NO341560B1 - Fluorineringsframgangsmåter, nye forbindelser, samt radiofarmasøytiske sett og kassetter - Google Patents
Fluorineringsframgangsmåter, nye forbindelser, samt radiofarmasøytiske sett og kassetterInfo
- Publication number
- NO341560B1 NO341560B1 NO20081167A NO20081167A NO341560B1 NO 341560 B1 NO341560 B1 NO 341560B1 NO 20081167 A NO20081167 A NO 20081167A NO 20081167 A NO20081167 A NO 20081167A NO 341560 B1 NO341560 B1 NO 341560B1
- Authority
- NO
- Norway
- Prior art keywords
- radiopharmaceutical
- cassettes
- sets
- well
- new compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
- C07C209/68—Preparation of compounds containing amino groups bound to a carbon skeleton from amines, by reactions not involving amino groups, e.g. reduction of unsaturated amines, aromatisation, or substitution of the carbon skeleton
- C07C209/74—Preparation of compounds containing amino groups bound to a carbon skeleton from amines, by reactions not involving amino groups, e.g. reduction of unsaturated amines, aromatisation, or substitution of the carbon skeleton by halogenation, hydrohalogenation, dehalogenation, or dehydrohalogenation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C17/00—Preparation of halogenated hydrocarbons
- C07C17/093—Preparation of halogenated hydrocarbons by replacement by halogens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/041—Heterocyclic compounds
- A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
- A61K51/0453—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/24—Stationary reactors without moving elements inside
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/43—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
- C07C211/44—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having amino groups bound to only one six-membered aromatic ring
- C07C211/45—Monoamines
- C07C211/46—Aniline
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/64—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2
- C07D277/66—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2 with aromatic rings or ring systems directly attached in position 2
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/24—Stationary reactors without moving elements inside
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Optics & Photonics (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
Oppfinnelsen angår en framgangsmåte for framstilling av en forbindelse av formel (I): der R1 er valgt blant C1-6-alkyl, C2-6-alkenyl, og C2-6-alkynyl, som omfatter: (i) reaksjon mellom fluorid, gjerne [18F]fluorid, og en tilsvarende forbindelse av formel (II): der R2 er valgt blant hydrogen, C1-10-alkyl, C1-10-halogenalkyl, C6-14-aryl, C6-14-arylalkyl, -(CH2CH2O)q-CH3 der q er et heltall fra 1 til 10, R1 er som definert for forbindelsen av formel (I), og R3 er en utgående gruppe. Visse nye forløpere av formel (II) og radiofarmasøytiske sett som inneholder slike forløpere er også omfattet av oppfinnelsen.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0516564.2A GB0516564D0 (en) | 2005-08-12 | 2005-08-12 | Fluorination process |
PCT/GB2006/003009 WO2007020400A1 (en) | 2005-08-12 | 2006-08-11 | Fluorination process of anilide derivatives and benzothiazole fluorinate derivatives as in vivo imaging agents |
Publications (2)
Publication Number | Publication Date |
---|---|
NO20081167L NO20081167L (no) | 2008-03-05 |
NO341560B1 true NO341560B1 (no) | 2017-12-04 |
Family
ID=35098197
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20081167A NO341560B1 (no) | 2005-08-12 | 2008-03-05 | Fluorineringsframgangsmåter, nye forbindelser, samt radiofarmasøytiske sett og kassetter |
Country Status (21)
Country | Link |
---|---|
US (3) | US8410312B2 (no) |
EP (1) | EP1915330B1 (no) |
JP (2) | JP5566605B2 (no) |
KR (2) | KR101409608B1 (no) |
CN (2) | CN101282920B (no) |
AU (1) | AU2006281216B2 (no) |
BR (1) | BRPI0614752B1 (no) |
CA (1) | CA2618448C (no) |
DK (1) | DK1915330T3 (no) |
ES (1) | ES2527864T3 (no) |
GB (1) | GB0516564D0 (no) |
HK (1) | HK1177463A1 (no) |
IL (1) | IL188933A0 (no) |
MX (2) | MX341173B (no) |
NO (1) | NO341560B1 (no) |
NZ (1) | NZ565333A (no) |
PL (1) | PL1915330T3 (no) |
PT (1) | PT1915330E (no) |
RU (1) | RU2419601C2 (no) |
WO (1) | WO2007020400A1 (no) |
ZA (1) | ZA200801860B (no) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0516564D0 (en) * | 2005-08-12 | 2005-09-21 | Ge Healthcare Ltd | Fluorination process |
US20100150835A1 (en) * | 2007-02-27 | 2010-06-17 | Bengt Langstrom | Synthesis of [18F] Fluoromethyl Benzene Using Benzyl Pentafluorobenzenesulfonate |
AU2008292201B2 (en) * | 2007-08-30 | 2014-09-04 | Ge Healthcare Limited | Radiopharmaceutical composition |
BRPI0821681A2 (pt) | 2008-01-03 | 2015-06-16 | Ge Healthcare Ltd | Método para preparar uma solução de fluoreto e para realizar rádio-fluoretação, composto, e, aparelho para preparar uma solução de fluoreto. |
SI2338059T1 (sl) | 2008-09-23 | 2015-08-31 | Wista Laboratories Ltd. | Ligandi za agregirane molekule tau |
GB0921967D0 (en) * | 2009-12-17 | 2010-02-03 | Ge Healthcare Ltd | Novel Aryloxyanilide Derivatives |
GB201019303D0 (en) | 2010-11-15 | 2010-12-29 | Strom Hans E P | Agents and methods for visualising analytes |
CN103613589B (zh) * | 2013-11-29 | 2016-03-30 | 江苏华益科技有限公司 | 一种用于神经退行性疾病领域的新型pet显像剂前体及标准品的合成方法 |
CN106999603B (zh) | 2014-12-04 | 2022-05-27 | 通用电气健康护理有限公司 | 从放射性药物中除去乙醛的方法 |
JP6485914B2 (ja) | 2015-10-28 | 2019-03-20 | 日本メジフィジックス株式会社 | フルテメタモルの製造方法 |
JP6955347B2 (ja) * | 2017-02-28 | 2021-10-27 | 日本メジフィジックス株式会社 | フルテメタモルの製造方法 |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2004083195A1 (en) * | 2003-03-14 | 2004-09-30 | University Of Pittsburgh | Benzothiazole derivative compounds, compositions and uses |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3878206A (en) * | 1973-06-06 | 1975-04-15 | Morton Norwich Products Inc | 9-(Substituted amino)imidazo{8 4,5-f{9 quinolines |
FR2449677B1 (fr) | 1979-02-26 | 1986-03-28 | Fabre Sa Pierre | Nouveaux derives de benzoyl-2 glycylanilides substitues, leur preparation et leur application en tant que medicaments anxiolytiques |
FR2693781B1 (fr) * | 1992-07-15 | 1994-10-28 | Otis Elevator Co | Dispositif de réglage de la tension d'un câble faisant boucle. |
DE4402056A1 (de) | 1994-01-25 | 1995-07-27 | Basf Ag | p-Phenylendiamin-Derivate und sie enthaltende fungizide Mittel |
US7270800B2 (en) * | 2000-08-24 | 2007-09-18 | University Of Pittsburgh | Thioflavin derivatives for use in antemortem diagnosis of Alzheimer's disease and in vivo imaging and prevention of amyloid deposition |
GB0229686D0 (en) * | 2002-12-20 | 2003-01-29 | Amersham Plc | Solid-phase fluorination of benzothiazoles |
BRPI0408274B8 (pt) * | 2003-03-14 | 2021-05-25 | Univ Pittsburgh | compostos de ligação de amiloide e composição farmacêutica |
CN101137397A (zh) * | 2004-07-02 | 2008-03-05 | 匹兹堡大学高等教育联邦体系 | 淀粉样蛋白成像作为抗淀粉样蛋白疗法的功效的替代标记物 |
GB0516564D0 (en) * | 2005-08-12 | 2005-09-21 | Ge Healthcare Ltd | Fluorination process |
-
2005
- 2005-08-12 GB GBGB0516564.2A patent/GB0516564D0/en not_active Ceased
-
2006
- 2006-08-11 BR BRPI0614752-6A patent/BRPI0614752B1/pt active IP Right Grant
- 2006-08-11 PL PL06765263T patent/PL1915330T3/pl unknown
- 2006-08-11 JP JP2008525644A patent/JP5566605B2/ja active Active
- 2006-08-11 US US12/063,470 patent/US8410312B2/en active Active
- 2006-08-11 CN CN200680037139.7A patent/CN101282920B/zh active Active
- 2006-08-11 MX MX2013013741A patent/MX341173B/es unknown
- 2006-08-11 DK DK06765263.6T patent/DK1915330T3/en active
- 2006-08-11 EP EP06765263.6A patent/EP1915330B1/en active Active
- 2006-08-11 CN CN201210177977.1A patent/CN102731432B/zh active Active
- 2006-08-11 MX MX2008002068A patent/MX2008002068A/es active IP Right Grant
- 2006-08-11 RU RU2008103989/04A patent/RU2419601C2/ru active
- 2006-08-11 WO PCT/GB2006/003009 patent/WO2007020400A1/en active Application Filing
- 2006-08-11 ES ES06765263.6T patent/ES2527864T3/es active Active
- 2006-08-11 AU AU2006281216A patent/AU2006281216B2/en active Active
- 2006-08-11 PT PT67652636T patent/PT1915330E/pt unknown
- 2006-08-11 CA CA2618448A patent/CA2618448C/en active Active
- 2006-08-11 NZ NZ565333A patent/NZ565333A/en unknown
- 2006-08-11 KR KR1020137025584A patent/KR101409608B1/ko active IP Right Grant
-
2008
- 2008-01-22 IL IL188933A patent/IL188933A0/en active IP Right Grant
- 2008-02-11 KR KR1020087003263A patent/KR101392538B1/ko active Protection Beyond IP Right Term
- 2008-02-27 ZA ZA200801860A patent/ZA200801860B/xx unknown
- 2008-03-05 NO NO20081167A patent/NO341560B1/no unknown
-
2013
- 2013-03-22 US US13/848,877 patent/US9126961B2/en active Active
- 2013-04-17 HK HK13104661.5A patent/HK1177463A1/zh unknown
- 2013-09-24 JP JP2013196384A patent/JP2014028837A/ja not_active Withdrawn
-
2015
- 2015-07-27 US US14/809,497 patent/US9468694B2/en active Active
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2004083195A1 (en) * | 2003-03-14 | 2004-09-30 | University Of Pittsburgh | Benzothiazole derivative compounds, compositions and uses |
Non-Patent Citations (5)
Title |
---|
BERGMANN, ERNST D. ET AL. An improved method for the preparation of fluorine-substituted aromatic amines. The Journal of organic chemistry. 1954, 19, s. 1594-1599 page 1595-1596, p-fluoroacetanilide, Dated: 01.01.0001 * |
FORSYTH D.A. ET AL. Intrinsic and Equilibrium NMR Isotope Shift Evidence for Negative Hyperconjugation. Journal of the American Chemical Society. 1986, Vol. 108, s. 2157-2161 page 2161, synthesis of N-methyl—4-fluoroaniline , Dated: 01.01.0001 * |
MILNER, D. J. Fluoroaromatics from arylamines, a convenient one-pot conversion using Nitrosonium Tetrafluoroborate. 1992, Vol 22, Nr 1, s. 73-82., Dated: 01.01.0001 * |
STAVBER S, KOSIR I, ZUPAN M: "NEW, MILD, DIRECTED AND HIGH YIELD METHOD FOR THE FLUOROFUNCTIONALISATION OF AROMATIC MOLECULES", JOURNAL OF FLUORINE CHEMISTRY, ELSEVIER, NL, vol. 54, no. 1-3, 1 January 1991 (1991-01-01), NL, pages 268 - 268, XP002406242, ISSN: 0022-1139, DOI: 10.1016/S0022-1139(00)83777-X * |
ZAKRZEWSKA A. ET AL. 4-F1uoroanilines:synthesis and decomposition. Journal of Fluorine Chemistry. 2001, Vol. 111, nr. 1, s. 1-10 , Dated: 01.01.0001 * |
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
NO341560B1 (no) | Fluorineringsframgangsmåter, nye forbindelser, samt radiofarmasøytiske sett og kassetter | |
WO2006135641A3 (en) | PROCESS FOR THE SYNTHESIS OF 5- (METHYL-lH-IMIDAZOL-l-YL) -3- (TRI FLUOROME TH YL) -BENZENEAMINE | |
TW200510381A (en) | Novel 2-pyridinecarboxamide derivatives | |
MX2007006630A (es) | Metodo para preparar n-fenilpirazol-1-carboxamidas. | |
MX2009008465A (es) | Nuevas 2-aminooxazolinas como ligandos de taar1. | |
IL192253A0 (en) | Substituted cyclohexylmethyl derivatives | |
NO20091626L (no) | MGLUR5-modulatorer | |
NO20082116L (no) | Kjemisk fremgangsmate for fremstilling av en amido-fenoksybenzosyreforbindelse | |
MX2009004343A (es) | Compuestos organicos. | |
ATE345334T1 (de) | Umgelagerte pentanole, ein verfahren zu ihrer herstellung und ihre verwendung als entz ndungshemmer | |
SG153856A1 (en) | Chemical process | |
NO20071253L (no) | Fremgangsmate for syntese av C-2, C-3 substituerte N-alkylerte indoler anvendbare som CPLA2-inhibitorer. | |
WO2008103367A3 (en) | Method for assembling high-purity chemical libraries, proapoptotic compounds discovered by same | |
NO20062492L (no) | Fremgangsmate for fremstilling av tubulininhibitorer | |
TW200619201A (en) | Process for the preparation of pyrazoles | |
GB0215392D0 (en) | Chemical compounds | |
NO20092210L (no) | Salter av dihydroksyantrakinon-karboksylsyrer og deres terapeutiske anvendelse | |
NO20052197L (no) | Fremgangsmate for fremstilling av pyrazol | |
NO20073213L (no) | Fremgangsmate for fremstilling av tiofenglykosidderivater | |
NO20070776L (no) | Forbedret prosess for fremstilling av mirtazapin | |
GB0320738D0 (en) | Novel process | |
TW200730524A (en) | Process for making heteroaryl amine intermediate compounds | |
NO20052330L (no) | Nye substituerte [1,4]benzodioksino[2,3]isoindolforbindelser, fremgangsmate for deres fremstilling og farmasoytiske sammensetninger inneholdende dem | |
MX2010003587A (es) | Procedimiento para la preparacion de haluro de 6-sustituido-imidazo[2,1-b]tiazol-5-sulfonilo. | |
TW200517394A (en) | Method for stabilization of diarylvinylene compounds |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
CREP | Change of representative |
Representative=s name: ZACCO NORWAY AS, POSTBOKS 2003 VIKA |