NO923240L - Nye heparinderivater - Google Patents
Nye heparinderivaterInfo
- Publication number
- NO923240L NO923240L NO92923240A NO923240A NO923240L NO 923240 L NO923240 L NO 923240L NO 92923240 A NO92923240 A NO 92923240A NO 923240 A NO923240 A NO 923240A NO 923240 L NO923240 L NO 923240L
- Authority
- NO
- Norway
- Prior art keywords
- heparin derivatives
- treating
- approximately
- temperature
- heparin
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Polymers & Plastics (AREA)
- Materials Engineering (AREA)
- Biochemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Diabetes (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Hematology (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Abstract
Lav-molekylvekt heparinderivater og salter derav er fremstilt ved behandling av et kvaternært ammoniumsalt av et heparin, opplest i et heterosyklisk organisk opplesningsmiddel eller i et aprotisk opplesningsmiddel, ned et alkylerende middel, som har fra 6-30 karbonatomer, ved en temperatur på tilnærmet 20°-60°C, i en forlenget tidsperiode, og behandling av det resulterende reaksjonsprodukt, ved en temperatur på tilnærmet 5e-120°C, med en uorganisk eller organisk base, såsom et alkalisk hydroksid, i vandig opplesning, og isolering av de oppnådde heparinderi- vater i sin frie form eller som et alkalisk salt derav. Heparinderivatene oppnådd i henhold til fremgangsmåten i den foreliggende oppfinnelse utgjør en blanding av for det meste depolymeriserte produkter med molekylvekter innenfor et trangt område. Disse produkter er nyttige som antitrombotiske midler.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT04175290A IT1243300B (it) | 1990-12-20 | 1990-12-20 | Derivati dell'eparina |
PCT/EP1991/002479 WO1992011294A1 (en) | 1990-12-20 | 1991-12-20 | Heparin derivatives |
Publications (2)
Publication Number | Publication Date |
---|---|
NO923240D0 NO923240D0 (no) | 1992-08-18 |
NO923240L true NO923240L (no) | 1992-10-19 |
Family
ID=11253436
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO92923240A NO923240L (no) | 1990-12-20 | 1992-08-18 | Nye heparinderivater |
Country Status (13)
Country | Link |
---|---|
EP (1) | EP0516792A1 (no) |
JP (1) | JPH05504785A (no) |
KR (1) | KR920703644A (no) |
CN (1) | CN1062537A (no) |
AU (1) | AU658594B2 (no) |
BR (1) | BR9106234A (no) |
CA (1) | CA2075970A1 (no) |
FI (1) | FI923762A0 (no) |
HU (1) | HUT62917A (no) |
IT (1) | IT1243300B (no) |
NO (1) | NO923240L (no) |
PT (1) | PT99898A (no) |
WO (1) | WO1992011294A1 (no) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2663639B1 (fr) * | 1990-06-26 | 1994-03-18 | Rhone Poulenc Sante | Melanges de polysaccharides de bas poids moleculaires procede de preparation et utilisation. |
FR2704861B1 (fr) * | 1993-05-07 | 1995-07-28 | Sanofi Elf | Fractions d'héparine purifiées, procédé d'obtention et compositions pharmaceutiques les contenant. |
ES2077533B1 (es) * | 1994-02-28 | 1996-07-01 | Bioiberica | Procedimiento de obtencion de fracciones de oligosacaridos por despolimerizacion quimica de heparina. |
US5639469A (en) * | 1994-06-15 | 1997-06-17 | Minnesota Mining And Manufacturing Company | Transmucosal delivery system |
US5744457A (en) * | 1995-03-31 | 1998-04-28 | Hamilton Civic Hospitals Research Development Inc. | Compositions and methods for inhibiting thrombogenesis |
US5763427A (en) * | 1995-03-31 | 1998-06-09 | Hamilton Civic Hospitals Research Development Inc. | Compositions and methods for inhibiting thrombogenesis |
US6001820A (en) * | 1995-03-31 | 1999-12-14 | Hamilton Civic Hospitals Research Development Inc. | Compositions and methods for inhibiting thrombogenesis |
CN1114410C (zh) * | 1996-03-15 | 2003-07-16 | 宝酒造株式会社 | 糖醛酸类的热处理产物、以及含有这种产物的食品、饮料和药物 |
US5767269A (en) * | 1996-10-01 | 1998-06-16 | Hamilton Civic Hospitals Research Development Inc. | Processes for the preparation of low-affinity, low molecular weight heparins useful as antithrombotics |
FR2763848B1 (fr) * | 1997-05-28 | 2000-01-28 | Rhone Poulenc Rorer Sa | Utilisation des heparines de bas poids moleculaire pour la prevention et le traitement du trauma du systeme nerveux central |
DE10217557A1 (de) * | 2002-04-19 | 2003-11-06 | Degussa Bioactives Gmbh | Funktionsnahrungsmittel enthaltend eine Phospholipid-haltige stabile Matrix |
WO2003088949A2 (de) * | 2002-04-19 | 2003-10-30 | Bioghurt Biogarde Gmbh & Co. Kg. | Matrix mit einer bioaktiven phospholipid-haltigen komponente |
CN100335506C (zh) * | 2004-05-20 | 2007-09-05 | 汕头市金丰医疗器械科技有限公司 | 一种肝素化合物及其制备方法和应用 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2482603A1 (fr) * | 1980-05-14 | 1981-11-20 | Pharmindustrie | Nouveaux esters d'heparine utilisables pour la preparation de medicaments, et procedes pour leur preparation |
ES2071608T3 (es) * | 1986-08-20 | 1995-07-01 | Univ Miami | Esteres de alcanoilo de heparina de bajo peso molecular. |
SE8702254D0 (sv) * | 1987-05-29 | 1987-05-29 | Kabivitrum Ab | Novel heparin derivatives |
-
1990
- 1990-12-20 IT IT04175290A patent/IT1243300B/it active IP Right Grant
-
1991
- 1991-12-20 PT PT99898A patent/PT99898A/pt not_active Application Discontinuation
- 1991-12-20 JP JP4501399A patent/JPH05504785A/ja active Pending
- 1991-12-20 EP EP92901426A patent/EP0516792A1/en not_active Withdrawn
- 1991-12-20 WO PCT/EP1991/002479 patent/WO1992011294A1/en not_active Application Discontinuation
- 1991-12-20 KR KR1019920701996A patent/KR920703644A/ko not_active Application Discontinuation
- 1991-12-20 AU AU90964/91A patent/AU658594B2/en not_active Ceased
- 1991-12-20 BR BR919106234A patent/BR9106234A/pt unknown
- 1991-12-20 CA CA002075970A patent/CA2075970A1/en not_active Abandoned
- 1991-12-20 CN CN91111853A patent/CN1062537A/zh active Pending
- 1991-12-20 HU HU922685A patent/HUT62917A/hu unknown
-
1992
- 1992-08-18 NO NO92923240A patent/NO923240L/no unknown
- 1992-08-20 FI FI923762A patent/FI923762A0/fi not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
IT9041752A0 (it) | 1990-12-20 |
IT9041752A1 (it) | 1992-06-21 |
JPH05504785A (ja) | 1993-07-22 |
PT99898A (pt) | 1992-12-31 |
BR9106234A (pt) | 1993-03-30 |
FI923762A (fi) | 1992-08-20 |
FI923762A0 (fi) | 1992-08-20 |
KR920703644A (ko) | 1992-12-18 |
WO1992011294A1 (en) | 1992-07-09 |
CA2075970A1 (en) | 1992-06-21 |
EP0516792A1 (en) | 1992-12-09 |
AU658594B2 (en) | 1995-04-27 |
CN1062537A (zh) | 1992-07-08 |
IT1243300B (it) | 1994-05-26 |
NO923240D0 (no) | 1992-08-18 |
AU9096491A (en) | 1992-07-22 |
HUT62917A (en) | 1993-06-28 |
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