NO328979B1 - Anvendelse av diklorbenzylalkohol for fremstilling av et preparat for topisk behandling av inflammasjon - Google Patents

Anvendelse av diklorbenzylalkohol for fremstilling av et preparat for topisk behandling av inflammasjon Download PDF

Info

Publication number: NO328979B1
Authority: NO; Norway
Prior art keywords: preparation; dichlorobenzyl alcohol; inflammation; treatment; dcba
Prior art date: 1997-01-09

Application number

NO19993355A

Other languages

English (en)

Norwegian (no)

Other versions

NO993355D0 (no

NO993355L (no

Inventor

A M Pedersen

Hans Holmen

Original Assignee

Bifodan As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-01-09

Filing date

1999-07-07

Publication date

2010-07-05

1999-07-07 Application filed by Bifodan As filed Critical Bifodan As

1999-07-07 Publication of NO993355D0 publication Critical patent/NO993355D0/no

1999-08-18 Publication of NO993355L publication Critical patent/NO993355L/no

2010-07-05 Publication of NO328979B1 publication Critical patent/NO328979B1/no

Links

238000002360 preparation method Methods 0.000 title claims abstract description 29
DBHODFSFBXJZNY-UHFFFAOYSA-N 2,4-dichlorobenzyl alcohol Chemical compound OCC1=CC=C(Cl)C=C1Cl DBHODFSFBXJZNY-UHFFFAOYSA-N 0.000 title claims abstract description 25
229960004698 dichlorobenzyl alcohol Drugs 0.000 title claims abstract description 25
206010061218 Inflammation Diseases 0.000 title claims abstract description 19
230000004054 inflammatory process Effects 0.000 title claims abstract description 19
230000000699 topical effect Effects 0.000 title claims abstract description 6
239000000203 mixture Substances 0.000 title description 16
210000004877 mucosa Anatomy 0.000 claims abstract description 5
239000000227 bioadhesive Substances 0.000 claims description 12
239000000463 material Substances 0.000 claims description 10
239000000126 substance Substances 0.000 claims description 9
DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims description 3
239000001768 carboxy methyl cellulose Substances 0.000 claims description 3
239000000416 hydrocolloid Substances 0.000 claims description 3
230000014759 maintenance of location Effects 0.000 claims description 3
235000019812 sodium carboxymethyl cellulose Nutrition 0.000 claims description 3
229920001027 sodium carboxymethylcellulose Polymers 0.000 claims description 3
IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 claims description 2
241000416162 Astragalus gummifer Species 0.000 claims description 2
108010010803 Gelatin Proteins 0.000 claims description 2
229920000569 Gum karaya Polymers 0.000 claims description 2
229920002125 Sokalan® Polymers 0.000 claims description 2
241000934878 Sterculia Species 0.000 claims description 2
229920001615 Tragacanth Polymers 0.000 claims description 2
238000013270 controlled release Methods 0.000 claims description 2
239000008273 gelatin Substances 0.000 claims description 2
229920000159 gelatin Polymers 0.000 claims description 2
229940014259 gelatin Drugs 0.000 claims description 2
235000019322 gelatine Nutrition 0.000 claims description 2
235000011852 gelatine desserts Nutrition 0.000 claims description 2
235000010494 karaya gum Nutrition 0.000 claims description 2
239000000231 karaya gum Substances 0.000 claims description 2
229940039371 karaya gum Drugs 0.000 claims description 2
229920000609 methyl cellulose Polymers 0.000 claims description 2
239000001923 methylcellulose Substances 0.000 claims description 2
235000010981 methylcellulose Nutrition 0.000 claims description 2
229960002900 methylcellulose Drugs 0.000 claims description 2
230000002035 prolonged effect Effects 0.000 claims description 2
235000010413 sodium alginate Nutrition 0.000 claims description 2
239000000661 sodium alginate Substances 0.000 claims description 2
229940005550 sodium alginate Drugs 0.000 claims description 2
235000010487 tragacanth Nutrition 0.000 claims description 2
239000000196 tragacanth Substances 0.000 claims description 2
229940116362 tragacanth Drugs 0.000 claims description 2
MQFLXLMNOHHPTC-UHFFFAOYSA-N 1-isothiocyanato-9-(methylsulfinyl)nonane Chemical compound CS(=O)CCCCCCCCCN=C=S MQFLXLMNOHHPTC-UHFFFAOYSA-N 0.000 claims 2
229920000591 gum Polymers 0.000 claims 1
230000004968 inflammatory condition Effects 0.000 abstract description 10
241000233866 Fungi Species 0.000 abstract description 5
241000894006 Bacteria Species 0.000 abstract description 4
239000003795 chemical substances by application Substances 0.000 abstract description 4
239000006071 cream Substances 0.000 abstract description 4
208000006877 Insect Bites and Stings Diseases 0.000 abstract description 3
208000003251 Pruritus Diseases 0.000 abstract description 2
201000004681 Psoriasis Diseases 0.000 abstract description 2
239000000645 desinfectant Substances 0.000 abstract description 2
239000002674 ointment Substances 0.000 abstract description 2
208000017520 skin disease Diseases 0.000 abstract description 2
241000699670 Mus sp. Species 0.000 description 19
239000000499 gel Substances 0.000 description 17
230000000694 effects Effects 0.000 description 11
241001465754 Metazoa Species 0.000 description 6
150000001875 compounds Chemical class 0.000 description 6
239000002324 mouth wash Substances 0.000 description 6
229940051866 mouthwash Drugs 0.000 description 6
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 6
206010015150 Erythema Diseases 0.000 description 5
230000006378 damage Effects 0.000 description 5
231100000321 erythema Toxicity 0.000 description 5
239000000243 solution Substances 0.000 description 5
230000003110 anti-inflammatory effect Effects 0.000 description 4
239000012620 biological material Substances 0.000 description 4
230000037396 body weight Effects 0.000 description 4
239000000551 dentifrice Substances 0.000 description 4
210000000214 mouth Anatomy 0.000 description 4
238000012360 testing method Methods 0.000 description 4
DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
239000013543 active substance Substances 0.000 description 3
230000000844 anti-bacterial effect Effects 0.000 description 3
239000004599 antimicrobial Substances 0.000 description 3
230000001580 bacterial effect Effects 0.000 description 3
230000009286 beneficial effect Effects 0.000 description 3
210000005069 ears Anatomy 0.000 description 3
208000015181 infectious disease Diseases 0.000 description 3
239000002085 irritant Substances 0.000 description 3
231100000021 irritant Toxicity 0.000 description 3
238000004519 manufacturing process Methods 0.000 description 3
238000005259 measurement Methods 0.000 description 3
244000005700 microbiome Species 0.000 description 3
210000004400 mucous membrane Anatomy 0.000 description 3
CQRYARSYNCAZFO-UHFFFAOYSA-N salicyl alcohol Chemical compound OCC1=CC=CC=C1O CQRYARSYNCAZFO-UHFFFAOYSA-N 0.000 description 3
238000004659 sterilization and disinfection Methods 0.000 description 3
210000001519 tissue Anatomy 0.000 description 3
CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
241000590002 Helicobacter pylori Species 0.000 description 2
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
241000699666 Mus <mouse, genus> Species 0.000 description 2
208000027418 Wounds and injury Diseases 0.000 description 2
230000002421 anti-septic effect Effects 0.000 description 2
239000003899 bactericide agent Substances 0.000 description 2
229960004311 betamethasone valerate Drugs 0.000 description 2
SNHRLVCMMWUAJD-SUYDQAKGSA-N betamethasone valerate Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)CO)(OC(=O)CCCC)[C@@]1(C)C[C@@H]2O SNHRLVCMMWUAJD-SUYDQAKGSA-N 0.000 description 2
210000000988 bone and bone Anatomy 0.000 description 2
230000001055 chewing effect Effects 0.000 description 2
238000011109 contamination Methods 0.000 description 2
230000000249 desinfective effect Effects 0.000 description 2
239000006196 drop Substances 0.000 description 2
230000002500 effect on skin Effects 0.000 description 2
238000000605 extraction Methods 0.000 description 2
238000009472 formulation Methods 0.000 description 2
125000000524 functional group Chemical group 0.000 description 2
229940037467 helicobacter pylori Drugs 0.000 description 2
-1 household items Substances 0.000 description 2
230000000415 inactivating effect Effects 0.000 description 2
238000011835 investigation Methods 0.000 description 2
230000007794 irritation Effects 0.000 description 2
239000006210 lotion Substances 0.000 description 2
230000003232 mucoadhesive effect Effects 0.000 description 2
201000001245 periodontitis Diseases 0.000 description 2
239000000758 substrate Substances 0.000 description 2
230000008961 swelling Effects 0.000 description 2
208000024891 symptom Diseases 0.000 description 2
239000002562 thickening agent Substances 0.000 description 2
239000000606 toothpaste Substances 0.000 description 2
229940034610 toothpaste Drugs 0.000 description 2
231100000331 toxic Toxicity 0.000 description 2
230000002588 toxic effect Effects 0.000 description 2
230000004580 weight loss Effects 0.000 description 2
244000215068 Acacia senegal Species 0.000 description 1
206010003399 Arthropod bite Diseases 0.000 description 1
206010003402 Arthropod sting Diseases 0.000 description 1
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208000001695 Dry Socket Diseases 0.000 description 1
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208000012895 Gastric disease Diseases 0.000 description 1
229920000084 Gum arabic Polymers 0.000 description 1
206010020751 Hypersensitivity Diseases 0.000 description 1
208000031888 Mycoses Diseases 0.000 description 1
208000001143 Periodontal Abscess Diseases 0.000 description 1
201000007100 Pharyngitis Diseases 0.000 description 1
208000004210 Pressure Ulcer Diseases 0.000 description 1
240000004808 Saccharomyces cerevisiae Species 0.000 description 1
VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
208000000311 Tooth Migration Diseases 0.000 description 1
208000025865 Ulcer Diseases 0.000 description 1
208000036142 Viral infection Diseases 0.000 description 1
206010052428 Wound Diseases 0.000 description 1
210000001015 abdomen Anatomy 0.000 description 1
238000005299 abrasion Methods 0.000 description 1
230000002745 absorbent Effects 0.000 description 1
239000002250 absorbent Substances 0.000 description 1
235000010489 acacia gum Nutrition 0.000 description 1
239000000205 acacia gum Substances 0.000 description 1
239000002253 acid Substances 0.000 description 1
150000007513 acids Chemical class 0.000 description 1
239000012190 activator Substances 0.000 description 1
230000001154 acute effect Effects 0.000 description 1
230000006978 adaptation Effects 0.000 description 1
239000000853 adhesive Substances 0.000 description 1
230000001070 adhesive effect Effects 0.000 description 1
239000003463 adsorbent Substances 0.000 description 1
239000013566 allergen Substances 0.000 description 1
230000007815 allergy Effects 0.000 description 1
CKGWFZQGEQJZIL-UHFFFAOYSA-N amylmetacresol Chemical compound CCCCCC1=CC=C(C)C=C1O CKGWFZQGEQJZIL-UHFFFAOYSA-N 0.000 description 1
229960005213 amylmetacresol Drugs 0.000 description 1
230000003444 anaesthetic effect Effects 0.000 description 1
239000003242 anti bacterial agent Substances 0.000 description 1
239000002260 anti-inflammatory agent Substances 0.000 description 1
230000000845 anti-microbial effect Effects 0.000 description 1
229940088710 antibiotic agent Drugs 0.000 description 1
239000002585 base Substances 0.000 description 1
201000003984 candidiasis Diseases 0.000 description 1
230000002925 chemical effect Effects 0.000 description 1
238000006243 chemical reaction Methods 0.000 description 1
230000001684 chronic effect Effects 0.000 description 1
239000011248 coating agent Substances 0.000 description 1
238000000576 coating method Methods 0.000 description 1
239000008119 colloidal silica Substances 0.000 description 1
239000002537 cosmetic Substances 0.000 description 1
230000008260 defense mechanism Effects 0.000 description 1
125000003963 dichloro group Chemical group Cl* 0.000 description 1
239000003085 diluting agent Substances 0.000 description 1
239000003814 drug Substances 0.000 description 1
239000003221 ear drop Substances 0.000 description 1
229940047652 ear drops Drugs 0.000 description 1
241001233061 earthworms Species 0.000 description 1
230000002884 effect on inflammation Effects 0.000 description 1
230000007717 exclusion Effects 0.000 description 1
238000002474 experimental method Methods 0.000 description 1
230000002349 favourable effect Effects 0.000 description 1
238000001914 filtration Methods 0.000 description 1
235000013305 food Nutrition 0.000 description 1
239000000417 fungicide Substances 0.000 description 1
230000035876 healing Effects 0.000 description 1
239000000017 hydrogel Substances 0.000 description 1
229910052739 hydrogen Inorganic materials 0.000 description 1
239000001257 hydrogen Substances 0.000 description 1
230000002757 inflammatory effect Effects 0.000 description 1
208000014674 injury Diseases 0.000 description 1
230000007803 itching Effects 0.000 description 1
238000012332 laboratory investigation Methods 0.000 description 1
239000010985 leather Substances 0.000 description 1
235000021056 liquid food Nutrition 0.000 description 1
239000003589 local anesthetic agent Substances 0.000 description 1
239000007937 lozenge Substances 0.000 description 1
239000000041 non-steroidal anti-inflammatory agent Substances 0.000 description 1
229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 description 1
239000003960 organic solvent Substances 0.000 description 1
229940124641 pain reliever Drugs 0.000 description 1
239000002245 particle Substances 0.000 description 1
239000008188 pellet Substances 0.000 description 1
239000008194 pharmaceutical composition Substances 0.000 description 1
239000000546 pharmaceutical excipient Substances 0.000 description 1
239000000825 pharmaceutical preparation Substances 0.000 description 1
229920000515 polycarbonate Polymers 0.000 description 1
239000004417 polycarbonate Substances 0.000 description 1
229920000642 polymer Polymers 0.000 description 1
239000013641 positive control Substances 0.000 description 1
230000003389 potentiating effect Effects 0.000 description 1
230000002265 prevention Effects 0.000 description 1
230000000069 prophylactic effect Effects 0.000 description 1
108090000623 proteins and genes Proteins 0.000 description 1
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239000008213 purified water Substances 0.000 description 1
238000011160 research Methods 0.000 description 1
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239000002453 shampoo Substances 0.000 description 1
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239000004753 textile Substances 0.000 description 1
210000004357 third molar Anatomy 0.000 description 1
230000009974 thixotropic effect Effects 0.000 description 1
230000036269 ulceration Effects 0.000 description 1
230000009385 viral infection Effects 0.000 description 1
230000029663 wound healing Effects 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Dermatology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Epidemiology (AREA)
Emergency Medicine (AREA)
Birds (AREA)
Oral & Maxillofacial Surgery (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicinal Preparation (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

NO19993355A 1997-01-09 1999-07-07 Anvendelse av diklorbenzylalkohol for fremstilling av et preparat for topisk behandling av inflammasjon NO328979B1 (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DK2697		1997-01-09
PCT/DK1998/000011 WO1998030214A1 (en)	1997-01-09	1998-01-09	Use of dichlorobenzyl alcohol for preparing a preparation for topical treatment of inflammation and a preparation containing dichlorobenzyl alcohol

Publications (3)

Publication Number	Publication Date
NO993355D0 NO993355D0 (no)	1999-07-07
NO993355L NO993355L (no)	1999-08-18
NO328979B1 true NO328979B1 (no)	2010-07-05

Family

ID=8088912

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO19993355A NO328979B1 (no)	1997-01-09	1999-07-07	Anvendelse av diklorbenzylalkohol for fremstilling av et preparat for topisk behandling av inflammasjon

Country Status (18)

Country	Link
US (1)	US6251371B1 (ja)
EP (1)	EP0988033B1 (ja)
JP (1)	JP4663036B2 (ja)
KR (1)	KR100573206B1 (ja)
CN (1)	CN1128614C (ja)
AT (1)	ATE206047T1 (ja)
AU (1)	AU719836B2 (ja)
BR (1)	BR9807056A (ja)
CA (1)	CA2277207C (ja)
DE (1)	DE69801820T2 (ja)
DK (1)	DK0988033T3 (ja)
ES (1)	ES2162410T3 (ja)
NO (1)	NO328979B1 (ja)
NZ (1)	NZ336600A (ja)
PL (1)	PL189398B1 (ja)
PT (1)	PT988033E (ja)
RU (1)	RU2184538C2 (ja)
WO (1)	WO1998030214A1 (ja)

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PL196077B1 (pl) *	1998-03-19	2007-12-31	Bifodan As	Kompozycja dezynfekująca
AU2002222589A1 (en) *	2000-12-08	2002-06-18	Kyowa Hakko Kogyo Co. Ltd.	Oral preprations having itching-relievign or antipruritic activity
US7887842B2 (en)	2003-02-07	2011-02-15	Teikoku Pharma Usa, Inc.	Methods of administering a dermatological agent to a subject
MX2012010769A (es) *	2010-03-19	2013-02-27	Oxygen Biotherapeutics Inc	Formulaciones perfluorocarbonadas oftalmicas en forma de crema.
WO2012044963A2 (en) *	2010-10-01	2012-04-05	Oxygen Biotherapeutics, Inc.	Perfluorocarbons for use in treating pruritus
CN104173204B (zh) *	2014-09-17	2015-03-11	沈广阳	一种水包油乳液组合物
BR112017005884A2 (pt) *	2014-09-26	2018-02-06	Koninklijke Philips Nv	sistemas destinados a fornecer uma composição para tratamento bucal, e aplicador adaptado para introduzir uma composição mucoadesiva
US9980975B2 (en)	2015-01-22	2018-05-29	Ems S.A.	Dosage forms containing fluticasone propionate for the treatment of inflammatory conditions of the esophagus
CN111297802A (zh) *	2018-12-12	2020-06-19	成都一平医药科技发展有限公司	一种用于抗炎及抗菌的组合物

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US3123528A (en) *		1964-03-03		New therapeutic compositions
BE750969A (fr) *	1970-05-26	1970-11-03	Geigy Ag J R	Composition pour combattre les micro-organismes,
US4167583A (en) *	1973-07-03	1979-09-11	Bayer Aktiengesellschaft	Microbial composition and formulations
GB8411731D0 (en) *	1984-05-09	1984-06-13	Unilever Plc	Oral compositions
US4663077A (en) *	1984-06-11	1987-05-05	Morton Thiokol Inc.	Microbiocidal compositions comprising an aryl alkanol and a microbiocidal compound dissolved therein
GB9108080D0 (en) *	1991-04-15	1991-06-05	Smithkline Beecham Plc	Pharmaceutical composition
IL106142A (en) *	1992-06-29	1997-03-18	Merck & Co Inc	Morpholine and thiomorpholine tachykinin receptor antagonists, their preparation and pharmaceutical compositions containing them
WO1994018165A1 (en) *	1993-02-12	1994-08-18	Pfizer Inc.	Sulfonamide compounds as opioid k-receptor agonists
JPH07242666A (ja) *	1994-03-08	1995-09-19	Fujisawa Pharmaceut Co Ltd	複素環化合物
US5708023A (en) *	1994-03-28	1998-01-13	The Trustees Of Columbia University In The City Of New York	Zinc gluconate gel compositions
CN1158566A (zh) *	1994-06-20	1997-09-03	库特·伯格	用于预防和/或治疗病毒感染和各种炎症的药物组合物及其治疗方法
JP3466350B2 (ja) *	1994-12-13	2003-11-10	サンメディカル株式会社	象牙質知覚過敏症用歯科用組成物
CA2165013C (en) *	1994-12-13	2004-01-06	Nobuo Nakabayashi	Dental composition for relieving dentin hypersensitivity
IT1275955B1 (it) *	1995-03-22	1997-10-24	Dompe Spa	Formulazioni farmaceutiche in forma di gel tissotropico
ZA962455B (en) *	1995-03-31	1996-10-02	B Eugene Guthery	Fast acting and persistent topical antiseptic
GB9507883D0 (en)	1995-04-18	1995-05-31	Retroscreen Ltd	Compounds
ATE240088T1 (de) *	1996-12-13	2003-05-15	Vesifact Ag	Kosmetische präparate in form einer nanodispersion
US5989527A (en) *	1998-01-26	1999-11-23	Inolex Investment Corporation	Compositions and methods for improving the performance of chemical exfoliating agents, sunless tanning agents, skin lightening agents and insect repellents

1998
- 1998-01-09 ES ES98900272T patent/ES2162410T3/es not_active Expired - Lifetime
- 1998-01-09 US US09/341,427 patent/US6251371B1/en not_active Expired - Lifetime
- 1998-01-09 KR KR1019997006205A patent/KR100573206B1/ko not_active IP Right Cessation
- 1998-01-09 PT PT98900272T patent/PT988033E/pt unknown
- 1998-01-09 PL PL98334679A patent/PL189398B1/pl not_active IP Right Cessation
- 1998-01-09 BR BR9807056-8A patent/BR9807056A/pt not_active Application Discontinuation
- 1998-01-09 NZ NZ336600A patent/NZ336600A/xx not_active IP Right Cessation
- 1998-01-09 DE DE69801820T patent/DE69801820T2/de not_active Expired - Lifetime
- 1998-01-09 WO PCT/DK1998/000011 patent/WO1998030214A1/en active IP Right Grant
- 1998-01-09 EP EP98900272A patent/EP0988033B1/en not_active Expired - Lifetime
- 1998-01-09 DK DK98900272T patent/DK0988033T3/da active
- 1998-01-09 RU RU99117143/14A patent/RU2184538C2/ru active
- 1998-01-09 AU AU54783/98A patent/AU719836B2/en not_active Ceased
- 1998-01-09 AT AT98900272T patent/ATE206047T1/de active
- 1998-01-09 JP JP53047998A patent/JP4663036B2/ja not_active Expired - Fee Related
- 1998-01-09 CA CA002277207A patent/CA2277207C/en not_active Expired - Fee Related
- 1998-01-09 CN CN98801761A patent/CN1128614C/zh not_active Expired - Fee Related
1999
- 1999-07-07 NO NO19993355A patent/NO328979B1/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
BR9807056A (pt)	2000-05-02
DK0988033T3 (da)	2001-10-22
NO993355D0 (no)	1999-07-07
PL334679A1 (en)	2000-03-13
RU2184538C2 (ru)	2002-07-10
DE69801820T2 (de)	2002-04-11
US6251371B1 (en)	2001-06-26
PT988033E (pt)	2002-02-28
AU5478398A (en)	1998-08-03
DE69801820D1 (de)	2001-10-31
KR20000069990A (ko)	2000-11-25
ATE206047T1 (de)	2001-10-15
AU719836B2 (en)	2000-05-18
KR100573206B1 (ko)	2006-04-28
EP0988033B1 (en)	2001-09-26
PL189398B1 (pl)	2005-07-29
WO1998030214A1 (en)	1998-07-16
NO993355L (no)	1999-08-18
JP4663036B2 (ja)	2011-03-30
EP0988033A1 (en)	2000-03-29
CA2277207A1 (en)	1998-07-16
CA2277207C (en)	2008-02-19
CN1128614C (zh)	2003-11-26
JP2001507708A (ja)	2001-06-12
ES2162410T3 (es)	2001-12-16
CN1243437A (zh)	2000-02-02
NZ336600A (en)	2000-07-28

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Date	Code	Title	Description
2014-08-25	MM1K	Lapsed by not paying the annual fees

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