ES467190A1 - Un procedimiento para la produccion de un reactivo para pruebas inmunologicas. - Google Patents

Un procedimiento para la produccion de un reactivo para pruebas inmunologicas.

Info

Publication number
ES467190A1
ES467190A1 ES467190A ES467190A ES467190A1 ES 467190 A1 ES467190 A1 ES 467190A1 ES 467190 A ES467190 A ES 467190A ES 467190 A ES467190 A ES 467190A ES 467190 A1 ES467190 A1 ES 467190A1
Authority
ES
Spain
Prior art keywords
amino groups
latex
modified
immunological
appropriate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES467190A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ortho Clinical Diagnostics Inc
Original Assignee
Ortho Diagnostic Systems Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ortho Diagnostic Systems Inc filed Critical Ortho Diagnostic Systems Inc
Publication of ES467190A1 publication Critical patent/ES467190A1/es
Expired legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54353—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals with ligand attached to the carrier via a chemical coupling agent
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/806—Antigenic peptides or proteins
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/81—Carrier - bound or immobilized peptides or proteins and the preparation thereof, e.g. biological cell or cell fragment as carrier
    • Y10S530/812—Peptides or proteins is immobilized on, or in, an organic carrier
    • Y10S530/815—Carrier is a synthetic polymer
    • Y10S530/816—Attached to the carrier via a bridging agent

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Un procedimiento en dos etapas para conseguir un enlace covalente entre polímeros de látex y sustancias inmunológicas, la primera de las cuales consiste en hacer reaccionar las partículas de látex poseedoras de un grupo carboxilo reactivo con una diamina, en presencia de una carbodiimida apropiada como agente condensante. El producto resultante, que podemos denominar látex modificado, es una amida que termina en grupos amino primarios o secundarios. Este producto se hace reaccionar después con el reactivo inmunológico apropiado, tal como un antígeno o anticuerpo, modificado si es necesario para que contenga grupos amino, en presencia de un aldehído bifuncional para dar lugar a la condensación de los grupos amino del reactivo inmunológico con los grupos amino del látex modificado mediante un radical enlazante aldehídico intermedio.
ES467190A 1977-03-25 1978-02-21 Un procedimiento para la produccion de un reactivo para pruebas inmunologicas. Expired ES467190A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/781,256 US4140662A (en) 1977-03-25 1977-03-25 Attachment of proteins to inert particles

Publications (1)

Publication Number Publication Date
ES467190A1 true ES467190A1 (es) 1979-08-01

Family

ID=25122157

Family Applications (1)

Application Number Title Priority Date Filing Date
ES467190A Expired ES467190A1 (es) 1977-03-25 1978-02-21 Un procedimiento para la produccion de un reactivo para pruebas inmunologicas.

Country Status (19)

Country Link
US (1) US4140662A (es)
JP (1) JPS53118517A (es)
AR (1) AR217685A1 (es)
AT (1) AT361636B (es)
AU (1) AU3431278A (es)
BE (1) BE865195A (es)
BR (1) BR7801779A (es)
CA (1) CA1089764A (es)
DE (1) DE2812845A1 (es)
DK (1) DK128078A (es)
ES (1) ES467190A1 (es)
FR (1) FR2384789A1 (es)
GB (1) GB1600434A (es)
IT (1) IT1111074B (es)
NL (1) NL7803209A (es)
NO (1) NO781039L (es)
NZ (1) NZ186763A (es)
SE (1) SE7803241L (es)
ZA (1) ZA781719B (es)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4264766A (en) * 1877-09-19 1981-04-28 Hoffmann-La Roche Inc. Immunological diagnostic reagents
CH628738A5 (de) * 1977-08-03 1982-03-15 Hoffmann La Roche Immunologisches diagnose-reagenz.
CA1101330A (en) * 1977-09-19 1981-05-19 Ernst A. Fischer Immunological material bonded to carboxylated latex polymer and process for making it
GB2013688B (en) * 1978-01-26 1982-06-30 Technicon Instr Insolubilised proteins and immunoassays utilising them
GB2027031A (en) * 1978-08-02 1980-02-13 Hoffmann La Roche Diagnostic Reagent Comprising a Proteinaceous Material Bonded to a Latex
DE3069477D1 (en) * 1979-02-16 1984-11-29 Hoffmann La Roche Immunological diagnostic reagent for pregnancy detection, process for its preparation and its use in pregnancy detection
FR2450877A1 (fr) * 1979-03-06 1980-10-03 Inst Nat Sante Rech Med Nouveaux tests par agglutination pour la detection des virus de la grippe, et reactifs pour la realisation de ces tests
US4279787A (en) * 1979-07-30 1981-07-21 Tetra Consultants Inc. Method of binding antigens to insoluble polymeric substances
US4421896A (en) * 1979-11-13 1983-12-20 The Dow Chemical Company Method of coupling a protein to a polymer particle containing hydrazide groups in a polymer latex and the products formed therefrom
EP0054685B1 (de) * 1980-12-23 1986-07-09 Roche Diagnostics GmbH Hydrophile Latexpartikel, Verfahren zu deren Herstellung und deren Verwendung
DE3116995A1 (de) * 1981-04-29 1982-11-25 Röhm GmbH, 6100 Darmstadt Latex zur immobilisierung von biologisch wirksamen substanzen
US6936694B1 (en) * 1982-05-06 2005-08-30 Intermune, Inc. Manufacture and expression of large structural genes
US4652639A (en) * 1982-05-06 1987-03-24 Amgen Manufacture and expression of structural genes
US4745075A (en) * 1984-09-06 1988-05-17 Burroughs Wellcome Co. Diagnostic test methods
US4560504A (en) * 1984-12-06 1985-12-24 Uop Inc. Carboxyl anchored immobilized antibodies
JPH0697219B2 (ja) * 1985-02-25 1994-11-30 財団法人化学及血清療法研究所 免疫センサー用電極及びその製造方法
DE3664729D1 (en) * 1985-04-09 1989-09-07 Terumo Corp Immunoglobulin adsorbent and adsorption apparatus
WO1987007150A1 (en) * 1986-05-30 1987-12-03 The Johns Hopkins University Receptor-targeted drug delivery systems
AU8173387A (en) * 1986-10-10 1988-05-06 Peter Grandics A novel immunoaffinity purification system
US5166077A (en) * 1987-04-30 1992-11-24 Nitto Denko Corporation Latex for immobilization of physiologically active substances for immuno nephelometry
US5132242A (en) * 1987-07-15 1992-07-21 Cheung Sau W Fluorescent microspheres and methods of using them
US5194300A (en) * 1987-07-15 1993-03-16 Cheung Sau W Methods of making fluorescent microspheres
FR2638234B1 (fr) * 1988-10-21 1992-11-27 Rhone Poulenc Chimie Support pour molecules biologiquement actives ou lui-meme biologiquement actif, son procede de preparation et son application en biologie
JPH0750110B2 (ja) * 1988-12-22 1995-05-31 積水化学工業株式会社 免疫測定法
JPH0750111B2 (ja) * 1988-12-22 1995-05-31 積水化学工業株式会社 疎水性物質の固定化用担体およびそれを用いた疎水性物質の固定化方法
US5149737A (en) * 1990-06-18 1992-09-22 Eastman Kodak Company Carboxy containing monomers and polymers and latices prepared from same
US5210289A (en) * 1990-06-18 1993-05-11 Eastman Kodak Company Carboxy containing monomers
US5262297A (en) * 1990-06-18 1993-11-16 Eastman Kodak Company Specific binding analytical and separation methods using carboxy containing polymers
US5147777A (en) * 1990-06-18 1992-09-15 Eastman Kodak Company Biologically active reagents prepared from carboxy-containing polymer, analytical element and methods of use
US5552064A (en) * 1993-02-26 1996-09-03 Ortho Diagnostic Systems, Inc. Column agglutination assay and device using biphasic centrifugation
US5665558A (en) * 1994-05-17 1997-09-09 Gamma Biologicals, Inc. Method and apparatus useful for detecting bloodgroup antigens and antibodies
US5905028A (en) * 1994-05-17 1999-05-18 Gamma Biologicals, Inc. Method and apparatus useful for detecting bloodgroup antigens and antibodies
US5627080A (en) * 1994-07-29 1997-05-06 Beckman Instruments, Inc. Detergent-facilitated immunoassay for the rapid and quantitative assay of pharmacological agents
EP1692090A1 (en) * 2003-09-25 2006-08-23 Solexa Limited Conversion of amine- to carboxyl groups on solid surfaces
FR2874385B1 (fr) * 2004-08-18 2006-12-08 Biopep Sa Procede et dispositif de mesure d'une activite enzymatique dans un fluide biologique
US8475652B2 (en) * 2009-10-19 2013-07-02 Jan A. K. Paul Method for purification of uncatalyzed natural fuels from metal ions by means of at least one hemeprotein and use of the at least on hemeprotein
US8377672B2 (en) * 2010-02-18 2013-02-19 3M Innovative Properties Company Ligand functionalized polymers
WO2017042303A1 (en) * 2015-09-08 2017-03-16 Danmarks Tekniske Universitet Binding of hydrophobic antigens to surfaces
CN111579767A (zh) * 2020-05-28 2020-08-25 吉林基蛋生物科技有限公司 一种羧基微球偶联氨基的方法、致敏胶乳及试剂盒

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE343210B (es) * 1967-12-20 1972-03-06 Pharmacia Ab
US3639558A (en) * 1968-02-19 1972-02-01 Louis Csizmas Immunological reagent particles having proteinaceous materials covalently bonded thereto
US3857931A (en) * 1971-02-01 1974-12-31 Hoffmann La Roche Latex polymer reagents for diagnostic tests
FR2234311B1 (es) * 1973-06-21 1976-04-30 Air Liquide
US4007089A (en) * 1975-04-30 1977-02-08 Nelson Research & Development Company Method for binding biologically active compounds
US4045384A (en) * 1976-07-23 1977-08-30 The Dow Chemical Company Method for forming an amide bond between a latex and protein

Also Published As

Publication number Publication date
CA1089764A (en) 1980-11-18
AT361636B (de) 1981-03-25
AU3431278A (en) 1979-09-27
FR2384789A1 (fr) 1978-10-20
GB1600434A (en) 1981-10-14
ATA213578A (de) 1980-08-15
DE2812845A1 (de) 1978-09-28
US4140662A (en) 1979-02-20
BR7801779A (pt) 1978-12-19
AR217685A1 (es) 1980-04-15
BE865195A (fr) 1978-09-22
IT7848583A0 (it) 1978-03-23
NO781039L (no) 1978-09-26
ZA781719B (en) 1979-11-28
DK128078A (da) 1978-09-26
JPS53118517A (en) 1978-10-17
IT1111074B (it) 1986-01-13
NZ186763A (en) 1980-08-26
NL7803209A (nl) 1978-09-27
SE7803241L (sv) 1978-09-26

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