NO810870L - Fremgangsmaate til fremstilling av pyrimidylkinazoliner - Google Patents

Fremgangsmaate til fremstilling av pyrimidylkinazoliner

Info

Publication number: NO810870L
Authority: NO; Norway
Prior art keywords: formula; compound; acid; atoms; amino
Prior art date: 1980-03-27

Application number

NO810870A

Other languages

English (en)

Norwegian (no)

Inventor

Heinz Bender

Thomas Raabe

Helmut Bohn

Piero Martorana

Original Assignee

Cassella Farbwerke Mainkur Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1980-03-27

Filing date

1981-03-13

Publication date

1981-09-28

1981-03-13 Application filed by Cassella Farbwerke Mainkur Ag filed Critical Cassella Farbwerke Mainkur Ag

1981-09-28 Publication of NO810870L publication Critical patent/NO810870L/no

Links

238000000034 method Methods 0.000 title claims description 12
238000002360 preparation method Methods 0.000 title claims description 11
150000001875 compounds Chemical class 0.000 claims description 31
239000002253 acid Substances 0.000 claims description 19
238000006243 chemical reaction Methods 0.000 claims description 19
125000004432 carbon atom Chemical group C* 0.000 claims description 12
125000000217 alkyl group Chemical group 0.000 claims description 10
239000011230 binding agent Substances 0.000 claims description 9
239000002270 dispersing agent Substances 0.000 claims description 9
229910052739 hydrogen Inorganic materials 0.000 claims description 9
239000001257 hydrogen Substances 0.000 claims description 9
150000003839 salts Chemical class 0.000 claims description 9
125000004435 hydrogen atom Chemical class [H]* 0.000 claims description 8
-1 nitro, amino Chemical group 0.000 claims description 8
239000000460 chlorine Substances 0.000 claims description 7
239000002904 solvent Substances 0.000 claims description 7
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WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims description 6
GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Chemical group BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims description 6
229910052794 bromium Chemical group 0.000 claims description 6
229910052801 chlorine Inorganic materials 0.000 claims description 6
ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims description 5
125000003342 alkenyl group Chemical group 0.000 claims description 5
125000005843 halogen group Chemical group 0.000 claims description 5
LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims description 5
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125000001424 substituent group Chemical group 0.000 claims description 3
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FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 1
125000000738 acetamido group Chemical group [H]C([H])([H])C(=O)N([H])[*] 0.000 description 1
230000002378 acidificating effect Effects 0.000 description 1
239000004480 active ingredient Substances 0.000 description 1
230000010933 acylation Effects 0.000 description 1
238000005917 acylation reaction Methods 0.000 description 1
239000001361 adipic acid Substances 0.000 description 1
235000011037 adipic acid Nutrition 0.000 description 1
239000000443 aerosol Substances 0.000 description 1
150000001298 alcohols Chemical class 0.000 description 1
125000004448 alkyl carbonyl group Chemical group 0.000 description 1
239000002160 alpha blocker Substances 0.000 description 1
BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 description 1
229910000147 aluminium phosphate Inorganic materials 0.000 description 1
229960003153 aprobarbital Drugs 0.000 description 1
UORJNBVJVRLXMQ-UHFFFAOYSA-N aprobarbital Chemical compound C=CCC1(C(C)C)C(=O)NC(=O)NC1=O UORJNBVJVRLXMQ-UHFFFAOYSA-N 0.000 description 1
239000008346 aqueous phase Substances 0.000 description 1
239000007864 aqueous solution Substances 0.000 description 1
235000010323 ascorbic acid Nutrition 0.000 description 1
239000011668 ascorbic acid Substances 0.000 description 1
229960005070 ascorbic acid Drugs 0.000 description 1
229940049706 benzodiazepine Drugs 0.000 description 1
235000010233 benzoic acid Nutrition 0.000 description 1
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125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 description 1
230000015572 biosynthetic process Effects 0.000 description 1
238000005422 blasting Methods 0.000 description 1
239000008280 blood Substances 0.000 description 1
210000004369 blood Anatomy 0.000 description 1
230000036772 blood pressure Effects 0.000 description 1
230000004531 blood pressure lowering effect Effects 0.000 description 1
230000037396 body weight Effects 0.000 description 1
230000031709 bromination Effects 0.000 description 1
238000005893 bromination reaction Methods 0.000 description 1
125000001246 bromo group Chemical group Br* 0.000 description 1
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239000000168 bronchodilator agent Substances 0.000 description 1
KDYFGRWQOYBRFD-NUQCWPJISA-N butanedioic acid Chemical compound O[14C](=O)CC[14C](O)=O KDYFGRWQOYBRFD-NUQCWPJISA-N 0.000 description 1
239000002775 capsule Substances 0.000 description 1
BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical compound OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 description 1
230000000747 cardiac effect Effects 0.000 description 1
210000001715 carotid artery Anatomy 0.000 description 1
239000000969 carrier Substances 0.000 description 1
239000003054 catalyst Substances 0.000 description 1
210000003169 central nervous system Anatomy 0.000 description 1
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ANTSCNMPPGJYLG-UHFFFAOYSA-N chlordiazepoxide Chemical compound O=N=1CC(NC)=NC2=CC=C(Cl)C=C2C=1C1=CC=CC=C1 ANTSCNMPPGJYLG-UHFFFAOYSA-N 0.000 description 1
ZPEIMTDSQAKGNT-UHFFFAOYSA-N chlorpromazine Chemical compound C1=C(Cl)C=C2N(CCCN(C)C)C3=CC=CC=C3SC2=C1 ZPEIMTDSQAKGNT-UHFFFAOYSA-N 0.000 description 1
229960001076 chlorpromazine Drugs 0.000 description 1
239000003245 coal Substances 0.000 description 1
230000000052 comparative effect Effects 0.000 description 1
125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 description 1
125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 description 1
229960003529 diazepam Drugs 0.000 description 1
AAOVKJBEBIDNHE-UHFFFAOYSA-N diazepam Chemical compound N=1CC(=O)N(C)C2=CC=C(Cl)C=C2C=1C1=CC=CC=C1 AAOVKJBEBIDNHE-UHFFFAOYSA-N 0.000 description 1
238000009826 distribution Methods 0.000 description 1
239000002934 diuretic Substances 0.000 description 1
229940030606 diuretics Drugs 0.000 description 1
239000003937 drug carrier Substances 0.000 description 1
230000000694 effects Effects 0.000 description 1
239000000839 emulsion Substances 0.000 description 1
150000002170 ethers Chemical class 0.000 description 1
235000019439 ethyl acetate Nutrition 0.000 description 1
238000001704 evaporation Methods 0.000 description 1
230000008020 evaporation Effects 0.000 description 1
238000002474 experimental method Methods 0.000 description 1
239000000706 filtrate Substances 0.000 description 1
229910052731 fluorine Inorganic materials 0.000 description 1
239000011737 fluorine Substances 0.000 description 1
238000011010 flushing procedure Methods 0.000 description 1
VGGRCVDNFAQIKO-UHFFFAOYSA-N formic anhydride Chemical compound O=COC=O VGGRCVDNFAQIKO-UHFFFAOYSA-N 0.000 description 1
238000009472 formulation Methods 0.000 description 1
239000001530 fumaric acid Substances 0.000 description 1
ZZUFCTLCJUWOSV-UHFFFAOYSA-N furosemide Chemical compound C1=C(Cl)C(S(=O)(=O)N)=CC(C(O)=O)=C1NCC1=CC=CO1 ZZUFCTLCJUWOSV-UHFFFAOYSA-N 0.000 description 1
229960003883 furosemide Drugs 0.000 description 1
229920000159 gelatin Polymers 0.000 description 1
235000019322 gelatine Nutrition 0.000 description 1
235000011852 gelatine desserts Nutrition 0.000 description 1
239000000174 gluconic acid Substances 0.000 description 1
235000012208 gluconic acid Nutrition 0.000 description 1
229940093915 gynecological organic acid Drugs 0.000 description 1
IXCSERBJSXMMFS-UHFFFAOYSA-N hydrogen chloride Substances Cl.Cl IXCSERBJSXMMFS-UHFFFAOYSA-N 0.000 description 1
229910000041 hydrogen chloride Inorganic materials 0.000 description 1
238000001802 infusion Methods 0.000 description 1
238000011835 investigation Methods 0.000 description 1
229910052740 iodine Inorganic materials 0.000 description 1
125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 description 1
229960001317 isoprenaline Drugs 0.000 description 1
125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
239000004310 lactic acid Substances 0.000 description 1
235000014655 lactic acid Nutrition 0.000 description 1
235000019359 magnesium stearate Nutrition 0.000 description 1
229910052943 magnesium sulfate Inorganic materials 0.000 description 1
235000019341 magnesium sulphate Nutrition 0.000 description 1
239000011976 maleic acid Substances 0.000 description 1
239000001630 malic acid Substances 0.000 description 1
235000011090 malic acid Nutrition 0.000 description 1
238000005259 measurement Methods 0.000 description 1
229960004815 meprobamate Drugs 0.000 description 1
LMOINURANNBYCM-UHFFFAOYSA-N metaproterenol Chemical compound CC(C)NCC(O)C1=CC(O)=CC(O)=C1 LMOINURANNBYCM-UHFFFAOYSA-N 0.000 description 1
125000005394 methallyl group Chemical group 0.000 description 1
229940098779 methanesulfonic acid Drugs 0.000 description 1
150000007522 mineralic acids Chemical class 0.000 description 1
LNOPIUAQISRISI-UHFFFAOYSA-N n'-hydroxy-2-propan-2-ylsulfonylethanimidamide Chemical compound CC(C)S(=O)(=O)CC(N)=NO LNOPIUAQISRISI-UHFFFAOYSA-N 0.000 description 1
AYOOGWWGECJQPI-NSHDSACASA-N n-[(1s)-1-(5-fluoropyrimidin-2-yl)ethyl]-3-(3-propan-2-yloxy-1h-pyrazol-5-yl)imidazo[4,5-b]pyridin-5-amine Chemical compound N1C(OC(C)C)=CC(N2C3=NC(N[C@@H](C)C=4N=CC(F)=CN=4)=CC=C3N=C2)=N1 AYOOGWWGECJQPI-NSHDSACASA-N 0.000 description 1
125000001280 n-hexyl group Chemical group C(CCCCC)* 0.000 description 1
125000000740 n-pentyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
YZMHQCWXYHARLS-UHFFFAOYSA-N naphthalene-1,2-disulfonic acid Chemical compound C1=CC=CC2=C(S(O)(=O)=O)C(S(=O)(=O)O)=CC=C21 YZMHQCWXYHARLS-UHFFFAOYSA-N 0.000 description 1
238000006396 nitration reaction Methods 0.000 description 1
XULSCZPZVQIMFM-IPZQJPLYSA-N odevixibat Chemical compound C12=CC(SC)=C(OCC(=O)N[C@@H](C(=O)N[C@@H](CC)C(O)=O)C=3C=CC(O)=CC=3)C=C2S(=O)(=O)NC(CCCC)(CCCC)CN1C1=CC=CC=C1 XULSCZPZVQIMFM-IPZQJPLYSA-N 0.000 description 1
239000003921 oil Substances 0.000 description 1
235000019198 oils Nutrition 0.000 description 1
229960002657 orciprenaline Drugs 0.000 description 1
150000007524 organic acids Chemical class 0.000 description 1
235000005985 organic acids Nutrition 0.000 description 1
239000012074 organic phase Substances 0.000 description 1
235000006408 oxalic acid Nutrition 0.000 description 1
FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 1
BRBAEHHXGZRCBK-UHFFFAOYSA-N pentrinitrol Chemical compound [O-][N+](=O)OCC(CO)(CO[N+]([O-])=O)CO[N+]([O-])=O BRBAEHHXGZRCBK-UHFFFAOYSA-N 0.000 description 1
229950006286 pentrinitrol Drugs 0.000 description 1
UXCDUFKZSUBXGM-UHFFFAOYSA-N phosphoric tribromide Chemical compound BrP(Br)(Br)=O UXCDUFKZSUBXGM-UHFFFAOYSA-N 0.000 description 1
239000006187 pill Substances 0.000 description 1
IUGYQRQAERSCNH-UHFFFAOYSA-N pivalic acid Chemical compound CC(C)(C)C(O)=O IUGYQRQAERSCNH-UHFFFAOYSA-N 0.000 description 1
239000000843 powder Substances 0.000 description 1
239000003755 preservative agent Substances 0.000 description 1
230000002335 preservative effect Effects 0.000 description 1
235000019260 propionic acid Nutrition 0.000 description 1
AQHHHDLHHXJYJD-UHFFFAOYSA-N propranolol Chemical compound C1=CC=C2C(OCC(O)CNC(C)C)=CC=CC2=C1 AQHHHDLHHXJYJD-UHFFFAOYSA-N 0.000 description 1
150000003230 pyrimidines Chemical class 0.000 description 1
125000000714 pyrimidinyl group Chemical group 0.000 description 1
JWVCLYRUEFBMGU-UHFFFAOYSA-N quinazoline Chemical compound N1=CN=CC2=CC=CC=C21 JWVCLYRUEFBMGU-UHFFFAOYSA-N 0.000 description 1
150000003246 quinazolines Chemical class 0.000 description 1
IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 description 1
238000010992 reflux Methods 0.000 description 1
230000029058 respiratory gaseous exchange Effects 0.000 description 1
229960004889 salicylic acid Drugs 0.000 description 1
125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
229940125723 sedative agent Drugs 0.000 description 1
239000000932 sedative agent Substances 0.000 description 1
230000002269 spontaneous effect Effects 0.000 description 1
239000008107 starch Substances 0.000 description 1
235000019698 starch Nutrition 0.000 description 1
229940127230 sympathomimetic drug Drugs 0.000 description 1
239000011975 tartaric acid Substances 0.000 description 1
235000002906 tartaric acid Nutrition 0.000 description 1
125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
235000015961 tonic Nutrition 0.000 description 1
230000001256 tonic effect Effects 0.000 description 1
229960000716 tonics Drugs 0.000 description 1
210000003437 trachea Anatomy 0.000 description 1
VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
229940099259 vaseline Drugs 0.000 description 1
229940124549 vasodilator Drugs 0.000 description 1
239000003071 vasodilator agent Substances 0.000 description 1
235000015112 vegetable and seed oil Nutrition 0.000 description 1
239000008158 vegetable oil Substances 0.000 description 1
210000003462 vein Anatomy 0.000 description 1
238000009423 ventilation Methods 0.000 description 1
210000002385 vertebral artery Anatomy 0.000 description 1
239000000080 wetting agent Substances 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Hospice & Palliative Care (AREA)
Diabetes (AREA)
Hematology (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Pretreatment Of Seeds And Plants (AREA)
Catching Or Destruction (AREA)
Solid-Sorbent Or Filter-Aiding Compositions (AREA)

NO810870A 1980-03-27 1981-03-13 Fremgangsmaate til fremstilling av pyrimidylkinazoliner NO810870L (no)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE19803011809 DE3011809A1 (de)	1980-03-27	1980-03-27	Pyrimidyl-chinazoline, verfahren zu ihrer herstellung, sie enthaltende pharmazeutische praeparate und ihre verwendung

Publications (1)

Publication Number	Publication Date
NO810870L true NO810870L (no)	1981-09-28

Family

ID=6098481

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO810870A NO810870L (no)	1980-03-27	1981-03-13	Fremgangsmaate til fremstilling av pyrimidylkinazoliner

Country Status (18)

Country	Link
EP (1)	EP0037495A1 (de)
JP (1)	JPS56150088A (de)
AR (1)	AR227542A1 (de)
AU (1)	AU6877481A (de)
CA (1)	CA1156656A (de)
CS (1)	CS219898B2 (de)
DD (1)	DD157614A5 (de)
DE (1)	DE3011809A1 (de)
DK (1)	DK115581A (de)
ES (1)	ES8202000A1 (de)
FI (1)	FI810778L (de)
GR (1)	GR71870B (de)
IL (1)	IL62495A0 (de)
NO (1)	NO810870L (de)
PL (2)	PL230320A1 (de)
PT (1)	PT72724B (de)
SU (1)	SU1052158A3 (de)
ZA (1)	ZA812034B (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS61140568A (ja) *	1984-12-14	1986-06-27	Mitsui Petrochem Ind Ltd	キナゾリン誘導体及びそれを有効成分とする血圧降下剤
JPS6267077A (ja) *	1985-09-18	1987-03-26	Mitsui Petrochem Ind Ltd	キナゾリン誘導体及び医薬
UA85871C2 (uk) *	2004-03-15	2009-03-10	Такеда Фармасьютікал Компані Лімітед	Інгібітори дипептидилпептидази
PT1778236E (pt)	2004-07-02	2010-10-19	Corcept Therapeutics Inc	Moduladores do receptor de glucocorticóide de pirimidina modificada
JP6039587B2 (ja)	2011-03-18	2016-12-07	コーセプトセラピューティクス，インコーポレイテッド	ピリミジンシクロヘキシルグルココルチコイドレセプター調節因子
WO2019236487A1 (en)	2018-06-04	2019-12-12	Corcept Therapeutics Incorporated	Pyrimidine cyclohexenyl glucocorticoid receptor modulators
US11903945B2 (en)	2019-12-11	2024-02-20	Corcept Therapeutics Incorporated	Methods of treating antipsychotic-induced weight gain with miricorilant
JP2023524780A (ja)	2020-05-06	2023-06-13	コーセプトセラピューティクス，インコーポレイテッド	ピリミジンシクロヘキシルグルココルチコイド受容体モジュレーターの多形
CN116848092A (zh)	2020-12-21	2023-10-03	科赛普特治疗公司	制备嘧啶环己基糖皮质激素受体调节剂的方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB2007656B (en) *	1977-11-05	1982-05-19	Pfizer Ltd	Therapeutic agents

1980
- 1980-03-27 DE DE19803011809 patent/DE3011809A1/de not_active Withdrawn
- 1980-12-15 GR GR64485A patent/GR71870B/el unknown
1981
- 1981-03-13 NO NO810870A patent/NO810870L/no unknown
- 1981-03-13 DK DK115581A patent/DK115581A/da not_active Application Discontinuation
- 1981-03-13 FI FI810778A patent/FI810778L/fi not_active Application Discontinuation
- 1981-03-20 EP EP81102088A patent/EP0037495A1/de not_active Ceased
- 1981-03-24 PT PT72724A patent/PT72724B/de unknown
- 1981-03-25 PL PL23032081A patent/PL230320A1/xx unknown
- 1981-03-25 DD DD81228589A patent/DD157614A5/de unknown
- 1981-03-25 JP JP4257181A patent/JPS56150088A/ja active Pending
- 1981-03-25 CS CS812182A patent/CS219898B2/cs unknown
- 1981-03-25 SU SU813261941A patent/SU1052158A3/ru active
- 1981-03-25 PL PL23388281A patent/PL233882A1/xx unknown
- 1981-03-26 AU AU68774/81A patent/AU6877481A/en not_active Abandoned
- 1981-03-26 AR AR284752A patent/AR227542A1/es active
- 1981-03-26 IL IL62495A patent/IL62495A0/xx unknown
- 1981-03-26 CA CA000373945A patent/CA1156656A/en not_active Expired
- 1981-03-26 ES ES500738A patent/ES8202000A1/es not_active Expired
- 1981-03-26 ZA ZA00812034A patent/ZA812034B/xx unknown

Also Published As

Publication number	Publication date
PT72724B (de)	1982-03-24
ZA812034B (en)	1982-05-26
CA1156656A (en)	1983-11-08
ES500738A0 (es)	1982-01-16
GR71870B (de)	1983-07-08
PL233882A1 (de)	1982-05-10
JPS56150088A (en)	1981-11-20
PL230320A1 (de)	1982-03-29
CS219898B2 (en)	1983-03-25
PT72724A (de)	1981-04-01
IL62495A0 (en)	1981-05-20
SU1052158A3 (ru)	1983-10-30
FI810778L (fi)	1981-09-28
DD157614A5 (de)	1982-11-24
AU6877481A (en)	1981-10-01
AR227542A1 (es)	1982-11-15
ES8202000A1 (es)	1982-01-16
DE3011809A1 (de)	1981-10-01
EP0037495A1 (de)	1981-10-14
DK115581A (da)	1981-09-28

Publication	Publication Date	Title
KR100446877B1 (ko)	2004-11-06	알파1아드레날린수용체길항물질로서의피리미딘디온,피리미딘트리온,트리아진디온,테트라히드로퀴나졸린디온유도체
DE2912105C2 (de)	1985-08-29	Neue carbostyrilderivate, verfahren zu deren herstellung und diese enthaltende mittel
FI88504C (fi)	1993-05-25	Foerfarande foer framstaellning av terapeutiskt anvaendbara 4-benzyl-1-(2H)-ftalazinonderivat
DE69208263T2 (de)	1996-07-18	Substituierte aminopyrimidine als angiotensin ii antagonisten
US4746664A (en)	1988-05-24	Substituted-3,4-dihydro-4-(2,4,6-trimethoxyphenylimino)-2(1H)-pyrimidones useful as cardiotonic, antihypertensive, cerebrovascular vasodilator and anti-platelet agent
EP0168262A2 (de)	1986-01-15	Pyrimidinderivate, Verfahren zu deren Herstellung und deren Verwendung
NO115800B (de)	1968-12-09
NO822643L (no)	1983-02-21	Fremgangsmaate til fremstilling av nye piperazinoner og deres anvendelse.
CA1265796A (en)	1990-02-13	Dihydropyridine anti-ischaemic and antihypertensive agents
JPH0351706B2 (de)	1991-08-07
HU200337B (en)	1990-05-28	Process for producing substituted 6-phenyldihydro-3/2h/-pyridazinone derivatives and pharmaceutical compositions comprising such compounds
NO810870L (no)	1981-09-28	Fremgangsmaate til fremstilling av pyrimidylkinazoliner
JPS6354714B2 (de)	1988-10-28
NL194966C (nl)	2003-09-02	3(2H)-Pyridazinonderivaten en werkwijze voor de bereiding ervan; farmaceutische samenstelling.
JPH0466B2 (de)	1992-01-06
HU186975B (en)	1985-10-28	Process for preparing new triazolo-quinazolone derivatives
EP0145019B1 (de)	1990-11-07	Pyridazinon-Derivate und deren Salze
US4841051A (en)	1989-06-20	Phenylpiperazine derivatives
HU195786B (en)	1988-07-28	Process for producing 5-substituted-6-aminopyrimidine-derivatives and pharmaceutical preparations containing same
JPS63208580A (ja)	1988-08-30	Ｎ置換３，４−ジヒドロピリミジン誘導体および循環器系疾患治療剤
JP4472337B2 (ja)	2010-06-02	アルキルアミノピリダジノン誘導体、この調製方法、およびこれを含む医薬組成物
US4847251A (en)	1989-07-11	Pyridazinone derivatives, and pharmaceutical compositions containing them
EP0220735B1 (de)	1993-05-19	3(2H)-Pyridazinonderivate, Verfahren und Zwischenprodukte zu deren Herstellung und diese und/oder andere 3(2H)-Pyridazinonderivate enthaltende Heilmittel
HUT76266A (en)	1997-07-28	New piperazinyl-alkylthio-pyrimidine derivatives, pharmaceutical compositions containing them, and process for producing the active components
JPH0546340B2 (de)	1993-07-13