FI960032A0 - Pharmaceutical preparations for poorly soluble active substances - Google Patents

Pharmaceutical preparations for poorly soluble active substances

Info

Publication number
FI960032A0
FI960032A0 FI960032A FI960032A FI960032A0 FI 960032 A0 FI960032 A0 FI 960032A0 FI 960032 A FI960032 A FI 960032A FI 960032 A FI960032 A FI 960032A FI 960032 A0 FI960032 A0 FI 960032A0
Authority
FI
Finland
Prior art keywords
active agent
component
active substances
pharmaceutical preparations
poorly soluble
Prior art date
Application number
FI960032A
Other languages
Finnish (fi)
Swedish (sv)
Other versions
FI960032A (en
FI116197B (en
Inventor
Ulrich Posanski
Original Assignee
Ciba Geigy Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=6492300&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FI960032(A0) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag
Publication of FI960032A0 publication Critical patent/FI960032A0/en
Publication of FI960032A publication Critical patent/FI960032A/en
Application granted granted Critical
Publication of FI116197B publication Critical patent/FI116197B/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13—Cyclosporins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Abstract

Pharmaceutical prepn. comprises () a pharmaceutically active agent which is sparingly soluble in water; and (b) a carrier compsn. comprising (i) at least one polyglycerine fatty acid ester and/or at least one sorbitan fatty acid ester, (ii) at least 1 conventional pharmaceutical oil contg. a triglyceride as lipophilic component and (iii) at least 1 nonionic surfactant with a HLB value of at least 10. The active agent is pref. a cyclosporin, rapamycin, tacrolimus, deoxyspergualine, nifedipine, nimodipine, etoposide, ibuprofen or alpha-lipoic acid. The active agent has a solubility, in distilled water, of less than 500mg/1000ml. The active agent concn. is 1-30 wt.%, based on the carrier compsn. The carrier compsn. comprises 10-50 wt.% component (i), 5-40 wt% component (ii) and 10-50 wt % component (iii).
FI960032A 1993-07-08 1996-01-03 Process for the preparation of pharmaceutical compositions for poorly soluble active substances FI116197B (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE4322826 1993-07-08
DE4322826A DE4322826A1 (en) 1993-07-08 1993-07-08 Pharmaceutical preparation
PCT/EP1994/002248 WO1995001786A1 (en) 1993-07-08 1994-07-08 Pharmaceutical compositions for hardly soluble active substances
EP9402248 1994-07-08

Publications (3)

Publication Number Publication Date
FI960032A0 true FI960032A0 (en) 1996-01-03
FI960032A FI960032A (en) 1996-02-09
FI116197B FI116197B (en) 2005-10-14

Family

ID=6492300

Family Applications (2)

Application Number Title Priority Date Filing Date
FI960032A FI116197B (en) 1993-07-08 1996-01-03 Process for the preparation of pharmaceutical compositions for poorly soluble active substances
FI960042A FI116714B (en) 1993-07-08 1996-01-04 The method produces pharmaceutical preparations for sparingly soluble active substances

Family Applications After (1)

Application Number Title Priority Date Filing Date
FI960042A FI116714B (en) 1993-07-08 1996-01-04 The method produces pharmaceutical preparations for sparingly soluble active substances

Country Status (24)

Country Link
EP (3) EP0710103B1 (en)
JP (4) JPH08512303A (en)
KR (2) KR100359044B1 (en)
CN (2) CN1313154C (en)
AT (3) ATE201985T1 (en)
AU (2) AU689486B2 (en)
BR (1) BR9407002A (en)
CA (2) CA2164100A1 (en)
CY (2) CY2308B1 (en)
CZ (1) CZ291401B6 (en)
DE (6) DE4322826A1 (en)
DK (3) DK0710104T3 (en)
ES (3) ES2218046T3 (en)
FI (2) FI116197B (en)
GR (1) GR3036571T3 (en)
HU (2) HU228127B1 (en)
NO (2) NO306929B1 (en)
NZ (2) NZ269552A (en)
PL (1) PL179717B1 (en)
PT (2) PT1092429E (en)
RU (1) RU2140291C1 (en)
SI (1) SI1092429T1 (en)
SK (1) SK280615B6 (en)
WO (2) WO1995001785A1 (en)

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Also Published As

Publication number Publication date
AU7385094A (en) 1995-02-06
DE59410365D1 (en) 2004-04-22
NO960069D0 (en) 1996-01-05
NO960062L (en) 1996-01-05
EP0710103A1 (en) 1996-05-08
PL179717B1 (en) 2000-10-31
CZ4596A3 (en) 1996-04-17
DE59407239D1 (en) 1998-12-10
HU228127B1 (en) 2012-12-28
NZ269808A (en) 1996-07-26
JP2009138008A (en) 2009-06-25
SI1092429T1 (en) 2004-08-31
RU2140291C1 (en) 1999-10-27
DK0710104T3 (en) 1999-07-19
JP2011153150A (en) 2011-08-11
NZ269552A (en) 1996-07-26
FI116714B (en) 2006-02-15
DK0710103T3 (en) 2001-09-24
JPH08512301A (en) 1996-12-24
AU689486B2 (en) 1998-04-02
BR9407002A (en) 1996-09-03
CN1128495A (en) 1996-08-07
CA2166204C (en) 2009-04-14
KR100359044B1 (en) 2003-02-05
HUT73427A (en) 1996-07-29
ES2218046T3 (en) 2004-11-16
EP1092429A1 (en) 2001-04-18
SK1996A3 (en) 1997-04-09
WO1995001785A1 (en) 1995-01-19
PL312255A1 (en) 1996-04-01
CZ291401B6 (en) 2003-03-12
AU7345794A (en) 1995-02-06
SK280615B6 (en) 2000-05-16
PT710103E (en) 2001-11-30
FI960032A (en) 1996-02-09
CN1121853C (en) 2003-09-24
ATE172876T1 (en) 1998-11-15
HU9503965D0 (en) 1996-03-28
DE4494850D2 (en) 1996-08-22
HU223073B1 (en) 2004-03-01
DE4494851D2 (en) 1996-12-19
NO960069L (en) 1996-01-05
HUT73661A (en) 1996-09-30
EP0710104B1 (en) 1998-11-04
DE59409787D1 (en) 2001-07-19
DE4322826A1 (en) 1995-01-12
KR100386533B1 (en) 2003-08-21
NO960062D0 (en) 1996-01-05
NO306929B1 (en) 2000-01-17
WO1995001786A1 (en) 1995-01-19
DK1092429T3 (en) 2004-07-19
PT1092429E (en) 2004-08-31
JPH08512303A (en) 1996-12-24
CN1496743A (en) 2004-05-19
HU9503868D0 (en) 1996-02-28
ES2124420T3 (en) 1999-02-01
FI960042A (en) 1996-01-04
CN1313154C (en) 2007-05-02
GR3036571T3 (en) 2001-12-31
ES2159564T3 (en) 2001-10-16
ATE201985T1 (en) 2001-06-15
FI960042A0 (en) 1996-01-04
EP1092429B1 (en) 2004-03-17
CY2308B1 (en) 2003-11-14
CA2164100A1 (en) 1995-01-19
CA2166204A1 (en) 1995-01-19
CY2604B2 (en) 2010-04-28
NO306763B1 (en) 1999-12-20
EP0710103B1 (en) 2001-06-13
FI116197B (en) 2005-10-14
EP0710104A1 (en) 1996-05-08
ATE261720T1 (en) 2004-04-15

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