NO921906L - Nye 2-amino-5-cyano-1,4-dihydropyridiner, deres fremstilling og anvendelse i legemidler - Google Patents
Nye 2-amino-5-cyano-1,4-dihydropyridiner, deres fremstilling og anvendelse i legemidlerInfo
- Publication number
- NO921906L NO921906L NO92921906A NO921906A NO921906L NO 921906 L NO921906 L NO 921906L NO 92921906 A NO92921906 A NO 92921906A NO 921906 A NO921906 A NO 921906A NO 921906 L NO921906 L NO 921906L
- Authority
- NO
- Norway
- Prior art keywords
- dihydropyridines
- cyano
- amino
- preparation
- new
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D215/14—Radicals substituted by oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Heart & Thoracic Surgery (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Saccharide Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyrrole Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
2-amino-5-cyano-4-kinolin-l,4-dihydropyridiner med den generelle formel (I): (I) NH, der R1 er C6.10-aryl som eventuelt kan være substituert likt eller forskjellig opptil tre ganger med halogen, nitro, cyano, trifluormetyl, trifluormetoksy, trifluprmetyltio, eller med rett eller forgrenet alkyl med opptil 8 karbonatomer, som i sin tur kan være substituert med C6.10-aryl, eller er substitu- ert med rett eller forgrenet alkoksy eller alkoksykarbonyl, i begge tilfeller med opptil 8 karbonatomer, karboksy, amino eller med en gruppe med formelen -NR4R5, der R4 og R5 er like eller forskjellige og betyr hydrogen, rett eller forgrenet alkyl med opptil 8 karbonatomer, fenyl eller benzyl, eller betyr tienyl, R2 betyr hydrogen, eller betyr cykloalkyl med 5 til 8 karbonatomer eller betyr rett eller forgrenet alkyl, alkenyl, alkadienyl eller alkinyl med hver gang opptil 10 karbonatomer, som eventuelt er substituert en eller to ganger, likt eller forskjellig, med halogen, hydroksy, karboksy, cyano, nitro eller med rett eller forgrenet alkyltio, alkoksy, alkoksykc-rbonyl, acyl eller acyloksy med hver gang opptil 8 karbonatomer eller med cykloalkyl med 3 til 8 karbonatomer, fenoksy eller fenyl, hvorved de sistnevnte i sin tur kan være substituert opptil to ganger, likt eller forskjellig, med halogen, rett eller forgrenet alkyl eller alkoksy med hver gang opptil 6 karbonatomer, eller er substituert med gruppen -NR*R", der R' og P5 har den ovenfor angitte betydning, R3 betyr hydrogen eller rett eller forgrenet alkyl med opptil 8 karboratomer, og deres fysiologisk godtagbare salter. Forbindelsene med formel (I) rapporteres å ha terapeutiske virkning og finner anvendelse ved fremstilling av hjertekrets- løpvirksomme legemidler. Forbindelsenes fremstilling beskri- ves. Videru beskrives ylidenforbindelser med formel (V): (V), der R1 og R3 har den ovenfor angitte betydning, samt deres fremstilling.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE4117750A DE4117750A1 (de) | 1991-05-30 | 1991-05-30 | Neue 2-amino-5-cyano-1,4-dihydropyridine, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln |
Publications (2)
Publication Number | Publication Date |
---|---|
NO921906D0 NO921906D0 (no) | 1992-05-14 |
NO921906L true NO921906L (no) | 1992-12-01 |
Family
ID=6432811
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO92921906A NO921906L (no) | 1991-05-30 | 1992-05-14 | Nye 2-amino-5-cyano-1,4-dihydropyridiner, deres fremstilling og anvendelse i legemidler |
NO970573A NO970573D0 (no) | 1991-05-30 | 1997-02-07 | Ylidenforbindelser og deres fremstilling |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO970573A NO970573D0 (no) | 1991-05-30 | 1997-02-07 | Ylidenforbindelser og deres fremstilling |
Country Status (22)
Country | Link |
---|---|
US (3) | US5225558A (no) |
EP (1) | EP0515940B1 (no) |
JP (1) | JPH05186459A (no) |
KR (1) | KR920021530A (no) |
AT (1) | ATE140455T1 (no) |
AU (2) | AU656374B2 (no) |
CA (1) | CA2069860A1 (no) |
CZ (1) | CZ158692A3 (no) |
DE (2) | DE4117750A1 (no) |
DK (1) | DK0515940T3 (no) |
ES (1) | ES2089286T3 (no) |
FI (1) | FI922428A (no) |
GR (1) | GR3020575T3 (no) |
HU (2) | HUT61538A (no) |
IE (1) | IE921771A1 (no) |
IL (3) | IL116384A (no) |
MX (1) | MX9202366A (no) |
NO (2) | NO921906L (no) |
NZ (2) | NZ242932A (no) |
RU (1) | RU2081872C1 (no) |
SK (1) | SK158692A3 (no) |
ZA (1) | ZA923935B (no) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2683819B1 (fr) * | 1991-10-28 | 1994-02-11 | Synthelabo | Derives de quinoleine, leur procede de preparation et leur application en therapeutique. |
ES2113933T3 (es) * | 1991-11-12 | 1998-05-16 | Coatex Sa | Agente de trituracion y/o dispersion a base de polimeros y/o copolimeros neutralizados parcialmente por magnesio para suspensiones acuosas de materiales minerales para la aplicacion de pigmentos. |
DE4233586A1 (de) * | 1992-10-06 | 1994-04-07 | Bayer Ag | 3-Imino-3-alkoxy-propionsäurelactate und deren tautomere Acrylsäurelactate |
DE4313697A1 (de) * | 1993-04-27 | 1994-11-03 | Bayer Ag | Chinolyl-dihydropyridinester, Verfahren zu ihrer Herstellung und ihre Verwendung in Arzneimitteln |
DE4313692A1 (de) * | 1993-04-27 | 1994-11-03 | Bayer Ag | 3-Chinolyl substituierte Dihydropyridine, Verfahren zu ihrer Herstellung und ihre Verwendung in Arzneimitteln |
DE4313693A1 (de) * | 1993-04-27 | 1994-11-03 | Bayer Ag | 2-Amino-4-chinolin-dihydropyridine, Verfahren zu ihrer Herstellung und ihre Verwendung |
DE4313696A1 (de) * | 1993-04-27 | 1994-11-03 | Bayer Ag | 2-Amino-4-heteroaryl-1,4-dihydropyridine, Verfahren zu ihrer Herstellung und ihre Verwendung in Arzneimitteln |
DE4313691A1 (de) * | 1993-04-27 | 1994-11-03 | Bayer Ag | 2,6-Disubstituierte 4-Chinolyl-dihydropyridine |
DE4313695A1 (de) * | 1993-04-27 | 1994-11-03 | Bayer Ag | 2-Amino-5-cyano-4-chinolyldihydropyridinester, Verfahren zu ihrer Herstellung und ihre Verwendung in Arzneimitteln |
DE4432378A1 (de) * | 1994-09-12 | 1996-03-14 | Bayer Ag | Injizierbare liposomale Arzneizubereitungen |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2359329A (en) * | 1943-06-18 | 1944-10-03 | Burroughs Wellcome Co | Quinoline substituted dihydropyridines |
US4001258A (en) * | 1972-03-06 | 1977-01-04 | Bayer Aktiengesellschaft | 2-amino-1,4-dihydropyridine derivatives |
US3996234A (en) * | 1972-04-18 | 1976-12-07 | Bayer Aktiengesellschaft | 1,4-Dihydropyridine carboxylic acid esters |
US3989708A (en) * | 1972-08-31 | 1976-11-02 | Bayer Aktiengesellschaft | 2-Amino-1,4-dihydropyridine derivatives |
DE2242786A1 (de) * | 1972-08-31 | 1974-03-14 | Bayer Ag | Verfahren zur herstellung von neuen 2-amino-1,4-dihydropyridinen mit einer carbonylfunktion sowie ihre verwendung als arzneimittel |
DE2310747A1 (de) * | 1973-03-03 | 1974-09-12 | Bayer Ag | Verfahren zur herstellung von neuen amino-3,4-dihydropyridinen und ihre verwendung als arzneimittel |
US4002762A (en) * | 1973-03-03 | 1977-01-11 | Bayer Aktiengesellschaft | 2-Amino-3,4-dihydropyridines used to effect coronary vessel dilation and treat hypertension |
DE2412750A1 (de) * | 1974-03-16 | 1975-09-18 | Bayer Ag | Verfahren zur herstellung von 4-amino2,2,6,6-tetramethyl-piperidin |
DE2623170C2 (de) * | 1976-05-22 | 1982-03-11 | Basf Ag, 6700 Ludwigshafen | Verfahren zur Herstellung von α-Cyanzimtaldehyd-Derivaten und 3,4,5-Trimethoxy-α-Cyanzimtaldehyd |
DE2658804A1 (de) * | 1976-12-24 | 1978-07-06 | Bayer Ag | Kreislaufbeeinflussende mittel |
DE2935451A1 (de) * | 1979-09-01 | 1981-03-19 | Bayer Ag, 5090 Leverkusen | Optisch aktive 1,4-dihydropyridine, verfahren zu ihrer herstellung und ihre verwendung als arneimittel |
DE3015219A1 (de) * | 1980-04-19 | 1981-10-22 | Bayer Ag, 5090 Leverkusen | 6-amino-4,5-dihydropyridin-3-carbonsaeureester, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
NZ201395A (en) * | 1981-07-30 | 1987-02-20 | Bayer Ag | Pharmaceutical compositions containing 1,4-dihydropyridines and certain of these dihydropyridines |
DE3134945A1 (de) * | 1981-09-03 | 1983-03-17 | Bayer Ag, 5090 Leverkusen | Substituierte 2-amino-3,4-dihydropyridinderivate, verfahren zu ihrer herstellung und ihre verwendung in arzneimittel |
US5001381A (en) * | 1987-12-08 | 1991-03-19 | Akio Takahashi | Electro-static motor |
DE4011105A1 (de) * | 1990-04-06 | 1991-10-10 | Bayer Ag | Neue 4-chinolyl-dihydropyridine, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln |
-
1991
- 1991-05-30 DE DE4117750A patent/DE4117750A1/de not_active Withdrawn
-
1992
- 1992-05-05 AU AU16045/92A patent/AU656374B2/en not_active Ceased
- 1992-05-14 NO NO92921906A patent/NO921906L/no unknown
- 1992-05-18 AT AT92108324T patent/ATE140455T1/de not_active IP Right Cessation
- 1992-05-18 DK DK92108324.2T patent/DK0515940T3/da active
- 1992-05-18 EP EP92108324A patent/EP0515940B1/de not_active Expired - Lifetime
- 1992-05-18 DE DE59206772T patent/DE59206772D1/de not_active Expired - Fee Related
- 1992-05-18 ES ES92108324T patent/ES2089286T3/es not_active Expired - Lifetime
- 1992-05-20 MX MX9202366A patent/MX9202366A/es not_active IP Right Cessation
- 1992-05-20 US US07/886,644 patent/US5225558A/en not_active Expired - Fee Related
- 1992-05-25 JP JP4156248A patent/JPH05186459A/ja active Pending
- 1992-05-26 SK SK1586-92A patent/SK158692A3/sk unknown
- 1992-05-26 CZ CS921586A patent/CZ158692A3/cs unknown
- 1992-05-27 FI FI922428A patent/FI922428A/fi not_active Application Discontinuation
- 1992-05-27 CA CA002069860A patent/CA2069860A1/en not_active Abandoned
- 1992-05-28 NZ NZ242932A patent/NZ242932A/en unknown
- 1992-05-28 IL IL11638492A patent/IL116384A/en not_active IP Right Cessation
- 1992-05-28 IL IL10203292A patent/IL102032A/en active IP Right Grant
- 1992-05-28 NZ NZ264151A patent/NZ264151A/en unknown
- 1992-05-29 ZA ZA923935A patent/ZA923935B/xx unknown
- 1992-05-29 HU HU9201799A patent/HUT61538A/hu unknown
- 1992-05-29 KR KR1019920009260A patent/KR920021530A/ko not_active Application Discontinuation
- 1992-05-29 RU SU925011791A patent/RU2081872C1/ru active
- 1992-07-01 IE IE177192A patent/IE921771A1/en not_active Application Discontinuation
-
1993
- 1993-01-21 US US08/006,432 patent/US5380851A/en not_active Expired - Fee Related
-
1994
- 1994-08-30 US US08/298,013 patent/US5432282A/en not_active Expired - Fee Related
-
1995
- 1995-03-30 AU AU16199/95A patent/AU1619995A/en not_active Abandoned
- 1995-06-29 HU HU95P/P00559P patent/HU211579A9/hu unknown
- 1995-12-14 IL IL11638495A patent/IL116384A0/xx unknown
-
1996
- 1996-07-18 GR GR960401870T patent/GR3020575T3/el unknown
-
1997
- 1997-02-07 NO NO970573A patent/NO970573D0/no unknown
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