NO312898B1 - Nye pyrimidon-derivater med fungicid aktivitet - Google Patents

Nye pyrimidon-derivater med fungicid aktivitet Download PDF

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Publication number
NO312898B1
NO312898B1 NO19971470A NO971470A NO312898B1 NO 312898 B1 NO312898 B1 NO 312898B1 NO 19971470 A NO19971470 A NO 19971470A NO 971470 A NO971470 A NO 971470A NO 312898 B1 NO312898 B1 NO 312898B1
Authority
NO
Norway
Prior art keywords
arom
methyl
group
hydroxy
propyl
Prior art date
Application number
NO19971470A
Other languages
English (en)
Norwegian (no)
Other versions
NO971470L (no
NO971470D0 (no
Inventor
Javier Bartroli
Enric Turmo
Manuel Anguita
Original Assignee
Uriach & Cia Sa J
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from ES9501564A external-priority patent/ES2107376B1/es
Priority claimed from ES9600646A external-priority patent/ES2120885B1/es
Application filed by Uriach & Cia Sa J filed Critical Uriach & Cia Sa J
Publication of NO971470L publication Critical patent/NO971470L/no
Publication of NO971470D0 publication Critical patent/NO971470D0/no
Publication of NO312898B1 publication Critical patent/NO312898B1/no

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D231/00Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/64Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with three nitrogen atoms as the only ring hetero atoms
    • A01N43/647Triazoles; Hydrogenated triazoles
    • A01N43/6531,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/72Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
    • A01N43/74Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,3
    • A01N43/761,3-Oxazoles; Hydrogenated 1,3-oxazoles
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/72Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
    • A01N43/74Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,3
    • A01N43/781,3-Thiazoles; Hydrogenated 1,3-thiazoles
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/72Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
    • A01N43/80Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,2
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/72Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
    • A01N43/82Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with three ring hetero atoms
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/90Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10Antimycotics
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D249/00Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/081,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D495/00Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04Ortho-condensed systems
NO19971470A 1995-08-02 1997-04-01 Nye pyrimidon-derivater med fungicid aktivitet NO312898B1 (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
ES9501564A ES2107376B1 (es) 1995-08-02 1995-08-02 Nuevos derivados de pirimidona con actividad antifungica.
ES9600646A ES2120885B1 (es) 1996-03-15 1996-03-15 Nuevas tienopirimidonas con actividad antifungica.
PCT/EP1996/003420 WO1997005130A1 (en) 1995-08-02 1996-08-02 New pyrimidone derivatives with antifungal activity

Publications (3)

Publication Number Publication Date
NO971470L NO971470L (no) 1997-04-01
NO971470D0 NO971470D0 (no) 1997-04-01
NO312898B1 true NO312898B1 (no) 2002-07-15

Family

ID=26154906

Family Applications (1)

Application Number Title Priority Date Filing Date
NO19971470A NO312898B1 (no) 1995-08-02 1997-04-01 Nye pyrimidon-derivater med fungicid aktivitet

Country Status (16)

Country Link
US (1) US5807854A (de)
EP (1) EP0783501B9 (de)
JP (1) JP4049207B2 (de)
KR (1) KR100423590B1 (de)
AT (1) ATE198593T1 (de)
AU (1) AU6870396A (de)
BR (1) BR9606547A (de)
CA (1) CA2201477C (de)
DE (1) DE69611512T2 (de)
DK (1) DK0783501T3 (de)
ES (1) ES2153975T3 (de)
GR (1) GR3035621T3 (de)
MX (1) MX9702382A (de)
NO (1) NO312898B1 (de)
PT (1) PT783501E (de)
WO (1) WO1997005130A1 (de)

Families Citing this family (31)

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AU5871000A (en) * 1999-06-11 2001-01-02 Paul G. Abrams High dose radionuclide complexes for bone marrow suppression
US7094885B2 (en) * 1999-07-11 2006-08-22 Neorx Corporation Skeletal-targeted radiation to treat bone-associated pathologies
ES2159488B1 (es) * 2000-03-07 2002-04-16 Uriach & Cia Sa J Procedimiento para la preparacion de derivados de pirimidona con actividad antifungica.
JP2004501913A (ja) 2000-06-23 2004-01-22 ブリストル−マイヤーズ スクイブ ファーマ カンパニー ヘテロアリール−フェニル置換Xa因子阻害剤
WO2002062398A2 (en) 2001-01-08 2002-08-15 Neorx Corporation Radioactively labelled conjugates of phosphonates
PA8539401A1 (es) * 2001-02-14 2002-10-28 Warner Lambert Co Quinazolinas como inhibidores de mmp-13
HUP0303249A3 (en) 2001-02-22 2007-03-28 Sankyo Co Water-soluble triazole fungicide compounds and pharmaceutical compositions containing them
US8329924B2 (en) * 2001-06-11 2012-12-11 Vertex Pharmaceuticals (Canada) Incorporated Compounds and methods for the treatment or prevention of Flavivirus infections
SK288015B6 (sk) * 2001-06-11 2012-11-05 Virochem Pharma Inc. Thiophene derivatives as antiviral agents for flavivirus infection
AU2002364552A1 (en) 2001-12-13 2003-06-30 Dow Global Technologies Inc. Treatment of osteomyelitis with radiopharmaceuticals
EP1534070A4 (de) * 2002-08-20 2008-07-09 Doren M Pinnel Verfahren zur behandlung von pilzinfektionen
CN100413861C (zh) 2002-12-10 2008-08-27 维勒凯姆制药股份有限公司 用于治疗或预防黄病毒感染的化合物
JP5055263B2 (ja) * 2005-03-30 2012-10-24 ダエウン ファーマシューティカル カンパニー リミテッド 抗真菌性トリアゾール誘導体
JP5132069B2 (ja) * 2006-03-31 2013-01-30 三井化学アグロ株式会社 3−(ジヒドロ(又はテトラヒドロ)イソキノリン−1−イル)キノリン化合物を含む医薬用抗真菌剤
EP2009009A1 (de) * 2007-06-26 2008-12-31 Palau Pharma, S.A. Antifungale Kristallverbindungen
EP1887004A1 (de) * 2006-08-07 2008-02-13 Palau Pharma, S.A. Kristalline Formen von (1R,2R)-7-Chloro-3-[2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]chinazolin-4(3H)-on
BRPI0716026A2 (pt) * 2006-08-07 2013-08-06 Stiefel Laboratories compostos antiféngicos cristalinos
NZ576780A (en) 2006-11-15 2011-12-22 Virochem Pharma Inc Thiophene analogues for the treatment or prevention of flavivirus infections
UY30892A1 (es) 2007-02-07 2008-09-02 Smithkline Beckman Corp Inhibidores de la actividad akt
US20080255161A1 (en) * 2007-04-11 2008-10-16 Dmitry Koltun 3-HYDROQUINAZOLIN-4-ONE DERIVATIVES FOR USE AS STEAROYL CoA DESATURASE INHIBITORS
EP2257555B1 (de) 2008-03-03 2012-07-04 National Chemical Laboratory Thieno[2,3-d]-pyrimidin-4(3h)-on-verbindungen mit antimykotischen eigenschaften und verfahren dafür
ES2548998T3 (es) * 2009-05-29 2015-10-22 Palau Pharma, S.A. Composiciones antifúngicas de azol
US9655363B2 (en) * 2013-02-04 2017-05-23 Syngenta Participations Ag Microbiocides
TW201636329A (zh) 2015-02-02 2016-10-16 佛瑪治療公司 作為hdac抑制劑之雙環[4,6,0]異羥肟酸
US10112915B2 (en) 2015-02-02 2018-10-30 Forma Therapeutics, Inc. 3-aryl bicyclic [4,5,0] hydroxamic acids as HDAC inhibitors
EA025187B1 (ru) * 2015-04-17 2016-11-30 Тагир Аббасели оглы Сулейманов Производное дитиокарбамата 2-((4-(4-метилпиперазин-1-ил)фенил)амино)-2-оксоетил4-этилпиперазин-1-карбодитиоат, обладающее антифунгальной активностью
WO2017009751A1 (en) 2015-07-15 2017-01-19 Pfizer Inc. Pyrimidine derivatives
US10555935B2 (en) 2016-06-17 2020-02-11 Forma Therapeutics, Inc. 2-spiro-5- and 6-hydroxamic acid indanes as HDAC inhibitors
CN110997646B (zh) 2017-08-10 2023-06-20 住友化学株式会社 环氧醇化合物的制造方法
CN111018839B (zh) * 2019-12-02 2022-12-23 中国人民解放军第二军医大学 三氮唑醇类衍生物及其制备方法和应用
WO2023118082A1 (en) 2021-12-22 2023-06-29 Palau Pharma, S.L.U. Multiparticulate albaconazole composition

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US4482558A (en) * 1982-06-18 1984-11-13 Pfizer Inc. Antifungal amide and urea derivatives of (3-amino-2-aryl-2-hydroxyprop-1-yl)-1H-1,2,4-triazoles
EP0293500A1 (de) * 1987-06-01 1988-12-07 American Cyanamid Company 3-Heteroalkyl-2,4-quinazolinedione, 3-Heteroaryl-1,2,3-benzotriazin-4(3H)-one, 3-Heteroarylalkyl-4-quinazolinon
GB8819308D0 (en) * 1988-08-13 1988-09-14 Pfizer Ltd Triazole antifungal agents
TW218017B (de) * 1992-04-28 1993-12-21 Takeda Pharm Industry Co Ltd

Also Published As

Publication number Publication date
GR3035621T3 (en) 2001-06-29
PT783501E (pt) 2001-04-30
BR9606547A (pt) 1997-10-14
WO1997005130A1 (en) 1997-02-13
MX9702382A (es) 1998-02-28
ATE198593T1 (de) 2001-01-15
JP4049207B2 (ja) 2008-02-20
KR970705558A (ko) 1997-10-09
AU6870396A (en) 1997-02-26
EP0783501B1 (de) 2001-01-10
ES2153975T3 (es) 2001-03-16
EP0783501A1 (de) 1997-07-16
CA2201477C (en) 2005-05-03
US5807854A (en) 1998-09-15
JPH10508317A (ja) 1998-08-18
DE69611512T2 (de) 2001-05-31
DK0783501T3 (da) 2001-01-29
NO971470L (no) 1997-04-01
NO971470D0 (no) 1997-04-01
DE69611512D1 (de) 2001-02-15
CA2201477A1 (en) 1997-02-13
EP0783501B9 (de) 2001-07-25
KR100423590B1 (ko) 2004-09-10

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