ES2154674T3 - Derivados de 1,5-benzodiacepinas con actividad antagonista o agonista de cck. - Google Patents

Derivados de 1,5-benzodiacepinas con actividad antagonista o agonista de cck.

Info

Publication number
ES2154674T3
ES2154674T3 ES94913580T ES94913580T ES2154674T3 ES 2154674 T3 ES2154674 T3 ES 2154674T3 ES 94913580 T ES94913580 T ES 94913580T ES 94913580 T ES94913580 T ES 94913580T ES 2154674 T3 ES2154674 T3 ES 2154674T3
Authority
ES
Spain
Prior art keywords
cck
benzodiacepins
antagonist
derivatives
agonist activity
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94913580T
Other languages
English (en)
Inventor
Elizabeth Ellen Sugg
Christopher Joseph Aquino
Jerzy Ryszard Szewczyk
Harry Finch
Robin Arthur Ellis Carr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Corp
Original Assignee
Glaxo Wellcome Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Wellcome Inc filed Critical Glaxo Wellcome Inc
Application granted granted Critical
Publication of ES2154674T3 publication Critical patent/ES2154674T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0207—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)4-C(=0), e.g. 'isosters', replacing two amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0827—Tripeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

SE PRESENTAN NUEVOS COMPUESTOS DE BENZODIACEPINA DE LA FORMULA (I) QUE EXHIBEN ACTIVIDAD ANTAGONISTA CON LOS RECEPTORES DEL CCKA HACIENDO POSIBLE QUE MODULEN LAS HORMONAS GASTRINA Y COLECISTOQUININA (CCK) EN LOS MAMIFEROS Y SE UTILIZAN EN MEDICINAS COMO AGENTES ANORECTICOS EN LA REGULACION DEL APETITO, EL TRATAMIENTO DE LA OBESIDAD Y EL MANTENIMIENTO DE LA PERDIDA DE PESO.
ES94913580T 1993-04-15 1994-04-14 Derivados de 1,5-benzodiacepinas con actividad antagonista o agonista de cck. Expired - Lifetime ES2154674T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB939307833A GB9307833D0 (en) 1993-04-15 1993-04-15 Modulators of cholecystokinin and gastrin

Publications (1)

Publication Number Publication Date
ES2154674T3 true ES2154674T3 (es) 2001-04-16

Family

ID=10733915

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94913580T Expired - Lifetime ES2154674T3 (es) 1993-04-15 1994-04-14 Derivados de 1,5-benzodiacepinas con actividad antagonista o agonista de cck.

Country Status (34)

Country Link
US (2) US5646140A (es)
EP (1) EP0694039B1 (es)
JP (1) JP3406317B2 (es)
KR (1) KR100364948B1 (es)
CN (1) CN1058487C (es)
AP (2) AP512A (es)
AT (1) ATE198894T1 (es)
AU (1) AU681139B2 (es)
CA (1) CA2158973C (es)
CZ (1) CZ286695B6 (es)
DE (1) DE69426624T2 (es)
DK (1) DK0694039T3 (es)
EC (1) ECSP941066A (es)
ES (1) ES2154674T3 (es)
FI (1) FI954853A (es)
GB (1) GB9307833D0 (es)
GR (1) GR3035641T3 (es)
HK (1) HK1003943A1 (es)
HU (1) HU223467B1 (es)
IL (2) IL109316A (es)
IS (2) IS4147A (es)
MY (2) MY131569A (es)
NO (1) NO311133B1 (es)
NZ (1) NZ265272A (es)
OA (1) OA10355A (es)
PE (2) PE50594A1 (es)
PH (1) PH30897A (es)
PL (1) PL178790B1 (es)
PT (1) PT694039E (es)
RU (1) RU2135486C1 (es)
SK (1) SK281211B6 (es)
TW (1) TW487703B (es)
WO (1) WO1994024149A1 (es)
ZA (2) ZA942571B (es)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995018110A1 (fr) * 1993-12-28 1995-07-06 Shionogi & Co., Ltd. Nouveau derive de benzodiazepine
US5739129A (en) * 1994-04-14 1998-04-14 Glaxo Wellcome Inc. CCK or gastrin modulating 5-heterocyclic-1, 5 benzodiazepines
ATE181737T1 (de) * 1994-04-14 1999-07-15 Glaxo Wellcome Inc Cck oder gastrin modulierende 5-heterocyclicyl- 1,5-benzodiazepine
US5795887A (en) * 1994-04-15 1998-08-18 Glaxo Wellcome Inc. Method of inducing cholecystokinin agonist activity using 1,4- Benzodiazepine compounds
PE27497A1 (es) * 1994-04-15 1997-08-07 Glaxo Inc Derivados de 1,5 benzodiazepina
GB9420747D0 (en) * 1994-10-14 1994-11-30 Glaxo Inc 1,5 benzodiazepine derivatives
US5910495A (en) * 1994-10-14 1999-06-08 Glaxo Wellcome Inc. Use of 1,5-benzo b!1,4-diazepines to control gastric emptying
GB9420748D0 (en) * 1994-10-14 1994-11-30 Glaxo Inc 1,5 benzodiazepine derivatives
US5780464A (en) * 1994-10-14 1998-07-14 Glaxo Wellcome Inc. Enteric coated compositions of 1,5-benzodiazepine derivatives having CCK antagonistic or agonistic activity
GB9420763D0 (en) * 1994-10-14 1994-11-30 Glaxo Inc Acetamide derivatives
US5750353A (en) * 1995-12-11 1998-05-12 New England Medical Center Hospitals, Inc. Assay for non-peptide agonists to peptide hormone receptors
IL124808A0 (en) 1995-12-11 1999-01-26 New England Medical Center Inc Assay for and uses of peptide hormone receptor ligands
US6239131B1 (en) * 1996-12-10 2001-05-29 Zeria Pharmaceutical Co., Ltd. 1,5 Benzodiazepine derivatives
KR100891756B1 (ko) 1997-04-15 2009-04-07 씨에스아이알 식욕 억제 활성을 갖는 약학 조성물
AR022044A1 (es) * 1999-05-06 2002-09-04 Glaxo Group Ltd Derivados de 1,5-benzodiazepina
GB2396815B (en) 1999-10-27 2004-09-08 Phytopharm Plc A composition comprising a pregnenone derivative and an NSAID
GB2363985B (en) 2000-06-30 2004-09-29 Phytopharm Plc Extracts,compounds & pharmaceutical compositions having anti-diabetic activity and their use
US6768024B1 (en) 2000-08-04 2004-07-27 Lion Bioscience Ag Triamine derivative melanocortin receptor ligands and methods of using same
US20020180095A1 (en) * 2001-05-29 2002-12-05 Berard Steven O. Thermally conductive carbon fiber extrusion compounder and method of using same
US7074805B2 (en) * 2002-02-20 2006-07-11 Abbott Laboratories Fused azabicyclic compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor
JP4614662B2 (ja) * 2002-02-20 2011-01-19 アボット・ラボラトリーズ バニロイド受容体サブタイプ１（ｖｒ１）受容体を阻害する縮合アザ二環式化合物
US6933311B2 (en) * 2003-02-11 2005-08-23 Abbott Laboratories Fused azabicyclic compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor
US7015233B2 (en) 2003-06-12 2006-03-21 Abbott Laboratories Fused compounds that inhibit vanilloid subtype 1 (VR1) receptor
EP1753766A1 (en) * 2004-05-25 2007-02-21 Pfizer Products Inc. Tetraazabenzo(e)azulene derivatives and analogs thereof
CN1333077C (zh) * 2005-04-15 2007-08-22 华南农业大学 缩胆囊素活性片段的串联表达及其应用
EP2054390B1 (en) * 2006-08-25 2012-04-11 Abbott Laboratories Indazole derivatives that inhibit trpv1 and uses thereof
WO2008079683A2 (en) * 2006-12-20 2008-07-03 Abbott Laboratories N- (5, 6, 7, 8-tetrahydronaphthalen-1-yl) urea derivatives and related compounds as trpv1 vanilloid receptor antagonists for the treatment of pain
WO2009117626A2 (en) * 2008-03-20 2009-09-24 Abbott Laboratories Methods for making central nervous system agents that are trpv1 antagonists
CN103102285B (zh) * 2013-01-30 2015-07-29 淮阴师范学院 对氨基苯乙腈的制备方法
US9422281B2 (en) 2013-11-18 2016-08-23 Forma Therapeutics, Inc. Benzopiperazine compositions as BET bromodomain inhibitors
RS61519B1 (sr) 2013-11-18 2021-03-31 Forma Therapeutics Inc Sastavi tetrahidrohinolina kao inhibitori bet bromodomena
PL3324977T3 (pl) 2015-07-22 2022-11-14 Enanta Pharmaceuticals, Inc. Pochodne benzodiazepiny jako inhibitory rsv
AU2017213628B2 (en) 2016-02-05 2021-07-29 Denali Therapeutics Inc. Inhibitors of receptor-interacting protein kinase 1
WO2018107060A1 (en) 2016-12-09 2018-06-14 Denali Therapeutics Inc. Compounds, compositions and methods
KR102573499B1 (ko) 2017-02-16 2023-08-31 이난타 파마슈티칼스, 인코포레이티드 벤조디아제핀 유도체의 제조 방법
WO2018226801A1 (en) * 2017-06-07 2018-12-13 Enanta Pharmaceuticals, Inc. Aryldiazepine derivatives as rsv inhibitors
WO2019006295A1 (en) 2017-06-30 2019-01-03 Enanta Pharmaceuticals, Inc. HETEROCYCLIC COMPOUNDS AS RSV INHIBITORS
US10851115B2 (en) 2017-06-30 2020-12-01 Enanta Pharmaceuticals, Inc. Heterocyclic compounds as RSV inhibitors
WO2019067864A1 (en) 2017-09-29 2019-04-04 Enanta Pharmaceuticals, Inc. PHARMACEUTICAL AGENTS IN COMBINATION AS INHIBITORS OF RSV
US10647711B2 (en) 2017-11-13 2020-05-12 Enanta Pharmaceuticals, Inc. Azepin-2-one derivatives as RSV inhibitors
US10975094B2 (en) 2018-04-11 2021-04-13 Enanta Pharmaceuticals, Inc. Heterocyclic compounds as RSV inhibitors
AU2020240024A1 (en) 2019-03-18 2021-10-14 Enanta Pharmaceuticals, Inc. Benzodiazepine derivatives as RSV inhibitors
US11179400B2 (en) 2019-04-09 2021-11-23 Enanta Pharmaceuticals, Inc. Heterocyclic compounds as RSV inhibitors
US11505558B1 (en) 2019-10-04 2022-11-22 Enanta Pharmaceuticals, Inc. Antiviral heterocyclic compounds
UY39032A (es) 2020-01-24 2021-07-30 Enanta Pharm Inc Compuestos heterocíclicos como agentes antivirales
US11534439B2 (en) 2020-07-07 2022-12-27 Enanta Pharmaceuticals, Inc. Dihydroquinoxaline and dihydropyridopyrazine derivatives as RSV inhibitors
WO2022086840A1 (en) 2020-10-19 2022-04-28 Enanta Pharmaceuticals, Inc. Heterocyclic compounds as anti-viral agents
US11999750B2 (en) 2022-01-12 2024-06-04 Denali Therapeutics Inc. Crystalline forms of (S)-5-benzyl-N-(5-methyl-4-oxo-2,3,4,5-tetrahydropyrido [3,2-B][1,4]oxazepin-3-yl)-4H-1,2,4-triazole-3-carboxamide

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2641280B1 (fr) * 1988-12-29 1994-01-21 Roussel Uclaf Nouveaux derives de la 2,4-dioxo 2,3,4,5-tetrahydro 1h-1,5-benzodiazepine, leur procede de preparation et leur application comme medicaments
FR2659653B1 (fr) * 1990-03-13 1992-05-22 Rhone Poulenc Sante Derives de l'uree, leur preparation et les medicaments les contenant.
US5206234A (en) * 1990-10-22 1993-04-27 Merck & Co., Inc. Benzolactam analogs as antagonists of cck
JP2904941B2 (ja) * 1991-01-28 1999-06-14 出光興産株式会社 スチレン系重合体の精製方法
GB9201180D0 (en) * 1992-01-21 1992-03-11 Glaxo Group Ltd Chemical compounds
ATE181737T1 (de) * 1994-04-14 1999-07-15 Glaxo Wellcome Inc Cck oder gastrin modulierende 5-heterocyclicyl- 1,5-benzodiazepine

Also Published As

Publication number Publication date
HU9502978D0 (en) 1995-12-28
WO1994024149A1 (en) 1994-10-27
MY131569A (en) 2007-08-30
IL109315A0 (en) 1994-07-31
HU223467B1 (hu) 2004-07-28
HK1003943A1 (en) 1998-11-13
OA10355A (en) 2001-10-19
FI954853A0 (fi) 1995-10-12
AP9400634A0 (en) 1994-04-30
EP0694039B1 (en) 2001-01-24
NZ265272A (en) 1997-07-27
AU6567694A (en) 1994-11-08
ECSP941066A (es) 1994-11-16
US5646140A (en) 1997-07-08
EP0694039A1 (en) 1996-01-31
PE50994A1 (es) 1995-01-06
AU681139B2 (en) 1997-08-21
AP512A (en) 1996-07-29
IS4148A (is) 1994-10-16
AP462A (en) 1996-02-19
SK281211B6 (sk) 2001-01-18
HUT74102A (en) 1996-11-28
RU2135486C1 (ru) 1999-08-27
MY112237A (en) 2001-05-31
ZA942570B (en) 1994-11-11
NO954090D0 (no) 1995-10-13
CZ286695B6 (en) 2000-06-14
GR3035641T3 (en) 2001-06-29
JP3406317B2 (ja) 2003-05-12
IL109316A (en) 1999-03-12
AP9400635A0 (en) 1994-04-30
TW487703B (en) 2002-05-21
JPH08508744A (ja) 1996-09-17
KR100364948B1 (ko) 2003-03-29
NO311133B1 (no) 2001-10-15
FI954853A (fi) 1995-10-12
NO954090L (no) 1995-12-13
PE50594A1 (es) 1995-01-06
CN1058487C (zh) 2000-11-15
DE69426624D1 (de) 2001-03-01
PH30897A (en) 1997-12-23
CN1120843A (zh) 1996-04-17
DK0694039T3 (da) 2001-05-21
PL311084A1 (en) 1996-02-05
ZA942571B (en) 1994-11-11
GB9307833D0 (en) 1993-06-02
CZ267595A3 (en) 1996-04-17
PL178790B1 (pl) 2000-06-30
ATE198894T1 (de) 2001-02-15
CA2158973A1 (en) 1994-10-27
IS4147A (is) 1994-10-16
SK125395A3 (en) 1996-06-05
US5585376A (en) 1996-12-17
CA2158973C (en) 2006-06-06
IL109316A0 (en) 1994-07-31
DE69426624T2 (de) 2001-06-21
PT694039E (pt) 2001-06-29

Similar Documents

Publication Publication Date Title
ES2154674T3 (es) Derivados de 1,5-benzodiacepinas con actividad antagonista o agonista de cck.
ES2174989T3 (es) Pirido(3,2-e)pirazinonas con antiasmatica y procedimiento para su preparacion.
ES2107518T3 (es) Polimeros estabilizados con heteroatomos en la cadena principal.
ECSP941135A (es) Antagonistas triciclicos de vasopresina de benzacepina
ES2093694T3 (es) Nuevos derivados de dihidro-isoquinoleina.
ES2080739T3 (es) Nitro-compuestos insecticidamente activos.
ES2058185T3 (es) Derivados de camptotecina y procedimiento para su preparacion.
ES2134226T3 (es) Derivados de s-triazina como fotoestabilizadores.
ES2076688T3 (es) Derivados de 2-hidroxi-2-feniletilamina utiles como agonistas de beta-3-adrenoceptores.
ES2154262T3 (es) Uso de compuestos macrolidos para enfermedades oculares.
ES2059841T3 (es) Nitro compuestos con actividad insecticida.
ES2153907T3 (es) Compuestos espiro tetraciclicos, procedimiento para su preparacion y su uso como antagonistas del receptor 5ht1d.
MX9203647A (es) Materiales absorbentes y metodos para su produccion.
MX9201356A (es) Derivados de piperidina, procedimiento para su preparacion y composicion farmaceutica que los contiene.
ES2084339T3 (es) Tetrahidropiridinas e hidroxipiperidinas sustituidas utiles como agentes para el sistema nervioso central.
ES2076595T3 (es) Derivados de amidinofenilalanina, procedimiento para su preparacion, su empleo y agentes que los contienen.
ES2059534T3 (es) Nuevos derivados benzopiranos antihipertensivos.
MX9302034A (es) Bencidazoles, medicamentos que contienen estos compuestos y procedimientos para su preparacion.
ES2056153T3 (es) Expectorante que comprende un derivado hidroxialquilcisteina.
ES2177811T3 (es) Uso de nitroflavonoides para el tratamiento de la ansiedad.
MX9304424A (es) Bencimidazoles, medicamentos que contienen estos compuestos y procedimiento para su preparacion.
ES2196069T3 (es) Derivados morfinoides condensados con heterociclos.
ES2062202T3 (es) Derivado del indol.
IS4367A (is) CCK eða gastrín temprandi 5-heterósýklísk-1,5-bensódíazepín
AR001813A1 (es) Derivados de cromona procedimiento para prepararlos y las composiciones farmacéutica que los contienen

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 694039

Country of ref document: ES