NO841234L - Fremgangsmaate for kvantitativ bestemmelse av konsentrasjonen av hemoglobin i en biologisk proeve - Google Patents
Fremgangsmaate for kvantitativ bestemmelse av konsentrasjonen av hemoglobin i en biologisk proeveInfo
- Publication number
- NO841234L NO841234L NO841234A NO841234A NO841234L NO 841234 L NO841234 L NO 841234L NO 841234 A NO841234 A NO 841234A NO 841234 A NO841234 A NO 841234A NO 841234 L NO841234 L NO 841234L
- Authority
- NO
- Norway
- Prior art keywords
- hemoglobin
- porphyrin
- acid
- sample
- conversion
- Prior art date
Links
- 108010054147 Hemoglobins Proteins 0.000 title claims description 134
- 102000001554 Hemoglobins Human genes 0.000 title claims description 134
- 238000000034 method Methods 0.000 title claims description 50
- 238000012360 testing method Methods 0.000 title claims description 33
- 150000004032 porphyrins Chemical class 0.000 claims description 93
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 claims description 88
- 239000000523 sample Substances 0.000 claims description 64
- 238000006243 chemical reaction Methods 0.000 claims description 53
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims description 40
- 235000006408 oxalic acid Nutrition 0.000 claims description 29
- 239000003153 chemical reaction reagent Substances 0.000 claims description 27
- 210000003608 fece Anatomy 0.000 claims description 23
- 229910052742 iron Inorganic materials 0.000 claims description 20
- 210000002700 urine Anatomy 0.000 claims description 19
- 239000012895 dilution Substances 0.000 claims description 18
- 238000010790 dilution Methods 0.000 claims description 18
- 210000004051 gastric juice Anatomy 0.000 claims description 17
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 14
- 238000010438 heat treatment Methods 0.000 claims description 10
- 150000001875 compounds Chemical class 0.000 claims description 9
- 239000000243 solution Substances 0.000 claims description 8
- 239000011668 ascorbic acid Substances 0.000 claims description 7
- 229960005070 ascorbic acid Drugs 0.000 claims description 7
- 235000010323 ascorbic acid Nutrition 0.000 claims description 7
- 150000003839 salts Chemical class 0.000 claims description 7
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims description 6
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 6
- 229930195725 Mannitol Natural products 0.000 claims description 6
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims description 6
- LEHOTFFKMJEONL-UHFFFAOYSA-N Uric Acid Chemical compound N1C(=O)NC(=O)C2=C1NC(=O)N2 LEHOTFFKMJEONL-UHFFFAOYSA-N 0.000 claims description 6
- TVWHNULVHGKJHS-UHFFFAOYSA-N Uric acid Natural products N1C(=O)NC(=O)C2NC(=O)NC21 TVWHNULVHGKJHS-UHFFFAOYSA-N 0.000 claims description 6
- 239000000594 mannitol Substances 0.000 claims description 6
- 235000010355 mannitol Nutrition 0.000 claims description 6
- 229940116269 uric acid Drugs 0.000 claims description 6
- 239000002253 acid Substances 0.000 claims description 5
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 claims description 4
- 239000003795 chemical substances by application Substances 0.000 claims description 4
- BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 claims description 4
- 235000011007 phosphoric acid Nutrition 0.000 claims description 4
- 238000002360 preparation method Methods 0.000 claims description 4
- PWHULOQIROXLJO-UHFFFAOYSA-N Manganese Chemical compound [Mn] PWHULOQIROXLJO-UHFFFAOYSA-N 0.000 claims description 3
- ATJFFYVFTNAWJD-UHFFFAOYSA-N Tin Chemical compound [Sn] ATJFFYVFTNAWJD-UHFFFAOYSA-N 0.000 claims description 3
- 239000010941 cobalt Substances 0.000 claims description 3
- 229910017052 cobalt Inorganic materials 0.000 claims description 3
- GUTLYIVDDKVIGB-UHFFFAOYSA-N cobalt atom Chemical compound [Co] GUTLYIVDDKVIGB-UHFFFAOYSA-N 0.000 claims description 3
- TVZISJTYELEYPI-UHFFFAOYSA-N hypodiphosphoric acid Chemical compound OP(O)(=O)P(O)(O)=O TVZISJTYELEYPI-UHFFFAOYSA-N 0.000 claims description 3
- 229910052748 manganese Inorganic materials 0.000 claims description 3
- 239000011572 manganese Substances 0.000 claims description 3
- OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 claims description 2
- 230000002378 acidificating effect Effects 0.000 claims description 2
- VHJLVAABSRFDPM-QWWZWVQMSA-N dithiothreitol Chemical compound SC[C@@H](O)[C@H](O)CS VHJLVAABSRFDPM-QWWZWVQMSA-N 0.000 claims description 2
- 238000012921 fluorescence analysis Methods 0.000 claims description 2
- 235000019253 formic acid Nutrition 0.000 claims description 2
- 150000002815 nickel Chemical class 0.000 claims description 2
- 238000004458 analytical method Methods 0.000 claims 9
- 239000000538 analytical sample Substances 0.000 claims 1
- 239000000356 contaminant Substances 0.000 claims 1
- 238000007865 diluting Methods 0.000 claims 1
- 150000003278 haem Chemical class 0.000 description 43
- 239000011541 reaction mixture Substances 0.000 description 42
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 27
- 239000000203 mixture Substances 0.000 description 15
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 10
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 9
- 230000002550 fecal effect Effects 0.000 description 9
- 239000000126 substance Substances 0.000 description 9
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 8
- 239000012620 biological material Substances 0.000 description 8
- -1 heme compounds Chemical class 0.000 description 8
- 210000004369 blood Anatomy 0.000 description 7
- 239000008280 blood Substances 0.000 description 7
- 238000012113 quantitative test Methods 0.000 description 6
- 150000003254 radicals Chemical class 0.000 description 6
- 238000007086 side reaction Methods 0.000 description 6
- 241000894006 Bacteria Species 0.000 description 5
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 description 5
- 239000012470 diluted sample Substances 0.000 description 5
- 238000000605 extraction Methods 0.000 description 5
- 244000005709 gut microbiome Species 0.000 description 5
- 238000002156 mixing Methods 0.000 description 5
- 238000000746 purification Methods 0.000 description 5
- 230000009467 reduction Effects 0.000 description 5
- 230000009466 transformation Effects 0.000 description 5
- 229960000583 acetic acid Drugs 0.000 description 4
- 239000003638 chemical reducing agent Substances 0.000 description 4
- 239000000975 dye Substances 0.000 description 4
- 230000000968 intestinal effect Effects 0.000 description 4
- ZXEKIIBDNHEJCQ-UHFFFAOYSA-N isobutanol Chemical compound CC(C)CO ZXEKIIBDNHEJCQ-UHFFFAOYSA-N 0.000 description 4
- 239000000463 material Substances 0.000 description 4
- 229940123457 Free radical scavenger Drugs 0.000 description 3
- 102000008015 Hemeproteins Human genes 0.000 description 3
- 108010089792 Hemeproteins Proteins 0.000 description 3
- 239000012472 biological sample Substances 0.000 description 3
- 230000015572 biosynthetic process Effects 0.000 description 3
- 229930002875 chlorophyll Natural products 0.000 description 3
- 235000019804 chlorophyll Nutrition 0.000 description 3
- ATNHDLDRLWWWCB-AENOIHSZSA-M chlorophyll a Chemical compound C1([C@@H](C(=O)OC)C(=O)C2=C3C)=C2N2C3=CC(C(CC)=C3C)=[N+]4C3=CC3=C(C=C)C(C)=C5N3[Mg-2]42[N+]2=C1[C@@H](CCC(=O)OC\C=C(/C)CCC[C@H](C)CCC[C@H](C)CCCC(C)C)[C@H](C)C2=C5 ATNHDLDRLWWWCB-AENOIHSZSA-M 0.000 description 3
- 230000037213 diet Effects 0.000 description 3
- 235000005911 diet Nutrition 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 210000001035 gastrointestinal tract Anatomy 0.000 description 3
- 239000000049 pigment Substances 0.000 description 3
- 239000002516 radical scavenger Substances 0.000 description 3
- OKIRBHVFJGXOIS-UHFFFAOYSA-N 1,2-di(propan-2-yl)benzene Chemical compound CC(C)C1=CC=CC=C1C(C)C OKIRBHVFJGXOIS-UHFFFAOYSA-N 0.000 description 2
- KSFOVUSSGSKXFI-GAQDCDSVSA-N CC1=C/2NC(\C=C3/N=C(/C=C4\N\C(=C/C5=N/C(=C\2)/C(C=C)=C5C)C(C=C)=C4C)C(C)=C3CCC(O)=O)=C1CCC(O)=O Chemical compound CC1=C/2NC(\C=C3/N=C(/C=C4\N\C(=C/C5=N/C(=C\2)/C(C=C)=C5C)C(C=C)=C4C)C(C)=C3CCC(O)=O)=C1CCC(O)=O KSFOVUSSGSKXFI-GAQDCDSVSA-N 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 2
- 150000007513 acids Chemical class 0.000 description 2
- 239000012670 alkaline solution Substances 0.000 description 2
- 238000009835 boiling Methods 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 230000005284 excitation Effects 0.000 description 2
- 239000012362 glacial acetic acid Substances 0.000 description 2
- BTIJJDXEELBZFS-QDUVMHSLSA-K hemin Chemical compound CC1=C(CCC(O)=O)C(C=C2C(CCC(O)=O)=C(C)\C(N2[Fe](Cl)N23)=C\4)=N\C1=C/C2=C(C)C(C=C)=C3\C=C/1C(C)=C(C=C)C/4=N\1 BTIJJDXEELBZFS-QDUVMHSLSA-K 0.000 description 2
- 229940025294 hemin Drugs 0.000 description 2
- 239000012535 impurity Substances 0.000 description 2
- 230000002452 interceptive effect Effects 0.000 description 2
- 229940035429 isobutyl alcohol Drugs 0.000 description 2
- 235000013372 meat Nutrition 0.000 description 2
- 229950003776 protoporphyrin Drugs 0.000 description 2
- 230000002829 reductive effect Effects 0.000 description 2
- 230000035945 sensitivity Effects 0.000 description 2
- 238000011282 treatment Methods 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 description 1
- UJKPHYRXOLRVJJ-MLSVHJFASA-N CC(O)C1=C(C)/C2=C/C3=N/C(=C\C4=C(CCC(O)=O)C(C)=C(N4)/C=C4\N=C(\C=C\1/N\2)C(C)=C4C(C)O)/C(CCC(O)=O)=C3C Chemical compound CC(O)C1=C(C)/C2=C/C3=N/C(=C\C4=C(CCC(O)=O)C(C)=C(N4)/C=C4\N=C(\C=C\1/N\2)C(C)=C4C(C)O)/C(CCC(O)=O)=C3C UJKPHYRXOLRVJJ-MLSVHJFASA-N 0.000 description 1
- 229910021580 Cobalt(II) chloride Inorganic materials 0.000 description 1
- 102000018832 Cytochromes Human genes 0.000 description 1
- 108010052832 Cytochromes Proteins 0.000 description 1
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 241000147041 Guaiacum officinale Species 0.000 description 1
- 102000036675 Myoglobin Human genes 0.000 description 1
- 108010062374 Myoglobin Proteins 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 229960001138 acetylsalicylic acid Drugs 0.000 description 1
- 239000003929 acidic solution Substances 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 239000003125 aqueous solvent Substances 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 235000015278 beef Nutrition 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 238000009534 blood test Methods 0.000 description 1
- 238000004364 calculation method Methods 0.000 description 1
- CCGSUNCLSOWKJO-UHFFFAOYSA-N cimetidine Chemical compound N#CNC(=N/C)\NCCSCC1=NC=N[C]1C CCGSUNCLSOWKJO-UHFFFAOYSA-N 0.000 description 1
- 229960001380 cimetidine Drugs 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 210000003743 erythrocyte Anatomy 0.000 description 1
- 239000002024 ethyl acetate extract Substances 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 102000018146 globin Human genes 0.000 description 1
- 108060003196 globin Proteins 0.000 description 1
- 229940091561 guaiac Drugs 0.000 description 1
- 229960003569 hematoporphyrin Drugs 0.000 description 1
- 108010036302 hemoglobin AS Proteins 0.000 description 1
- 229960000443 hydrochloric acid Drugs 0.000 description 1
- 238000005286 illumination Methods 0.000 description 1
- 238000010348 incorporation Methods 0.000 description 1
- 239000000543 intermediate Substances 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 229960003284 iron Drugs 0.000 description 1
- 150000004698 iron complex Chemical class 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 210000002429 large intestine Anatomy 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- SQQMAOCOWKFBNP-UHFFFAOYSA-L manganese(II) sulfate Chemical compound [Mn+2].[O-]S([O-])(=O)=O SQQMAOCOWKFBNP-UHFFFAOYSA-L 0.000 description 1
- 229910000357 manganese(II) sulfate Inorganic materials 0.000 description 1
- QMMRZOWCJAIUJA-UHFFFAOYSA-L nickel dichloride Chemical compound Cl[Ni]Cl QMMRZOWCJAIUJA-UHFFFAOYSA-L 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 150000002978 peroxides Chemical class 0.000 description 1
- 150000003016 phosphoric acids Chemical class 0.000 description 1
- 235000015277 pork Nutrition 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000009257 reactivity Effects 0.000 description 1
- 239000001054 red pigment Substances 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 239000012898 sample dilution Substances 0.000 description 1
- 239000012488 sample solution Substances 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 230000009278 visceral effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
- A61B10/0038—Devices for taking faeces samples; Faecal examination devices
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/72—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood pigments, e.g. haemoglobin, bilirubin or other porphyrins; involving occult blood
- G01N33/721—Haemoglobin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Pathology (AREA)
- Chemical & Material Sciences (AREA)
- Urology & Nephrology (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Medical Informatics (AREA)
- Surgery (AREA)
- Public Health (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Microbiology (AREA)
- Veterinary Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Physics & Mathematics (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/480,871 US4526869A (en) | 1980-09-24 | 1983-03-31 | Method for quantitatively determining the concentration of hemoglobin in a biological sample |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO841234L true NO841234L (no) | 1984-10-01 |
Family
ID=23909679
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO841234A NO841234L (no) | 1983-03-31 | 1984-03-28 | Fremgangsmaate for kvantitativ bestemmelse av konsentrasjonen av hemoglobin i en biologisk proeve |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US4526869A (da) |
| EP (1) | EP0123868A3 (da) |
| JP (1) | JPS6089756A (da) |
| AU (1) | AU2635084A (da) |
| CA (1) | CA1219794A (da) |
| DK (1) | DK173884A (da) |
| FI (1) | FI841145A (da) |
| NO (1) | NO841234L (da) |
| NZ (1) | NZ207634A (da) |
| ZA (1) | ZA842076B (da) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4673654A (en) * | 1985-10-31 | 1987-06-16 | Warner-Lambert Company | Composition for determining peroxidase-like activity of hemoglobin |
| US5182191A (en) * | 1988-10-14 | 1993-01-26 | Pacific Biotech, Inc. | Occult blood sampling device and assay |
| US4938224A (en) * | 1988-11-16 | 1990-07-03 | Rysavy Joseph A | Process for detecting accidental contact with body fluids |
| US5834315A (en) * | 1994-12-23 | 1998-11-10 | Coulter Corporation | Cyanide-free reagent and method for hemoglobin determination and leukocyte differentitation |
| DE69625581T2 (de) * | 1996-03-07 | 2003-09-25 | Coulter International Corp., Miami | Cyanidfreies Reagenz und Verfahren zur Bestimmung von Hämoglobin und Leukozytendifferenzierung |
| US6844195B2 (en) * | 2000-12-01 | 2005-01-18 | Western Research Company | Method for determining location of gastrointestinal bleeding |
| US8053203B2 (en) | 2007-10-30 | 2011-11-08 | John Wan | Methods and device for the detection of occult blood |
| JP5761660B2 (ja) * | 2009-05-29 | 2015-08-12 | 国立大学法人九州工業大学 | 金属プロトポルフィリン錯体の定量方法及びそれに用いる酵素センサー |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2290436A (en) * | 1940-09-26 | 1942-07-21 | Miles Lab | Diagnostic composition and method |
| US2838377A (en) * | 1950-03-09 | 1958-06-10 | Miles Lab | Blood test |
| US3012976A (en) * | 1959-11-02 | 1961-12-12 | Miles Lab | Specific test composition for occult blood |
| US3092464A (en) * | 1959-11-02 | 1963-06-04 | Miles Lab | Blood detecting composition |
| US3092463A (en) * | 1959-11-02 | 1963-06-04 | Miles Lab | Stable blood detecting composition |
| NL277911A (da) * | 1961-05-04 | |||
| NL126365C (da) * | 1963-06-24 | |||
| HU164637B (da) * | 1970-02-02 | 1974-03-28 | ||
| US3663175A (en) * | 1970-10-05 | 1972-05-16 | Bio Dynamics Inc | Method of determining hemoglobin in blood |
| US3718431A (en) * | 1971-02-01 | 1973-02-27 | J Wild | Method of stool sample collection and testing apparatus therefor |
| US3874852A (en) * | 1974-07-05 | 1975-04-01 | Coulter Diagnostics Inc | Reagent and method for determining leukocytes and hemoglobin in the blood |
| CS175782B1 (da) * | 1974-10-16 | 1977-05-31 | ||
| US3936373A (en) * | 1974-11-19 | 1976-02-03 | Arnold David Studer | Fecal examination device |
| US3964865A (en) * | 1975-01-30 | 1976-06-22 | Sigma Chemical Company | Lyophilized human hemoglobin standard for colorimetric determination of total hemoglobin |
| US4005984A (en) * | 1975-05-16 | 1977-02-01 | Reese Fell Alsop | Diagnostic composition and method of using the same |
| US4035150A (en) * | 1975-09-24 | 1977-07-12 | The United States Of America As Represented By The Secretary Of The Department Of Health, Education And Welfare | Test for occult blood in an emulsified aqueous/organic system |
| JPS5263794A (en) * | 1975-11-21 | 1977-05-26 | Shionogi Seiyaku Kk | Test piece for latent blood |
| FI52256C (fi) * | 1975-12-08 | 1977-07-11 | Osmo Antero Suovaniemi | Laite näytteiden ottamista varten näytteiden kuljettamiseksi ja analys oimiseksi. |
| DE2716061C2 (de) * | 1977-04-09 | 1982-03-25 | Boehringer Mannheim Gmbh, 6800 Mannheim | Guajaconsäure A, Verfahren zu ihrer Herstellung und die Verwendung dieser Substanz als diagnostische Mittel |
| DE2729924C2 (de) * | 1977-07-02 | 1985-06-05 | Boehringer Mannheim Gmbh, 6800 Mannheim | Vorrichtung zur Dosierung von Stuhlmengen auf Reagenzpapieren |
| US4175923A (en) * | 1978-06-26 | 1979-11-27 | Friend William G | Method and apparatus for occult blood testing in the home |
| US4378971A (en) * | 1980-09-24 | 1983-04-05 | Regents Of The University Of Minnesota | Method and apparatus for quantitatively determining the level of hemoglobin in a biological sample |
| US4567148A (en) * | 1980-09-24 | 1986-01-28 | Regents Of The University Of Minnesota | Method for quantitatively determining the amount of hemoglobin in a biological sample |
-
1983
- 1983-03-31 US US06/480,871 patent/US4526869A/en not_active Expired - Lifetime
-
1984
- 1984-03-20 ZA ZA842076A patent/ZA842076B/xx unknown
- 1984-03-20 EP EP84103065A patent/EP0123868A3/en not_active Withdrawn
- 1984-03-21 FI FI841145A patent/FI841145A/fi not_active Application Discontinuation
- 1984-03-26 NZ NZ207634A patent/NZ207634A/en unknown
- 1984-03-28 NO NO841234A patent/NO841234L/no unknown
- 1984-03-30 AU AU26350/84A patent/AU2635084A/en not_active Abandoned
- 1984-03-30 CA CA000450920A patent/CA1219794A/en not_active Expired
- 1984-03-30 DK DK173884A patent/DK173884A/da active IP Right Grant
- 1984-03-31 JP JP59065031A patent/JPS6089756A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| AU2635084A (en) | 1984-10-04 |
| FI841145A (fi) | 1984-10-01 |
| NZ207634A (en) | 1987-04-30 |
| US4526869A (en) | 1985-07-02 |
| ZA842076B (en) | 1985-11-27 |
| EP0123868A2 (en) | 1984-11-07 |
| JPS6089756A (ja) | 1985-05-20 |
| FI841145A0 (fi) | 1984-03-21 |
| DK173884A (da) | 1984-10-01 |
| EP0123868A3 (en) | 1988-01-20 |
| DK173884D0 (da) | 1984-03-30 |
| CA1219794A (en) | 1987-03-31 |
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