NO940805L - O-heteroaryl, O-alkylheteroaryl, O-alkenylheteroaryl og O-alkynylheteroarylmakrolider - Google Patents
O-heteroaryl, O-alkylheteroaryl, O-alkenylheteroaryl og O-alkynylheteroarylmakroliderInfo
- Publication number
- NO940805L NO940805L NO940805A NO940805A NO940805L NO 940805 L NO940805 L NO 940805L NO 940805 A NO940805 A NO 940805A NO 940805 A NO940805 A NO 940805A NO 940805 L NO940805 L NO 940805L
- Authority
- NO
- Norway
- Prior art keywords
- heteroaryl
- macrolides
- alkynyl
- alkenyl
- alkyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Transplantation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measurement Of Force In General (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US75694691A | 1991-09-09 | 1991-09-09 | |
US07/921,851 US5252732A (en) | 1991-09-09 | 1992-08-05 | D-heteroaryl, O-alkylheteroaryl, O-alkenylheteroaryl and O-alkynylheteroarylmacrolides having immunosuppressive activity |
PCT/US1992/007508 WO1993005058A1 (en) | 1991-09-09 | 1992-09-02 | O-heteroaryl, o-alkylheteroaryl, o-alkenylheteroaryl and o-alkynylheteroarylmacrolides |
Publications (2)
Publication Number | Publication Date |
---|---|
NO940805D0 NO940805D0 (no) | 1994-03-08 |
NO940805L true NO940805L (no) | 1994-05-06 |
Family
ID=27116312
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO940805A NO940805L (no) | 1991-09-09 | 1994-03-08 | O-heteroaryl, O-alkylheteroaryl, O-alkenylheteroaryl og O-alkynylheteroarylmakrolider |
Country Status (21)
Country | Link |
---|---|
US (2) | US5252732A (ja) |
EP (1) | EP0532088B1 (ja) |
JP (1) | JPH0813819B2 (ja) |
KR (1) | KR930006030A (ja) |
CN (1) | CN1073443A (ja) |
AT (1) | ATE145915T1 (ja) |
AU (1) | AU647665B2 (ja) |
BG (1) | BG98639A (ja) |
CA (1) | CA2077331A1 (ja) |
CZ (1) | CZ53194A3 (ja) |
DE (1) | DE69215615T2 (ja) |
FI (1) | FI941085A (ja) |
HU (1) | HUT66855A (ja) |
IL (1) | IL103009A0 (ja) |
MX (1) | MX9205137A (ja) |
NO (1) | NO940805L (ja) |
NZ (1) | NZ244153A (ja) |
RO (1) | RO114331B1 (ja) |
SK (1) | SK26094A3 (ja) |
WO (1) | WO1993005058A1 (ja) |
YU (1) | YU89792A (ja) |
Families Citing this family (53)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5565560A (en) * | 1991-05-13 | 1996-10-15 | Merck & Co., Inc. | O-Aryl,O-alkyl,O-alkenyl and O-alkynylmacrolides having immunosuppressive activity |
US5561137A (en) * | 1991-09-05 | 1996-10-01 | Abbott Laboratories | Thio-heterocyclic macrolactam immunomodulators |
US5563172A (en) * | 1991-09-05 | 1996-10-08 | Abbott Laboratories | Macrocyclic amide and urea immunomodulators |
US5252732A (en) * | 1991-09-09 | 1993-10-12 | Merck & Co., Inc. | D-heteroaryl, O-alkylheteroaryl, O-alkenylheteroaryl and O-alkynylheteroarylmacrolides having immunosuppressive activity |
US5247076A (en) * | 1991-09-09 | 1993-09-21 | Merck & Co., Inc. | Imidazolidyl macrolides having immunosuppressive activity |
US5310903A (en) * | 1993-03-05 | 1994-05-10 | Merck & Co., Inc. | Imidazolidyl rapamycin derivatives |
US5310901A (en) * | 1993-03-05 | 1994-05-10 | Merck & Co., Inc. | O-heteroaryl, O-alkylheteroaryl, O-alkenylheteroaryl and O-alkynlheteroarylrapamycin derivatives |
US5457194A (en) * | 1993-03-17 | 1995-10-10 | Abbott Laboratories | Substituted aliphatic amine-containing macrocyclic immunomodulators |
US5352783A (en) * | 1993-06-09 | 1994-10-04 | Merck & Co., Inc. | Microbial transformation product having immunosuppressive activity |
TW270114B (ja) * | 1993-10-22 | 1996-02-11 | Hoffmann La Roche | |
WO1995015328A1 (en) * | 1993-11-30 | 1995-06-08 | Abbott Laboratories | Macrocyclic immunomodulators with novel cyclohexyl ring replacements |
US5612350A (en) * | 1993-11-30 | 1997-03-18 | Abbott Laboratories | Macrocyclic immunomodulators with novel cyclohexyl ring replacements |
US5496831A (en) * | 1994-05-13 | 1996-03-05 | The General Hospital Corporation | Inhibition of insulin-induced adiposis |
US5880280A (en) * | 1994-06-15 | 1999-03-09 | Merck & Co., Inc. | Aryl, alkyl, alkenyl and alkynylmacrolides having immunosuppressive activity |
US5693648A (en) * | 1994-09-30 | 1997-12-02 | Merck & Co., Inc. | O-aryl, O-alkyl, O-alkenyl and O-alkynyl-macrolides having immunosuppressive activity |
EP0786986B1 (en) | 1994-10-26 | 2002-03-20 | Novartis AG | Use of an unsaturated fatty alcohol |
AR004480A1 (es) * | 1995-04-06 | 1998-12-16 | Amico Derin C D | Compuestos de ascomicina que poseen actividad antiinflamatoria, pro cedimiento para prepararlos, uso de dichos compuestos para preparar agentesfarmaceuticos y composiciones farmaceuticas que los incluyen |
US6187757B1 (en) | 1995-06-07 | 2001-02-13 | Ariad Pharmaceuticals, Inc. | Regulation of biological events using novel compounds |
US5777105A (en) * | 1995-08-24 | 1998-07-07 | Merck & Co., Inc. | Process for the preparation of imidazolyl macrolide immunosuppressants |
CA2229718A1 (en) * | 1995-08-24 | 1997-03-06 | David J. Mathre | Process for the preparation of imidazolyl macrolide immunosuppressants |
US5877184A (en) * | 1996-08-06 | 1999-03-02 | Merck & Co., Inc. | Macrolides having immunosuppressive activity |
MEP30008A (en) | 1998-03-26 | 2010-10-10 | Astellas Pharma Inc | Sustained release preparations |
GB9817064D0 (en) * | 1998-08-05 | 1998-10-07 | Fujisawa Pharmaceutical Co | New use |
GB9826656D0 (en) | 1998-12-03 | 1999-01-27 | Novartis Ag | Organic compounds |
US7063857B1 (en) | 1999-04-30 | 2006-06-20 | Sucampo Ag | Use of macrolide compounds for the treatment of dry eye |
IL147803A0 (en) * | 1999-08-24 | 2002-08-14 | Ariad Gene Therapeutics Inc | 28-epirapalogs |
US7067526B1 (en) | 1999-08-24 | 2006-06-27 | Ariad Gene Therapeutics, Inc. | 28-epirapalogs |
EP1554572B1 (en) | 2001-07-25 | 2009-10-14 | Raptor Pharmaceutical Inc. | Compositions and methods for modulating blood-brain barrier transport |
PL216224B1 (pl) * | 2002-02-01 | 2014-03-31 | Ariad Pharmaceuticals | Pochodne rapamycyny zawierające fosfor, kompozycja je zawierająca oraz ich zastosowanie |
JP2006516548A (ja) | 2002-12-30 | 2006-07-06 | アンジオテック インターナショナル アクツィエン ゲゼルシャフト | 迅速ゲル化ポリマー組成物からの薬物送達法 |
CA2552305A1 (en) * | 2003-12-30 | 2005-07-14 | Astellas Pharma Inc. | Use of macrolides for treating or preventing airflow obstruction |
EP1768662A2 (en) | 2004-06-24 | 2007-04-04 | Novartis Vaccines and Diagnostics, Inc. | Small molecule immunopotentiators and assays for their detection |
CA2580286A1 (en) * | 2004-09-16 | 2006-03-23 | Bayer Healthcare Ag | Dermally applicable formulations for treating skin diseases in animals |
US20060189551A1 (en) * | 2004-10-04 | 2006-08-24 | Duke University | Combination therapies for fungal pathogens |
WO2006078724A2 (en) * | 2005-01-20 | 2006-07-27 | Array Biopharma Nc. | Macrocyclic analogs for the treatment of immunoregulatory disorders and respiratory diseases |
AU2006239221C1 (en) | 2005-04-28 | 2012-08-16 | Otsuka Pharmaceutical Co., Ltd. | Pharma-informatics system |
WO2007021693A2 (en) * | 2005-08-10 | 2007-02-22 | Replidyne, Inc. | Transition metal catalyzed cross-coupling of 1-halo-1-haloalkene compounds |
WO2008036682A2 (en) | 2006-09-18 | 2008-03-27 | Raptor Pharmaceutical Inc. | Treatment of liver disorders by administration of receptor-associated protein (rap)-conjugates |
AU2007319825B2 (en) * | 2006-11-14 | 2014-01-23 | Ariad Pharmaceuticals, Inc. | Oral formulations |
US8921642B2 (en) * | 2008-01-11 | 2014-12-30 | Massachusetts Eye And Ear Infirmary | Conditional-stop dimerizable caspase transgenic animals |
KR101741629B1 (ko) | 2009-05-06 | 2017-05-31 | 라보라토리 스킨 케어, 인크. | 활성제-칼슘 포스페이트 입자 복합체를 포함하는 피부 전달 조성물 및 이들을 이용하는 방법 |
US20120077778A1 (en) | 2010-09-29 | 2012-03-29 | Andrea Bourdelais | Ladder-Frame Polyether Conjugates |
US8409807B2 (en) | 2010-10-22 | 2013-04-02 | T2 Biosystems, Inc. | NMR systems and methods for the rapid detection of analytes |
US8563298B2 (en) | 2010-10-22 | 2013-10-22 | T2 Biosystems, Inc. | NMR systems and methods for the rapid detection of analytes |
WO2012054639A2 (en) | 2010-10-22 | 2012-04-26 | T2 Biosystems, Inc. | Nmr systems and methods for the rapid detection of analytes |
EP2839038B1 (en) | 2012-04-20 | 2019-01-16 | T2 Biosystems, Inc. | Compositions and methods for detection of candida species |
US9593356B2 (en) | 2013-06-11 | 2017-03-14 | Takara Bio Usa, Inc. | Protein enriched microvesicles and methods of making and using the same |
US10143682B2 (en) | 2014-10-28 | 2018-12-04 | Koushi Yamaguchi | Medicine for improving state of pregnancy, and use thereof |
US11519016B2 (en) | 2016-01-21 | 2022-12-06 | T2 Biosystems, Inc. | NMR methods and systems for the rapid detection of bacteria |
CN106074367A (zh) * | 2016-07-20 | 2016-11-09 | 中山大学中山眼科中心 | 含fk506类化合物/fkbp蛋白二聚体的药物组合物及其制备方法 |
JP7465806B2 (ja) | 2018-08-10 | 2024-04-11 | 晃史 山口 | 母体と胎児との関係における液性免疫関連疾患の治療薬 |
CN109467579B (zh) * | 2018-11-01 | 2021-10-15 | 海南大学 | 一种具有免疫抑制活性的pks i型聚酮类化合物及其制备方法和应用 |
AU2019401108A1 (en) | 2018-12-18 | 2021-07-01 | Koushi Yamaguchi | Agent for improving infertility, recurrent miscarriage, and state of pregnancy |
Family Cites Families (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3244592A (en) * | 1962-06-09 | 1966-04-05 | Arai Tadashi | Ascomycin and process for its production |
US4894366A (en) * | 1984-12-03 | 1990-01-16 | Fujisawa Pharmaceutical Company, Ltd. | Tricyclo compounds, a process for their production and a pharmaceutical composition containing the same |
EP0346427B1 (en) * | 1987-12-09 | 1995-03-29 | FISONS plc | Macrocyclic compounds |
EP0356399A3 (en) * | 1988-08-26 | 1991-03-20 | Sandoz Ag | Substituted 4-azatricyclo (22.3.1.04.9) octacos-18-ene derivatives, their preparation and pharmaceutical compositions containing them |
EP0402931A1 (en) * | 1989-06-14 | 1990-12-19 | Sandoz Ltd. | Heteroatoms-containing tricyclic compounds |
IE904050A1 (en) * | 1989-11-13 | 1991-05-22 | Merck & Co Inc | Aminomacrolides and derivatives having immunosuppressive¹activity |
US5208228A (en) * | 1989-11-13 | 1993-05-04 | Merck & Co., Inc. | Aminomacrolides and derivatives having immunosuppressive activity |
US5064835A (en) * | 1990-03-01 | 1991-11-12 | Merck & Co., Inc. | Hydroxymacrolide derivatives having immunosuppressive activity |
US5190950A (en) * | 1990-06-25 | 1993-03-02 | Merck & Co., Inc. | Antagonists of immunosuppressive macrolides |
GB9014136D0 (en) * | 1990-06-25 | 1990-08-15 | Fujisawa Pharmaceutical Co | Tricyclo compounds,a process for their production and a pharmaceutical composition containing the same |
CA2044846A1 (en) * | 1990-06-25 | 1991-12-26 | Thomas R. Beattie | Antagonists of immunosuppressive macrolides |
GB2245891A (en) * | 1990-07-09 | 1992-01-15 | Fujisawa Pharmaceutical Co | Tricyclo compounds |
US5384316A (en) * | 1990-08-18 | 1995-01-24 | Fisons Plc | 4,16-diazatetracyclo[23.3.1.1.Hu 14,17=b . 0 Hu 4,9 triaconta-16,19-diene-2,3,10-trione derivatives |
JPH04165249A (ja) * | 1990-10-29 | 1992-06-11 | Matsushita Electric Ind Co Ltd | 多室型空気調和機 |
US5143918A (en) * | 1990-10-11 | 1992-09-01 | Merck & Co., Inc. | Halomacrolides and derivatives having immunosuppressive activity |
US5250678A (en) * | 1991-05-13 | 1993-10-05 | Merck & Co., Inc. | O-aryl, O-alkyl, O-alkenyl and O-alkynylmacrolides having immunosuppressive activity |
US5162334A (en) * | 1991-05-13 | 1992-11-10 | Merck & Co., Inc. | Amino O-alkyl, O-alkenyl and O-alkynlmacrolides having immunosuppressive activity |
US5262533A (en) * | 1991-05-13 | 1993-11-16 | Merck & Co., Inc. | Amino O-aryl macrolides having immunosuppressive activity |
US5118677A (en) * | 1991-05-20 | 1992-06-02 | American Home Products Corporation | Amide esters of rapamycin |
US5189042A (en) * | 1991-08-22 | 1993-02-23 | Merck & Co. Inc. | Fluoromacrolides having immunosuppressive activity |
US5247076A (en) * | 1991-09-09 | 1993-09-21 | Merck & Co., Inc. | Imidazolidyl macrolides having immunosuppressive activity |
US5208241A (en) * | 1991-09-09 | 1993-05-04 | Merck & Co., Inc. | N-heteroaryl, n-alkylheteroaryl, n-alkenylheteroaryl and n-alkynylheteroarylmacrolides having immunosuppressive activity |
US5252732A (en) * | 1991-09-09 | 1993-10-12 | Merck & Co., Inc. | D-heteroaryl, O-alkylheteroaryl, O-alkenylheteroaryl and O-alkynylheteroarylmacrolides having immunosuppressive activity |
-
1992
- 1992-08-05 US US07/921,851 patent/US5252732A/en not_active Expired - Lifetime
- 1992-08-31 NZ NZ244153A patent/NZ244153A/en unknown
- 1992-09-01 IL IL103009A patent/IL103009A0/xx unknown
- 1992-09-01 CA CA002077331A patent/CA2077331A1/en not_active Abandoned
- 1992-09-02 SK SK260-94A patent/SK26094A3/sk unknown
- 1992-09-02 RO RO94-00351A patent/RO114331B1/ro unknown
- 1992-09-02 WO PCT/US1992/007508 patent/WO1993005058A1/en not_active Application Discontinuation
- 1992-09-02 DE DE69215615T patent/DE69215615T2/de not_active Expired - Fee Related
- 1992-09-02 EP EP92202658A patent/EP0532088B1/en not_active Expired - Lifetime
- 1992-09-02 CZ CS94531A patent/CZ53194A3/cs unknown
- 1992-09-02 HU HU9400686A patent/HUT66855A/hu unknown
- 1992-09-02 AT AT92202658T patent/ATE145915T1/de not_active IP Right Cessation
- 1992-09-08 MX MX9205137A patent/MX9205137A/es not_active IP Right Cessation
- 1992-09-08 KR KR1019920016373A patent/KR930006030A/ko not_active Application Discontinuation
- 1992-09-08 CN CN92111209A patent/CN1073443A/zh active Pending
- 1992-09-08 AU AU22829/92A patent/AU647665B2/en not_active Ceased
- 1992-09-09 JP JP4283408A patent/JPH0813819B2/ja not_active Expired - Lifetime
- 1992-10-07 YU YU89792A patent/YU89792A/sh unknown
-
1993
- 1993-10-12 US US08/135,200 patent/US5349061A/en not_active Expired - Fee Related
-
1994
- 1994-03-07 BG BG98639A patent/BG98639A/bg unknown
- 1994-03-08 NO NO940805A patent/NO940805L/no unknown
- 1994-03-08 FI FI941085A patent/FI941085A/fi unknown
Also Published As
Publication number | Publication date |
---|---|
BG98639A (bg) | 1995-03-31 |
EP0532088A1 (en) | 1993-03-17 |
CN1073443A (zh) | 1993-06-23 |
NO940805D0 (no) | 1994-03-08 |
ATE145915T1 (de) | 1996-12-15 |
NZ244153A (en) | 1995-04-27 |
DE69215615T2 (de) | 1997-06-26 |
US5252732A (en) | 1993-10-12 |
EP0532088B1 (en) | 1996-12-04 |
FI941085A (fi) | 1994-05-03 |
CZ53194A3 (en) | 1994-08-17 |
HU9400686D0 (en) | 1994-06-28 |
YU89792A (sh) | 1996-01-08 |
US5349061A (en) | 1994-09-20 |
AU2282992A (en) | 1993-03-11 |
HUT66855A (en) | 1995-01-30 |
SK26094A3 (en) | 1994-08-10 |
WO1993005058A1 (en) | 1993-03-18 |
AU647665B2 (en) | 1994-03-24 |
JPH0813819B2 (ja) | 1996-02-14 |
FI941085A0 (fi) | 1994-03-08 |
DE69215615D1 (de) | 1997-01-16 |
RO114331B1 (ro) | 1999-03-30 |
MX9205137A (es) | 1993-04-01 |
JPH06116274A (ja) | 1994-04-26 |
CA2077331A1 (en) | 1993-03-10 |
KR930006030A (ko) | 1993-04-20 |
IL103009A0 (en) | 1993-02-21 |
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