NO330055B1 - Karbamatforbindelser til anvendelse for fremstilling av et medikament for forebygging eller terapi av neuropatisk smerte samt cluster- og migrenehodepineassosiert smerte - Google Patents

Karbamatforbindelser til anvendelse for fremstilling av et medikament for forebygging eller terapi av neuropatisk smerte samt cluster- og migrenehodepineassosiert smerte Download PDF

Info

Publication number: NO330055B1
Authority: NO; Norway
Prior art keywords: enantiomer; formula; alkyl; enantiomers; pain
Prior art date: 2000-07-21

Application number

NO20030299A

Other languages

English (en)

Norwegian (no)

Other versions

NO20030299D0 (no

NO20030299L (no

Inventor

Richard P Shank

Ellen C Codd

Carlos R Plata-Salaman

Katherine E Rogers

Boyu Zhao

Original Assignee

Ortho Mcneil Pharm Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-07-21

Filing date

2003-01-20

Publication date

2011-02-14

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22820176&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO330055(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2003-01-20 Application filed by Ortho Mcneil Pharm Inc filed Critical Ortho Mcneil Pharm Inc

2003-01-20 Publication of NO20030299D0 publication Critical patent/NO20030299D0/no

2003-03-12 Publication of NO20030299L publication Critical patent/NO20030299L/no

2011-02-14 Publication of NO330055B1 publication Critical patent/NO330055B1/no

Links

208000002193 Pain Diseases 0.000 title claims abstract description 47
230000036407 pain Effects 0.000 title claims abstract description 45
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238000004519 manufacturing process Methods 0.000 title claims description 9
150000004657 carbamic acid derivatives Chemical class 0.000 title description 4
HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims abstract description 52
239000000203 mixture Substances 0.000 claims abstract description 37
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims abstract description 27
229910052739 hydrogen Inorganic materials 0.000 claims abstract description 19
239000001257 hydrogen Substances 0.000 claims abstract description 19
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims abstract description 16
125000001424 substituent group Chemical group 0.000 claims abstract description 12
229910052736 halogen Inorganic materials 0.000 claims abstract description 10
150000002367 halogens Chemical group 0.000 claims abstract description 10
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims abstract description 10
125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims abstract description 10
229910052801 chlorine Inorganic materials 0.000 claims abstract description 9
239000000460 chlorine Substances 0.000 claims abstract description 9
125000004093 cyano group Chemical group *C#N 0.000 claims abstract description 9
ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 claims abstract description 7
WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims abstract description 7
ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims abstract description 7
PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims abstract description 7
GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims abstract description 7
229910052794 bromium Inorganic materials 0.000 claims abstract description 7
229910052731 fluorine Inorganic materials 0.000 claims abstract description 7
239000011737 fluorine Substances 0.000 claims abstract description 7
125000005843 halogen group Chemical group 0.000 claims abstract description 7
229910052740 iodine Inorganic materials 0.000 claims abstract description 6
239000011630 iodine Substances 0.000 claims abstract description 6
125000000217 alkyl group Chemical group 0.000 claims description 31
125000003545 alkoxy group Chemical group 0.000 claims description 7
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Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/27—Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents

Landscapes

Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Neurosurgery (AREA)
General Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Epidemiology (AREA)
Emergency Medicine (AREA)
Pain & Pain Management (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

NO20030299A 2000-07-21 2003-01-20 Karbamatforbindelser til anvendelse for fremstilling av et medikament for forebygging eller terapi av neuropatisk smerte samt cluster- og migrenehodepineassosiert smerte NO330055B1 (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US21965700P	2000-07-21	2000-07-21
PCT/US2001/022322 WO2002007822A2 (en)	2000-07-21	2001-07-16	Carbamate compounds for use in preventing or treating neuropathic pain and cluster and migraine headache-associated pain

Publications (3)

Publication Number	Publication Date
NO20030299D0 NO20030299D0 (no)	2003-01-20
NO20030299L NO20030299L (no)	2003-03-12
NO330055B1 true NO330055B1 (no)	2011-02-14

Family

ID=22820176

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20030299A NO330055B1 (no)	2000-07-21	2003-01-20	Karbamatforbindelser til anvendelse for fremstilling av et medikament for forebygging eller terapi av neuropatisk smerte samt cluster- og migrenehodepineassosiert smerte

Country Status (28)

Country	Link
US (4)	US20020107283A1 (xx)
EP (1)	EP1305082B1 (xx)
JP (1)	JP5271473B2 (xx)
KR (1)	KR100792814B1 (xx)
CN (1)	CN1250213C (xx)
AT (1)	ATE267629T1 (xx)
AU (2)	AU7349301A (xx)
BG (1)	BG107529A (xx)
BR (1)	BR0112713A (xx)
CA (1)	CA2416819C (xx)
CZ (1)	CZ2003445A3 (xx)
DE (1)	DE60103546T2 (xx)
DK (1)	DK1305082T3 (xx)
EA (1)	EA005648B1 (xx)
ES (1)	ES2221651T3 (xx)
HU (1)	HUP0302940A3 (xx)
IL (2)	IL154052A0 (xx)
MX (1)	MXPA03000619A (xx)
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NO (1)	NO330055B1 (xx)
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SK (1)	SK1962003A3 (xx)
TR (1)	TR200401511T4 (xx)
UA (1)	UA74195C2 (xx)
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ZA (1)	ZA200301403B (xx)

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2001
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- 2001-07-16 AT AT01952773T patent/ATE267629T1/de not_active IP Right Cessation
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- 2001-07-16 CN CNB01815798XA patent/CN1250213C/zh not_active Expired - Fee Related
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- 2001-07-16 BR BR0112713-6A patent/BR0112713A/pt not_active Application Discontinuation
- 2001-07-16 US US09/906,251 patent/US20020107283A1/en not_active Abandoned
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- 2001-07-16 KR KR1020037000914A patent/KR100792814B1/ko active IP Right Grant
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- 2001-07-16 DK DK01952773T patent/DK1305082T3/da active
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- 2001-07-16 AU AU2001273493A patent/AU2001273493B2/en not_active Ceased
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2004
- 2004-06-15 US US10/868,633 patent/US20040266866A1/en not_active Abandoned
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Also Published As

Publication number	Publication date
TR200401511T4 (tr)	2004-08-23
ATE267629T1 (de)	2004-06-15
UA74195C2 (uk)	2005-11-15
IL154052A (en)	2008-07-08
MXPA03000619A (es)	2004-07-30
EA005648B1 (ru)	2005-04-28
JP5271473B2 (ja)	2013-08-21
AU7349301A (en)	2002-02-05
CZ2003445A3 (cs)	2004-08-18
US20060183795A1 (en)	2006-08-17
ZA200301403B (en)	2004-06-15
CN1250213C (zh)	2006-04-12
PL365701A1 (en)	2005-01-10
PT1305082E (pt)	2004-09-30
CN1458853A (zh)	2003-11-26
EP1305082A2 (en)	2003-05-02
NO20030299D0 (no)	2003-01-20
KR20030022300A (ko)	2003-03-15
DK1305082T3 (da)	2004-09-13
NZ523851A (en)	2004-09-24
WO2002007822A2 (en)	2002-01-31
DE60103546T2 (de)	2005-06-09
AU2001273493B2 (en)	2005-08-11
HUP0302940A2 (hu)	2003-12-29
DE60103546D1 (de)	2004-07-01
SK1962003A3 (en)	2004-08-03
EA200300042A1 (ru)	2003-06-26
US20040266866A1 (en)	2004-12-30
MY127317A (en)	2006-11-30
WO2002007822A3 (en)	2002-05-30
BG107529A (bg)	2003-09-30
CA2416819C (en)	2011-03-22
KR100792814B1 (ko)	2008-01-14
EP1305082B1 (en)	2004-05-26
BR0112713A (pt)	2003-07-22
ES2221651T3 (es)	2005-01-01
US20020107283A1 (en)	2002-08-08
CA2416819A1 (en)	2002-01-31
NO20030299L (no)	2003-03-12
JP2004504362A (ja)	2004-02-12
IL154052A0 (en)	2003-07-31
HUP0302940A3 (en)	2012-02-28
US20090281179A1 (en)	2009-11-12

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Publication	Publication Date	Title
KR20080035565A (ko)	2008-04-23	수면-각성 장애의 치료
US20090281179A1 (en)	2009-11-12	Carbamate compounds for use in preventing or treating neuropathic pain and cluster and migraine headache associated pain
AU2001273493A1 (en)	2002-05-02	Carbamate compounds for use in preventing or treating neuropathic pain and cluster and migraine headache-associated pain
US20050250847A1 (en)	2005-11-10	Carbamate compounds for use in preventing or treating neuropathic pain and cluster and migraine headache-associated pain
JP4362368B2 (ja)	2009-11-11	神経因性疼痛および群発および偏頭痛に伴う疼痛の防止または処置に使用するためのカルバメート化合物
AU2002322442B2 (en)	2007-06-07	Carbamate compounds for use in preventing or treating neuropathic pain and cluster and migraine headache-associated pain
AU2002354909A1 (en)	2003-05-22	Carbamate compounds for use in preventing or treating neuropathic pain and cluster and migraine headache-associated pain
AU2002322442A1 (en)	2003-05-22	Carbamate compounds for use in preventing or treating neuropathic pain and cluster and migraine headache-associated pain
ZA200401156B (en)	2005-06-22	Carbamate compounds for use in preventing or treating neuropathic pain and cluster and migraine headache-associated pain.