NO327605B1 - Transdermalt terapeutisk system, fremgangsmate for fremstilling samt andvendelse av dette - Google Patents

Transdermalt terapeutisk system, fremgangsmate for fremstilling samt andvendelse av dette Download PDF

Info

Publication number: NO327605B1
Authority: NO; Norway
Prior art keywords: transdermal therapeutic; therapeutic system; layer; cover layer; range
Prior art date: 1997-09-05

Application number

NO20001003A

Other languages

English (en)

Norwegian (no)

Other versions

NO20001003D0 (no

NO20001003L (no

Inventor

Lothar Deurer

Thomas Hille

Original Assignee

Lohmann Therapie Syst Lts

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-09-05

Filing date

2000-02-28

Publication date

2009-08-31

2000-02-28 Application filed by Lohmann Therapie Syst Lts filed Critical Lohmann Therapie Syst Lts

2000-02-28 Publication of NO20001003D0 publication Critical patent/NO20001003D0/no

2000-02-28 Publication of NO20001003L publication Critical patent/NO20001003L/no

2009-08-31 Publication of NO327605B1 publication Critical patent/NO327605B1/no

Links

230000001225 therapeutic effect Effects 0.000 title claims description 33
238000000034 method Methods 0.000 title description 7
239000010410 layer Substances 0.000 claims description 80
239000013543 active substance Substances 0.000 claims description 25
239000000853 adhesive Substances 0.000 claims description 22
239000000463 material Substances 0.000 claims description 22
230000001070 adhesive effect Effects 0.000 claims description 18
239000011888 foil Substances 0.000 claims description 12
238000004519 manufacturing process Methods 0.000 claims description 12
229920000728 polyester Polymers 0.000 claims description 11
239000011241 protective layer Substances 0.000 claims description 11
LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims description 10
239000011505 plaster Substances 0.000 claims description 9
239000002253 acid Substances 0.000 claims description 8
239000004744 fabric Substances 0.000 claims description 8
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 8
-1 polyethylene Polymers 0.000 claims description 7
229920000642 polymer Polymers 0.000 claims description 7
RMRJXGBAOAMLHD-IHFGGWKQSA-N buprenorphine Chemical compound C([C@]12[C@H]3OC=4C(O)=CC=C(C2=4)C[C@@H]2[C@]11CC[C@]3([C@H](C1)[C@](C)(O)C(C)(C)C)OC)CN2CC1CC1 RMRJXGBAOAMLHD-IHFGGWKQSA-N 0.000 claims description 6
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RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 4
KKEYFWRCBNTPAC-UHFFFAOYSA-N Terephthalic acid Chemical compound OC(=O)C1=CC=C(C(O)=O)C=C1 KKEYFWRCBNTPAC-UHFFFAOYSA-N 0.000 claims description 4
239000012790 adhesive layer Substances 0.000 claims description 4
WNLRTRBMVRJNCN-UHFFFAOYSA-N adipic acid Chemical compound OC(=O)CCCCC(O)=O WNLRTRBMVRJNCN-UHFFFAOYSA-N 0.000 claims description 4
WERYXYBDKMZEQL-UHFFFAOYSA-N butane-1,4-diol Chemical compound OCCCCO WERYXYBDKMZEQL-UHFFFAOYSA-N 0.000 claims description 4
WOZVHXUHUFLZGK-UHFFFAOYSA-N dimethyl terephthalate Chemical compound COC(=O)C1=CC=C(C(=O)OC)C=C1 WOZVHXUHUFLZGK-UHFFFAOYSA-N 0.000 claims description 4
239000013013 elastic material Substances 0.000 claims description 4
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QQVIHTHCMHWDBS-UHFFFAOYSA-N isophthalic acid Chemical compound OC(=O)C1=CC=CC(C(O)=O)=C1 QQVIHTHCMHWDBS-UHFFFAOYSA-N 0.000 claims description 4
230000035699 permeability Effects 0.000 claims description 4
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CXMXRPHRNRROMY-UHFFFAOYSA-N sebacic acid Chemical compound OC(=O)CCCCCCCCC(O)=O CXMXRPHRNRROMY-UHFFFAOYSA-N 0.000 claims description 4
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VOXZDWNPVJITMN-ZBRFXRBCSA-N 17β-estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 VOXZDWNPVJITMN-ZBRFXRBCSA-N 0.000 claims description 2
FWQNYUYRXNWOOM-UHFFFAOYSA-N 2-nonylpropanedioic acid Chemical compound CCCCCCCCCC(C(O)=O)C(O)=O FWQNYUYRXNWOOM-UHFFFAOYSA-N 0.000 claims description 2
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YIMQCDZDWXUDCA-UHFFFAOYSA-N [4-(hydroxymethyl)cyclohexyl]methanol Chemical compound OCC1CCC(CO)CC1 YIMQCDZDWXUDCA-UHFFFAOYSA-N 0.000 claims description 2
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ALOUNLDAKADEEB-UHFFFAOYSA-N dimethyl sebacate Chemical compound COC(=O)CCCCCCCCC(=O)OC ALOUNLDAKADEEB-UHFFFAOYSA-N 0.000 claims description 2
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229960005309 estradiol Drugs 0.000 claims description 2
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WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 claims description 2
OJURWUUOVGOHJZ-UHFFFAOYSA-N methyl 2-[(2-acetyloxyphenyl)methyl-[2-[(2-acetyloxyphenyl)methyl-(2-methoxy-2-oxoethyl)amino]ethyl]amino]acetate Chemical compound C=1C=CC=C(OC(C)=O)C=1CN(CC(=O)OC)CCN(CC(=O)OC)CC1=CC=CC=C1OC(C)=O OJURWUUOVGOHJZ-UHFFFAOYSA-N 0.000 claims description 2
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229920001223 polyethylene glycol Polymers 0.000 claims description 2
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PPBRXRYQALVLMV-UHFFFAOYSA-N Styrene Chemical compound C=CC1=CC=CC=C1 PPBRXRYQALVLMV-UHFFFAOYSA-N 0.000 description 2
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230000002457 bidirectional effect Effects 0.000 description 2
IISBACLAFKSPIT-UHFFFAOYSA-N bisphenol A Chemical compound C=1C=C(O)C=CC=1C(C)(C)C1=CC=C(O)C=C1 IISBACLAFKSPIT-UHFFFAOYSA-N 0.000 description 2
229920001577 copolymer Polymers 0.000 description 2
229940079593 drug Drugs 0.000 description 2
ASUTZQLVASHGKV-JDFRZJQESA-N galanthamine Chemical compound O1C(=C23)C(OC)=CC=C2CN(C)CC[C@]23[C@@H]1C[C@@H](O)C=C2 ASUTZQLVASHGKV-JDFRZJQESA-N 0.000 description 2
239000000734 parasympathomimetic agent Substances 0.000 description 2
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QCHFTSOMWOSFHM-WPRPVWTQSA-N (+)-Pilocarpine Chemical compound C1OC(=O)[C@@H](CC)[C@H]1CC1=CN=CN1C QCHFTSOMWOSFHM-WPRPVWTQSA-N 0.000 description 1
HJRTVQOQSGKXOM-UHFFFAOYSA-N (2-ethoxy-6-fluorophenyl)boronic acid Chemical compound CCOC1=CC=CC(F)=C1B(O)O HJRTVQOQSGKXOM-UHFFFAOYSA-N 0.000 description 1
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PIJVFDBKTWXHHD-UHFFFAOYSA-N Physostigmine Natural products C12=CC(OC(=O)NC)=CC=C2N(C)C2C1(C)CCN2C PIJVFDBKTWXHHD-UHFFFAOYSA-N 0.000 description 1
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QCHFTSOMWOSFHM-UHFFFAOYSA-N SJ000285536 Natural products C1OC(=O)C(CC)C1CC1=CN=CN1C QCHFTSOMWOSFHM-UHFFFAOYSA-N 0.000 description 1
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240000008042 Zea mays Species 0.000 description 1
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230000002745 absorbent Effects 0.000 description 1
239000002250 absorbent Substances 0.000 description 1
OIPILFWXSMYKGL-UHFFFAOYSA-N acetylcholine Chemical compound CC(=O)OCC[N+](C)(C)C OIPILFWXSMYKGL-UHFFFAOYSA-N 0.000 description 1
229960004373 acetylcholine Drugs 0.000 description 1
229930013930 alkaloid Natural products 0.000 description 1
239000004411 aluminium Substances 0.000 description 1
229910052782 aluminium Inorganic materials 0.000 description 1
XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
NZUPCNDJBJXXRF-UHFFFAOYSA-O bethanechol Chemical compound C[N+](C)(C)CC(C)OC(N)=O NZUPCNDJBJXXRF-UHFFFAOYSA-O 0.000 description 1
229960000910 bethanechol Drugs 0.000 description 1
229940106691 bisphenol a Drugs 0.000 description 1
229920001400 block copolymer Polymers 0.000 description 1
229960004484 carbachol Drugs 0.000 description 1
AIXAANGOTKPUOY-UHFFFAOYSA-N carbachol Chemical compound [Cl-].C[N+](C)(C)CCOC(N)=O AIXAANGOTKPUOY-UHFFFAOYSA-N 0.000 description 1
239000003795 chemical substances by application Substances 0.000 description 1
239000000544 cholinesterase inhibitor Substances 0.000 description 1
235000005822 corn Nutrition 0.000 description 1
238000005520 cutting process Methods 0.000 description 1
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YHKBUDZECQDYBR-UHFFFAOYSA-L demecarium bromide Chemical compound [Br-].[Br-].C=1C=CC([N+](C)(C)C)=CC=1OC(=O)N(C)CCCCCCCCCCN(C)C(=O)OC1=CC=CC([N+](C)(C)C)=C1 YHKBUDZECQDYBR-UHFFFAOYSA-L 0.000 description 1
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239000012895 dilution Substances 0.000 description 1
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230000007613 environmental effect Effects 0.000 description 1
150000002170 ethers Chemical class 0.000 description 1
230000002349 favourable effect Effects 0.000 description 1
229960003980 galantamine Drugs 0.000 description 1
ASUTZQLVASHGKV-UHFFFAOYSA-N galanthamine hydrochloride Natural products O1C(=C23)C(OC)=CC=C2CN(C)CCC23C1CC(O)C=C2 ASUTZQLVASHGKV-UHFFFAOYSA-N 0.000 description 1
238000000265 homogenisation Methods 0.000 description 1
238000003780 insertion Methods 0.000 description 1
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239000002648 laminated material Substances 0.000 description 1
229910052751 metal Inorganic materials 0.000 description 1
239000002184 metal Substances 0.000 description 1
NZWOPGCLSHLLPA-UHFFFAOYSA-N methacholine Chemical compound C[N+](C)(C)CC(C)OC(C)=O NZWOPGCLSHLLPA-UHFFFAOYSA-N 0.000 description 1
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230000000813 microbial effect Effects 0.000 description 1
229960002362 neostigmine Drugs 0.000 description 1
ALWKGYPQUAPLQC-UHFFFAOYSA-N neostigmine Chemical compound CN(C)C(=O)OC1=CC=CC([N+](C)(C)C)=C1 ALWKGYPQUAPLQC-UHFFFAOYSA-N 0.000 description 1
BARWIPMJPCRCTP-UHFFFAOYSA-N oleic acid oleyl ester Natural products CCCCCCCCC=CCCCCCCCCOC(=O)CCCCCCCC=CCCCCCCCC BARWIPMJPCRCTP-UHFFFAOYSA-N 0.000 description 1
BARWIPMJPCRCTP-CLFAGFIQSA-N oleyl oleate Chemical compound CCCCCCCC\C=C/CCCCCCCCOC(=O)CCCCCCC\C=C/CCCCCCCC BARWIPMJPCRCTP-CLFAGFIQSA-N 0.000 description 1
239000003960 organic solvent Substances 0.000 description 1
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229960001416 pilocarpine Drugs 0.000 description 1
239000000902 placebo Substances 0.000 description 1
229940068196 placebo Drugs 0.000 description 1
229920000191 poly(N-vinyl pyrrolidone) Polymers 0.000 description 1
229920001281 polyalkylene Polymers 0.000 description 1
229960002151 pyridostigmine bromide Drugs 0.000 description 1
150000003248 quinolines Chemical class 0.000 description 1
238000009666 routine test Methods 0.000 description 1
238000007790 scraping Methods 0.000 description 1
238000007789 sealing Methods 0.000 description 1
230000036556 skin irritation Effects 0.000 description 1
231100000475 skin irritation Toxicity 0.000 description 1
239000000243 solution Substances 0.000 description 1
239000002904 solvent Substances 0.000 description 1
229940100640 transdermal system Drugs 0.000 description 1
230000005068 transpiration Effects 0.000 description 1
229930195735 unsaturated hydrocarbon Natural products 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
- A61K9/7061—Polyacrylates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7084—Transdermal patches having a drug layer or reservoir, and one or more separate drug-free skin-adhesive layers, e.g. between drug reservoir and skin, or surrounding the drug reservoir; Liquid-filled reservoir patches
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones

Landscapes

Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Dermatology (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Diabetes (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Psychiatry (AREA)
Endocrinology (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Medicinal Preparation (AREA)
Materials For Medical Uses (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

NO20001003A 1997-09-05 2000-02-28 Transdermalt terapeutisk system, fremgangsmate for fremstilling samt andvendelse av dette NO327605B1 (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE19738855A DE19738855C2 (de)	1997-09-05	1997-09-05	Transdermales therapeutisches System mit haftklebender Reservoirschicht und unidirektional elastischer Rückschicht
PCT/EP1998/005321 WO1999012529A2 (de)	1997-09-05	1998-08-21	Transdermales therapeutisches system mit haftklebender reservoirschicht und unidirektional elastischer rückschicht

Publications (3)

Publication Number	Publication Date
NO20001003D0 NO20001003D0 (no)	2000-02-28
NO20001003L NO20001003L (no)	2000-02-28
NO327605B1 true NO327605B1 (no)	2009-08-31

Family

ID=7841309

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20001003A NO327605B1 (no)	1997-09-05	2000-02-28	Transdermalt terapeutisk system, fremgangsmate for fremstilling samt andvendelse av dette

Country Status (14)

Country	Link
US (2)	US6814976B1 (ko)
EP (1)	EP1009393B1 (ko)
JP (1)	JP3847088B2 (ko)
KR (1)	KR100515007B1 (ko)
AT (1)	ATE215364T1 (ko)
AU (1)	AU738033B2 (ko)
CA (1)	CA2302601C (ko)
DE (2)	DE19738855C2 (ko)
DK (1)	DK1009393T3 (ko)
ES (1)	ES2175792T3 (ko)
NO (1)	NO327605B1 (ko)
PT (1)	PT1009393E (ko)
SI (1)	SI1009393T1 (ko)
WO (1)	WO1999012529A2 (ko)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5968547A (en)	1997-02-24	1999-10-19	Euro-Celtique, S.A.	Method of providing sustained analgesia with buprenorphine
DE19923427A1 (de) *	1999-05-21	2000-11-23	Lohmann Therapie Syst Lts	Vorrichtung und Verfahren zur Steigerung der transdermalen Permeation von Arzneistoffen
DE10042412B4 (de) *	2000-08-30	2005-12-22	Lts Lohmann Therapie-Systeme Ag	Transdermales therapeutisches System zur Abgabe von Venlafaxin, und seine Verwendung
GB0117583D0 (en) *	2001-07-19	2001-09-12	Astrazeneca Ab	Novel compounds
DE10159745A1 (de)	2001-12-05	2003-07-03	Lohmann Therapie Syst Lts	Transdermales Therapeutisches System mit verbessertem Langzeittragekomfort
DK1485051T3 (da) *	2002-03-20	2008-09-08	Euro Celtique Sa	Fremgangsmåde til indgivelse af buprenorphin til behandling af depression
EP1795189A3 (en) *	2002-03-20	2007-08-15	Euro-Celtique S.A.	Method of administering buprenorphine to treat depression
DE10305137A1 (de) *	2003-02-07	2004-08-26	Novosis Ag	Transdermale therapeutische Abgabesysteme mit einem Butenolid
US20060058336A1 (en) *	2003-02-27	2006-03-16	Shigetada Nakanishi	Pharmaceutical composition for treatment of drug dependence
US7052052B2 (en) *	2003-03-13	2006-05-30	Donaldson Company, Inc.	Sealing gasket for a clamp
CN100457064C (zh) *	2003-10-28	2009-02-04	诺芬药品公司	透皮递药装置
DE102004012442C5 (de) *	2004-03-13	2012-01-26	Paul Hartmann Ag	Elastisches Bandagesegment
US8252321B2 (en)	2004-09-13	2012-08-28	Chrono Therapeutics, Inc.	Biosynchronous transdermal drug delivery for longevity, anti-aging, fatigue management, obesity, weight loss, weight management, delivery of nutraceuticals, and the treatment of hyperglycemia, alzheimer's disease, sleep disorders, parkinson's disease, aids, epilepsy, attention deficit disorder, nicotine addiction, cancer, headache and pain control, asthma, angina, hypertension, depression, cold, flu and the like
JP5254616B2 (ja)	2004-09-13	2013-08-07	クロノセラピューティクス、インコーポレイテッド	生物学的同調性（ｂｉｏｓｙｎｃｈｒｏｎｏｕｓ）経皮的薬物送達
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1998
- 1998-08-21 WO PCT/EP1998/005321 patent/WO1999012529A2/de active IP Right Grant
- 1998-08-21 JP JP2000510427A patent/JP3847088B2/ja not_active Expired - Lifetime
- 1998-08-21 AT AT98948853T patent/ATE215364T1/de active
- 1998-08-21 SI SI9830189T patent/SI1009393T1/xx unknown
- 1998-08-21 PT PT98948853T patent/PT1009393E/pt unknown
- 1998-08-21 DK DK98948853T patent/DK1009393T3/da active
- 1998-08-21 ES ES98948853T patent/ES2175792T3/es not_active Expired - Lifetime
- 1998-08-21 EP EP98948853A patent/EP1009393B1/de not_active Expired - Lifetime
- 1998-08-21 CA CA002302601A patent/CA2302601C/en not_active Expired - Lifetime
- 1998-08-21 DE DE59803647T patent/DE59803647D1/de not_active Expired - Lifetime
- 1998-08-21 US US09/486,266 patent/US6814976B1/en not_active Expired - Lifetime
- 1998-08-21 KR KR10-2000-7002344A patent/KR100515007B1/ko not_active IP Right Cessation
- 1998-08-21 AU AU95329/98A patent/AU738033B2/en not_active Ceased
2000
- 2000-02-28 NO NO20001003A patent/NO327605B1/no not_active IP Right Cessation
2004
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ES2175792T3 (es)	2002-11-16
WO1999012529A3 (de)	1999-05-27
WO1999012529A2 (de)	1999-03-18
US6814976B1 (en)	2004-11-09
JP2001515856A (ja)	2001-09-25
ATE215364T1 (de)	2002-04-15
DE59803647D1 (de)	2002-05-08
US20040253301A1 (en)	2004-12-16
NO20001003D0 (no)	2000-02-28
US7384651B2 (en)	2008-06-10
CA2302601C (en)	2006-06-13
EP1009393B1 (de)	2002-04-03
JP3847088B2 (ja)	2006-11-15
PT1009393E (pt)	2002-09-30
KR100515007B1 (ko)	2005-09-14
AU9532998A (en)	1999-03-29
AU738033B2 (en)	2001-09-06
EP1009393A2 (de)	2000-06-21
NO20001003L (no)	2000-02-28
DE19738855A1 (de)	1999-03-11
KR20010023691A (ko)	2001-03-26
CA2302601A1 (en)	1999-03-18
DE19738855C2 (de)	2001-01-04
SI1009393T1 (en)	2002-10-31
DK1009393T3 (da)	2002-07-22

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Date	Code	Title	Description
2013-03-25	MM1K	Lapsed by not paying the annual fees

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NO327605B1 (no)	2009-08-31	Transdermalt terapeutisk system, fremgangsmate for fremstilling samt andvendelse av dette
CA2542688C (en)	2013-06-18	Adhesive preparation
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JPH10511353A (ja)	1998-11-04	接着剤オーバーレイおよび剥離性シールディスクを用いた経皮送達システム
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US6315854B1 (en)	2001-11-13	Transdermal therapeutic plaster
EP1450773B1 (de)	2008-05-28	Transdermales therapeutisches system mit verbessertem langzeittragekomfort
JPH05309128A (ja)	1993-11-22	貼付剤および貼付製剤
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KR20010073008A (ko)	2001-07-31	3개의 기능 층을 갖는 약제 함유 플라스터
MXPA01002344A (en)	2001-11-21	Plaster containing a medicament, with three functional layers
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JPH08188530A (ja)	1996-07-23	貼付剤および貼付製剤
JPH09124463A (ja)	1997-05-13	貼付剤