NO954692L - Substituerte beta-aryl og beta-heteroaryl-alfa-cyanoakrylamid-derivater som tyrosinkinase inhibitorer - Google Patents

Substituerte beta-aryl og beta-heteroaryl-alfa-cyanoakrylamid-derivater som tyrosinkinase inhibitorer

Info

Publication number
NO954692L
NO954692L NO954692A NO954692A NO954692L NO 954692 L NO954692 L NO 954692L NO 954692 A NO954692 A NO 954692A NO 954692 A NO954692 A NO 954692A NO 954692 L NO954692 L NO 954692L
Authority
NO
Norway
Prior art keywords
beta
alkyl
pct
hydrogen
tyrosine kinase
Prior art date
Application number
NO954692A
Other languages
English (en)
Other versions
NO954692D0 (no
Inventor
Franco Buzzetti
Angelo Crugnola
Antonio Longo
Gabriella Maria Brasca
Dario Ballinari
Original Assignee
Pharmacia Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia Spa filed Critical Pharmacia Spa
Publication of NO954692D0 publication Critical patent/NO954692D0/no
Publication of NO954692L publication Critical patent/NO954692L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/32—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring
    • C07C255/41—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by carboxyl groups, other than cyano groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/24—Oxygen atoms attached in position 8
    • C07D215/26—Alcohols; Ethers thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
    • C07D217/16—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline

Abstract

Nye forbindelser med formel (I), hvor A er en bicyklisk ring valgt fra naftalen, tetrahydronaftalen, quinolin, isoqulnolln og indol; B er en R2 substituert benzenrlng eller en usubstituert pyridin eller tlfenring; R er hydrogen, C^-Cfj alkyl, halogen, nitro, cyano, karboksy eller en gruppe NR3R4, hvor hver av R3 og R4 uavhengig er hydrogen eller C^-Cfc alkyl; R1 er hydrogen, C^-Cf, alkyl eller Ci-Cb alkanoyl; R2 er hydrogen, C1-Cb alkyl, halogen, nitro, cyano, karboksy, hydroksy, C^-C^ alkoksy, Cj-Cfc alkanoyloksy eller en gruppe NR3R4, hvor R3 og R4 er som definert ovenfor; n er null eller et tall på l til 2; x er null eller et tall på l til 5; og det farmasøytiske akseptable saltet derav, er be- skrevet. Forbindelsene er nyttige som tyrosinkinase- inhlbitorer.
NO954692A 1994-03-28 1995-11-20 Substituerte beta-aryl og beta-heteroaryl-alfa-cyanoakrylamid-derivater som tyrosinkinase inhibitorer NO954692L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9406137A GB9406137D0 (en) 1994-03-28 1994-03-28 N-substituted beta-aryl- and betaheteroaryl-alpha-cyanoacrylamide derivatives and process for their preparation
PCT/EP1995/000758 WO1995026341A1 (en) 1994-03-28 1995-03-02 Substituted beta-aryl and beta-heteroaryl-alpha-cyanoacrylamide derivatives as tyrosine kinase inhibitors

Publications (2)

Publication Number Publication Date
NO954692D0 NO954692D0 (no) 1995-11-20
NO954692L true NO954692L (no) 1995-11-20

Family

ID=10752648

Family Applications (1)

Application Number Title Priority Date Filing Date
NO954692A NO954692L (no) 1994-03-28 1995-11-20 Substituerte beta-aryl og beta-heteroaryl-alfa-cyanoakrylamid-derivater som tyrosinkinase inhibitorer

Country Status (21)

Country Link
US (1) US5652250A (no)
EP (1) EP0700388B1 (no)
JP (1) JPH08511562A (no)
KR (1) KR960702442A (no)
CN (1) CN1125942A (no)
AT (1) ATE224371T1 (no)
AU (1) AU685599B2 (no)
DE (1) DE69528229T2 (no)
ES (1) ES2183866T3 (no)
FI (1) FI955661A (no)
GB (1) GB9406137D0 (no)
HU (1) HUT73811A (no)
IL (1) IL113044A0 (no)
MX (1) MX9504895A (no)
MY (1) MY130160A (no)
NO (1) NO954692L (no)
NZ (1) NZ281630A (no)
PL (1) PL311745A1 (no)
TW (1) TW347386B (no)
WO (1) WO1995026341A1 (no)
ZA (1) ZA952423B (no)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9613021D0 (en) * 1996-06-21 1996-08-28 Pharmacia Spa Bicyclic 4-aralkylaminopyrimidine derivatives as tyrosine kinase inhibitors
WO1997049653A2 (en) * 1996-06-24 1997-12-31 Irori Solid phase tyrphostin library linked to matrices with memories
EP1060160A2 (en) 1998-02-27 2000-12-20 THE UNITED STATES GOVERNMENT as represented by THE DEPARTMENT OF HEALTH AND HUMAN SERVICES Disubstituted lavendustin a analogs and pharmaceutical compositions comprising the analogs
HUP0000920A3 (en) * 2000-02-28 2002-03-28 Sanofi Synthelabo Pde4 inhibitor isoquinolinylidene derivatives, process for their preparation and medicaments containing them
EP1752446A3 (en) * 2000-04-13 2007-03-21 HSC Research and Development Limited Partnership Compounds for modulating cell proliferation
JP2003531133A (ja) 2000-04-13 2003-10-21 エイチエスシー リサーチ アンド ディベロップメント リミテッド パートナーシップ 細胞増殖を調節する新規化合物
US20050014690A1 (en) * 2001-10-11 2005-01-20 Chaim Roifman Styryl acrylonitrile compounds and their use to promote myelopoiesis
JP4751336B2 (ja) * 2003-12-11 2011-08-17 ボード・オブ・リージエンツ，ザ・ユニバーシテイ・オブ・テキサス・システム 細胞増殖性疾患を治療する化合
US7598419B2 (en) 2004-03-26 2009-10-06 Hsc Research And Development Limited Partnership Compounds for modulating cell proliferation
US20100292229A1 (en) * 2006-06-30 2010-11-18 The Board Of Regents Of The University Of Texas System Tryphostin-analogs for the treatment of cell proliferative diseases
EP2307367B1 (en) 2008-07-08 2014-09-24 Board of Regents, The University of Texas System Novel inhibitors of proliferation and activation of signal transducer and activator of transcription (stats)
EP2558099A4 (en) * 2009-11-16 2013-07-17 Univ California San Francisco Kinase Inhibitors
CN103459371A (zh) * 2011-04-02 2013-12-18 中国人民解放军军事医学科学院毒物药物研究所 芳基丙烯酰胺化合物及其用于制备免疫抑制剂的用途
HUE048834T2 (hu) * 2011-05-17 2020-08-28 Univ California Kináz inhibitorok
US10214476B2 (en) * 2011-12-30 2019-02-26 Ecole Nationale Superieure De Chimie De Clermont Ferrand Pain relief compounds
JP2016537316A (ja) * 2013-10-10 2016-12-01 ザ リージェンツ オブ ザ ユニバーシティー オブ ミシガン デユビキチナーゼ阻害剤およびその使用方法
CN108276366B (zh) * 2018-01-08 2021-09-03 四川大学 一种丙烯酰胺类衍生物及其制备方法与应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9000939D0 (en) * 1990-01-16 1990-03-14 Erba Carlo Spa Improvement in the total synthesis of erbstatin analogs
GB9000950D0 (en) * 1990-01-16 1990-03-14 Erba Carlo Spa New arylvinylamide derivatives and process for their preparation
GB9004483D0 (en) * 1990-02-28 1990-04-25 Erba Carlo Spa New aryl-and heteroarylethenylene derivatives and process for their preparation
US5196446A (en) * 1990-04-16 1993-03-23 Yissum Research Development Company Of The Hebrew University Of Jerusalem Certain indole compounds which inhibit EGF receptor tyrosine kinase
AU662480B2 (en) * 1990-04-16 1995-09-07 Yissum Research Development Company Of The Hebrew University Of Jerusalem Heterocyclicethenediyl compounds which inhibit EGF receptor tyrosine kinase
GB9115160D0 (en) * 1991-07-12 1991-08-28 Erba Carlo Spa Methylen-oxindole derivatives and process for their preparation
CA2080554A1 (en) * 1991-10-15 1993-04-16 Mitsubishi Chemical Corporation Styrene derivatives
GB9204945D0 (en) * 1992-03-06 1992-04-22 Erba Carlo Spa 3-aryl-glycidic ester derivatives and process for their preparation
GB9226855D0 (en) * 1992-12-23 1993-02-17 Erba Carlo Spa Vinylene-azaindole derivatives and process for their preparation

Also Published As

Publication number Publication date
AU685599B2 (en) 1998-01-22
ATE224371T1 (de) 2002-10-15
ZA952423B (en) 1995-12-19
TW347386B (en) 1998-12-11
IL113044A0 (en) 1995-06-29
HUT73811A (en) 1996-09-30
NZ281630A (en) 1998-02-26
EP0700388A1 (en) 1996-03-13
JPH08511562A (ja) 1996-12-03
MY130160A (en) 2007-06-29
NO954692D0 (no) 1995-11-20
DE69528229T2 (de) 2003-08-14
HU9503714D0 (en) 1996-02-28
CN1125942A (zh) 1996-07-03
MX9504895A (es) 1998-03-31
PL311745A1 (en) 1996-03-18
US5652250A (en) 1997-07-29
EP0700388B1 (en) 2002-09-18
KR960702442A (ko) 1996-04-27
ES2183866T3 (es) 2003-04-01
WO1995026341A1 (en) 1995-10-05
AU1849895A (en) 1995-10-17
FI955661A0 (fi) 1995-11-24
FI955661A (fi) 1996-01-19
DE69528229D1 (en) 2002-10-24
GB9406137D0 (en) 1994-05-18

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