NO942977L - Piperazine and piperidine derivatives and their use as antipsychotic agents - Google Patents

Piperazine and piperidine derivatives and their use as antipsychotic agents

Info

Publication number
NO942977L
NO942977L NO942977A NO942977A NO942977L NO 942977 L NO942977 L NO 942977L NO 942977 A NO942977 A NO 942977A NO 942977 A NO942977 A NO 942977A NO 942977 L NO942977 L NO 942977L
Authority
NO
Norway
Prior art keywords
piperazine
piperidine derivatives
antipsychotic agents
group
therapy
Prior art date
Application number
NO942977A
Other languages
Norwegian (no)
Other versions
NO942977D0 (en
Inventor
Henry Mark Norman
Frank Navas
Original Assignee
Wellcome Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellcome Found filed Critical Wellcome Found
Publication of NO942977D0 publication Critical patent/NO942977D0/en
Publication of NO942977L publication Critical patent/NO942977L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
    • C07D275/04—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

En gruppe plperazln og piperldinderivater, fremgangs- måte for fremstilling derav, farmasøytiske sammen- setninger Inneholdende disse og anvendelse l terapi, spesielt for behandling psykotiske forstyrrelser, er beskrevet. hvor Y betyr en gruppe med formel (a), (b) eller (c): (a) hvor en enkeltllnje ledsaget av en stiplet linje (---) betyr en enkeltblndlng eller en dobbeltblnding.A group of piperazine and piperidine derivatives, their method of preparation, pharmaceutical compositions containing them and their use in therapy, particularly for the treatment of psychotic disorders, are described. wherein Y means a group of formula (a), (b) or (c): (a) wherein a single line accompanied by a dashed line (---) means a single or double blend.

NO942977A 1992-02-12 1994-08-11 Piperazine and piperidine derivatives and their use as antipsychotic agents NO942977L (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB929202915A GB9202915D0 (en) 1992-02-12 1992-02-12 Chemical compounds
PCT/GB1993/000285 WO1993016073A1 (en) 1992-02-12 1993-02-11 Piperazine and piperidine derivatives, and their use as antipsychotics

Publications (2)

Publication Number Publication Date
NO942977D0 NO942977D0 (en) 1994-08-11
NO942977L true NO942977L (en) 1994-10-10

Family

ID=10710223

Family Applications (1)

Application Number Title Priority Date Filing Date
NO942977A NO942977L (en) 1992-02-12 1994-08-11 Piperazine and piperidine derivatives and their use as antipsychotic agents

Country Status (16)

Country Link
EP (1) EP0625978A1 (en)
JP (1) JPH07503723A (en)
KR (1) KR950700290A (en)
AU (1) AU3460393A (en)
CA (1) CA2117434A1 (en)
CZ (1) CZ194994A3 (en)
FI (1) FI943718A0 (en)
GB (1) GB9202915D0 (en)
HU (1) HUT72309A (en)
IL (1) IL104690A0 (en)
MX (1) MX9300786A (en)
NO (1) NO942977L (en)
RU (1) RU94038064A (en)
SK (1) SK96494A3 (en)
WO (1) WO1993016073A1 (en)
ZA (1) ZA93958B (en)

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US5776963A (en) * 1989-05-19 1998-07-07 Hoechst Marion Roussel, Inc. 3-(heteroaryl)-1- (2,3-dihydro-1h-isoindol-2-yl)alkyl!pyrrolidines and 3-(heteroaryl)-1- (2,3-dihydro-1h-indol-1-yl)alkyl!pyrrolidines and related compounds and their therapeutic untility
US5364866A (en) * 1989-05-19 1994-11-15 Hoechst-Roussel Pharmaceuticals, Inc. Heteroarylpiperidines, pyrrolidines and piperazines and their use as antipsychotics and analetics
RU2118322C1 (en) * 1993-07-05 1998-08-27 Дюфар Интернэшнл Рисерч Б.В. 2,3-dihydro-1,4-benzodioxine-5-yl-pyrerazine derivatives and salts thereof
ATE246682T1 (en) * 1993-12-24 2003-08-15 Daiichi Suntory Pharma Co Ltd BENZOTHIAZINE DERIVATIVES
US5874429A (en) * 1993-12-24 1999-02-23 Suntory Limited Benzothiazine derivative
JPH0912562A (en) * 1995-06-22 1997-01-14 Suntory Ltd Substituted benzothiazine derivative
US6001827A (en) * 1993-12-24 1999-12-14 Suntory Limited Benzothiazine derivative
JP3948744B2 (en) * 1994-11-04 2007-07-25 大日本住友製薬株式会社 Novel lactam derivatives
EP0732332B1 (en) * 1995-03-17 2001-12-19 Aventis Pharmaceuticals Inc. Substituted benzothienylpiperazines, their use as medicaments, and processes for their preparation
US6087364A (en) * 1998-01-29 2000-07-11 Warner-Lambert Company Dopamine D4 receptor antagonists
DE19814084B4 (en) 1998-03-30 2005-12-22 Lts Lohmann Therapie-Systeme Ag D2 agonist-containing transdermal therapeutic system for the treatment of Parkinson's syndrome and process for its preparation
US7030142B1 (en) 1999-04-06 2006-04-18 Sepracor Inc. Methods for the treatment of neuroleptic and related disorders using ziprasidone metabolites
EP1165083A2 (en) * 1999-04-06 2002-01-02 Sepracor Inc. Methods and compositions for the treatment of psychotic and related disorders using ziprasidone metabolites
AR028685A1 (en) 2000-06-14 2003-05-21 Lundbeck & Co As H INDOL DERIVATIVES
US8246979B2 (en) 2002-07-30 2012-08-21 Ucb Pharma Gmbh Transdermal delivery system for the administration of rotigotine
DE10234673B4 (en) 2002-07-30 2007-08-16 Schwarz Pharma Ag Hot-melt TTS for the administration of rotigotine and process for its preparation, and use of rotigotine in the manufacture of a hot-melt TTS
US8246980B2 (en) 2002-07-30 2012-08-21 Ucb Pharma Gmbh Transdermal delivery system
DE60327634D1 (en) 2002-08-22 2009-06-25 Dainippon Sumitomo Pharma Co MEANS FOR TREATING THE INTEGRATION DYSFUNCTION SYNDROME
DE10261696A1 (en) 2002-12-30 2004-07-15 Schwarz Pharma Ag Device for the transdermal administration of rotigotine base
EP1637530A4 (en) * 2003-06-23 2009-04-01 Dainippon Sumitomo Pharma Co Therapeutic agent for senile dementia
DE10334188B4 (en) 2003-07-26 2007-07-05 Schwarz Pharma Ag Use of rotigotine to treat depression
EP1726952A4 (en) 2004-02-20 2008-06-18 Dainippon Sumitomo Pharma Co Method of in vivo screening of therapeutic agent for memory/learning dysfunction by schizophrenia
EA200900937A1 (en) * 2007-01-03 2009-12-30 Кортекс Фармасеутикалс, Инк. COMPOUNDS OF 3-SUBSTITUTED- [1,2,3] BENZOTRIAZINONE FOR STRENGTHENING GLUTAMATERGIC SYNAPTIC RESPONSES
US8258139B2 (en) 2010-11-08 2012-09-04 Dainippon Sumitomo Pharma Co., Ltd. Method of treatment for mental disorders
GB201102248D0 (en) 2011-02-09 2011-03-23 Isis Innovation Treatment of bipolar disorder
EP2736905A4 (en) * 2011-07-28 2015-07-29 Mapi Pharma Ltd Intermediate compounds and process for the preparation of lurasidone and salts thereof
WO2015014442A1 (en) * 2013-07-31 2015-02-05 Merck Patent Gmbh Oxoquinazolinyl-butanamide derivatives
CN105669665A (en) * 2016-03-15 2016-06-15 烟台贝森医药科技有限公司 Preparation method of perospirone
US11246905B2 (en) 2016-08-15 2022-02-15 President And Fellows Of Harvard College Treating infections using IdsD from Proteus mirabilis
CN115124464B (en) * 2022-07-04 2023-06-06 新乡学院 Quinoline diketone sulfonyl piperazine hybrid, and preparation method and application thereof

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FR2258843B1 (en) * 1974-01-30 1977-09-09 Roussel Uclaf
US4335127A (en) * 1979-01-08 1982-06-15 Janssen Pharmaceutica, N.V. Piperidinylalkyl quinazoline compounds, composition and method of use
JPH0625181B2 (en) * 1985-03-27 1994-04-06 住友製薬株式会社 New imide derivative
JP2660407B2 (en) * 1986-09-26 1997-10-08 住友製薬株式会社 New imide derivatives
CA1335289C (en) * 1987-10-26 1995-04-18 Fujio Antoku Piperidinyl benzisoxazole derivatives, their production and pharmaceutical use
US5001130A (en) * 1988-02-18 1991-03-19 Bristol-Myers Company Psychotropic heterobicycloalkylpiperazine derivatives
US4780466A (en) * 1988-03-17 1988-10-25 Hoechst-Roussel Pharmaceuticals, Inc. Arylpiperazinylalkoxy derivatives of cyclic imides
NZ230045A (en) * 1988-08-05 1990-11-27 Janssen Pharmaceutica Nv 3-piperazinylbenzazole derivatives and pharmaceutical compositions
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JP2800953B2 (en) * 1990-07-06 1998-09-21 住友製薬株式会社 New imide derivatives

Also Published As

Publication number Publication date
ZA93958B (en) 1994-08-11
AU3460393A (en) 1993-09-03
EP0625978A1 (en) 1994-11-30
KR950700290A (en) 1995-01-16
SK96494A3 (en) 1995-07-11
FI943718A (en) 1994-08-11
NO942977D0 (en) 1994-08-11
MX9300786A (en) 1994-03-31
CZ194994A3 (en) 1995-09-13
GB9202915D0 (en) 1992-03-25
FI943718A0 (en) 1994-08-11
WO1993016073A1 (en) 1993-08-19
HU9402343D0 (en) 1994-10-28
CA2117434A1 (en) 1993-08-19
IL104690A0 (en) 1993-06-10
HUT72309A (en) 1996-04-29
JPH07503723A (en) 1995-04-20
RU94038064A (en) 1997-05-27

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