NO781039L - Immunologisk testreagens samt fremgangsmaate til dens fremstilling - Google Patents

Immunologisk testreagens samt fremgangsmaate til dens fremstilling

Info

Publication number: NO781039L
Authority: NO; Norway
Prior art keywords: latex; carbodiimide; formula; polymer; reagent
Prior art date: 1977-03-25

Application number

NO781039A

Other languages

English (en)

Norwegian (no)

Inventor

Rudolph Reckel

Johanne Harris

Original Assignee

Ortho Diagnostics

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1977-03-25

Filing date

1978-03-22

Publication date

1978-09-26

1978-03-22 Application filed by Ortho Diagnostics filed Critical Ortho Diagnostics

1978-09-26 Publication of NO781039L publication Critical patent/NO781039L/no

Links

230000001900 immune effect Effects 0.000 title claims description 30
239000003153 chemical reaction reagent Substances 0.000 title claims description 24
238000000034 method Methods 0.000 title claims description 24
238000002360 preparation method Methods 0.000 title claims description 7
238000012360 testing method Methods 0.000 title claims description 6
239000004816 latex Substances 0.000 claims description 73
229920000126 latex Polymers 0.000 claims description 73
239000002245 particle Substances 0.000 claims description 52
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 33
229920000642 polymer Polymers 0.000 claims description 22
150000004985 diamines Chemical class 0.000 claims description 19
125000003277 amino group Chemical group 0.000 claims description 18
150000001718 carbodiimides Chemical class 0.000 claims description 16
239000000126 substance Substances 0.000 claims description 13
102000011022 Chorionic Gonadotropin Human genes 0.000 claims description 12
108010062540 Chorionic Gonadotropin Proteins 0.000 claims description 12
SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical compound O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 claims description 12
102000006771 Gonadotropins Human genes 0.000 claims description 12
108010086677 Gonadotropins Proteins 0.000 claims description 12
239000002622 gonadotropin Substances 0.000 claims description 12
239000000203 mixture Substances 0.000 claims description 12
125000004432 carbon atom Chemical group C* 0.000 claims description 10
-1 carbodiimide compound Chemical class 0.000 claims description 9
ZNZYKNKBJPZETN-WELNAUFTSA-N Dialdehyde 11678 Chemical compound N1C2=CC=CC=C2C2=C1[C@H](C[C@H](/C(=C/O)C(=O)OC)[C@@H](C=C)C=O)NCC2 ZNZYKNKBJPZETN-WELNAUFTSA-N 0.000 claims description 8
229940084986 human chorionic gonadotropin Drugs 0.000 claims description 8
125000002947 alkylene group Chemical group 0.000 claims description 7
LMDZBCPBFSXMTL-UHFFFAOYSA-N 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide Chemical compound CCN=C=NCCCN(C)C LMDZBCPBFSXMTL-UHFFFAOYSA-N 0.000 claims description 5
239000012736 aqueous medium Substances 0.000 claims description 5
229940015047 chorionic gonadotropin Drugs 0.000 claims description 4
238000009833 condensation Methods 0.000 claims description 4
230000005494 condensation Effects 0.000 claims description 4
239000007859 condensation product Substances 0.000 claims description 4
239000002861 polymer material Substances 0.000 claims description 4
FPQQSJJWHUJYPU-UHFFFAOYSA-N 3-(dimethylamino)propyliminomethylidene-ethylazanium;chloride Chemical compound Cl.CCN=C=NCCCN(C)C FPQQSJJWHUJYPU-UHFFFAOYSA-N 0.000 claims description 3
150000001412 amines Chemical group 0.000 claims description 3
239000003795 chemical substances by application Substances 0.000 claims description 3
230000008569 process Effects 0.000 claims description 3
229920003176 water-insoluble polymer Polymers 0.000 claims description 3
239000002253 acid Substances 0.000 claims description 2
125000000217 alkyl group Chemical group 0.000 claims description 2
125000000753 cycloalkyl group Chemical group 0.000 claims description 2
125000004805 propylene group Chemical group [H]C([H])([H])C([H])([*:1])C([H])([H])[*:2] 0.000 claims description 2
150000003839 salts Chemical class 0.000 claims description 2
NAQMVNRVTILPCV-UHFFFAOYSA-N hexane-1,6-diamine Chemical compound NCCCCCCN NAQMVNRVTILPCV-UHFFFAOYSA-N 0.000 claims 4
OTBHHUPVCYLGQO-UHFFFAOYSA-N bis(3-aminopropyl)amine Chemical group NCCCNCCCN OTBHHUPVCYLGQO-UHFFFAOYSA-N 0.000 claims 2
125000002843 carboxylic acid group Chemical group 0.000 claims 2
150000001875 compounds Chemical class 0.000 claims 2
XNPOFXIBHOVFFH-UHFFFAOYSA-N N-cyclohexyl-N'-(2-(4-morpholinyl)ethyl)carbodiimide Chemical compound C1CCCCC1N=C=NCCN1CCOCC1 XNPOFXIBHOVFFH-UHFFFAOYSA-N 0.000 claims 1
PPBRXRYQALVLMV-UHFFFAOYSA-N Styrene Chemical compound C=CC1=CC=CC=C1 PPBRXRYQALVLMV-UHFFFAOYSA-N 0.000 claims 1
229920002587 poly(1,3-butadiene) polymer Polymers 0.000 claims 1
QQONPFPTGQHPMA-UHFFFAOYSA-N propylene Natural products CC=C QQONPFPTGQHPMA-UHFFFAOYSA-N 0.000 claims 1
238000006243 chemical reaction Methods 0.000 description 39
RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 description 30
239000000872 buffer Substances 0.000 description 24
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 20
239000000427 antigen Substances 0.000 description 18
102000036639 antigens Human genes 0.000 description 18
108091007433 antigens Proteins 0.000 description 18
239000000463 material Substances 0.000 description 14
102000004169 proteins and genes Human genes 0.000 description 10
108090000623 proteins and genes Proteins 0.000 description 10
239000011780 sodium chloride Substances 0.000 description 10
239000007787 solid Substances 0.000 description 8
BTBUEUYNUDRHOZ-UHFFFAOYSA-N Borate Chemical compound [O-]B([O-])[O-] BTBUEUYNUDRHOZ-UHFFFAOYSA-N 0.000 description 7
229940088597 hormone Drugs 0.000 description 7
239000005556 hormone Substances 0.000 description 7
239000002174 Styrene-butadiene Substances 0.000 description 6
MTAZNLWOLGHBHU-UHFFFAOYSA-N butadiene-styrene rubber Chemical compound C=CC=C.C=CC1=CC=CC=C1 MTAZNLWOLGHBHU-UHFFFAOYSA-N 0.000 description 6
239000000376 reactant Substances 0.000 description 6
239000011541 reaction mixture Substances 0.000 description 6
239000011115 styrene butadiene Substances 0.000 description 6
229920003048 styrene butadiene rubber Polymers 0.000 description 6
150000001299 aldehydes Chemical class 0.000 description 5
239000006227 byproduct Substances 0.000 description 5
238000004132 cross linking Methods 0.000 description 5
230000000984 immunochemical effect Effects 0.000 description 5
238000009597 pregnancy test Methods 0.000 description 5
239000000047 product Substances 0.000 description 5
230000015572 biosynthetic process Effects 0.000 description 4
238000002405 diagnostic procedure Methods 0.000 description 4
239000012530 fluid Substances 0.000 description 4
238000000703 high-speed centrifugation Methods 0.000 description 4
238000004519 manufacturing process Methods 0.000 description 4
239000004793 Polystyrene Substances 0.000 description 3
239000007795 chemical reaction product Substances 0.000 description 3
WEHWNAOGRSTTBQ-UHFFFAOYSA-N dipropylamine Chemical compound CCCNCCC WEHWNAOGRSTTBQ-UHFFFAOYSA-N 0.000 description 3
229920002223 polystyrene Polymers 0.000 description 3
125000006850 spacer group Chemical group 0.000 description 3
239000000725 suspension Substances 0.000 description 3
KAKZBPTYRLMSJV-UHFFFAOYSA-N Butadiene Chemical compound C=CC=C KAKZBPTYRLMSJV-UHFFFAOYSA-N 0.000 description 2
102000003886 Glycoproteins Human genes 0.000 description 2
108090000288 Glycoproteins Proteins 0.000 description 2
230000004520 agglutination Effects 0.000 description 2
150000001408 amides Chemical class 0.000 description 2
239000012876 carrier material Substances 0.000 description 2
239000003054 catalyst Substances 0.000 description 2
229920001577 copolymer Polymers 0.000 description 2
LEQAOMBKQFMDFZ-UHFFFAOYSA-N glyoxal Chemical compound O=CC=O LEQAOMBKQFMDFZ-UHFFFAOYSA-N 0.000 description 2
238000011534 incubation Methods 0.000 description 2
150000002500 ions Chemical class 0.000 description 2
125000005936 piperidyl group Chemical group 0.000 description 2
125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 2
230000000405 serological effect Effects 0.000 description 2
125000000383 tetramethylene group Chemical group [H]C([H])([*:1])C([H])([H])C([H])([H])C([H])([H])[*:2] 0.000 description 2
VXNZUUAINFGPBY-UHFFFAOYSA-N 1-Butene Chemical group CCC=C VXNZUUAINFGPBY-UHFFFAOYSA-N 0.000 description 1
NLHHRLWOUZZQLW-UHFFFAOYSA-N Acrylonitrile Chemical compound C=CC#N NLHHRLWOUZZQLW-UHFFFAOYSA-N 0.000 description 1
102000004506 Blood Proteins Human genes 0.000 description 1
108010017384 Blood Proteins Proteins 0.000 description 1
SNRUBQQJIBEYMU-UHFFFAOYSA-N Dodecane Natural products CCCCCCCCCCCC SNRUBQQJIBEYMU-UHFFFAOYSA-N 0.000 description 1
PIICEJLVQHRZGT-UHFFFAOYSA-N Ethylenediamine Chemical compound NCCN PIICEJLVQHRZGT-UHFFFAOYSA-N 0.000 description 1
108060003951 Immunoglobulin Proteins 0.000 description 1
241001465754 Metazoa Species 0.000 description 1
229920002845 Poly(methacrylic acid) Polymers 0.000 description 1
229920002125 Sokalan® Polymers 0.000 description 1
239000002250 absorbent Substances 0.000 description 1
230000002745 absorbent Effects 0.000 description 1
238000010521 absorption reaction Methods 0.000 description 1
WRVRNZNDLRUXSW-UHFFFAOYSA-N acetic acid;prop-2-enoic acid Chemical compound CC(O)=O.OC(=O)C=C WRVRNZNDLRUXSW-UHFFFAOYSA-N 0.000 description 1
230000002378 acidificating effect Effects 0.000 description 1
XECAHXYUAAWDEL-UHFFFAOYSA-N acrylonitrile butadiene styrene Chemical compound C=CC=C.C=CC#N.C=CC1=CC=CC=C1 XECAHXYUAAWDEL-UHFFFAOYSA-N 0.000 description 1
229920000122 acrylonitrile butadiene styrene Polymers 0.000 description 1
239000004676 acrylonitrile butadiene styrene Substances 0.000 description 1
230000009471 action Effects 0.000 description 1
230000004913 activation Effects 0.000 description 1
238000005054 agglomeration Methods 0.000 description 1
230000002776 aggregation Effects 0.000 description 1
125000003172 aldehyde group Chemical group 0.000 description 1
125000001931 aliphatic group Chemical group 0.000 description 1
125000003282 alkyl amino group Chemical group 0.000 description 1
IYABWNGZIDDRAK-UHFFFAOYSA-N allene Chemical group C=C=C IYABWNGZIDDRAK-UHFFFAOYSA-N 0.000 description 1
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 description 1
230000001588 bifunctional effect Effects 0.000 description 1
230000008275 binding mechanism Effects 0.000 description 1
239000012620 biological material Substances 0.000 description 1
210000001124 body fluid Anatomy 0.000 description 1
239000010839 body fluid Substances 0.000 description 1
210000004027 cell Anatomy 0.000 description 1
238000005119 centrifugation Methods 0.000 description 1
230000008859 change Effects 0.000 description 1
238000006482 condensation reaction Methods 0.000 description 1
238000001816 cooling Methods 0.000 description 1
125000002704 decyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
238000004925 denaturation Methods 0.000 description 1
230000036425 denaturation Effects 0.000 description 1
230000001419 dependent effect Effects 0.000 description 1
238000000502 dialysis Methods 0.000 description 1
108091022884 dihydropyrimidinase Proteins 0.000 description 1
125000004914 dipropylamino group Chemical group C(CC)N(CCC)* 0.000 description 1
239000012153 distilled water Substances 0.000 description 1
125000003438 dodecyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
229940079593 drug Drugs 0.000 description 1
239000003814 drug Substances 0.000 description 1
210000003743 erythrocyte Anatomy 0.000 description 1
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
239000012467 final product Substances 0.000 description 1
238000009472 formulation Methods 0.000 description 1
229940015043 glyoxal Drugs 0.000 description 1
229940094892 gonadotropins Drugs 0.000 description 1
208000006454 hepatitis Diseases 0.000 description 1
231100000283 hepatitis Toxicity 0.000 description 1
125000003187 heptyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
125000004836 hexamethylene group Chemical group [H]C([H])([*:2])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[*:1] 0.000 description 1
230000008105 immune reaction Effects 0.000 description 1
102000018358 immunoglobulin Human genes 0.000 description 1
229940072221 immunoglobulins Drugs 0.000 description 1
239000000677 immunologic agent Substances 0.000 description 1
229940124541 immunological agent Drugs 0.000 description 1
125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 description 1
125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
239000007788 liquid Substances 0.000 description 1
239000002609 medium Substances 0.000 description 1
RTWNYYOXLSILQN-UHFFFAOYSA-N methanediamine Chemical compound NCN RTWNYYOXLSILQN-UHFFFAOYSA-N 0.000 description 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 description 1
125000002757 morpholinyl group Chemical group 0.000 description 1
125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
125000000740 n-pentyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
230000007935 neutral effect Effects 0.000 description 1
229910052757 nitrogen Inorganic materials 0.000 description 1
125000004433 nitrogen atom Chemical group N* 0.000 description 1
125000001400 nonyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
125000002347 octyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
230000000704 physical effect Effects 0.000 description 1
239000004584 polyacrylic acid Substances 0.000 description 1
JUJWROOIHBZHMG-UHFFFAOYSA-N pyridine Substances C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 1
125000004076 pyridyl group Chemical group 0.000 description 1
229920005989 resin Polymers 0.000 description 1
239000011347 resin Substances 0.000 description 1
201000005404 rubella Diseases 0.000 description 1
125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
125000000467 secondary amino group Chemical group [H]N([*:1])[*:2] 0.000 description 1
238000007086 side reaction Methods 0.000 description 1
229910000162 sodium phosphate Inorganic materials 0.000 description 1
239000001488 sodium phosphate Substances 0.000 description 1
239000012265 solid product Substances 0.000 description 1
230000002269 spontaneous effect Effects 0.000 description 1
229920003002 synthetic resin Polymers 0.000 description 1
239000000057 synthetic resin Substances 0.000 description 1
125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
KMZJRCPGGAQHGC-UHFFFAOYSA-N trisodium boric acid borate Chemical compound [Na+].[Na+].[Na+].OB(O)O.[O-]B([O-])[O-] KMZJRCPGGAQHGC-UHFFFAOYSA-N 0.000 description 1
RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
125000002948 undecyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
229920002554 vinyl polymer Polymers 0.000 description 1
230000000007 visual effect Effects 0.000 description 1
238000012800 visualization Methods 0.000 description 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
239000002759 woven fabric Substances 0.000 description 1

Classifications

- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54353—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals with ligand attached to the carrier via a chemical coupling agent
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/806—Antigenic peptides or proteins
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/81—Carrier - bound or immobilized peptides or proteins and the preparation thereof, e.g. biological cell or cell fragment as carrier
- Y10S530/812—Peptides or proteins is immobilized on, or in, an organic carrier
- Y10S530/815—Carrier is a synthetic polymer
- Y10S530/816—Attached to the carrier via a bridging agent

Landscapes

Health & Medical Sciences (AREA)
Immunology (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Molecular Biology (AREA)
Biomedical Technology (AREA)
Chemical & Material Sciences (AREA)
Hematology (AREA)
Urology & Nephrology (AREA)
Food Science & Technology (AREA)
Biochemistry (AREA)
Cell Biology (AREA)
Biotechnology (AREA)
Medicinal Chemistry (AREA)
Physics & Mathematics (AREA)
Analytical Chemistry (AREA)
Microbiology (AREA)
General Health & Medical Sciences (AREA)
General Physics & Mathematics (AREA)
Pathology (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

NO781039A 1977-03-25 1978-03-22 Immunologisk testreagens samt fremgangsmaate til dens fremstilling NO781039L (no)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US05/781,256 US4140662A (en)	1977-03-25	1977-03-25	Attachment of proteins to inert particles

Publications (1)

Publication Number	Publication Date
NO781039L true NO781039L (no)	1978-09-26

Family

ID=25122157

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO781039A NO781039L (no)	1977-03-25	1978-03-22	Immunologisk testreagens samt fremgangsmaate til dens fremstilling

Country Status (19)

Country	Link
US (1)	US4140662A (de)
JP (1)	JPS53118517A (de)
AR (1)	AR217685A1 (de)
AT (1)	AT361636B (de)
AU (1)	AU3431278A (de)
BE (1)	BE865195A (de)
BR (1)	BR7801779A (de)
CA (1)	CA1089764A (de)
DE (1)	DE2812845A1 (de)
DK (1)	DK128078A (de)
ES (1)	ES467190A1 (de)
FR (1)	FR2384789A1 (de)
GB (1)	GB1600434A (de)
IT (1)	IT1111074B (de)
NL (1)	NL7803209A (de)
NO (1)	NO781039L (de)
NZ (1)	NZ186763A (de)
SE (1)	SE7803241L (de)
ZA (1)	ZA781719B (de)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4264766A (en) *	1877-09-19	1981-04-28	Hoffmann-La Roche Inc.	Immunological diagnostic reagents
CH628738A5 (de) *	1977-08-03	1982-03-15	Hoffmann La Roche	Immunologisches diagnose-reagenz.
CA1101330A (en) *	1977-09-19	1981-05-19	Ernst A. Fischer	Immunological material bonded to carboxylated latex polymer and process for making it
GB2013688B (en) *	1978-01-26	1982-06-30	Technicon Instr	Insolubilised proteins and immunoassays utilising them
GB2027031A (en) *	1978-08-02	1980-02-13	Hoffmann La Roche	Diagnostic Reagent Comprising a Proteinaceous Material Bonded to a Latex
DE3069477D1 (en) *	1979-02-16	1984-11-29	Hoffmann La Roche	Immunological diagnostic reagent for pregnancy detection, process for its preparation and its use in pregnancy detection
FR2450877A1 (fr) *	1979-03-06	1980-10-03	Inst Nat Sante Rech Med	Nouveaux tests par agglutination pour la detection des virus de la grippe, et reactifs pour la realisation de ces tests
US4279787A (en) *	1979-07-30	1981-07-21	Tetra Consultants Inc.	Method of binding antigens to insoluble polymeric substances
US4421896A (en) *	1979-11-13	1983-12-20	The Dow Chemical Company	Method of coupling a protein to a polymer particle containing hydrazide groups in a polymer latex and the products formed therefrom
EP0054685B1 (de) *	1980-12-23	1986-07-09	Roche Diagnostics GmbH	Hydrophile Latexpartikel, Verfahren zu deren Herstellung und deren Verwendung
DE3116995A1 (de) *	1981-04-29	1982-11-25	Röhm GmbH, 6100 Darmstadt	Latex zur immobilisierung von biologisch wirksamen substanzen
US6936694B1 (en) *	1982-05-06	2005-08-30	Intermune, Inc.	Manufacture and expression of large structural genes
US4652639A (en) *	1982-05-06	1987-03-24	Amgen	Manufacture and expression of structural genes
US4745075A (en) *	1984-09-06	1988-05-17	Burroughs Wellcome Co.	Diagnostic test methods
US4560504A (en) *	1984-12-06	1985-12-24	Uop Inc.	Carboxyl anchored immobilized antibodies
JPH0697219B2 (ja) *	1985-02-25	1994-11-30	財団法人化学及血清療法研究所	免疫センサー用電極及びその製造方法
DE3664729D1 (en) *	1985-04-09	1989-09-07	Terumo Corp	Immunoglobulin adsorbent and adsorption apparatus
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1978
- 1978-02-02 CA CA296,191A patent/CA1089764A/en not_active Expired
- 1978-02-21 ES ES467190A patent/ES467190A1/es not_active Expired
- 1978-02-21 GB GB6831/78A patent/GB1600434A/en not_active Expired
- 1978-03-20 AU AU34312/78A patent/AU3431278A/en active Pending
- 1978-03-21 SE SE7803241A patent/SE7803241L/xx unknown
- 1978-03-21 DK DK128078A patent/DK128078A/da not_active Application Discontinuation
- 1978-03-22 AR AR271517A patent/AR217685A1/es active
- 1978-03-22 NO NO781039A patent/NO781039L/no unknown
- 1978-03-22 BE BE186186A patent/BE865195A/xx unknown
- 1978-03-22 BR BR7801779A patent/BR7801779A/pt unknown
- 1978-03-22 NZ NZ186763A patent/NZ186763A/xx unknown
- 1978-03-23 NL NL7803209A patent/NL7803209A/xx not_active Application Discontinuation
- 1978-03-23 DE DE2812845A patent/DE2812845A1/de not_active Withdrawn
- 1978-03-23 JP JP3244478A patent/JPS53118517A/ja active Pending
- 1978-03-23 IT IT48583/78A patent/IT1111074B/it active
- 1978-03-23 ZA ZA00781719A patent/ZA781719B/xx unknown
- 1978-03-24 AT AT213578A patent/AT361636B/de not_active IP Right Cessation
- 1978-03-24 FR FR7808756A patent/FR2384789A1/fr active Pending

Also Published As

Publication number	Publication date
CA1089764A (en)	1980-11-18
ES467190A1 (es)	1979-08-01
AT361636B (de)	1981-03-25
AU3431278A (en)	1979-09-27
FR2384789A1 (fr)	1978-10-20
GB1600434A (en)	1981-10-14
ATA213578A (de)	1980-08-15
DE2812845A1 (de)	1978-09-28
US4140662A (en)	1979-02-20
BR7801779A (pt)	1978-12-19
AR217685A1 (es)	1980-04-15
BE865195A (fr)	1978-09-22
IT7848583A0 (it)	1978-03-23
ZA781719B (en)	1979-11-28
DK128078A (da)	1978-09-26
JPS53118517A (en)	1978-10-17
IT1111074B (it)	1986-01-13
NZ186763A (en)	1980-08-26
NL7803209A (nl)	1978-09-27
SE7803241L (sv)	1978-09-26

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JPH02129550A (ja)	1990-05-17	固相指示薬の赤血球およびその調製法
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BONFANTI et al.	1985	DIRECT ENZYME IMMUNOASSAY FOR DETECTION OF SPECIFIC IgG