NO951277L - Desulfatohirudin med höy molekylvekt - Google Patents
Desulfatohirudin med höy molekylvektInfo
- Publication number
- NO951277L NO951277L NO951277A NO951277A NO951277L NO 951277 L NO951277 L NO 951277L NO 951277 A NO951277 A NO 951277A NO 951277 A NO951277 A NO 951277A NO 951277 L NO951277 L NO 951277L
- Authority
- NO
- Norway
- Prior art keywords
- desulfatohirudin
- molecular weight
- high molecular
- desulfato
- thrombin
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/55—Protease inhibitors
- A61K38/57—Protease inhibitors from animals; from humans
- A61K38/58—Protease inhibitors from animals; from humans from leeches, e.g. hirudin, eglin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Biophysics (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Zoology (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
Abstract
Thrombininhibitorer og produksjon av modifiserte desulfatohlrudlner ved hjelp av genetisk omkonstruerlng samt en fremgangsmåte for denaturerlng og renaturerlng av et modifisert desulfatohlrudln til en biologisk aktiv thromblnlnhibitor og kombinasjonen av to eller flere desulfatohlrudlner for å danne thrmombin- inhlbltorer med høyere molekylvekt, er beskrevet.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP93810552 | 1993-08-04 | ||
PCT/EP1994/002438 WO1995004823A1 (en) | 1993-08-04 | 1994-07-23 | High molecular weight desulphatohirudin |
Publications (2)
Publication Number | Publication Date |
---|---|
NO951277D0 NO951277D0 (no) | 1995-04-03 |
NO951277L true NO951277L (no) | 1995-04-03 |
Family
ID=8215008
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO951277A NO951277L (no) | 1993-08-04 | 1995-04-03 | Desulfatohirudin med höy molekylvekt |
Country Status (15)
Country | Link |
---|---|
US (1) | US5661001A (no) |
EP (1) | EP0663009A1 (no) |
JP (1) | JPH08502661A (no) |
KR (1) | KR950703645A (no) |
CN (1) | CN1113389A (no) |
AU (1) | AU685835B2 (no) |
CA (1) | CA2144523A1 (no) |
FI (1) | FI951541A (no) |
HU (1) | HUT72926A (no) |
IL (1) | IL110540A0 (no) |
NO (1) | NO951277L (no) |
NZ (1) | NZ271088A (no) |
SG (1) | SG49862A1 (no) |
WO (1) | WO1995004823A1 (no) |
ZA (1) | ZA945775B (no) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MXPA03007563A (es) * | 2001-02-23 | 2003-12-11 | Immunex Corp | Recuperacion incrementada de proteinas activas. |
CN1328380C (zh) * | 2001-09-24 | 2007-07-25 | 天津天士力制药股份有限公司 | 高效表达水蛭素及其生产方法 |
EP1906990B1 (en) * | 2005-07-05 | 2013-12-11 | Baker Medical Research Institute | Anticoagulation agent |
CN101993489B (zh) * | 2009-08-20 | 2013-10-23 | 重庆富进生物医药有限公司 | 可逆转水蛭素 |
US7803762B1 (en) | 2009-08-20 | 2010-09-28 | The Medicines Company | Ready-to-use bivalirudin compositions |
US7985733B1 (en) | 2010-01-06 | 2011-07-26 | The Medicines Company | Buffer-based method for preparing bivalirudin drug product |
CN117683081A (zh) * | 2021-09-24 | 2024-03-12 | 江西康之康中药科技有限公司 | 一种降血压肽及其在降血压制品上的应用 |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4620948A (en) * | 1982-12-22 | 1986-11-04 | Genentech, Inc. | Purification and activity assurance of precipitated heterologous proteins |
EP0143081B1 (en) * | 1983-11-21 | 1989-08-23 | Ciba-Geigy Ag | Synthesis of tissue plasminogen activator(tpa) by yeast |
US4572798A (en) * | 1984-12-06 | 1986-02-25 | Cetus Corporation | Method for promoting disulfide bond formation in recombinant proteins |
GB8508340D0 (en) * | 1985-03-29 | 1985-05-09 | Creighton T E | Production of protein |
GB8528321D0 (en) * | 1985-11-18 | 1985-12-24 | Ciba Geigy Ag | Modified fibrinolytic agents |
IL86090A (en) * | 1987-04-16 | 1993-03-15 | Cetus Oncology Corp | Production of purified, biologically active, bacterially produced recombinant human csf-1 |
EP0368857B1 (en) * | 1987-05-11 | 1997-08-06 | Chiron Corporation | Process for recovering purified, oxidized, renatured recombinant interleukin-2 from microorganisms |
CA1340646C (en) * | 1987-05-21 | 1999-07-13 | John L. Krstenansky | Cyclic anticoagulant peptides |
US5236898A (en) * | 1987-05-21 | 1993-08-17 | Merrell Dow Pharmaceuticals Inc. | Cyclic anticoagulant peptides |
GB8809860D0 (en) * | 1988-04-26 | 1988-06-02 | Ciba Geigy Ag | Process for production of polypeptides |
AU614121B2 (en) * | 1988-05-04 | 1991-08-22 | Novartis Ag | Improvements in the production of polypeptides |
EP0347376B1 (en) * | 1988-06-11 | 1994-03-23 | Ciba-Geigy Ag | Novel polypeptides with an anticoagulant activity |
US5112615A (en) * | 1988-08-03 | 1992-05-12 | New England Deaconess Hospital Corporation | Soluble hirudin conjugates |
JP3187044B2 (ja) * | 1989-12-01 | 2001-07-11 | ビーエーエスエフ アクチェンゲゼルシャフト | ヒルジン突然変異蛋白質及びヒルジンポリアルキレングリコール複合体 |
GB8927722D0 (en) * | 1989-12-07 | 1990-02-07 | British Bio Technology | Proteins and nucleic acids |
IT1248565B (it) * | 1991-06-27 | 1995-01-19 | Erba Carlo Spa | Anticorpi policlonali anti-irudina e loro utilizzo per la identificazione, l`immunopurificazione e la determinazione quantitativa dell`uridina. |
-
1994
- 1994-07-23 AU AU74605/94A patent/AU685835B2/en not_active Ceased
- 1994-07-23 KR KR1019950701272A patent/KR950703645A/ko not_active Application Discontinuation
- 1994-07-23 SG SG9607691A patent/SG49862A1/en unknown
- 1994-07-23 JP JP7506182A patent/JPH08502661A/ja active Pending
- 1994-07-23 NZ NZ271088A patent/NZ271088A/en unknown
- 1994-07-23 WO PCT/EP1994/002438 patent/WO1995004823A1/en not_active Application Discontinuation
- 1994-07-23 CA CA002144523A patent/CA2144523A1/en not_active Abandoned
- 1994-07-23 US US08/406,948 patent/US5661001A/en not_active Expired - Fee Related
- 1994-07-23 CN CN94190578A patent/CN1113389A/zh active Pending
- 1994-07-23 EP EP94924281A patent/EP0663009A1/en not_active Withdrawn
- 1994-07-23 HU HU9500689A patent/HUT72926A/hu unknown
- 1994-08-02 IL IL11054094A patent/IL110540A0/xx unknown
- 1994-08-03 ZA ZA945775A patent/ZA945775B/xx unknown
-
1995
- 1995-03-31 FI FI951541A patent/FI951541A/fi unknown
- 1995-04-03 NO NO951277A patent/NO951277L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
AU7460594A (en) | 1995-02-28 |
IL110540A0 (en) | 1994-11-11 |
EP0663009A1 (en) | 1995-07-19 |
FI951541A0 (fi) | 1995-03-31 |
NZ271088A (en) | 1996-10-28 |
JPH08502661A (ja) | 1996-03-26 |
AU685835B2 (en) | 1998-01-29 |
US5661001A (en) | 1997-08-26 |
NO951277D0 (no) | 1995-04-03 |
ZA945775B (en) | 1995-02-06 |
HU9500689D0 (en) | 1995-06-28 |
SG49862A1 (en) | 2002-03-19 |
WO1995004823A1 (en) | 1995-02-16 |
HUT72926A (en) | 1996-06-28 |
CN1113389A (zh) | 1995-12-13 |
KR950703645A (ko) | 1995-09-20 |
CA2144523A1 (en) | 1995-02-16 |
FI951541A (fi) | 1995-03-31 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FC2A | Withdrawal, rejection or dismissal of laid open patent application |