FI962589A - 2,4-disulfofenyylibutyylinitroni, sen suolat ja niiden käyttö farmaseuttisina aineina - Google Patents

2,4-disulfofenyylibutyylinitroni, sen suolat ja niiden käyttö farmaseuttisina aineina Download PDF

Info

Publication number
FI962589A
FI962589A FI962589A FI962589A FI962589A FI 962589 A FI962589 A FI 962589A FI 962589 A FI962589 A FI 962589A FI 962589 A FI962589 A FI 962589A FI 962589 A FI962589 A FI 962589A
Authority
FI
Finland
Prior art keywords
nervous system
central nervous
pharmaceutical agents
salts
disulfophenylbutylnitron
Prior art date
Application number
FI962589A
Other languages
English (en)
Swedish (sv)
Other versions
FI111718B (fi
FI962589A0 (fi
Inventor
John M Carney
Original Assignee
Oklahoma Med Res Found
Univ Kentucky Res Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oklahoma Med Res Found, Univ Kentucky Res Found filed Critical Oklahoma Med Res Found
Publication of FI962589A0 publication Critical patent/FI962589A0/fi
Publication of FI962589A publication Critical patent/FI962589A/fi
Application granted granted Critical
Publication of FI111718B publication Critical patent/FI111718B/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/28—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C309/45—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing nitrogen atoms, not being part of nitro or nitroso groups, bound to the carbon skeleton
    • C07C309/46—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing nitrogen atoms, not being part of nitro or nitroso groups, bound to the carbon skeleton having the sulfo groups bound to carbon atoms of non-condensed six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Toxicology (AREA)
  • Vascular Medicine (AREA)
  • Psychiatry (AREA)
  • Biochemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
FI962589A 1993-12-23 1996-06-20 Menetelmä 2,4-disulfonyylifenyylibutyylinitronin tai sen suolan valmistamiseksi FI111718B (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US08/173,579 US5488145A (en) 1993-12-23 1993-12-23 2,4-disulfonyl phenyl butyl nitrone, its salts, and their use as pharmaceutical free radical traps
US17357993 1993-12-23
US9414545 1994-12-22
PCT/US1994/014545 WO1995017876A2 (en) 1993-12-23 1994-12-22 2,4-disulphophenyl butylnitrone, its salts, and their use as pharmaceutical spintraps

Publications (3)

Publication Number Publication Date
FI962589A0 FI962589A0 (fi) 1996-06-20
FI962589A true FI962589A (fi) 1996-08-20
FI111718B FI111718B (fi) 2003-09-15

Family

ID=22632663

Family Applications (1)

Application Number Title Priority Date Filing Date
FI962589A FI111718B (fi) 1993-12-23 1996-06-20 Menetelmä 2,4-disulfonyylifenyylibutyylinitronin tai sen suolan valmistamiseksi

Country Status (29)

Country Link
US (4) US5488145A (fi)
EP (1) EP0736004B1 (fi)
JP (3) JP3412821B2 (fi)
KR (1) KR100370522B1 (fi)
CN (1) CN1070176C (fi)
AT (1) ATE192736T1 (fi)
AU (1) AU679835B2 (fi)
BR (2) BR9408378A (fi)
CA (1) CA2179521C (fi)
CZ (1) CZ289629B6 (fi)
DE (1) DE69424441T2 (fi)
DK (1) DK0736004T3 (fi)
ES (1) ES2145264T3 (fi)
FI (1) FI111718B (fi)
GR (1) GR3034134T3 (fi)
HK (2) HK1001768A1 (fi)
HR (1) HRP950358B1 (fi)
HU (1) HU221167B1 (fi)
MY (1) MY114178A (fi)
NO (1) NO306457B1 (fi)
NZ (1) NZ279025A (fi)
PL (1) PL185189B1 (fi)
PT (1) PT736004E (fi)
RU (1) RU2159231C2 (fi)
SG (1) SG64903A1 (fi)
SK (1) SK282403B6 (fi)
TW (1) TW299315B (fi)
UA (1) UA45964C2 (fi)
WO (1) WO1995017876A2 (fi)

Families Citing this family (64)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5723502A (en) * 1985-07-18 1998-03-03 Proctor; Peter H. Topical spin trap composition and method
US5622994A (en) * 1989-10-17 1997-04-22 Oklahoma Medical Research Foundation Spin trapping pharmaceutical compositions and methods for use thereof
AU653921B2 (en) * 1989-10-17 1994-10-20 Oklahoma Medical Research Foundation Method and compositions for inhibition of disorders associated with oxidative damage
US20050107366A1 (en) * 1991-06-18 2005-05-19 Carney John M. Spin trapping pharmaceutical compositions and methods for use thereof
US6002001A (en) * 1991-06-18 1999-12-14 Oklahoma Medical Research Foundation Spin trapping pharmaceutical compositions and methods for use thereof
US20040208875A1 (en) * 1995-03-15 2004-10-21 Queen's University At Kingston Method for treating amyloidosis
US5488145A (en) * 1993-12-23 1996-01-30 Oklahoma Medical Research Foundation 2,4-disulfonyl phenyl butyl nitrone, its salts, and their use as pharmaceutical free radical traps
CN1500787A (zh) * 1995-09-11 2004-06-02 ���µ�˹ҩ�﹫˾ 环状硝酮和含有它们的药用组合物
AU7739796A (en) 1995-11-17 1997-06-11 Florida International University Azulenyl nitrone spin trapping agents, methods of making and using same
CA2251800A1 (en) * 1996-04-17 1997-10-23 Oklahoma Medical Research Foundation Nitrone free radical trap treatment of dementia associated with aids virus (hiv-1) infection
US6376540B1 (en) * 1996-07-19 2002-04-23 Centaur Pharmaceuticals, Inc. Furan nitrone compounds
TW429241B (en) 1996-09-26 2001-04-11 Sumitomo Pharma Nitrone derivatives
MA26553A1 (fr) * 1997-10-17 2004-12-20 Centaur Pharmaceuticals Inc Alpha-aryl-n-alkylnitrones et compositions pharmaceutiques contenant ceux-la
CA2318555A1 (en) * 1998-01-16 1999-07-22 Yong-Kang Zhang Thiophene nitrone compounds
CA2318357A1 (en) * 1998-01-16 1999-07-22 Renovis, Inc. Thioether furan nitrone compounds
US6255353B1 (en) * 1998-03-13 2001-07-03 Centaur Pharmaceuticals, Inc. Inhibition of angiogenesis
US6083989A (en) * 1999-05-18 2000-07-04 Centaur Pharmaceuticals, Inc. Aryl nitrone therapeutics for the treatment of inflammatory bowel disease
AU3985799A (en) * 1998-05-19 1999-12-06 Centaur Pharmaceuticals, Inc. Furan nitrone therapeutics for the treatment of inflammatory bowel disease
UA66401C2 (en) 1998-12-02 2004-05-17 Sentor Pharmaceuticals Inc 3,4,5-trisubstituted aryl nitrone compounds and pharmaceutical composition containing the same
US6730700B2 (en) 1998-12-02 2004-05-04 Renovis, Inc. 3,4,5,-trisubstituted aryl nitrone compounds and pharmaceutical compositions containing the same
EP1155019B1 (en) 1999-01-25 2005-12-07 National Jewish Medical and Research Center Substituted porphyrins and their therapeutic use
DE60042896D1 (de) * 1999-04-28 2009-10-15 Bellus Health Int Ltd Zusammensetzungen und verfahren zur behandlung von amyloidosis mit sulphonatderivaten
BR9904931A (pt) * 1999-10-18 2001-06-12 Sergio Teixeira Ferreira Inibição de amiloidoses
AU1574701A (en) * 1999-10-22 2001-04-30 Wrair Walter Reed Army Institute Of Research A pharmaceutical composition containing pglu-glu-pro-nh2 and method for treating diseases and injuries to the brain, spinal cord and retina using same
US6815425B1 (en) 1999-10-22 2004-11-09 The United States Of America As Represented By The Secretary Of The Army Pharmaceutical composition containing pGLU-GLU-PRO-NH2 and method for treating diseases and injuries to the brain, spinal cord and retina using same
SE0000055D0 (sv) * 2000-01-10 2000-01-10 Centaur Pharmaceuticals Inc Novel process
SE0000056D0 (sv) * 2000-01-10 2000-01-10 Astrazeneca Ab Novel process
US20020022743A1 (en) * 2000-01-10 2002-02-21 Sergei Pouhov Method for the purification of aryl sulfonic acids and salts
SE0001916D0 (sv) * 2000-05-23 2000-05-23 Astrazeneca Ab Novel formulation
US6664297B1 (en) 2000-10-18 2003-12-16 Universidade Federal Do Rio De Janeiro Methods for inhibition and dissolution of amyloidoses by administration of compositions comprising 2,4-dinitrophenol
US6835754B2 (en) 2001-01-08 2004-12-28 Renovis, Inc. Use of aryl nitrone compounds in methods for treating neuropathic pain
WO2003010154A1 (en) * 2001-07-26 2003-02-06 Samsung Electronics Co. Ltd. Seleno compounds containing nitrone moiety, their preparation and their therapeutic uses
US20030045461A1 (en) * 2001-09-06 2003-03-06 Jen-Chang Hsia Composition and methods of esterified nitroxides gated with carboxylic acids
FR2846968B1 (fr) * 2002-11-08 2005-02-04 Salles Jean Pierre Nouveaux derives amphiphiles de l'alpha-c-phenyl-n-tert- butyl nitrone
US20070010573A1 (en) * 2003-06-23 2007-01-11 Xianqi Kong Methods and compositions for treating amyloid-related diseases
US7414076B2 (en) * 2003-06-23 2008-08-19 Neurochem (International) Limited Methods and compositions for treating amyloid-related diseases
US7244764B2 (en) * 2003-06-23 2007-07-17 Neurochem (International) Limited Methods and compositions for treating amyloid-related diseases
US20050059638A1 (en) * 2003-08-04 2005-03-17 Kelly Michael G. Aryl, heteroaromatic and bicyclic aryl nitrone compounds, prodrugs and pharmaceutical compositions of the same to treat human disorders
US20050182060A1 (en) * 2004-02-13 2005-08-18 Kelly Michael G. 2-Substituted and 4-substituted aryl nitrone compounds
MX2007005507A (es) * 2004-11-12 2008-03-13 Neurochem Int Ltd Metodos y composiciones fluoradas para el tratamiento de padecimientos relacionados con amiloides.
AU2005310979A1 (en) * 2004-11-16 2006-06-08 Bellus Health (International) Limited Compounds for the treatment of CNS and amyloid associated diseases
WO2006085149A2 (en) 2004-12-22 2006-08-17 Neurochem (International) Limited Methods and compositions for treating amyloid-related diseases
US20060235370A1 (en) * 2005-04-04 2006-10-19 Oblong John E Method of regulating mammalian keratinous tissue
TW200716088A (en) * 2005-04-15 2007-05-01 Neurochem Int Ltd Formulations and methods for treating amyloidosis
WO2007013842A1 (en) * 2005-07-26 2007-02-01 Astrazeneca Ab Use of 4-((tert-butylimino)methyl) benzene-1,3-disulfonate n-oxide against maemorrhagic changes in the brain
WO2007013841A1 (en) * 2005-07-26 2007-02-01 Astrazeneca Ab Use of 4-((tert-butylimine)methyl) benzene-1,3-disulfonate n-oxide against cerebral oedema
WO2007013843A1 (en) * 2005-07-26 2007-02-01 Astrazeneca Ab Use of 4-[(tert-butylimino)methyl]benzene-1,3-disulfonate n-oxide against myocardial ischaemia
WO2007013844A1 (en) * 2005-07-26 2007-02-01 Astrazeneca Ab Use of 4-[(tert-butylimino)benzene-1,3-disulfonate n-oxide against nausea
EP1968561B8 (en) * 2005-12-22 2010-10-20 Kiacta Sàrl Treatment of diabetic nephropathy
WO2008013866A2 (en) * 2006-07-25 2008-01-31 Hough Ear Institute Methods for treating acute acoustic trauma
DK2089417T3 (en) 2006-10-12 2015-03-23 Bhi Ltd Partnership Methods, Compounds, Compositions and Vehicles for Delivery of 3-Amion-1-Propanesulfonic Acid
CN101730529A (zh) * 2006-12-22 2010-06-09 贝鲁斯健康(国际)有限公司 用于治疗代谢疾病和糖尿病的方法、化合物和组合物
US20090082454A1 (en) * 2007-09-25 2009-03-26 Protia, Llc Deuterium-enriched disufenton
EP3443938B1 (en) 2007-09-26 2024-01-24 St. Jude Medical, LLC Collapsible prosthetic heart valves
CA2715326C (en) 2008-02-12 2017-06-13 Tosk, Incorporated Toxicity-reducing nitrone adjuvants for doxorubicin and use of the same
CA2725012C (en) * 2008-05-23 2019-05-07 National Jewish Health Methods for treating injury associated with exposure to an alkylating species
EP2326320B1 (en) 2008-09-02 2012-10-24 Oklahoma Medical Research Foundation 2, 4-disulfonyl pheny tert-butyl nitrone for the treatment of gliomas
ES2563777T3 (es) * 2009-08-24 2016-03-16 Hough Ear Institute Compuestos de nitrona para tratar la pérdida auditiva sensorineural
JP6099574B2 (ja) 2011-02-04 2017-03-22 ハフ イヤ インスティテュート 外傷性脳損傷を処置する方法
US10576125B2 (en) 2016-10-31 2020-03-03 Hough Ear Institute Methods for enhancing synaptogenesis and neuritogenesis
EP3570826A4 (en) 2017-01-19 2020-09-23 Otologic Pharmaceutics, Inc. N-ACETYLCYSTEIN FORMULATIONS AND THEIR USES
EP3684345A4 (en) 2017-09-20 2021-06-23 Oklahoma Medical Research Foundation TREATMENT OF DRUG RESISTANT GLIOMAS
US10829441B2 (en) 2017-11-14 2020-11-10 The University Of Toledo Reactive oxygen species-sensitive nitric oxide synthase inhibitors for the treatment of ischemic stroke
US20210137861A1 (en) 2018-05-03 2021-05-13 Hough Ear Institute Methods for reducing accumulated pathologic tau protein

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU653921B2 (en) * 1989-10-17 1994-10-20 Oklahoma Medical Research Foundation Method and compositions for inhibition of disorders associated with oxidative damage
US5036097A (en) * 1989-10-17 1991-07-30 Oklahoma Medical Research Foundation Phenylbutyl nitrone compositions and methods for prevention of gastric ulceration
US5025032A (en) * 1989-10-17 1991-06-18 Oklahoma Medical Research Foundation Phenyl butyl nitrone compositions and methods for treatment of oxidative tissue damage
WO1992022290A1 (en) * 1991-06-18 1992-12-23 Oklahoma Medical Research Foundation Use of spin trapping for the treatment of diseases associated with oxidation of lipids and proteins
US5488145A (en) * 1993-12-23 1996-01-30 Oklahoma Medical Research Foundation 2,4-disulfonyl phenyl butyl nitrone, its salts, and their use as pharmaceutical free radical traps

Also Published As

Publication number Publication date
HUT76788A (en) 1997-11-28
CA2179521C (en) 2002-03-19
PL185189B1 (pl) 2003-03-31
SG64903A1 (en) 1999-05-25
WO1995017876A3 (en) 1995-08-10
US5508305A (en) 1996-04-16
KR100370522B1 (ko) 2003-05-16
MY114178A (en) 2002-08-30
AU1552795A (en) 1995-07-17
ATE192736T1 (de) 2000-05-15
DK0736004T3 (da) 2000-10-09
NO306457B1 (no) 1999-11-08
NO962637D0 (no) 1996-06-20
BR1100626A (pt) 1999-11-23
SK282403B6 (sk) 2002-01-07
US5475032A (en) 1995-12-12
NO962637L (no) 1996-08-13
CZ289629B6 (cs) 2002-03-13
HRP950358A2 (en) 1997-08-31
CA2179521A1 (en) 1995-07-06
JP2004075696A (ja) 2004-03-11
CZ177596A3 (en) 1996-12-11
DE69424441D1 (de) 2000-06-15
PL315154A1 (en) 1996-10-14
FI111718B (fi) 2003-09-15
US5780510A (en) 1998-07-14
TW299315B (fi) 1997-03-01
EP0736004B1 (en) 2000-05-10
CN1070176C (zh) 2001-08-29
FI962589A0 (fi) 1996-06-20
HRP950358B1 (en) 2001-04-30
AU679835B2 (en) 1997-07-10
WO1995017876A2 (en) 1995-07-06
NZ279025A (en) 1998-02-26
HK1001768A1 (en) 1998-07-10
JPH09507232A (ja) 1997-07-22
HK1008294A1 (en) 1999-05-07
CN1156447A (zh) 1997-08-06
UA45964C2 (uk) 2002-05-15
DE69424441T2 (de) 2000-10-12
JP2001010953A (ja) 2001-01-16
BR9408378A (pt) 1997-08-19
JP3412821B2 (ja) 2003-06-03
RU2159231C2 (ru) 2000-11-20
PT736004E (pt) 2000-09-29
EP0736004A1 (en) 1996-10-09
US5488145A (en) 1996-01-30
ES2145264T3 (es) 2000-07-01
HU9601739D0 (en) 1996-08-28
GR3034134T3 (en) 2000-11-30
HU221167B1 (en) 2002-08-28
SK78896A3 (en) 1997-09-10

Similar Documents

Publication Publication Date Title
FI962589A (fi) 2,4-disulfofenyylibutyylinitroni, sen suolat ja niiden käyttö farmaseuttisina aineina
DE69331409D1 (de) Oral 1alpha-hydroxyprevitamin d
UA29469C2 (uk) Ліпосомальна фармацевтична композиція для внутрішньовенного введення
MX9602683A (es) Compuestos de 6-dimetilaminometil-1-fenil-ciclohexano como substancias farmaceuticamente activas.
ES2037385T3 (es) Un procedimiento de manufactura de una preparacion farmaceutica para administracion local.
ES2147788T3 (es) 3,4-diarilcromanos para el tratamiento de la dermatitis.
GEP20043162B (en) Derivatives of Isosorbid Mononitrate, Utilization as Vasodilator Agents with Reduced Tolerance
ES2159362T3 (es) Utilizacion de la 1-(2-naft-2-iletil)-4-(3-trifluorometilfenil)-1,2,3,6-tetrahidropiridina para la preparacion de medicamentos destinados para el tratamiento de la esclerosis lateral amiotrofica.
ES2062137T3 (es) Utilizacion de 5'-deoxi-5'-metil-tioadenosina, s-adenosilmetionina y sus sales para la preparacion de composiciones farmaceuticas reductoras de seborrea.
RS52011B (sr) Nova primena derivata taksoida
NO955313L (no) Anvendelse av ropivacain i fremstillingen av et farmasöytikum med analgetisk effekt som har minimal motorisk blokkering
DK0742716T3 (da) Farmaceutisk sammensætning til systemisk transdermal indgivelse med det aktive middel morphin-6-glucuronid
AR035986A1 (es) Uso de derivados anti-convulsivos para la manufactura de un medicamento util para el tratamiento del temblor esencial
BR0112874A (pt) Uso de fribratos para a preparação de um medicamento útil no tratamento de falha de coração congestiva
IT1254707B (it) Uso topico della calcitonima per la preparazione di medicamenti nella cataratta idiopatica senile e una composizione farmaceutica che la contiene
ZA968315B (en) Administration by inhalation of 2-amino-6n-propyl-amino-4,5,,7-tetrahydrobenzothiazole particularly the (-)-enan-tiomer thereof and the pharmacologically acceptable acid addition salts thereof
ITMI922040A1 (it) Composizioni farmaceutiche per il trattamento di stati di iperaggregabilita' piastrinica
IS1881B (is) 2,4-dísúlfónýlfenýlbútýlnítrón, sölt þess, lyfjablanda ásamt notkun á þessu efnasambandi við framleiðslu á lyfi
BR9609937A (pt) Composição contendo ácido mefenâmico em associação com codeìna
CO4180553A1 (es) Composiciones para el tratamiento de la peridontitis adulta

Legal Events

Date Code Title Description
MA Patent expired