en) | 2008-09-02 | 2014-01-21 | Oklahoma Medical Research Foundation | Adjuvant chemotherapy for anaplastic gliomas |
US10555915B2 (en) * | 2009-08-24 | 2020-02-11 | Hough Ear Institute | Methods for treating acute acoustic trauma |
EP2670403B1 (en) * | 2011-02-04 | 2021-08-18 | Hough Ear Institute | Methods for treating brain injury |
JP2019537582A (ja) * | 2016-10-31 | 2019-12-26 | ハフ イアー インスティテュート | シナプス形成および神経突起形成を増強するための方法 |
US11020354B2 (en) | 2017-01-19 | 2021-06-01 | Otologic Pharmaceuticals, Inc. | Formulations of n-acetylcysteine and uses thereof |
US11660280B2 (en) | 2017-09-20 | 2023-05-30 | Oklahoma Medical Research Foundation | Treatment of drug resistant gliomas |
US10829441B2 (en) | 2017-11-14 | 2020-11-10 | The University Of Toledo | Reactive oxygen species-sensitive nitric oxide synthase inhibitors for the treatment of ischemic stroke |
WO2019213245A1 (en) | 2018-05-03 | 2019-11-07 | Hough Ear Institute | Methods for reducing accumulated pathologic tau protein |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5025032A (en) * | 1989-10-17 | 1991-06-18 | Oklahoma Medical Research Foundation | Phenyl butyl nitrone compositions and methods for treatment of oxidative tissue damage |
US5036097A (en) * | 1989-10-17 | 1991-07-30 | Oklahoma Medical Research Foundation | Phenylbutyl nitrone compositions and methods for prevention of gastric ulceration |
DK0496796T3 (da) * | 1989-10-17 | 1994-10-03 | Oklahoma Med Res Found | Fremgangsmåde og præparater til inhibering af sygdomme i forbindelse med oxidativ beskadigelse |
ATE209908T1 (de) * | 1991-06-18 | 2001-12-15 | Oklahoma Med Res Found | RADIKALFÄNGER (ßSPIN TRAPSß) ZUR BEHANDLUNG VON MIT OXIDATION VON LIPIDEN UND PROTEINEN VERBUNDENEN ERKRANKUNGEN |
US5488145A (en) * | 1993-12-23 | 1996-01-30 | Oklahoma Medical Research Foundation | 2,4-disulfonyl phenyl butyl nitrone, its salts, and their use as pharmaceutical free radical traps |
-
1993
- 1993-12-23 US US08/173,579 patent/US5488145A/en not_active Expired - Lifetime
-
1994
- 1994-12-22 BR BR9408378A patent/BR9408378A/pt not_active Application Discontinuation
- 1994-12-22 JP JP51809895A patent/JP3412821B2/ja not_active Expired - Lifetime
- 1994-12-22 UA UA96072885A patent/UA45964C2/uk unknown
- 1994-12-22 PL PL94315154A patent/PL185189B1/pl not_active IP Right Cessation
- 1994-12-22 NZ NZ279025A patent/NZ279025A/en unknown
- 1994-12-22 SK SK788-96A patent/SK282403B6/sk unknown
- 1994-12-22 SG SG1996007103A patent/SG64903A1/en unknown
- 1994-12-22 KR KR1019960703367A patent/KR100370522B1/ko not_active IP Right Cessation
- 1994-12-22 ES ES95907224T patent/ES2145264T3/es not_active Expired - Lifetime
- 1994-12-22 EP EP95907224A patent/EP0736004B1/en not_active Expired - Lifetime
- 1994-12-22 CZ CZ19961775A patent/CZ289629B6/cs not_active IP Right Cessation
- 1994-12-22 WO PCT/US1994/014545 patent/WO1995017876A2/en active IP Right Grant
- 1994-12-22 DK DK95907224T patent/DK0736004T3/da active
- 1994-12-22 DE DE69424441T patent/DE69424441T2/de not_active Expired - Fee Related
- 1994-12-22 CN CN94194993A patent/CN1070176C/zh not_active Expired - Fee Related
- 1994-12-22 PT PT95907224T patent/PT736004E/pt unknown
- 1994-12-22 RU RU96115200/04A patent/RU2159231C2/ru not_active IP Right Cessation
- 1994-12-22 US US08/663,316 patent/US5780510A/en not_active Expired - Fee Related
- 1994-12-22 HU HU9601739A patent/HU221167B1/hu not_active IP Right Cessation
- 1994-12-22 CA CA002179521A patent/CA2179521C/en not_active Expired - Lifetime
- 1994-12-22 AT AT95907224T patent/ATE192736T1/de not_active IP Right Cessation
- 1994-12-22 AU AU15527/95A patent/AU679835B2/en not_active Ceased
-
1995
- 1995-01-27 TW TW084100747A patent/TW299315B/zh active
- 1995-04-24 US US08/426,961 patent/US5475032A/en not_active Expired - Lifetime
- 1995-06-06 US US08/468,564 patent/US5508305A/en not_active Expired - Lifetime
- 1995-06-20 MY MYPI95001668A patent/MY114178A/en unknown
- 1995-06-23 HR HR950358A patent/HRP950358B1/xx not_active IP Right Cessation
-
1996
- 1996-06-20 NO NO962637A patent/NO306457B1/no unknown
- 1996-06-20 FI FI962589A patent/FI111718B/fi not_active IP Right Cessation
-
1997
- 1997-05-13 BR BR1100626-9A patent/BR1100626A/pt active IP Right Grant
-
1998
- 1998-02-04 HK HK98100831A patent/HK1001768A1/xx not_active IP Right Cessation
- 1998-07-11 HK HK98109078A patent/HK1008294A1/xx not_active IP Right Cessation
-
2000
- 2000-05-22 JP JP2000150128A patent/JP2001010953A/ja not_active Withdrawn
- 2000-08-07 GR GR20000401829T patent/GR3034134T3/el not_active IP Right Cessation
-
2003
- 2003-12-02 JP JP2003403744A patent/JP2004075696A/ja not_active Withdrawn
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