NO306943B1 - Fremgangsmåte for fremstilling av enantiomerene av O- demetyltramadol - Google Patents

Fremgangsmåte for fremstilling av enantiomerene av O- demetyltramadol

Info

Publication number: NO306943B1
Authority: NO; Norway
Prior art keywords: demethyltramadol; enantiomers; preparation
Prior art date: 1996-01-19

Application number

NO970212A

Other languages

English (en)

Norwegian (no)

Other versions

NO970212D0 (no

NO970212L (no

Inventor

Helmut Buschmann

Werner Winter

Ivars Graudums

Peter Jansen

Wolfgang Werner A Strassburger

Elmar Josef Friderichs

Original Assignee

Gruenenthal Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-01-19

Filing date

1997-01-17

Publication date

2000-01-17

1997-01-17 Application filed by Gruenenthal Gmbh filed Critical Gruenenthal Gmbh

1997-01-17 Publication of NO970212D0 publication Critical patent/NO970212D0/no

1997-07-21 Publication of NO970212L publication Critical patent/NO970212L/no

2000-01-17 Publication of NO306943B1 publication Critical patent/NO306943B1/no

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C213/10—Separation; Purification; Stabilisation; Use of additives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C213/08—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions not involving the formation of amino groups, hydroxy groups or etherified or esterified hydroxy groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Neurosurgery (AREA)
Pharmacology & Pharmacy (AREA)
Biomedical Technology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pain & Pain Management (AREA)
Neurology (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

NO970212A 1996-01-19 1997-01-17 Fremgangsmåte for fremstilling av enantiomerene av O- demetyltramadol NO306943B1 (no)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE19601744A DE19601744C2 (de)	1996-01-19	1996-01-19	Verfahren zur Herstellung der Enantiomeren von O-Demethyltramadol

Publications (3)

Publication Number	Publication Date
NO970212D0 NO970212D0 (no)	1997-01-17
NO970212L NO970212L (no)	1997-07-21
NO306943B1 true NO306943B1 (no)	2000-01-17

Family

ID=7783111

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO970212A NO306943B1 (no)	1996-01-19	1997-01-17	Fremgangsmåte for fremstilling av enantiomerene av O- demetyltramadol

Country Status (32)

Country	Link
US (1)	US5728885A (pt)
EP (1)	EP0786450B1 (pt)
JP (1)	JPH09216857A (pt)
KR (1)	KR100507396B1 (pt)
CN (1)	CN1073085C (pt)
AR (1)	AR005390A1 (pt)
AT (1)	ATE191454T1 (pt)
AU (1)	AU705195B2 (pt)
BR (1)	BR9700079A (pt)
CA (1)	CA2195372C (pt)
CO (1)	CO4520186A1 (pt)
CZ (1)	CZ292427B6 (pt)
DE (2)	DE19601744C2 (pt)
DK (1)	DK0786450T3 (pt)
ES (1)	ES2147341T3 (pt)
GR (1)	GR3033390T3 (pt)
HK (1)	HK1004810A1 (pt)
HU (1)	HU223661B1 (pt)
IL (1)	IL120029A (pt)
IN (1)	IN181540B (pt)
MY (1)	MY116593A (pt)
NO (1)	NO306943B1 (pt)
NZ (1)	NZ299998A (pt)
PE (1)	PE29998A1 (pt)
PL (1)	PL187373B1 (pt)
PT (1)	PT786450E (pt)
RU (1)	RU2185371C2 (pt)
SI (1)	SI0786450T1 (pt)
SK (1)	SK282629B6 (pt)
UA (1)	UA45342C2 (pt)
UY (1)	UY24438A1 (pt)
ZA (1)	ZA97367B (pt)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE19712398A1 (de) *	1997-03-25	1998-10-01	Gruenenthal Gmbh	Orale Anwendung von (+)-0-Demethyltramadol als Schmerzmittel
PE20010623A1 (es)	1999-10-05	2001-07-07	Gruenenthal Chemie	Uso de (+)-tramadol y/o o-demetiltramadol para tratamiento de urgencia urinaria incrementada y/o incontinencia urinaria
WO2001034125A2 (en) *	1999-11-09	2001-05-17	Darwin Discovery Limited	Therapeutic use and formulation of (-)-tramadol
DE10049483A1 (de)	2000-09-29	2002-05-02	Gruenenthal Gmbh	Substituierte 1-Aminobutan-3-ol-Derivate
DE10108123A1 (de) *	2001-02-21	2002-10-02	Gruenenthal Gmbh	Wirkstoffkombination
DE10108122A1 (de)	2001-02-21	2002-10-02	Gruenenthal Gmbh	Arzneimittel auf Basis von Tramadol
DE10109763A1 (de) *	2001-02-28	2002-09-05	Gruenenthal Gmbh	Pharmazeutische Salze
US20050176790A1 (en)	2001-02-28	2005-08-11	Johannes Bartholomaus	Pharmaceutical salts
US6974839B2 (en)	2001-03-16	2005-12-13	Dmi Biosciences, Inc.	Method of delaying ejaculation
US6649783B2 (en) *	2001-10-03	2003-11-18	Euro-Celtique, S.A.	Synthesis of (+/-)-2-((dimethylamino)methyl)-1-(aryl)cyclohexanols
AU2002364517A1 (en)	2001-11-30	2003-06-17	Sepracor Inc.	Tramadol analogs and uses thereof
US20040248979A1 (en) *	2003-06-03	2004-12-09	Dynogen Pharmaceuticals, Inc.	Method of treating lower urinary tract disorders
DE102005033732B4 (de) *	2005-05-27	2014-02-13	Grünenthal GmbH	Trennung stereoisomerer N,N-Dialkylamino-2-alkyl-3-hydroxy-3-phenyl-alkane
EP1785412A1 (en) *	2005-11-14	2007-05-16	IPCA Laboratories Limited	Tramadol recovery process
SG178775A1 (en)	2007-02-12	2012-03-29	Dmi Biosciences Inc	Reducing side effects of tramadol
MX2009008491A (es)	2007-02-12	2010-01-20	Dmi Biosciences Inc	Tratamiento de disfuncion erectil y eyaculacion prematura copatologicas.
US20110251286A1 (en) *	2010-03-10	2011-10-13	Gruenenthal Gmbh	Crystalline salts and/or co-crystals of O-desmethyltramadol
EP2383255A1 (en)	2010-04-28	2011-11-02	Lacer, S.A.	New compounds, synthesis and use thereof in the treatment of pain
EP2530072A1 (en)	2011-06-03	2012-12-05	Lacer, S.A.	New compounds, synthesis and use thereof in the treatment of pain
US10702485B2 (en)	2011-07-09	2020-07-07	Syntrix Biosystems Inc.	Compositions and methods for overcoming resistance to tramadol
US10781163B2 (en)	2017-09-18	2020-09-22	R L Finechem Private Limited	Process for preparation of O-Desmethyltramadol and salts thereof
US11000488B2 (en)	2019-03-22	2021-05-11	Syntrix Biosystems Inc.	Treating pain using desmetramadol
CN118108610A (zh) *	2024-04-30	2024-05-31	山东新华制药股份有限公司	盐酸去甲曲马多的制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE1518663A1 (de) *	1965-08-02	1969-12-18	Gruenenthal Chemie	Basisch substituierte Cycloalken-derivate und Verfahren zu ihrer Herstellung
US3652589A (en) *	1967-07-27	1972-03-28	Gruenenthal Chemie	1-(m-substituted phenyl)-2-aminomethyl cyclohexanols
EP0534628B1 (en) *	1991-09-06	1996-11-20	Mcneilab, Inc.	Compositions comprising a tramadol material and any of codeine, oxycodone or hydrocodone, and their use
KR100243956B1 (ko)	1991-09-06	2000-03-02	랄프 알. 팔로	트라마돌 물질 및 아세트아미노펜을 포함하는 통증 치료용 약제학적 조성물
JPH06122686A (ja) *	1992-10-12	1994-05-06	Fujisawa Pharmaceut Co Ltd	ラセミ体の光学分割法

1996
- 1996-01-19 DE DE19601744A patent/DE19601744C2/de not_active Expired - Fee Related
- 1996-12-18 PE PE1996000931A patent/PE29998A1/es not_active Application Discontinuation
- 1996-12-21 DK DK96120727T patent/DK0786450T3/da active
- 1996-12-21 DE DE59604885T patent/DE59604885D1/de not_active Expired - Lifetime
- 1996-12-21 AT AT96120727T patent/ATE191454T1/de active
- 1996-12-21 EP EP96120727A patent/EP0786450B1/de not_active Expired - Lifetime
- 1996-12-21 PT PT96120727T patent/PT786450E/pt unknown
- 1996-12-21 SI SI9630187T patent/SI0786450T1/xx unknown
- 1996-12-21 ES ES96120727T patent/ES2147341T3/es not_active Expired - Lifetime
- 1996-12-23 NZ NZ299998A patent/NZ299998A/en not_active IP Right Cessation
- 1996-12-30 MY MYPI96005545A patent/MY116593A/en unknown
- 1996-12-30 CO CO96068522A patent/CO4520186A1/es unknown
1997
- 1997-01-07 AR ARP970100068A patent/AR005390A1/es active IP Right Grant
- 1997-01-09 IN IN46CA1997 patent/IN181540B/en unknown
- 1997-01-10 UY UY24438A patent/UY24438A1/es not_active IP Right Cessation
- 1997-01-10 BR BR9700079A patent/BR9700079A/pt not_active Application Discontinuation
- 1997-01-16 ZA ZA97367A patent/ZA97367B/xx unknown
- 1997-01-16 HU HU9700140A patent/HU223661B1/hu not_active IP Right Cessation
- 1997-01-17 CZ CZ1997157A patent/CZ292427B6/cs not_active IP Right Cessation
- 1997-01-17 PL PL97318002A patent/PL187373B1/pl not_active IP Right Cessation
- 1997-01-17 JP JP9006904A patent/JPH09216857A/ja not_active Ceased
- 1997-01-17 RU RU97100984/04A patent/RU2185371C2/ru not_active IP Right Cessation
- 1997-01-17 CN CN97102072A patent/CN1073085C/zh not_active Expired - Fee Related
- 1997-01-17 UA UA97010174A patent/UA45342C2/uk unknown
- 1997-01-17 SK SK67-97A patent/SK282629B6/sk not_active IP Right Cessation
- 1997-01-17 NO NO970212A patent/NO306943B1/no not_active IP Right Cessation
- 1997-01-17 KR KR1019970001204A patent/KR100507396B1/ko not_active IP Right Cessation
- 1997-01-17 IL IL12002997A patent/IL120029A/xx not_active IP Right Cessation
- 1997-01-17 US US08/784,078 patent/US5728885A/en not_active Expired - Lifetime
- 1997-01-17 AU AU12216/97A patent/AU705195B2/en not_active Ceased
- 1997-01-17 CA CA002195372A patent/CA2195372C/en not_active Expired - Fee Related
1998
- 1998-05-08 HK HK98103999A patent/HK1004810A1/xx not_active IP Right Cessation
2000
- 2000-05-09 GR GR20000401077T patent/GR3033390T3/el unknown

Also Published As

Publication number	Publication date
HU223661B1 (hu)	2004-11-29
MY116593A (en)	2004-02-28
US5728885A (en)	1998-03-17
CN1167107A (zh)	1997-12-10
DK0786450T3 (da)	2000-07-10
ES2147341T3 (es)	2000-09-01
NZ299998A (en)	1998-01-26
PL187373B1 (pl)	2004-06-30
BR9700079A (pt)	1998-11-10
UA45342C2 (uk)	2002-04-15
DE19601744A1 (de)	1997-07-31
KR970059161A (ko)	1997-08-12
CA2195372C (en)	2005-08-30
SI0786450T1 (en)	2000-08-31
AU705195B2 (en)	1999-05-20
DE19601744C2 (de)	1998-04-16
PT786450E (pt)	2000-08-31
EP0786450A3 (de)	1997-10-15
AU1221697A (en)	1997-07-24
GR3033390T3 (en)	2000-09-29
EP0786450A2 (de)	1997-07-30
IN181540B (pt)	1998-07-11
HK1004810A1 (en)	1998-12-11
UY24438A1 (es)	1997-01-10
CN1073085C (zh)	2001-10-17
SK282629B6 (sk)	2002-10-08
CO4520186A1 (es)	1997-10-15
CZ15797A3 (cs)	1998-05-13
SK6797A3 (en)	1997-08-06
RU2185371C2 (ru)	2002-07-20
ATE191454T1 (de)	2000-04-15
CZ292427B6 (cs)	2003-09-17
DE59604885D1 (de)	2000-05-11
EP0786450B1 (de)	2000-04-05
NO970212D0 (no)	1997-01-17
PL318002A1 (en)	1997-07-21
HUP9700140A2 (hu)	1998-01-28
CA2195372A1 (en)	1997-07-20
AR005390A1 (es)	1999-04-28
IL120029A (en)	2000-01-31
MX9700523A (es)	1997-07-31
ZA97367B (en)	1997-07-17
PE29998A1 (es)	1998-08-08
HUP9700140A3 (en)	2000-03-28
HU9700140D0 (en)	1997-03-28
KR100507396B1 (ko)	2005-12-20
NO970212L (no)	1997-07-21
JPH09216857A (ja)	1997-08-19
IL120029A0 (en)	1997-04-15

Legal Events

Date	Code	Title	Description
2014-08-25	MM1K	Lapsed by not paying the annual fees

Publication	Publication Date	Title
NO970212L (no)	1997-07-21	Fremgangsmåte for fremstilling av enantiomerene av O-demetyltramadol
NO20011936D0 (no)	2001-04-19	Fremgangsmåte for fremstilling av Citalopram
FI102474B1 (fi)	1998-12-15	Menetelmä moniarvoisten alkoholien valmistamiseksi
NO992375L (no)	1999-07-14	FremgangsmÕte for fremstilling av benzylethere
NO976121D0 (no)	1997-12-29	Fremgangsmåte for fremstilling av karbonylforbindelser
NO20001728D0 (no)	2000-04-04	Fremgangsmåte for fremstilling av chirale forbindelser
NO20000189L (no)	2000-03-14	Fremgangsmõte for fremstilling av heparin
NO972402D0 (no)	1997-05-27	Fremgangsmåte for fremstilling av bærere
NO983068D0 (no)	1998-07-02	FremgangsmÕte for fremstilling av bis-syklopentadienyl-dien komplekser
NO20024058D0 (no)	2002-08-26	Fremgangsmåte for fremstilling av et oksazolyletanolderivat
NO20003454D0 (no)	2000-07-04	FremgangsmÕte for fremstilling av (-)cis-3-hydroksy-1-metyl-4-
NO20062796L (no)	1998-04-24	Fremgangsmate for fremstilling av en dihydroksyaminoforbindelse
NO996432D0 (no)	1999-12-23	Fremgangsmåte for fremstilling av 4-substituert-1H-indol-3- glykosamider
NO984905D0 (no)	1998-10-21	FremgangsmÕte for fremstilling av b°rstevarer
NO985535D0 (no)	1998-11-27	FremgangsmÕte for fremstilling av 1,3-alkandioler
NO980316D0 (no)	1998-01-23	Fremgangsmåte for fremstilling av polymerisater av N-vinylkarprolaktam
NO972682D0 (no)	1997-06-11	Ny fremgangsmåte for fremstilling av sameridin
NO991055L (no)	1999-04-29	FremgangsmÕte for fremstilling av dinitratestere
NO20013219L (no)	1998-11-26	Fremgangsmåte for fremstilling av trinatrium-pentacyanoamino- ferrat (II)
NO20003077D0 (no)	2000-06-15	FremgangsmÕte for fremstilling av klorbenzooksazolen
NO972129D0 (no)	1997-05-07	Fremgangsmåte for fremstilling av 1-halo-3-trialkylsilanyl-benzenderivater
NO20012811D0 (no)	2001-06-07	Fremgangsmåte for fremstilling av p-klorfenyl-propanol- derivat
NO179866C (no)	1997-01-02	Fremgangsmåte for fremstilling av indoler
NO994557D0 (no)	1999-09-20	Fremgangsmaate for fremstilling av arylaminotriazolopyridiner
NO20002476L (no)	2000-05-12	FremgangsmÕte for fremstilling av formylimidazoler