NO941662D0 - Benzofuranyl- og -tiofenyl-alkankarboksylsyrederivater - Google Patents

Benzofuranyl- og -tiofenyl-alkankarboksylsyrederivater

Info

Publication number
NO941662D0
NO941662D0 NO941662A NO941662A NO941662D0 NO 941662 D0 NO941662 D0 NO 941662D0 NO 941662 A NO941662 A NO 941662A NO 941662 A NO941662 A NO 941662A NO 941662 D0 NO941662 D0 NO 941662D0
Authority
NO
Norway
Prior art keywords
benzofuranyl
thiophenyl
acid derivatives
alkanecarboxylic acid
compounds
Prior art date
Application number
NO941662A
Other languages
English (en)
Other versions
NO941662L (no
Inventor
Rudiger Fischer
Gabriele Braunlich
Klaus-Helmut Mohrs
Rudolf Hanko
John-Edward Butler-Ransohoff
Mazen Es-Sayed
Graham Sturton
Steve Tudhope
Trevor Abram
Wendy J Mcdonald-Gibson
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of NO941662D0 publication Critical patent/NO941662D0/no
Publication of NO941662L publication Critical patent/NO941662L/no

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/80Radicals substituted by oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/10Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D407/00Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Furan Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
NO941662A 1993-05-06 1994-05-05 Benzofuranyl- og -tiofenyl-alkankarboksylsyrederivater NO941662L (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB939309324A GB9309324D0 (en) 1993-05-06 1993-05-06 Venzofuranyl-and-thiophenyl-alkanecarboxyclic acids derivatives

Publications (2)

Publication Number Publication Date
NO941662D0 true NO941662D0 (no) 1994-05-05
NO941662L NO941662L (no) 1994-11-07

Family

ID=10735023

Family Applications (1)

Application Number Title Priority Date Filing Date
NO941662A NO941662L (no) 1993-05-06 1994-05-05 Benzofuranyl- og -tiofenyl-alkankarboksylsyrederivater

Country Status (21)

Country Link
US (1) US5504213A (no)
EP (1) EP0623607B1 (no)
JP (1) JP3452088B2 (no)
CN (1) CN1097749A (no)
AT (1) ATE168373T1 (no)
AU (1) AU678814B2 (no)
CA (1) CA2122788A1 (no)
CZ (1) CZ112994A3 (no)
DE (1) DE69411625T2 (no)
DK (1) DK0623607T3 (no)
ES (1) ES2118283T3 (no)
FI (1) FI942049A (no)
GB (1) GB9309324D0 (no)
GR (1) GR3027787T3 (no)
HU (1) HUT67847A (no)
IL (1) IL109526A0 (no)
NO (1) NO941662L (no)
NZ (1) NZ260445A (no)
RU (1) RU2125564C1 (no)
SK (1) SK53194A3 (no)
ZA (1) ZA943100B (no)

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US5721233A (en) * 1992-04-06 1998-02-24 Merrell Pharmaceuticals Inc. Derivatives of 2,3-dihydro benzofuranols
GB9312853D0 (en) 1993-06-22 1993-08-04 Euro Celtique Sa Chemical compounds
HRP950288A2 (en) * 1994-05-31 1997-08-31 Bayer Ag Oxalylamino-benzofuran- and benzothienyl-derivatives
EP0685475B1 (en) * 1994-05-31 1999-01-13 Bayer Ag Amino-benzofuryl-and thienyl-derivatives
GB9410877D0 (en) * 1994-05-31 1994-07-20 Bayer Ag Heterocyclycarbonyl substituted benzoduranyl-and-thiophenyl-alkanecarboxyclic acid derivatives
US5591776A (en) 1994-06-24 1997-01-07 Euro-Celtique, S.A. Pheynl or benzyl-substituted rolipram-based compounds for and method of inhibiting phosphodiesterase IV
US5922751A (en) 1994-06-24 1999-07-13 Euro-Celtique, S.A. Aryl pyrazole compound for inhibiting phosphodiesterase IV and methods of using same
EP0751126A4 (en) * 1995-01-06 1998-05-13 Toray Industries BENZOCONDENSE HETEROCYCLIC DERIVATIVE AND ITS USE
GB9504460D0 (en) * 1995-03-06 1995-04-26 Bayer Ag N-(3-Benzofuranyl)urea-derivatives
US6166041A (en) 1995-10-11 2000-12-26 Euro-Celtique, S.A. 2-heteroaryl and 2-heterocyclic benzoxazoles as PDE IV inhibitors for the treatment of asthma
US6075016A (en) 1996-04-10 2000-06-13 Euro-Celtique S.A. 6,5-fused aromatic ring systems having enhanced phosphodiesterase IV inhibitory activity
WO1997044337A1 (en) * 1996-05-20 1997-11-27 Darwin Discovery Limited Benzofuran carboxamides and their therapeutic use
GB9614718D0 (en) * 1996-07-12 1996-09-04 Bayer Ag 3-ureido-pyridofurans and -pyridothiophenes
DE19642451A1 (de) * 1996-10-15 1998-04-16 Merck Patent Gmbh Aminothiophencarbonsäureamide
DE19706396A1 (de) * 1996-12-09 1998-06-10 Bayer Ag Verfahren zur Herstellung von 3-(l-Hydroxiphenyl-l-alkoximinomethyl)dioxazinen
GB2350109A (en) * 1999-05-17 2000-11-22 Bayer Ag Pharmaceutically active benzofuranyl sulfonates
GB2350111A (en) * 1999-05-17 2000-11-22 Bayer Ag Oligohydroxyl substituted 3-urea-benzofuran and pyridofuran derivatives
EA006685B1 (ru) 1999-08-21 2006-02-24 Алтана Фарма Аг Синергетическая композиция
ES2376161T3 (es) 2001-01-29 2012-03-09 Janssen Pharmaceuticals, Inc. Indoles sustituidos y su utilización como antagonistas de integrinas.
US6872730B2 (en) 2001-04-27 2005-03-29 3-Dimensional Pharmaceuticals, Inc. Substituted benzofurans and benzothiophenes, methods of making and methods of use as integrin antagonists
CN1537018A (zh) 2001-05-23 2004-10-13 田边制药株式会社 一种用于软骨疾病再生治疗的组合物
EP1389468A4 (en) 2001-05-23 2007-01-10 Tanabe Seiyaku Co COMPOSITIONS PROMOTING THE GUISON OF A BONE FRACTURE
NZ534255A (en) * 2002-02-22 2007-06-29 Bayer Pharmaceuticals Corp Benzofuran and benzothiophene derivatives useful in the treatment of hyper-proliferative disorders
US7144885B2 (en) 2002-02-22 2006-12-05 Bayer Pharmaceuticals Corporation Fused tricyclic heterocycles useful for treating hyper-proliferative disorders
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
KR20050115331A (ko) 2003-04-01 2005-12-07 어플라이드 리서치 시스템스 에이알에스 홀딩 엔.브이. 불임증 포스포디에스터라제의 억제제
WO2004106317A1 (ja) * 2003-05-29 2004-12-09 The New Industry Research Organization ベンゾフラン化合物、およびそれを含有してなる医薬組成物
JP2005008631A (ja) * 2003-05-29 2005-01-13 New Industry Research Organization ベンゾフラン化合物、およびそれを含有してなる医薬組成物
AU2004268012B2 (en) * 2003-09-02 2008-11-20 Merck & Co., Inc. Ophthalmic compositions for treating ocular hypertension
AR051780A1 (es) * 2004-11-29 2007-02-07 Japan Tobacco Inc Compuestos en anillo fusionados que contienen nitrogeno y utilizacion de los mismos
EP2743268A3 (en) * 2006-06-27 2014-10-08 Takeda Pharmaceutical Company Limited Fused cyclic compounds as GPR40 receptor modulators
EP2056817A1 (en) * 2006-09-01 2009-05-13 Bayer HealthCare AG Benzofuran and benzothiophene derivatives useful in the treatment of cancers of the central nervous system
US20100120694A1 (en) 2008-06-04 2010-05-13 Synergy Pharmaceuticals, Inc. Agonists of Guanylate Cyclase Useful for the Treatment of Gastrointestinal Disorders, Inflammation, Cancer and Other Disorders
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
US7879802B2 (en) 2007-06-04 2011-02-01 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
EP2321341B1 (en) 2008-07-16 2017-02-22 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
MX357121B (es) 2011-03-01 2018-06-27 Synergy Pharmaceuticals Inc Star Proceso de preparacion de agonistas c de guanilato ciclasa.
CA2902348C (en) 2013-02-25 2021-11-30 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
EP2970384A1 (en) 2013-03-15 2016-01-20 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
CA2905435A1 (en) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Compositions useful for the treatment of gastrointestinal disorders
BR112015030326A2 (pt) 2013-06-05 2017-08-29 Synergy Pharmaceuticals Inc Agonistas ultrapuros de guanilato ciclase c, método de fabricar e usar os mesmos
WO2015021358A2 (en) 2013-08-09 2015-02-12 Dominique Charmot Compounds and methods for inhibiting phosphate transport
WO2015029062A1 (en) 2013-08-25 2015-03-05 Council Of Scientific And Industrial Rsearch A process for the preparation of anti-inflammatory aroylbenzofuran compounds
US10190077B2 (en) * 2014-02-25 2019-01-29 Ecolab Usa Inc. Sanitary cleaner
CN105254611B (zh) * 2015-11-09 2017-10-31 江西仁明医药化工有限公司 苯并噻吩‑2‑羧酸的制备方法
CN107935972B (zh) * 2017-11-14 2020-06-02 沈阳药科大学 5-[2-羟基-3-(异丙胺基)丙氧基]苯并呋喃类衍生物及其应用
CN107827849B (zh) * 2017-11-14 2020-06-02 沈阳药科大学 6-[2-羟基-3-(烷胺基)丙氧基]苯并呋喃类化合物及其应用
CN107857748B (zh) * 2017-11-14 2020-06-02 沈阳药科大学 5-[2-羟基-3-(烷胺基)丙氧基]苯并呋喃类化合物及其应用
US20200368223A1 (en) 2019-05-21 2020-11-26 Ardelyx, Inc. Methods for inhibiting phosphate transport
CN110938035B (zh) * 2019-10-28 2022-07-01 广西师范大学 9-苯磺酸-10-咪蒽腙及其合成方法和应用

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US4663347A (en) * 1983-10-31 1987-05-05 Merck Frosst Canada, Inc. Benzofuran 2-carboxylic acid esters useful as inhibitors of leukotriene biosynthesis
EP0146243A1 (en) * 1983-10-31 1985-06-26 Merck Frosst Canada Inc. Lipoxygenase inhibitors
US4482772A (en) * 1983-11-03 1984-11-13 Mobil Oil Corporation Multistage process for converting oxygenates to hydrocarbons

Also Published As

Publication number Publication date
CA2122788A1 (en) 1994-11-07
GB9309324D0 (en) 1993-06-16
DE69411625T2 (de) 1998-11-05
HU9401415D0 (en) 1994-08-29
GR3027787T3 (en) 1998-11-30
SK53194A3 (en) 1995-02-08
EP0623607B1 (en) 1998-07-15
ATE168373T1 (de) 1998-08-15
JPH06329652A (ja) 1994-11-29
DK0623607T3 (da) 1999-04-19
NO941662L (no) 1994-11-07
CN1097749A (zh) 1995-01-25
FI942049A0 (fi) 1994-05-04
HUT67847A (en) 1995-05-29
RU94015838A (ru) 1997-02-20
NZ260445A (en) 1995-08-28
EP0623607A1 (en) 1994-11-09
JP3452088B2 (ja) 2003-09-29
AU6055894A (en) 1994-11-10
CZ112994A3 (en) 1994-11-16
US5504213A (en) 1996-04-02
ZA943100B (en) 1995-01-09
RU2125564C1 (ru) 1999-01-27
DE69411625D1 (de) 1998-08-20
FI942049A (fi) 1994-11-07
IL109526A0 (en) 1994-08-26
ES2118283T3 (es) 1998-09-16
AU678814B2 (en) 1997-06-12

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