NO311133B1 - 1,5-benzodiazepinderivater med CCK-antagonistisk eller agonistisk aktivitet, anvendelse derav, farmasöytisk preparat samtfremgangsmåte for fremstilling derav - Google Patents
1,5-benzodiazepinderivater med CCK-antagonistisk eller agonistisk aktivitet, anvendelse derav, farmasöytisk preparat samtfremgangsmåte for fremstilling derav Download PDFInfo
- Publication number
- NO311133B1 NO311133B1 NO19954090A NO954090A NO311133B1 NO 311133 B1 NO311133 B1 NO 311133B1 NO 19954090 A NO19954090 A NO 19954090A NO 954090 A NO954090 A NO 954090A NO 311133 B1 NO311133 B1 NO 311133B1
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- Norway
- Prior art keywords
- group
- phenyl
- formula
- compound
- methyl
- Prior art date
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- 238000000034 method Methods 0.000 title claims description 23
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- 230000008569 process Effects 0.000 title claims description 3
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Classifications
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- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
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- A61P5/00—Drugs for disorders of the endocrine system
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0207—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)4-C(=0), e.g. 'isosters', replacing two amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
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-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Crystallography & Structural Chemistry (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB939307833A GB9307833D0 (en) | 1993-04-15 | 1993-04-15 | Modulators of cholecystokinin and gastrin |
PCT/EP1994/001131 WO1994024149A1 (en) | 1993-04-15 | 1994-04-14 | 1,5-benzodiazepine derivatives having cck antagonistic or agonistic activity |
Publications (3)
Publication Number | Publication Date |
---|---|
NO954090D0 NO954090D0 (no) | 1995-10-13 |
NO954090L NO954090L (no) | 1995-12-13 |
NO311133B1 true NO311133B1 (no) | 2001-10-15 |
Family
ID=10733915
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO19954090A NO311133B1 (no) | 1993-04-15 | 1995-10-13 | 1,5-benzodiazepinderivater med CCK-antagonistisk eller agonistisk aktivitet, anvendelse derav, farmasöytisk preparat samtfremgangsmåte for fremstilling derav |
Country Status (34)
Country | Link |
---|---|
US (2) | US5646140A (es) |
EP (1) | EP0694039B1 (es) |
JP (1) | JP3406317B2 (es) |
KR (1) | KR100364948B1 (es) |
CN (1) | CN1058487C (es) |
AP (2) | AP512A (es) |
AT (1) | ATE198894T1 (es) |
AU (1) | AU681139B2 (es) |
CA (1) | CA2158973C (es) |
CZ (1) | CZ286695B6 (es) |
DE (1) | DE69426624T2 (es) |
DK (1) | DK0694039T3 (es) |
EC (1) | ECSP941066A (es) |
ES (1) | ES2154674T3 (es) |
FI (1) | FI954853A0 (es) |
GB (1) | GB9307833D0 (es) |
GR (1) | GR3035641T3 (es) |
HK (1) | HK1003943A1 (es) |
HU (1) | HU223467B1 (es) |
IL (2) | IL109316A (es) |
IS (2) | IS4147A (es) |
MY (2) | MY131569A (es) |
NO (1) | NO311133B1 (es) |
NZ (1) | NZ265272A (es) |
OA (1) | OA10355A (es) |
PE (2) | PE50594A1 (es) |
PH (1) | PH30897A (es) |
PL (1) | PL178790B1 (es) |
PT (1) | PT694039E (es) |
RU (1) | RU2135486C1 (es) |
SK (1) | SK281211B6 (es) |
TW (1) | TW487703B (es) |
WO (1) | WO1994024149A1 (es) |
ZA (2) | ZA942570B (es) |
Families Citing this family (48)
Publication number | Priority date | Publication date | Assignee | Title |
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AU684871B2 (en) * | 1993-12-28 | 1998-01-08 | Shionogi & Co., Ltd. | Novel benzodiazepine derivative |
US5739129A (en) * | 1994-04-14 | 1998-04-14 | Glaxo Wellcome Inc. | CCK or gastrin modulating 5-heterocyclic-1, 5 benzodiazepines |
NZ283929A (en) * | 1994-04-14 | 1998-02-26 | Glaxo Wellcome Inc | 5-heterocyclic-1,5-benzodiazepine peptide analogs used to modulate effects of cck or gastrin |
WO1995028399A1 (en) * | 1994-04-15 | 1995-10-26 | Glaxo Wellcome Inc. | A method of inducing cholecystokinin agonist activity using 1,4-benzodiazepine compounds |
PE27497A1 (es) * | 1994-04-15 | 1997-08-07 | Glaxo Inc | Derivados de 1,5 benzodiazepina |
US5780464A (en) * | 1994-10-14 | 1998-07-14 | Glaxo Wellcome Inc. | Enteric coated compositions of 1,5-benzodiazepine derivatives having CCK antagonistic or agonistic activity |
US5910495A (en) * | 1994-10-14 | 1999-06-08 | Glaxo Wellcome Inc. | Use of 1,5-benzo b!1,4-diazepines to control gastric emptying |
GB9420748D0 (en) * | 1994-10-14 | 1994-11-30 | Glaxo Inc | 1,5 benzodiazepine derivatives |
GB9420763D0 (en) * | 1994-10-14 | 1994-11-30 | Glaxo Inc | Acetamide derivatives |
GB9420747D0 (en) * | 1994-10-14 | 1994-11-30 | Glaxo Inc | 1,5 benzodiazepine derivatives |
WO1997021731A1 (en) | 1995-12-11 | 1997-06-19 | New England Medical Center Hospitals, Inc. | Assay for and uses of peptide hormone receptor ligands |
US5750353A (en) * | 1995-12-11 | 1998-05-12 | New England Medical Center Hospitals, Inc. | Assay for non-peptide agonists to peptide hormone receptors |
JP3999819B2 (ja) * | 1996-12-10 | 2007-10-31 | ゼリア新薬工業株式会社 | 1,5―ベンゾジアセピン誘導体 |
SK141899A3 (en) | 1997-04-15 | 2000-09-12 | Csir Corporate Building | Pharmaceutical compositions having appetite suppressant activity |
AR022044A1 (es) * | 1999-05-06 | 2002-09-04 | Glaxo Group Ltd | Derivados de 1,5-benzodiazepina |
GB2396815B (en) | 1999-10-27 | 2004-09-08 | Phytopharm Plc | A composition comprising a pregnenone derivative and an NSAID |
GB2363985B (en) | 2000-06-30 | 2004-09-29 | Phytopharm Plc | Extracts,compounds & pharmaceutical compositions having anti-diabetic activity and their use |
US6768024B1 (en) | 2000-08-04 | 2004-07-27 | Lion Bioscience Ag | Triamine derivative melanocortin receptor ligands and methods of using same |
US20020180095A1 (en) * | 2001-05-29 | 2002-12-05 | Berard Steven O. | Thermally conductive carbon fiber extrusion compounder and method of using same |
US7074805B2 (en) * | 2002-02-20 | 2006-07-11 | Abbott Laboratories | Fused azabicyclic compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor |
ES2319886T3 (es) * | 2002-02-20 | 2009-05-14 | Abbott Laboratories | Compuestos azabiciclicos condensados que inhiben el sutipo 1 del receptor valinoide (vr1). |
US6933311B2 (en) * | 2003-02-11 | 2005-08-23 | Abbott Laboratories | Fused azabicyclic compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor |
US7015233B2 (en) * | 2003-06-12 | 2006-03-21 | Abbott Laboratories | Fused compounds that inhibit vanilloid subtype 1 (VR1) receptor |
EA010888B1 (ru) * | 2004-05-25 | 2008-12-30 | Пфайзер Продактс, Инк. | Тетраазабензо[е]азуленовые производные и их аналоги |
CN1333077C (zh) * | 2005-04-15 | 2007-08-22 | 华南农业大学 | 缩胆囊素活性片段的串联表达及其应用 |
TW200824687A (en) * | 2006-08-25 | 2008-06-16 | Abbott Lab | Compounds that inhibit TRPV1 and uses thereof |
CN101563318A (zh) * | 2006-12-20 | 2009-10-21 | 艾博特公司 | 作为trpv1香草素受体拮抗剂用于治疗疼痛的n-(5,6,7,8-四氢萘-1-基)脲衍生物以及相关化合物 |
CA2719018A1 (en) * | 2008-03-20 | 2009-09-24 | Abbott Laboratories | Methods for making central nervous system agents that are trpv1 antagonists |
CN103102285B (zh) * | 2013-01-30 | 2015-07-29 | 淮阴师范学院 | 对氨基苯乙腈的制备方法 |
WO2015074064A2 (en) | 2013-11-18 | 2015-05-21 | Bair Kenneth W | Tetrahydroquinoline compositions as bet bromodomain inhibitors |
US9422281B2 (en) | 2013-11-18 | 2016-08-23 | Forma Therapeutics, Inc. | Benzopiperazine compositions as BET bromodomain inhibitors |
RS63653B1 (sr) | 2015-07-22 | 2022-11-30 | Enanta Pharm Inc | Benzodiazepinski derivati kao inhibitori rsv |
SG10201913587WA (en) | 2016-02-05 | 2020-02-27 | Denali Therapeutics Inc | Inhibitors of receptor-interacting protein kinase 1 |
EP3552017B1 (en) | 2016-12-09 | 2022-02-23 | Denali Therapeutics Inc. | Compounds useful as ripk1 inhibitors |
US10358441B2 (en) | 2017-02-16 | 2019-07-23 | Enanta Pharmaceuticals, Inc. | Processes for the preparation of benzodiazepine derivatives |
US10752598B2 (en) * | 2017-06-07 | 2020-08-25 | Enanta Pharmaceuticals, Inc. | Aryldiazepine derivatives as RSV inhibitors |
WO2019006295A1 (en) | 2017-06-30 | 2019-01-03 | Enanta Pharmaceuticals, Inc. | HETEROCYCLIC COMPOUNDS AS RSV INHIBITORS |
WO2019006291A1 (en) | 2017-06-30 | 2019-01-03 | Enanta Pharmaceuticals, Inc. | HETEROCYCLIC COMPOUNDS AS RSV INHIBITORS |
CA3077309A1 (en) | 2017-09-29 | 2019-04-04 | Enanta Pharmaceuticals, Inc. | Combination pharmaceutical agents as rsv inhibitors |
WO2019094920A1 (en) | 2017-11-13 | 2019-05-16 | Enanta Pharmaceuticals, Inc. | Azepin-2-one derivatives as rsv inhibitors |
WO2019199908A1 (en) | 2018-04-11 | 2019-10-17 | Enanta Pharmaceuticals, Inc. | Heterocyclic compounds as rsv inhibitors |
US11254664B2 (en) | 2019-03-18 | 2022-02-22 | Enanta Pharmaceuticals, Inc. | Benzodiazepine derivatives as RSV inhibitors |
WO2020210246A1 (en) | 2019-04-09 | 2020-10-15 | Enanta Pharmaceuticals, Inc, | Heterocyclic compounds as rsv inhibitors |
US11505558B1 (en) | 2019-10-04 | 2022-11-22 | Enanta Pharmaceuticals, Inc. | Antiviral heterocyclic compounds |
UY39032A (es) | 2020-01-24 | 2021-07-30 | Enanta Pharm Inc | Compuestos heterocíclicos como agentes antivirales |
WO2022010882A1 (en) | 2020-07-07 | 2022-01-13 | Enanta Pharmaceuticals, Inc, | Dihydroquinoxaline and dihydropyridopyrazine derivatives as rsv inhibitors |
US11945824B2 (en) | 2020-10-19 | 2024-04-02 | Enanta Pharmaceuticals, Inc. | Heterocyclic compounds as anti-viral agents |
AU2023206890A1 (en) | 2022-01-12 | 2024-08-22 | Denali Therapeutics Inc. | Crystalline forms of (s)-5-benzyl-n-(5-methyl-4-oxo-2, 3,4,5- tetrahydropyrido [3,2-b] [l,4]oxazepin-3-yl)-4h-l,2,4-triazole-3-carboxamide |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2641280B1 (fr) * | 1988-12-29 | 1994-01-21 | Roussel Uclaf | Nouveaux derives de la 2,4-dioxo 2,3,4,5-tetrahydro 1h-1,5-benzodiazepine, leur procede de preparation et leur application comme medicaments |
FR2659653B1 (fr) * | 1990-03-13 | 1992-05-22 | Rhone Poulenc Sante | Derives de l'uree, leur preparation et les medicaments les contenant. |
US5206234A (en) * | 1990-10-22 | 1993-04-27 | Merck & Co., Inc. | Benzolactam analogs as antagonists of cck |
JP2904941B2 (ja) * | 1991-01-28 | 1999-06-14 | 出光興産株式会社 | スチレン系重合体の精製方法 |
GEP20001968B (en) * | 1992-01-21 | 2000-03-05 | Glaxo Spa | Arilthio Compounds as Antibacterial and Antiviral Agents |
NZ283929A (en) * | 1994-04-14 | 1998-02-26 | Glaxo Wellcome Inc | 5-heterocyclic-1,5-benzodiazepine peptide analogs used to modulate effects of cck or gastrin |
-
1993
- 1993-04-15 GB GB939307833A patent/GB9307833D0/en active Pending
-
1994
- 1994-01-04 US US08/525,659 patent/US5646140A/en not_active Expired - Lifetime
- 1994-04-11 IS IS4147A patent/IS4147A/is unknown
- 1994-04-11 IS IS4148A patent/IS4148A/is unknown
- 1994-04-12 MY MYPI94000884A patent/MY131569A/en unknown
- 1994-04-12 EC EC1994001066A patent/ECSP941066A/es unknown
- 1994-04-12 MY MYPI94000880A patent/MY112237A/en unknown
- 1994-04-13 IL IL10931694A patent/IL109316A/en not_active IP Right Cessation
- 1994-04-13 PE PE1994240028A patent/PE50594A1/es not_active Application Discontinuation
- 1994-04-13 PE PE1994240027A patent/PE50994A1/es not_active Application Discontinuation
- 1994-04-13 IL IL10931594A patent/IL109315A0/xx unknown
- 1994-04-13 US US08/522,363 patent/US5585376A/en not_active Expired - Fee Related
- 1994-04-13 AP APAP/P/1994/000635A patent/AP512A/en active
- 1994-04-13 AP APAP/P/1994/000634A patent/AP462A/en active
- 1994-04-14 WO PCT/EP1994/001131 patent/WO1994024149A1/en active IP Right Grant
- 1994-04-14 EP EP94913580A patent/EP0694039B1/en not_active Expired - Lifetime
- 1994-04-14 ES ES94913580T patent/ES2154674T3/es not_active Expired - Lifetime
- 1994-04-14 AU AU65676/94A patent/AU681139B2/en not_active Ceased
- 1994-04-14 PT PT94913580T patent/PT694039E/pt unknown
- 1994-04-14 ZA ZA942570A patent/ZA942570B/xx unknown
- 1994-04-14 SK SK1253-95A patent/SK281211B6/sk unknown
- 1994-04-14 DE DE69426624T patent/DE69426624T2/de not_active Expired - Lifetime
- 1994-04-14 CZ CZ19952675A patent/CZ286695B6/cs not_active IP Right Cessation
- 1994-04-14 PH PH48093A patent/PH30897A/en unknown
- 1994-04-14 DK DK94913580T patent/DK0694039T3/da active
- 1994-04-14 AT AT94913580T patent/ATE198894T1/de not_active IP Right Cessation
- 1994-04-14 ZA ZA942571A patent/ZA942571B/xx unknown
- 1994-04-14 RU RU95117974A patent/RU2135486C1/ru not_active IP Right Cessation
- 1994-04-14 CN CN94191773A patent/CN1058487C/zh not_active Expired - Fee Related
- 1994-04-14 HU HU9502978A patent/HU223467B1/hu not_active IP Right Cessation
- 1994-04-14 CA CA002158973A patent/CA2158973C/en not_active Expired - Fee Related
- 1994-04-14 PL PL94311084A patent/PL178790B1/pl unknown
- 1994-04-14 KR KR1019950704491A patent/KR100364948B1/ko not_active IP Right Cessation
- 1994-04-14 JP JP52273494A patent/JP3406317B2/ja not_active Expired - Fee Related
- 1994-04-14 NZ NZ265272A patent/NZ265272A/en not_active IP Right Cessation
- 1994-05-26 TW TW083104772A patent/TW487703B/zh not_active IP Right Cessation
-
1995
- 1995-10-12 FI FI954853A patent/FI954853A0/fi unknown
- 1995-10-12 OA OA60722A patent/OA10355A/en unknown
- 1995-10-13 NO NO19954090A patent/NO311133B1/no unknown
-
1998
- 1998-04-16 HK HK98103188A patent/HK1003943A1/xx not_active IP Right Cessation
-
2001
- 2001-03-27 GR GR20010400488T patent/GR3035641T3/el not_active IP Right Cessation
Also Published As
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