NO761681L - - Google Patents

Info

Publication number: NO761681L
Authority: NO; Norway
Prior art keywords: compound; formula; rifamycin; hydrogen; hours
Prior art date: 1975-05-15

Application number

NO761681A

Other languages

English (en)

Norwegian (no)

Inventor

L Marsili

V Rossetti

C Pasqualucci

Original Assignee

Archifar Ind Chim Trentino

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1975-05-15

Filing date

1976-05-14

Publication date

1976-11-16

1976-05-14 Application filed by Archifar Ind Chim Trentino filed Critical Archifar Ind Chim Trentino

1976-11-16 Publication of NO761681L publication Critical patent/NO761681L/no

Links

QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims description 24
150000001875 compounds Chemical class 0.000 claims description 16
UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 claims description 9
QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 claims description 7
238000000034 method Methods 0.000 claims description 7
RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 claims description 6
WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 claims description 6
239000001257 hydrogen Substances 0.000 claims description 5
229910052739 hydrogen Inorganic materials 0.000 claims description 5
125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 5
239000011541 reaction mixture Substances 0.000 claims description 5
239000002904 solvent Substances 0.000 claims description 5
XTHFKEDIFFGKHM-UHFFFAOYSA-N Dimethoxyethane Chemical compound COCCOC XTHFKEDIFFGKHM-UHFFFAOYSA-N 0.000 claims description 4
XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims description 4
-1 Rifamycin compound Chemical class 0.000 claims description 4
HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims description 4
238000006243 chemical reaction Methods 0.000 claims description 4
229930189077 Rifamycin Natural products 0.000 claims description 3
229910021529 ammonia Inorganic materials 0.000 claims description 3
239000007795 chemical reaction product Substances 0.000 claims description 3
229960003292 rifamycin Drugs 0.000 claims description 3
YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 claims description 3
239000011701 zinc Substances 0.000 claims description 3
229910052725 zinc Inorganic materials 0.000 claims description 3
150000004945 aromatic hydrocarbons Chemical class 0.000 claims description 2
229910052742 iron Inorganic materials 0.000 claims description 2
238000002360 preparation method Methods 0.000 claims 2
BTVYFIMKUHNOBZ-ZDHWWVNNSA-N Rifamycin S Natural products COC1C=COC2(C)Oc3c(C)c(O)c4C(=O)C(=CC(=O)c4c3C2=O)NC(=O)C(=C/C=C/C(C)C(O)C(C)C(O)C(C)C(OC(=O)C)C1C)C BTVYFIMKUHNOBZ-ZDHWWVNNSA-N 0.000 claims 1
150000002170 ethers Chemical class 0.000 claims 1
238000003756 stirring Methods 0.000 claims 1
HJYYPODYNSCCOU-ODRIEIDWSA-N rifamycin SV Chemical class OC1=C(C(O)=C2C)C3=C(O)C=C1NC(=O)\C(C)=C/C=C/[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@H](C)[C@@H](OC)\C=C\O[C@@]1(C)OC2=C3C1=O HJYYPODYNSCCOU-ODRIEIDWSA-N 0.000 abstract description 4
YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 18
239000000047 product Substances 0.000 description 10
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 7
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 6
SMPJCQGFZSDIHE-GVDHMVJUSA-N [(7S,9E,11S,12R,13S,14R,15R,16R,17S,18S,19E,21Z)-26-amino-2,15,17-trihydroxy-11-methoxy-3,7,12,14,16,18,22-heptamethyl-6,23,27,29-tetraoxo-8,30-dioxa-24-azatetracyclo[23.3.1.14,7.05,28]triaconta-1(28),2,4,9,19,21,25-heptaen-13-yl] acetate Chemical compound O=C1C(C(O)=C2C)=C3C(=O)C(N)=C1NC(=O)\C(C)=C/C=C/[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@H](C)[C@@H](OC)\C=C\O[C@@]1(C)OC2=C3C1=O SMPJCQGFZSDIHE-GVDHMVJUSA-N 0.000 description 6
PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 4
229920006395 saturated elastomer Polymers 0.000 description 4
229910052938 sodium sulfate Inorganic materials 0.000 description 4
235000011152 sodium sulphate Nutrition 0.000 description 4
XNWFRZJHXBZDAG-UHFFFAOYSA-N 2-METHOXYETHANOL Chemical compound COCCO XNWFRZJHXBZDAG-UHFFFAOYSA-N 0.000 description 3
238000001228 spectrum Methods 0.000 description 3
RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
XLYOFNOQVPJJNP-ZSJDYOACSA-N Heavy water Chemical compound [2H]O[2H] XLYOFNOQVPJJNP-ZSJDYOACSA-N 0.000 description 2
VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
238000000862 absorption spectrum Methods 0.000 description 2
BCNLNCHALTVDMC-UHFFFAOYSA-N benzene;methanol;4-methylpentan-2-one Chemical compound OC.C1=CC=CC=C1.CC(C)CC(C)=O BCNLNCHALTVDMC-UHFFFAOYSA-N 0.000 description 2
230000003115 biocidal effect Effects 0.000 description 2
239000000741 silica gel Substances 0.000 description 2
229910002027 silica gel Inorganic materials 0.000 description 2
238000004809 thin layer chromatography Methods 0.000 description 2
241000894006 Bacteria Species 0.000 description 1
KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 1
241000187479 Mycobacterium tuberculosis Species 0.000 description 1
CTQNGGLPUBDAKN-UHFFFAOYSA-N O-Xylene Chemical compound CC1=CC=CC=C1C CTQNGGLPUBDAKN-UHFFFAOYSA-N 0.000 description 1
241000786363 Rhampholeon spectrum Species 0.000 description 1
150000001298 alcohols Chemical class 0.000 description 1
238000004458 analytical method Methods 0.000 description 1
230000000844 anti-bacterial effect Effects 0.000 description 1
239000003638 chemical reducing agent Substances 0.000 description 1
UBHZUDXTHNMNLD-UHFFFAOYSA-N dimethylsilane Chemical compound C[SiH2]C UBHZUDXTHNMNLD-UHFFFAOYSA-N 0.000 description 1
238000001035 drying Methods 0.000 description 1
238000010828 elution Methods 0.000 description 1
150000002148 esters Chemical class 0.000 description 1
239000012044 organic layer Substances 0.000 description 1
239000003960 organic solvent Substances 0.000 description 1
239000003208 petroleum Substances 0.000 description 1
239000000843 powder Substances 0.000 description 1
239000002244 precipitate Substances 0.000 description 1
238000001953 recrystallisation Methods 0.000 description 1
239000011780 sodium chloride Substances 0.000 description 1
239000007858 starting material Substances 0.000 description 1
CZDYPVPMEAXLPK-UHFFFAOYSA-N tetramethylsilane Chemical compound C[Si](C)(C)C CZDYPVPMEAXLPK-UHFFFAOYSA-N 0.000 description 1
239000008096 xylene Substances 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/08—Bridged systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/06—Antibacterial agents for tuberculosis

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Communicable Diseases (AREA)
Veterinary Medicine (AREA)
Oncology (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Pulmonology (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

NO761681A 1975-05-15 1976-05-14 NO761681L (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IT05155/75A IT1048565B (it)	1975-05-15	1975-05-15	Amine aromatiche

Publications (1)

Publication Number	Publication Date
NO761681L true NO761681L (de)	1976-11-16

Family

ID=11118523

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO761681A NO761681L (de)	1975-05-15	1976-05-14

Country Status (24)

Country	Link
US (1)	US4017481A (de)
JP (1)	JPS51141897A (de)
AR (1)	AR211013A1 (de)
AT (1)	AT343808B (de)
BE (1)	BE841548A (de)
CA (1)	CA1057749A (de)
CH (1)	CH622022A5 (de)
DE (1)	DE2620782C2 (de)
DK (1)	DK215676A (de)
ES (1)	ES448421A1 (de)
FI (1)	FI761176A (de)
FR (1)	FR2311018A1 (de)
GB (1)	GB1534075A (de)
HU (1)	HU171395B (de)
IE (1)	IE42980B1 (de)
IL (1)	IL49516A (de)
IN (1)	IN143142B (de)
IT (1)	IT1048565B (de)
NL (1)	NL7605142A (de)
NO (1)	NO761681L (de)
PT (1)	PT65102B (de)
SE (1)	SE7604755L (de)
SU (1)	SU598565A3 (de)
ZA (1)	ZA762553B (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DK345977A (da) *	1976-09-30	1978-03-31	Archifar Ind Chim Trentino	G rifamycinforbindelser og fremgangsmaade til deres fremstillin
CH629212A5 (it) *	1976-10-18	1982-04-15	Erba Farmitalia	Procedimento per la preparazione di composti di rifamicina.
GB1576886A (en) *	1977-04-20	1980-10-15	Lepetit Spa	Rifamycin derivatives
IT1090772B (it) *	1977-12-20	1985-06-26	Alfa Farmaceutici Spa	Derivati della rifamicina e procedimento per la loro preparazione
BE886395A (fr) *	1980-02-13	1981-03-16	Erba Farmitalia	Derives de rifamycine
DE3228883A1 (de) *	1981-08-26	1983-03-10	Hydrocarbon Research Inc., 08648 Lawrenceville, N.J.	Verfahren zur herstellung von d-fructose
IT1201963B (it) *	1983-03-24	1989-02-02	Prodotti Antibiotici Spa	Derivati delle rifamicine e procedimento per la loro preparazione
US4631290A (en) *	1985-08-29	1986-12-23	American Home Products Corporation	Method of treating hepatitis
US4743619A (en) *	1985-08-29	1988-05-10	American Home Products Corporation	Method of treating hepatitis
WO2003045319A2 (en) *	2001-11-21	2003-06-05	Activbiotics, Inc.	Targeted therapeutics and uses thereof
US7820652B2 (en) *	2003-09-24	2010-10-26	Activbiotics Pharma, Llc	Regimen for the administration of rifamycin-class antibiotics
ITMI20071435A1 (it) *	2007-07-17	2009-01-18	Segix Italia Srl	Nuovi farmaci ad attivita' anticolestatica
CN105001236B (zh) *	2015-06-26	2017-05-31	重庆华邦制药有限公司	3‑氨基‑利福霉素s的制备方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CH512510A (de) *	1965-08-24	1971-09-15	Ciba Geigy Ag	Verfahren zur Herstellung von in 3-Stellung durch eine unsubstituierte oder substituierte Aminogruppe substituierten Derivaten von Rifamycin-S und Rifamycin-SV
GB1316689A (en) *	1971-01-18	1973-05-09	Lepetit Spa	Trifamycin derivatives

1975
- 1975-05-15 IT IT05155/75A patent/IT1048565B/it active
1976
- 1976-04-23 IE IE856/76A patent/IE42980B1/en unknown
- 1976-04-26 SE SE7604755A patent/SE7604755L/xx unknown
- 1976-04-27 US US05/680,771 patent/US4017481A/en not_active Expired - Lifetime
- 1976-04-27 GB GB16969/76A patent/GB1534075A/en not_active Expired
- 1976-04-28 ZA ZA762553A patent/ZA762553B/xx unknown
- 1976-04-28 FI FI761176A patent/FI761176A/fi not_active Application Discontinuation
- 1976-04-30 IN IN763/CAL/76A patent/IN143142B/en unknown
- 1976-05-03 CA CA251,689A patent/CA1057749A/en not_active Expired
- 1976-05-03 IL IL49516A patent/IL49516A/xx unknown
- 1976-05-05 AR AR263203A patent/AR211013A1/es active
- 1976-05-06 BE BE166810A patent/BE841548A/xx unknown
- 1976-05-06 CH CH568376A patent/CH622022A5/it not_active IP Right Cessation
- 1976-05-07 FR FR7613690A patent/FR2311018A1/fr active Granted
- 1976-05-11 AT AT343276A patent/AT343808B/de not_active IP Right Cessation
- 1976-05-11 DE DE2620782A patent/DE2620782C2/de not_active Expired
- 1976-05-13 DK DK215676A patent/DK215676A/da unknown
- 1976-05-13 NL NL7605142A patent/NL7605142A/xx active Search and Examination
- 1976-05-14 SU SU762356006A patent/SU598565A3/ru active
- 1976-05-14 HU HU76AI00000256A patent/HU171395B/hu unknown
- 1976-05-14 NO NO761681A patent/NO761681L/no unknown
- 1976-05-14 JP JP51055227A patent/JPS51141897A/ja active Granted
- 1976-05-14 ES ES448421A patent/ES448421A1/es not_active Expired
- 1976-05-14 PT PT65102A patent/PT65102B/pt unknown

Also Published As

Publication number	Publication date
ES448421A1 (es)	1977-07-01
AT343808B (de)	1978-06-26
AU1357476A (en)	1977-11-10
HU171395B (hu)	1978-01-28
FR2311018B1 (de)	1979-05-25
BE841548A (fr)	1976-09-01
FI761176A (de)	1976-11-16
ATA343276A (de)	1977-10-15
FR2311018A1 (fr)	1976-12-10
SE7604755L (sv)	1976-11-16
JPS51141897A (en)	1976-12-07
IL49516A (en)	1979-10-31
GB1534075A (en)	1978-11-29
JPS623154B2 (de)	1987-01-23
DK215676A (da)	1976-11-16
IT1048565B (it)	1980-12-20
PT65102B (en)	1977-09-14
SU598565A3 (ru)	1978-03-15
CA1057749A (en)	1979-07-03
IL49516A0 (en)	1976-07-30
NL7605142A (nl)	1976-11-17
ZA762553B (en)	1977-04-27
US4017481A (en)	1977-04-12
IN143142B (de)	1977-10-08
DE2620782A1 (de)	1976-11-25
PT65102A (en)	1976-06-01
CH622022A5 (de)	1981-03-13
IE42980L (en)	1976-11-15
IE42980B1 (en)	1980-11-19
AR211013A1 (es)	1977-10-14
DE2620782C2 (de)	1986-10-09

Publication	Publication Date	Title
Molinski et al.	1989	Varamines A and B, new cytotoxic thioalkaloids from Lissoclinum vareau
NO761681L (de)	1976-11-16
US4219478A (en)	1980-08-26	Rifamycin compounds
GrÄFe et al.	1986	Isolation and structure elucidation of 6-(3'-methylbuten-2'-yl) isatin, an unusual metabolite from Streptomyces albus
CA1081218A (en)	1980-07-08	Rifamycin compounds
YONEDA et al.	1975	A convenient synthesis of toxoflavins, toxoflavin 4-oxides and 1-demethyltoxoflavins
GB1561299A (en)	1980-02-20	Rifamycin compounds
CA1182450A (en)	1985-02-12	Cytostatic vinblastine compounds and processes for their preparation
Gasco et al.	1994	The Reduction of benzofuroxans by ferrous salts and by thiophenol
Rinehart Jr et al.	1977	Synthesis of phenazine and phenoxazinone derivatives of geldanamycin as potential polymerase inhibitors
Sudarsanam et al.	1982	Nitroimidazoles: Part XI. some halonitro-& dinitroimidazoles
KR800000907B1 (ko)	1980-09-10	리파마이신 화합물의 제조방법
Chapyshev et al.	1996	Effect of electronic factors on 1, 3-dipolar cycloaddition of 2, 4, 6-triazidopyridines to tert-butylphosphaacetylene
WATANABE et al.	1975	Stable Sulfur Ylides. IV. Reaction of Dimethylsulfonium Acetylmethoxycarbonylmethylide and Dimethylsulfonium Diacetylmethylide with Quinoline 1-Oxide
Kaminskii et al.	1992	Synthesis of pyrrolo [1, 2-a] quinoxaline derivatives by the reaction of 2-hydroxy-1, 5-diketones with o-phenylenediamine
CA1289949C (en)	1991-10-01	Method for the preparation of 4'-0- tetrahydropyranyladriamycin b
Díaz‐Guerra et al.	1995	Half‐Wave Potentials of 1‐AZA‐and 1, 8‐Diazaanthraquinones
Womack et al.	1981	Chemistry of the phenoxathiins and isosterically related heterocycles. XVII. First synthesis of a benzoxathiinopyridazine and the determination of structure by 13C‐NMR: 1‐Methoxy‐3, 4‐diazaphenoxathiin
Weintraub	1993	Heterocycles. 13. synthesis of [1, 2‐d] triazolo steroids
Agadzhanyan et al.	1992	Synthesis and transformations of polyhedral compounds. 14. Opening of hexahydropyrimidine ring of 2-substituted 1, 3-diazaadamantanes by electrophilic reagents
KR790001261B1 (ko)	1979-09-18	리파 마이신 화합물의 제조방법
SAWAYAMA et al.	1976	The Structures of Isatylidene-3-mercaptoacetic Acid and Its Related Compounds
Hatta et al.	1997	Synthesis of dithia‐and tetrathiacyclophanes incorporating isoxazole units
US4086344A (en)	1978-04-25	N,15-Didehydro-15-deoxo-3,15-epi(methano(alkylimino))rifamycins and antimicrobial compositions and methods employing them
Noravyan et al.	1983	Synthesis of 2-amino-1-acetyl-5, 5-dimethyl-3-cyano-4, 5, 6, 7-tetrahydropyrrolo-[2, 3-c] pyran and its acetylation