NO306929B1 - Pharmaceutical preparations for solubilization of cyclosporins - Google Patents
Pharmaceutical preparations for solubilization of cyclosporinsInfo
- Publication number
- NO306929B1 NO306929B1 NO960062A NO960062A NO306929B1 NO 306929 B1 NO306929 B1 NO 306929B1 NO 960062 A NO960062 A NO 960062A NO 960062 A NO960062 A NO 960062A NO 306929 B1 NO306929 B1 NO 306929B1
- Authority
- NO
- Norway
- Prior art keywords
- active agent
- component
- iii
- fatty acid
- acid ester
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
- A61K38/13—Cyclosporins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
Abstract
Pharmaceutical prepn. comprises () a pharmaceutically active agent which is sparingly soluble in water; and (b) a carrier compsn. comprising (i) at least one polyglycerine fatty acid ester and/or at least one sorbitan fatty acid ester, (ii) at least 1 conventional pharmaceutical oil contg. a triglyceride as lipophilic component and (iii) at least 1 nonionic surfactant with a HLB value of at least 10. The active agent is pref. a cyclosporin, rapamycin, tacrolimus, deoxyspergualine, nifedipine, nimodipine, etoposide, ibuprofen or alpha-lipoic acid. The active agent has a solubility, in distilled water, of less than 500mg/1000ml. The active agent concn. is 1-30 wt.%, based on the carrier compsn. The carrier compsn. comprises 10-50 wt.% component (i), 5-40 wt% component (ii) and 10-50 wt % component (iii).
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE4322826A DE4322826A1 (en) | 1993-07-08 | 1993-07-08 | Pharmaceutical preparation |
PCT/EP1994/002238 WO1995001785A1 (en) | 1993-07-08 | 1994-07-08 | Pharmaceutical compositions for hardly soluble active substances |
Publications (3)
Publication Number | Publication Date |
---|---|
NO960062L NO960062L (en) | 1996-01-05 |
NO960062D0 NO960062D0 (en) | 1996-01-05 |
NO306929B1 true NO306929B1 (en) | 2000-01-17 |
Family
ID=6492300
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO960062A NO306929B1 (en) | 1993-07-08 | 1996-01-05 | Pharmaceutical preparations for solubilization of cyclosporins |
NO960069A NO306763B1 (en) | 1993-07-08 | 1996-01-05 | Pharmaceutical compositions for the solubilization of highly soluble active substances |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO960069A NO306763B1 (en) | 1993-07-08 | 1996-01-05 | Pharmaceutical compositions for the solubilization of highly soluble active substances |
Country Status (24)
Country | Link |
---|---|
EP (3) | EP0710103B1 (en) |
JP (4) | JPH08512303A (en) |
KR (2) | KR100359044B1 (en) |
CN (2) | CN1313154C (en) |
AT (3) | ATE201985T1 (en) |
AU (2) | AU689486B2 (en) |
BR (1) | BR9407002A (en) |
CA (2) | CA2164100A1 (en) |
CY (2) | CY2308B1 (en) |
CZ (1) | CZ291401B6 (en) |
DE (6) | DE4322826A1 (en) |
DK (3) | DK0710104T3 (en) |
ES (3) | ES2218046T3 (en) |
FI (2) | FI116197B (en) |
GR (1) | GR3036571T3 (en) |
HU (2) | HU228127B1 (en) |
NO (2) | NO306929B1 (en) |
NZ (2) | NZ269552A (en) |
PL (1) | PL179717B1 (en) |
PT (2) | PT1092429E (en) |
RU (1) | RU2140291C1 (en) |
SI (1) | SI1092429T1 (en) |
SK (1) | SK280615B6 (en) |
WO (2) | WO1995001785A1 (en) |
Families Citing this family (66)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CH686761A5 (en) | 1993-05-27 | 1996-06-28 | Sandoz Ag | Pharmaceutical formulations. |
DE4322826A1 (en) * | 1993-07-08 | 1995-01-12 | Galenik Labor Freiburg Gmbh | Pharmaceutical preparation |
GB9409778D0 (en) | 1994-05-16 | 1994-07-06 | Dumex Ltd As | Compositions |
US6413536B1 (en) * | 1995-06-07 | 2002-07-02 | Southern Biosystems, Inc. | High viscosity liquid controlled delivery system and medical or surgical device |
US6696413B2 (en) * | 1995-06-16 | 2004-02-24 | Hexal Ag | Pharmaceutical preparation with cyclosporin A |
FR2736550B1 (en) | 1995-07-14 | 1998-07-24 | Sandoz Sa | PHARMACEUTICAL COMPOSITION IN THE FORM OF A SOLID DISPERSION COMPRISING A MACROLIDE AND A VEHICLE |
GB9514878D0 (en) * | 1995-07-20 | 1995-09-20 | Danbiosyst Uk | Vitamin E as a solubilizer for drugs contained in lipid vehicles |
GB2317562B (en) * | 1995-07-20 | 1999-08-18 | Danbiosyst Uk | Lipid vehicle drug delivery composition containing vitamin E |
US5597582A (en) * | 1995-09-12 | 1997-01-28 | Sanofi | Oral gel capsule formulation of 1,2,4-benzotriazine oxides |
DE19544507B4 (en) * | 1995-11-29 | 2007-11-15 | Novartis Ag | Cyclosporin containing preparations |
CZ288631B6 (en) * | 1996-01-18 | 2001-08-15 | Galena, A. S. | Therapeutic preparations containing cyclosporin |
CZ288739B6 (en) * | 1996-08-01 | 2001-08-15 | Galena, A. S. | Cyclosporin containing medicinal preparations |
US6458373B1 (en) | 1997-01-07 | 2002-10-01 | Sonus Pharmaceuticals, Inc. | Emulsion vehicle for poorly soluble drugs |
GB9705813D0 (en) * | 1997-03-20 | 1997-05-07 | Smithkline Beecham Plc | Novel compositions |
EP0978288A4 (en) * | 1997-04-11 | 2006-07-12 | Astellas Pharma Inc | Medicinal composition |
US6365180B1 (en) * | 1998-01-20 | 2002-04-02 | Glenn A. Meyer | Oral liquid compositions |
ID25908A (en) * | 1998-03-06 | 2000-11-09 | Novartis Ag | EMULSION PRACTONCENTRATES CONTAINING CYCLOSPORINE OR MACROLIDES |
US7030155B2 (en) | 1998-06-05 | 2006-04-18 | Sonus Pharmaceuticals, Inc. | Emulsion vehicle for poorly soluble drugs |
GB2344520A (en) * | 1998-12-08 | 2000-06-14 | Phares Pharm Res Nv | Pharmaceutical carriers comprising lipids and polymers |
CA2386277A1 (en) * | 1999-10-01 | 2001-04-12 | Natco Pharma Limited | An improved pharmaceutical composition and a process for its preparation |
US7732404B2 (en) | 1999-12-30 | 2010-06-08 | Dexcel Ltd | Pro-nanodispersion for the delivery of cyclosporin |
US20020035107A1 (en) | 2000-06-20 | 2002-03-21 | Stefan Henke | Highly concentrated stable meloxicam solutions |
EP1336408A4 (en) * | 2000-11-24 | 2005-01-19 | Yamanouchi Pharma Co Ltd | Water-soluble liquid internal medicine |
DE10161077A1 (en) | 2001-12-12 | 2003-06-18 | Boehringer Ingelheim Vetmed | Highly concentrated stable meloxicam solutions for needleless injection |
JP4251988B2 (en) | 2001-12-14 | 2009-04-08 | ヤーゴテック アクチェンゲゼルシャフト | Pharmaceutical formulations containing cyclosporine and uses thereof |
KR100533458B1 (en) | 2002-07-20 | 2005-12-07 | 대화제약 주식회사 | Composition for solubilization of paclitaxel and preparation method thereof |
GB2391473B (en) * | 2002-08-02 | 2004-07-07 | Satishchandra Punambhai Patel | Pharmaceutical compositions |
US8992980B2 (en) | 2002-10-25 | 2015-03-31 | Boehringer Ingelheim Vetmedica Gmbh | Water-soluble meloxicam granules |
WO2004069247A1 (en) | 2003-02-06 | 2004-08-19 | Cipla Ltd | Topical immunotherapy and compositions for use therein |
WO2004073692A1 (en) * | 2003-02-18 | 2004-09-02 | Yamashita, Shinji | Hard capsule of hardly water-soluble drug |
CA2533013C (en) * | 2003-07-17 | 2011-07-26 | Banner Pharmacaps, Inc. | Controlled release preparations |
EP1568369A1 (en) | 2004-02-23 | 2005-08-31 | Boehringer Ingelheim Vetmedica Gmbh | Use of meloxicam for the treatment of respiratory diseases in pigs |
TW200616681A (en) * | 2004-10-05 | 2006-06-01 | Recordati Ireland Ltd | Lercanidipine capsules |
GB0425255D0 (en) * | 2004-11-16 | 2004-12-15 | Novartis Ag | Pharmaceutical composition |
US20070027105A1 (en) | 2005-07-26 | 2007-02-01 | Alza Corporation | Peroxide removal from drug delivery vehicle |
EA200800451A1 (en) * | 2005-07-28 | 2008-08-29 | Релайэнт Фармасьютикалз, Инк. | TREATMENT OF DIHYDROPYRIDINE BLOCKERS OF CALCIUM CHANNELS AND FATTY ACIDS OF OMEGA-3 AND THEIR COMBINED PRODUCT |
GB0526419D0 (en) * | 2005-12-23 | 2006-02-08 | Cyclacel Ltd | Formulation |
PT2117521E (en) | 2006-11-03 | 2012-09-10 | Durect Corp | Transdermal delivery systems comprising bupivacaine |
EP1952807A1 (en) | 2007-01-24 | 2008-08-06 | LEK Pharmaceuticals D.D. | Sirolimus formulation |
ITMI20070720A1 (en) * | 2007-04-06 | 2008-10-07 | Monteresearch Srl | ORAL COMPOSITIONS CONTAINING TACROLIMUS IN AMORPHOUS FORM |
US11304960B2 (en) | 2009-01-08 | 2022-04-19 | Chandrashekar Giliyar | Steroidal compositions |
EA023244B1 (en) * | 2009-04-10 | 2016-05-31 | Хаян Ки | Method for preventing cell senescence |
CN102647971B (en) | 2009-10-12 | 2016-03-16 | 贝林格尔.英格海姆维特梅迪卡有限公司 | For comprising the container of the compositions of meloxicam |
AU2010347598B2 (en) | 2010-03-03 | 2014-11-27 | Boehringer Ingelheim Vetmedica Gmbh | Use of meloxicam for the long-term treatment of musculoskeletal disorders in cats |
US9795568B2 (en) | 2010-05-05 | 2017-10-24 | Boehringer Ingelheim Vetmedica Gmbh | Low concentration meloxicam tablets |
US9034858B2 (en) | 2010-11-30 | 2015-05-19 | Lipocine Inc. | High-strength testosterone undecanoate compositions |
US20180153904A1 (en) | 2010-11-30 | 2018-06-07 | Lipocine Inc. | High-strength testosterone undecanoate compositions |
US9358241B2 (en) | 2010-11-30 | 2016-06-07 | Lipocine Inc. | High-strength testosterone undecanoate compositions |
US20120148675A1 (en) | 2010-12-10 | 2012-06-14 | Basawaraj Chickmath | Testosterone undecanoate compositions |
JP5970224B2 (en) | 2011-07-11 | 2016-08-17 | 株式会社日本自動車部品総合研究所 | Spark plug for internal combustion engine |
KR20140071913A (en) * | 2012-12-04 | 2014-06-12 | 삼성정밀화학 주식회사 | Food composition and soft capsule including the same |
BR112015025347A2 (en) * | 2013-04-09 | 2017-07-18 | Boston Biomedical Inc | 2-acetyl naphtho [2-3-b] furan-4,9-dione for use in cancer treatment |
US9498485B2 (en) | 2014-08-28 | 2016-11-22 | Lipocine Inc. | Bioavailable solid state (17-β)-hydroxy-4-androsten-3-one esters |
US20170246187A1 (en) | 2014-08-28 | 2017-08-31 | Lipocine Inc. | (17-ß)-3-OXOANDROST-4-EN-17-YL TRIDECANOATE COMPOSITIONS AND METHODS OF THEIR PREPARATION AND USE |
CN107106644B (en) * | 2014-11-07 | 2022-04-15 | 卓越治疗有限公司 | Cyclosporin-containing compositions |
CN105828827A (en) | 2014-11-21 | 2016-08-03 | 杭州领业医药科技有限公司 | Solid preparation comprising tofogliflozin and method for producing same |
EP3445362B1 (en) | 2016-04-20 | 2021-09-22 | VeroScience LLC | Composition and method for treating metabolic disorders |
US11559530B2 (en) | 2016-11-28 | 2023-01-24 | Lipocine Inc. | Oral testosterone undecanoate therapy |
WO2019079623A1 (en) * | 2017-10-18 | 2019-04-25 | Veroscience Llc | Improved bromocriptine formulations |
MA51999B1 (en) * | 2018-03-14 | 2024-02-29 | Kandy Therapeutics Ltd | NEW PHARMACEUTICAL FORMULATION COMPRISING TWO NK-1/NK-3 RECEPTOR ANTAGONISTS. |
CN108853044B (en) * | 2018-07-06 | 2020-11-06 | 郑州明泽医药科技有限公司 | Nifedipine sustained release tablet and preparation method thereof |
WO2021146215A1 (en) | 2020-01-13 | 2021-07-22 | Durect Corporation | Sustained release drug delivery systems with reduced impurities and related methods |
KR102524312B1 (en) * | 2020-12-15 | 2023-04-21 | 윤관식 | Water-soluble emulsion composition comprising ecdysteroid |
KR102583074B1 (en) * | 2021-01-25 | 2023-09-25 | 윤관식 | Water-soluble emulsion composition comprising natural polyphenolic compound |
WO2022131656A1 (en) * | 2020-12-15 | 2022-06-23 | 윤관식 | Alkaloid-containing, water-soluble emulsified composition |
CN113041236B (en) * | 2021-03-23 | 2023-03-10 | 广州新济药业科技有限公司 | Flurbiprofen cataplasm and preparation method thereof |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1132518A (en) * | 1965-02-18 | 1968-11-06 | Richardson Merrell Inc | Medicinal composition |
IT1090703B (en) * | 1976-12-03 | 1985-06-26 | Scherer Ltd R P | IMPROVEMENT IN USEFUL COMPOSITIONS SUCH AS DRUG VEHICLES |
GB8903804D0 (en) * | 1989-02-20 | 1989-04-05 | Sandoz Ltd | Improvements in or relating to organic compounds |
GB8630273D0 (en) * | 1986-12-18 | 1987-01-28 | Til Medical Ltd | Pharmaceutical delivery systems |
GB2222770B (en) * | 1988-09-16 | 1992-07-29 | Sandoz Ltd | Pharmaceutical compositions containing cyclosporins |
WO1990014837A1 (en) * | 1989-05-25 | 1990-12-13 | Chiron Corporation | Adjuvant formulation comprising a submicron oil droplet emulsion |
JPH0525037A (en) * | 1991-07-01 | 1993-02-02 | Upjohn Co:The | Oral administrative enzyme sensitive enteric coating |
DE4322826A1 (en) * | 1993-07-08 | 1995-01-12 | Galenik Labor Freiburg Gmbh | Pharmaceutical preparation |
-
1993
- 1993-07-08 DE DE4322826A patent/DE4322826A1/en not_active Withdrawn
-
1994
- 1994-07-08 KR KR1019960700042A patent/KR100359044B1/en not_active IP Right Cessation
- 1994-07-08 AT AT94922269T patent/ATE201985T1/en active
- 1994-07-08 AT AT00122248T patent/ATE261720T1/en active
- 1994-07-08 NZ NZ269552A patent/NZ269552A/en not_active IP Right Cessation
- 1994-07-08 ES ES00122248T patent/ES2218046T3/en not_active Expired - Lifetime
- 1994-07-08 HU HU9503965A patent/HU228127B1/en not_active IP Right Cessation
- 1994-07-08 AT AT94923715T patent/ATE172876T1/en not_active IP Right Cessation
- 1994-07-08 AU AU73457/94A patent/AU689486B2/en not_active Expired
- 1994-07-08 KR KR1019960700026A patent/KR100386533B1/en not_active IP Right Cessation
- 1994-07-08 DK DK94923715T patent/DK0710104T3/en active
- 1994-07-08 PT PT00122248T patent/PT1092429E/en unknown
- 1994-07-08 DE DE59410365T patent/DE59410365D1/en not_active Expired - Lifetime
- 1994-07-08 JP JP7503833A patent/JPH08512303A/en active Pending
- 1994-07-08 AU AU73850/94A patent/AU7385094A/en not_active Abandoned
- 1994-07-08 WO PCT/EP1994/002238 patent/WO1995001785A1/en active IP Right Grant
- 1994-07-08 ES ES94923715T patent/ES2124420T3/en not_active Expired - Lifetime
- 1994-07-08 DE DE4494851T patent/DE4494851D2/en not_active Expired - Fee Related
- 1994-07-08 EP EP94922269A patent/EP0710103B1/en not_active Expired - Lifetime
- 1994-07-08 ES ES94922269T patent/ES2159564T3/en not_active Expired - Lifetime
- 1994-07-08 EP EP94923715A patent/EP0710104B1/en not_active Expired - Lifetime
- 1994-07-08 HU HU9503868A patent/HU223073B1/en active IP Right Grant
- 1994-07-08 DE DE59407239T patent/DE59407239D1/en not_active Expired - Fee Related
- 1994-07-08 CN CNB031522890A patent/CN1313154C/en not_active Expired - Lifetime
- 1994-07-08 PL PL94312255A patent/PL179717B1/en unknown
- 1994-07-08 PT PT94922269T patent/PT710103E/en unknown
- 1994-07-08 DK DK00122248T patent/DK1092429T3/en active
- 1994-07-08 RU RU96102012A patent/RU2140291C1/en active
- 1994-07-08 SK SK19-96A patent/SK280615B6/en not_active IP Right Cessation
- 1994-07-08 CN CN94192714A patent/CN1121853C/en not_active Expired - Lifetime
- 1994-07-08 WO PCT/EP1994/002248 patent/WO1995001786A1/en active IP Right Grant
- 1994-07-08 SI SI9430465T patent/SI1092429T1/en unknown
- 1994-07-08 CA CA002164100A patent/CA2164100A1/en not_active Abandoned
- 1994-07-08 CZ CZ199645A patent/CZ291401B6/en not_active IP Right Cessation
- 1994-07-08 DE DE4494850T patent/DE4494850D2/en not_active Expired - Fee Related
- 1994-07-08 JP JP7503830A patent/JPH08512301A/en active Pending
- 1994-07-08 BR BR9407002A patent/BR9407002A/en not_active Application Discontinuation
- 1994-07-08 EP EP00122248A patent/EP1092429B1/en not_active Expired - Lifetime
- 1994-07-08 DE DE59409787T patent/DE59409787D1/en not_active Expired - Lifetime
- 1994-07-08 DK DK94922269T patent/DK0710103T3/en active
- 1994-07-08 CA CA002166204A patent/CA2166204C/en not_active Expired - Fee Related
- 1994-07-08 NZ NZ269808A patent/NZ269808A/en not_active IP Right Cessation
-
1996
- 1996-01-03 FI FI960032A patent/FI116197B/en active IP Right Grant
- 1996-01-04 FI FI960042A patent/FI116714B/en not_active IP Right Cessation
- 1996-01-05 NO NO960062A patent/NO306929B1/en not_active IP Right Cessation
- 1996-01-05 NO NO960069A patent/NO306763B1/en not_active IP Right Cessation
-
2001
- 2001-09-10 GR GR20010401428T patent/GR3036571T3/en unknown
-
2002
- 2002-12-12 CY CY0200068A patent/CY2308B1/en unknown
-
2005
- 2005-09-08 CY CY0500049A patent/CY2604B2/en unknown
-
2009
- 2009-02-04 JP JP2009023837A patent/JP2009138008A/en not_active Withdrawn
-
2011
- 2011-03-24 JP JP2011066324A patent/JP2011153150A/en active Pending
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
NO306929B1 (en) | Pharmaceutical preparations for solubilization of cyclosporins | |
TR199500299A2 (en) | Pharmaceutical compositions. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
MK1K | Patent expired |