ES2088128T3 - Aminosulfonilureas inhibidoras de acat. - Google Patents

Aminosulfonilureas inhibidoras de acat.

Info

Publication number
ES2088128T3
ES2088128T3 ES92900981T ES92900981T ES2088128T3 ES 2088128 T3 ES2088128 T3 ES 2088128T3 ES 92900981 T ES92900981 T ES 92900981T ES 92900981 T ES92900981 T ES 92900981T ES 2088128 T3 ES2088128 T3 ES 2088128T3
Authority
ES
Spain
Prior art keywords
aminosulfonilureas
compounds
acat inhibitor
acat inhibitors
useful
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92900981T
Other languages
English (en)
Inventor
Joseph Armand Picard
Drago Robert Sliskovic
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Warner Lambert Co LLC
Original Assignee
Warner Lambert Co LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co LLC filed Critical Warner Lambert Co LLC
Application granted granted Critical
Publication of ES2088128T3 publication Critical patent/ES2088128T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
    • C07D211/96—Sulfur atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C307/00—Amides of sulfuric acids, i.e. compounds having singly-bound oxygen atoms of sulfate groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C307/04—Diamides of sulfuric acids
    • C07C307/06—Diamides of sulfuric acids having nitrogen atoms of the sulfamide groups bound to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C307/00—Amides of sulfuric acids, i.e. compounds having singly-bound oxygen atoms of sulfate groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C307/04—Diamides of sulfuric acids
    • C07C307/08—Diamides of sulfuric acids having nitrogen atoms of the sulfamide groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C307/00—Amides of sulfuric acids, i.e. compounds having singly-bound oxygen atoms of sulfate groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C307/04—Diamides of sulfuric acids
    • C07C307/10—Diamides of sulfuric acids having nitrogen atoms of the sulfamide groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D307/10—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/14—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Abstract

LA INVENCION SUMINISTRA COMPUESTOS FARMACEUTICAMENTE UTILES DEL COMPUESTO DE LA FORMULA I, QUE SON INHIBIDORES DE ACAT QUE LOS HACEN UTILES EN EL CONTROL DE LOS NIVELES DE COLESTEROL EN LA SANGRE, ASIMISMO SE PRESENTAN COMPOSICIONES FARMACEUTICAS Y METODOS QUE USAN LOS INHIBIDORES DE ACAT ASI COMO COMPUESTOS INTIMAMENTE RELACIONADOS QUE SON TAMBIEN COMPUESTOS DE UREA DE AMINOSULFONIL. EN LAS ESPECIFICACIONES SE DAN LOS VALORES DE R, R1, R2, R3 Y R4.
ES92900981T 1990-11-07 1991-11-05 Aminosulfonilureas inhibidoras de acat. Expired - Lifetime ES2088128T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US61028790A 1990-11-07 1990-11-07
US07/747,040 US5214206A (en) 1990-11-07 1991-08-19 Aminosulfonyl urea acat inhibitors

Publications (1)

Publication Number Publication Date
ES2088128T3 true ES2088128T3 (es) 1996-08-01

Family

ID=27086230

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92900981T Expired - Lifetime ES2088128T3 (es) 1990-11-07 1991-11-05 Aminosulfonilureas inhibidoras de acat.

Country Status (16)

Country Link
US (2) US5214206A (es)
EP (1) EP0556322B1 (es)
JP (2) JP3256541B2 (es)
AT (1) ATE139226T1 (es)
AU (1) AU657928B2 (es)
CA (1) CA2094806C (es)
DE (1) DE69120287T2 (es)
DK (1) DK0556322T3 (es)
ES (1) ES2088128T3 (es)
GR (1) GR3020355T3 (es)
IE (1) IE75379B1 (es)
MX (1) MX9101958A (es)
NZ (1) NZ240481A (es)
PH (1) PH30665A (es)
PT (1) PT99435B (es)
WO (1) WO1992008694A1 (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2098912A1 (en) * 1990-12-28 1992-06-29 Tatsuki Shiota Benzoxa condensed ring compound, process for producing the same and pharmaceutical composition comprising the same
US5576335A (en) * 1994-02-01 1996-11-19 Nisshin Flour Milling Co., Ltd. Urea derivatives and their use as ACAT inhibitors
US5491170A (en) * 1994-12-19 1996-02-13 Warner-Lambert Company β-carboxy sulfonamide ACAT inhibitors
US6103733A (en) * 1998-09-09 2000-08-15 Bachmann; Kenneth A. Method for increasing HDL cholesterol levels using heteroaromatic phenylmethanes
CA2369967A1 (en) * 2001-02-12 2002-08-12 Joseph Anthony Cornicelli Methods of treating nuclear factor-kappa b mediated diseases and disorders
EP1281399A3 (en) * 2001-08-01 2004-02-11 Warner-Lambert Company Dual inhibitors of wax ester and cholesteryl ester synthesis for inhibiting sebum production
DK2881392T3 (en) 2010-11-16 2018-07-23 Texas Heart Inst Agonists that enhance the binding of integrin-expressing cells to integrin receptors
CN103288749A (zh) * 2013-03-04 2013-09-11 盐城工学院 可作除草剂的氨基磺酰脲类化合物
EP3733209A1 (en) * 2014-10-03 2020-11-04 Synaffix B.V. Sulfamide linker, conjugates thereof, and methods of preparation
EP3578547B1 (en) * 2015-02-16 2021-05-26 The University of Queensland Sulfonylureas and related compounds and use of same
SG11201806745RA (en) * 2016-02-16 2018-09-27 Univ Queensland Sulfonylureas and related compounds and use of same
WO2019008025A1 (en) 2017-07-07 2019-01-10 Inflazome Limited NOVEL CARBOXAMIDE SULFONAMIDE COMPOUNDS
GB201721185D0 (en) * 2017-12-18 2018-01-31 Nodthera Ltd Sulphonyl urea derivatives
AU2019322546A1 (en) * 2018-08-15 2021-03-04 Inflazome Limited Novel sulfonamideurea compounds

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2312404A (en) * 1939-11-22 1943-03-02 Haack Erich Method of preparing n-sulphonylureas
CH396872A (de) * 1959-08-13 1965-08-15 Ciba Geigy Verfahren zur Herstellung neuer Harnstoffe
US3242174A (en) * 1962-02-06 1966-03-22 Pfizer & Co C 1-(tertiary aminosulfonyl)-3-(hydrocarbon) ureas
GB990860A (en) * 1962-02-08 1965-05-05 Pfizer & Co C N,n-disubstituted sulfamylureas and compositions thereof
US3245982A (en) * 1962-03-27 1966-04-12 Pfizer & Co C Sulfamylsemicarbazides
DE1518541A1 (de) * 1965-03-16 1969-09-11 Boehringer Mannheim Gmbh Verfahren zur Herstellung von Sulfonylharnstoffen und Sulfonylsemicarbaziden
CH649081A5 (de) * 1982-01-12 1985-04-30 Ciba Geigy Ag Triaza-verbindungen.

Also Published As

Publication number Publication date
IE913874A1 (en) 1992-05-20
PT99435A (pt) 1992-12-31
MX9101958A (es) 1992-07-08
US5214206A (en) 1993-05-25
IE75379B1 (en) 1997-09-10
DK0556322T3 (da) 1996-10-14
WO1992008694A1 (en) 1992-05-29
GR3020355T3 (en) 1996-09-30
CA2094806C (en) 2004-11-02
PH30665A (en) 1997-09-16
AU8959791A (en) 1992-06-11
PT99435B (pt) 1999-04-30
JP2001026574A (ja) 2001-01-30
AU657928B2 (en) 1995-03-30
JP3256541B2 (ja) 2002-02-12
US5288757A (en) 1994-02-22
EP0556322B1 (en) 1996-06-12
DE69120287T2 (de) 1996-10-10
ATE139226T1 (de) 1996-06-15
NZ240481A (en) 1994-06-27
JPH06501707A (ja) 1994-02-24
CA2094806A1 (en) 1992-05-08
EP0556322A1 (en) 1993-08-25
DE69120287D1 (en) 1996-07-18

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