NO950763L - Sulfaterte orer - Google Patents
Sulfaterte orerInfo
- Publication number
- NO950763L NO950763L NO950763A NO950763A NO950763L NO 950763 L NO950763 L NO 950763L NO 950763 A NO950763 A NO 950763A NO 950763 A NO950763 A NO 950763A NO 950763 L NO950763 L NO 950763L
- Authority
- NO
- Norway
- Prior art keywords
- sulfated
- integer
- ores
- independently
- selectin
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/02—Acyclic radicals, not substituted by cyclic structures
- C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
- C07H15/10—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical containing unsaturated carbon-to-carbon bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/02—Acyclic radicals, not substituted by cyclic structures
- C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Abstract
Sulfaterte a-glykolipidforbindelser med formelen R«0, OR" NHR OR* hvor R er en acylrest av en fettsyre, R1 er -(CH=CH)m-(CH2)n-CH3, R2, R3, R4 og R6 er uavhengig av hverandre minst to -SC^H, R2, R3, R4, R5 og R^ er hver uavhengig av hverandre hydrogen, usubstituert eller sub- stituert alkanoyl, aralkyl eller arylkarbonyl hvor substi- tuenten er valgt blant halogen, Cj^-alkyl, trifluormetyl, hydroksy og C^.^-alkoksy, m er et helt tall O eller l, n er et helt tall fra 5-14 inklusive, eller et ikke-toksisk, farmasøytisk akseptabelt salt, solvat eller hydrat derav som er inhibitorer av selectinforårsaket celleadhesjon og som er anvendelige til behandling eller hindring av beten- nelsessykdommer og andre patologiske tilstander i patte- dyr.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US20592894A | 1994-03-04 | 1994-03-04 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO950763D0 NO950763D0 (no) | 1995-02-28 |
| NO950763L true NO950763L (no) | 1995-09-05 |
Family
ID=22764246
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO950763A NO950763L (no) | 1994-03-04 | 1995-02-28 | Sulfaterte orer |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US5663151A (no) |
| EP (1) | EP0671407A2 (no) |
| JP (1) | JPH0841093A (no) |
| KR (1) | KR950032258A (no) |
| CN (1) | CN1112122A (no) |
| AU (1) | AU1360595A (no) |
| CA (1) | CA2142154A1 (no) |
| CZ (1) | CZ49895A3 (no) |
| FI (1) | FI951001A (no) |
| HU (1) | HUT70404A (no) |
| IL (1) | IL112756A0 (no) |
| NO (1) | NO950763L (no) |
| PL (1) | PL307524A1 (no) |
| RU (1) | RU95103100A (no) |
| ZA (1) | ZA95937B (no) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0957107B1 (en) | 1996-05-16 | 2004-07-21 | Nissin Food Products Co., Ltd. | Novel compounds having antiviral activity |
| US5700458A (en) | 1996-09-20 | 1997-12-23 | Geltex Pharmaceuticals Inc. | Acid-functionalized saccharides as polyvalent anti-infectives |
| DE19700774A1 (de) * | 1997-01-13 | 1998-07-16 | Hoechst Ag | Antiadhäsive Sulfatid-Mimetika |
| PL393941A1 (pl) * | 2001-11-21 | 2011-06-20 | University Of Aarhus | Zastosowanie glikozydów mono-i diacyloglicerolu jako środków przeciwzapalnych |
| CA2486106C (en) | 2002-05-16 | 2013-07-16 | Glycomimetics, Inc. | Compounds and methods for inhibiting selectin-mediated function |
| JP2006502986A (ja) * | 2002-07-03 | 2006-01-26 | グリコミメティクス， インコーポレイテッド | 新脈管形成に関与する医学的状態の診断および治療のための組成物および方法 |
| US20040219158A1 (en) * | 2003-05-02 | 2004-11-04 | Glycomimetics, Inc. | Compositions and methods for diagnosis and therapy of medical conditions involving infection with pseudomonas bacteria |
| WO2005051920A2 (en) * | 2003-11-19 | 2005-06-09 | Glycomimetics, Inc. | Specific antagonist for both e- and p-selectins |
| JP2007524658A (ja) * | 2003-11-19 | 2007-08-30 | グリコミメティクス， インコーポレイテッド | Ｅ−およびｐ−セレクチンの両方のための糖模倣物アンタゴニスト |
| US7481080B2 (en) * | 2004-07-01 | 2009-01-27 | General Electric Company | Clothes washer braking method and apparatus |
| DE102004036213B4 (de) | 2004-07-26 | 2011-02-24 | Johannes-Gutenberg-Universität Mainz | Nichtglykosidische und nichtpeptidische Selektininhibitoren, deren Herstellung und pharmazeutische Zusammensetzungen |
| JP5090928B2 (ja) * | 2004-12-28 | 2012-12-05 | ザ ロックフェラー ユニバーシティ | Ｎｋｔ細胞に対する抗原としての糖脂質及びその類似体 |
| US7923013B2 (en) * | 2004-12-28 | 2011-04-12 | The Rockefeller University | Glycolipids and analogues thereof as antigens for NKT cells |
| WO2006127906A1 (en) * | 2005-05-25 | 2006-11-30 | Glycomimetics, Inc. | Heterobifunctional compounds for selectin inhibition |
| AU2006280101B2 (en) * | 2005-08-09 | 2012-06-28 | Glycomimetics, Inc. | Glycomimetic inhibitors of the PA-IL lectin, PA-IIL lectin or both the lectins from Pseudomonas |
| AU2006284578B2 (en) | 2005-09-02 | 2011-01-27 | Glycomimetics, Inc. | Heterobifunctional pan-selectin inhibitors |
| WO2007143052A1 (en) * | 2006-06-01 | 2007-12-13 | Glycomimetics, Inc. | Galactosides and thiodigalactosides as inhibitors of pa-il lectin from pseudomonas |
| JP5298020B2 (ja) | 2006-10-12 | 2013-09-25 | グリコミメティクス， インコーポレイテッド | ヘキソースおよびｎ−アセチルヘキソサミンの糖模倣体置換 |
| JP5511390B2 (ja) * | 2007-02-09 | 2014-06-04 | グリコミメティクス， インコーポレイテッド | ヘキソースおよびｎ−アセチルヘキソサミンの置換体を有する糖模倣体の使用方法 |
| US8039442B2 (en) | 2007-07-18 | 2011-10-18 | Glycomimetics, Inc. | Compounds and methods for treatment of sickle cell disease or complications associated therewith |
| US8828952B2 (en) | 2007-10-16 | 2014-09-09 | Progen Pharmaceuticals Limited | Sulfated oligosaccharide derivatives |
| WO2009126556A1 (en) | 2008-04-08 | 2009-10-15 | Glycomimetics, Inc. | Pan-selectin inhibitor with enhanced pharmacokinetic activity |
| ES2426784T3 (es) * | 2008-06-13 | 2013-10-25 | Glycomimetics, Inc. | Tratamiento de cánceres de la sangre usando compuestos glicomiméticos seleccionados |
| CA2760292A1 (en) * | 2009-05-01 | 2010-11-04 | Glycomimetics, Inc. | Heterobifunctional inhibitors of e-selectins and cxcr4 chemokine receptors |
| WO2012037034A1 (en) | 2010-09-14 | 2012-03-22 | Glycomimetics, Inc. | E-selectin antagonists |
| JP2015500887A (ja) | 2011-12-22 | 2015-01-08 | グリコミメティクス， インコーポレイテッド | Ｅ−セレクチンアンタゴニスト化合物、組成物および使用方法 |
| AU2013355238B2 (en) | 2012-12-07 | 2017-12-14 | Glycomimetics, Inc. | Compounds, compositions and methods using E-selectin antagonists for mobilization of hematopoietic cells |
| SI3227310T1 (sl) | 2014-12-03 | 2019-11-29 | Glycomimetics Inc | Heterobifunkcionalni inhibitorji e-selektinov in receptorjev kemokina CXCR4 |
| CA3009836A1 (en) | 2016-01-22 | 2017-07-27 | Glycomimetics, Inc. | Glycomimetic inhibitors of pa-il and pa-iil lectins |
| US11291678B2 (en) | 2016-03-02 | 2022-04-05 | Glycomimetics, Inc | Methods for the treatment and/or prevention of cardiovascular disease by inhibition of E-selectin |
| WO2018031445A1 (en) | 2016-08-08 | 2018-02-15 | Glycomimetics, Inc. | Combination of t-cell checkpoint inhibitors with inhibitors of e-selectin or cxcr4, or with heterobifunctional inhibitors of both e-selectin and cxcr4 |
| JP7069136B2 (ja) | 2016-10-07 | 2022-05-17 | グリコミメティクス， インコーポレイテッド | 極めて強力な多量体ｅ－セレクチンアンタゴニスト |
| EP3596096A1 (en) | 2017-03-15 | 2020-01-22 | GlycoMimetics, Inc. | Galactopyranosyl-cyclohexyl derivatives as e-selectin antagonists |
| JP7275131B2 (ja) | 2017-11-30 | 2023-05-17 | グリコミメティクス， インコーポレイテッド | 骨髄浸潤リンパ球を動員する方法、およびその使用 |
| CN111566117A (zh) | 2017-12-29 | 2020-08-21 | 糖模拟物有限公司 | E-选择蛋白和半乳凝素-3的异双功能抑制剂 |
| JP7455064B2 (ja) | 2018-03-05 | 2024-03-25 | グリコミメティクス， インコーポレイテッド | 急性骨髄性白血病および関連状態を処置する方法 |
| WO2020139962A1 (en) | 2018-12-27 | 2020-07-02 | Glycomimetics, Inc. | Heterobifunctional inhibitors of e-selectin and galectin-3 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1164388A (en) * | 1966-06-14 | 1969-09-17 | Shionogi & Co | Crystalline Sulfur-Containing Glycolipid and the Production Thereof. |
| EP0146810A3 (de) * | 1983-12-05 | 1987-05-13 | Solco Basel AG | Verfahren zur Herstellung von Sphingosinderivaten |
| ATE71104T1 (de) * | 1985-08-13 | 1992-01-15 | Solco Basel Ag | Neues verfahren zur herstellung von sphingosinderivaten. |
| IT1235162B (it) * | 1988-12-02 | 1992-06-22 | Fidia Farmaceutici | Derivati di lisosfingolipidi |
| JPH0317020A (ja) * | 1989-06-14 | 1991-01-25 | Nippon Koutai Kenkyusho:Kk | 抗ｈｉｖ剤 |
| ATE224911T1 (de) * | 1990-07-17 | 2002-10-15 | Univ Oklahoma | Gmp-140 ligand |
| DK84691D0 (da) * | 1991-05-07 | 1991-05-07 | Karsten Buschard | Visse glycolipider og specifikke catchere for disse til anvendelse ved profylaxe eller terapi af diabetes, og/eller dermed forbundne komplikationer samt anvendelse af saadanne glycolipider til detektion af oe-celle-antistoffer (ica) i et individ og anvendelse af saadanne catchere til detektion af langerhans-oe-celler i pancreas-praeparater |
| WO1993005803A1 (en) * | 1991-09-25 | 1993-04-01 | Genetics Institute, Inc. | Anti-inflammatory selectin inhibitors |
| US5326752A (en) * | 1991-11-27 | 1994-07-05 | Glycomed Incorporated | Substituted lactose and lactosamine derivatives as cell adhesion inhibitors |
-
1995
- 1995-01-27 US US08/379,381 patent/US5663151A/en not_active Expired - Lifetime
- 1995-02-06 ZA ZA95937A patent/ZA95937B/xx unknown
- 1995-02-09 CA CA002142154A patent/CA2142154A1/en not_active Abandoned
- 1995-02-23 IL IL11275695A patent/IL112756A0/xx unknown
- 1995-02-24 CZ CZ95498A patent/CZ49895A3/cs unknown
- 1995-02-28 NO NO950763A patent/NO950763L/no unknown
- 1995-03-03 RU RU95103100/04A patent/RU95103100A/ru unknown
- 1995-03-03 EP EP95103169A patent/EP0671407A2/en not_active Withdrawn
- 1995-03-03 HU HU9500655A patent/HUT70404A/hu unknown
- 1995-03-03 AU AU13605/95A patent/AU1360595A/en not_active Abandoned
- 1995-03-03 PL PL95307524A patent/PL307524A1/xx unknown
- 1995-03-03 FI FI951001A patent/FI951001A/fi unknown
- 1995-03-03 CN CN95102477A patent/CN1112122A/zh active Pending
- 1995-03-04 KR KR1019950004462A patent/KR950032258A/ko not_active Application Discontinuation
- 1995-03-06 JP JP7083060A patent/JPH0841093A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CN1112122A (zh) | 1995-11-22 |
| FI951001A (fi) | 1995-09-05 |
| CA2142154A1 (en) | 1995-09-05 |
| NO950763D0 (no) | 1995-02-28 |
| FI951001A0 (fi) | 1995-03-03 |
| KR950032258A (ko) | 1995-12-20 |
| PL307524A1 (en) | 1995-09-18 |
| US5663151A (en) | 1997-09-02 |
| HU9500655D0 (en) | 1995-04-28 |
| HUT70404A (en) | 1995-10-30 |
| CZ49895A3 (en) | 1995-12-13 |
| RU95103100A (ru) | 1997-03-20 |
| EP0671407A3 (no) | 1995-10-25 |
| AU1360595A (en) | 1995-09-14 |
| ZA95937B (en) | 1996-08-06 |
| IL112756A0 (en) | 1995-05-26 |
| JPH0841093A (ja) | 1996-02-13 |
| EP0671407A2 (en) | 1995-09-13 |
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