NO305986B1 - Bifenylderivat, anvendelse derav, middel og preparat omfattende nevnte bifenylderivat, samt fenylpiperazinderivat - Google Patents
Bifenylderivat, anvendelse derav, middel og preparat omfattende nevnte bifenylderivat, samt fenylpiperazinderivatInfo
- Publication number
- NO305986B1 NO305986B1 NO951160A NO951160A NO305986B1 NO 305986 B1 NO305986 B1 NO 305986B1 NO 951160 A NO951160 A NO 951160A NO 951160 A NO951160 A NO 951160A NO 305986 B1 NO305986 B1 NO 305986B1
- Authority
- NO
- Norway
- Prior art keywords
- group
- lower alkyl
- alkyl group
- halogenated
- hydrogen atom
- Prior art date
Links
- ZUOUZKKEUPVFJK-UHFFFAOYSA-N diphenyl Chemical class C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 title abstract 3
- 239000003795 chemical substances by application Substances 0.000 title 1
- YZTJYBJCZXZGCT-UHFFFAOYSA-N phenylpiperazine Chemical class C1CNCCN1C1=CC=CC=C1 YZTJYBJCZXZGCT-UHFFFAOYSA-N 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 10
- 125000003545 alkoxy group Chemical group 0.000 abstract 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 3
- 125000005843 halogen group Chemical group 0.000 abstract 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 3
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 2
- 125000004656 alkyl sulfonylamino group Chemical group 0.000 abstract 2
- 230000008485 antagonism Effects 0.000 abstract 2
- 125000005161 aryl oxy carbonyl group Chemical group 0.000 abstract 2
- VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 abstract 2
- 125000004446 heteroarylalkyl group Chemical group 0.000 abstract 2
- 102000056834 5-HT2 Serotonin Receptors Human genes 0.000 abstract 1
- 108091005479 5-HT2 receptors Proteins 0.000 abstract 1
- 206010001488 Aggression Diseases 0.000 abstract 1
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- 208000019901 Anxiety disease Diseases 0.000 abstract 1
- 206010012218 Delirium Diseases 0.000 abstract 1
- 208000004547 Hallucinations Diseases 0.000 abstract 1
- 206010020651 Hyperkinesia Diseases 0.000 abstract 1
- 208000000269 Hyperkinesis Diseases 0.000 abstract 1
- 206010029333 Neurosis Diseases 0.000 abstract 1
- 206010036173 Poriomania Diseases 0.000 abstract 1
- 208000012545 Psychophysiologic disease Diseases 0.000 abstract 1
- 206010039966 Senile dementia Diseases 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 230000016571 aggressive behavior Effects 0.000 abstract 1
- 208000012761 aggressive behavior Diseases 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000004183 alkoxy alkyl group Chemical group 0.000 abstract 1
- 125000005083 alkoxyalkoxy group Chemical group 0.000 abstract 1
- 125000004471 alkyl aminosulfonyl group Chemical group 0.000 abstract 1
- 125000004644 alkyl sulfinyl group Chemical group 0.000 abstract 1
- 125000004390 alkyl sulfonyl group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 125000005099 aryl alkyl carbonyl group Chemical group 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000005141 aryl amino sulfonyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000004657 aryl sulfonyl amino group Chemical group 0.000 abstract 1
- 208000026106 cerebrovascular disease Diseases 0.000 abstract 1
- 229960003638 dopamine Drugs 0.000 abstract 1
- 230000004970 emotional disturbance Effects 0.000 abstract 1
- 230000005284 excitation Effects 0.000 abstract 1
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 230000003340 mental effect Effects 0.000 abstract 1
- 208000015238 neurotic disease Diseases 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 208000020016 psychiatric disease Diseases 0.000 abstract 1
- 102000005962 receptors Human genes 0.000 abstract 1
- 108020003175 receptors Proteins 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 201000000980 schizophrenia Diseases 0.000 abstract 1
Classifications
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- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
- C07D213/30—Oxygen atoms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
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- C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
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- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP8103094 | 1994-03-29 | ||
JP31134794 | 1994-11-22 | ||
JP33691994 | 1994-12-27 |
Publications (3)
Publication Number | Publication Date |
---|---|
NO951160D0 NO951160D0 (no) | 1995-03-27 |
NO951160L NO951160L (no) | 1995-10-02 |
NO305986B1 true NO305986B1 (no) | 1999-08-30 |
Family
ID=27303469
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO951160A NO305986B1 (no) | 1994-03-29 | 1995-03-27 | Bifenylderivat, anvendelse derav, middel og preparat omfattende nevnte bifenylderivat, samt fenylpiperazinderivat |
Country Status (16)
Country | Link |
---|---|
US (2) | US5849912A (fr) |
EP (1) | EP0675118B1 (fr) |
KR (1) | KR100199638B1 (fr) |
CN (2) | CN1114596C (fr) |
AT (1) | ATE225780T1 (fr) |
AU (1) | AU691561B2 (fr) |
BR (1) | BR9500996A (fr) |
CA (1) | CA2144669A1 (fr) |
DE (1) | DE69528485T2 (fr) |
ES (1) | ES2184772T3 (fr) |
FI (1) | FI113172B (fr) |
HU (1) | HUT72492A (fr) |
NO (1) | NO305986B1 (fr) |
NZ (1) | NZ270816A (fr) |
RU (1) | RU2125051C1 (fr) |
TW (1) | TW434229B (fr) |
Families Citing this family (42)
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CA2144669A1 (fr) * | 1994-03-29 | 1995-09-30 | Kozo Akasaka | Derives du biphenyle |
JP3274579B2 (ja) * | 1995-01-12 | 2002-04-15 | 住友製薬株式会社 | 脳血管障害に伴う精神症候治療剤 |
GB9801392D0 (en) | 1998-01-22 | 1998-03-18 | Smithkline Beecham Plc | Novel compounds |
USRE46117E1 (en) | 1999-12-22 | 2016-08-23 | Teva Pharmaceuticals International Gmbh | Modulators of dopamine neurotransmission |
SE9904723D0 (sv) | 1999-12-22 | 1999-12-22 | Carlsson A Research Ab | New modulators of dopamine neurotransmission II |
SE9904724D0 (sv) | 1999-12-22 | 1999-12-22 | Carlsson A Research Ab | New modulators of dopamine neurotransmission I |
GB0007907D0 (en) * | 2000-03-31 | 2000-05-17 | Merck Sharp & Dohme | Therapeutic agents |
IL158941A0 (en) | 2001-05-22 | 2004-05-12 | Neurogen Corp | Melanin concentrating hormone receptor ligands: substituted 1-benzyl-4-aryl piperazine analogues |
EP1935885A3 (fr) * | 2001-05-22 | 2008-10-15 | Neurogen Corporation | Ligands de récepteur d'hormones à concentration de mélanine : Analogues de pipérazine 1-benzyl-4-aryl substitué. |
WO2005060692A2 (fr) * | 2003-12-19 | 2005-07-07 | Smithkline Beecham Corporation | Composes, compositions et methodes |
US7851629B2 (en) | 2004-06-08 | 2010-12-14 | Nsab, Filial Af Neurosearch Sweden Ab, Sverige | Disubstituted phenylpiperidines as modulators of dopamine and serotonin neurotransmission |
DE602005017784D1 (de) | 2004-06-08 | 2009-12-31 | Nsab, Filial Af Neurosearch Sweden Ab | Neue disubstituierte phenylpiperidine als modulatoren der dopamin- und serotoninneurotransmission |
AU2005254726A1 (en) * | 2004-06-18 | 2005-12-29 | Neurosearch A/S | Novel alkyl substituted piperazine derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
EP1802573B1 (fr) | 2004-10-13 | 2016-09-28 | Teva Pharmaceuticals International GmbH | Procede de synthese de 4-(3-methanesulfonylphenyl)-1-n-propyl-piperidine |
US20080119477A1 (en) * | 2004-12-13 | 2008-05-22 | Smith Brian M | N-Biaryl and N-Arylheteroaryl Piperazine Derivatives as Modulators of the 5Ht2c Receptor Useful For the Treatment of Disorders Related Thereto |
US7968574B2 (en) | 2004-12-28 | 2011-06-28 | Kinex Pharmaceuticals, Llc | Biaryl compositions and methods for modulating a kinase cascade |
EP1836169B9 (fr) * | 2004-12-28 | 2012-07-04 | Kinex Pharmaceuticals, LLC | Compositions et procédés de traitement de troubles impliquant une prolifération cellulaire |
JP2008540665A (ja) | 2005-05-19 | 2008-11-20 | バーテックス ファーマシューティカルズ インコーポレイテッド | イオンチャネルのモジュレーターとして有用なビアリール |
JP5388574B2 (ja) | 2005-05-31 | 2014-01-15 | バーテックス ファーマシューティカルズ インコーポレイテッド | イオンチャネルのモジュレーターとして有用なヘテロ環式類 |
SE529246C2 (sv) | 2005-10-13 | 2007-06-12 | Neurosearch Sweden Ab | Nya disubstituerade fenyl-piperidiner som modulatorer för dopaminneurotransmission |
JP5209183B2 (ja) | 2006-04-28 | 2013-06-12 | 東ソー・ファインケム株式会社 | 不純物の低減された2−シアノフェニルボロン酸又はそのエステル体の製造方法 |
EP2041071B1 (fr) | 2006-06-29 | 2014-06-18 | Kinex Pharmaceuticals, LLC | Compositions de biaryle et procédés de modulation d'une cascade de kinases |
US7939529B2 (en) * | 2007-05-17 | 2011-05-10 | Kinex Pharmaceuticals, Llc | Process for the preparation of compositions for modulating a kinase cascade and methods of use thereof |
US7935697B2 (en) | 2006-12-28 | 2011-05-03 | Kinex Pharmaceuticals, Llc | Compositions for modulating a kinase cascade and methods of use thereof |
EP2146961B1 (fr) | 2007-04-12 | 2014-01-29 | IVAX International GmbH | Dérivés n-oxyde et di-n-oxyde de stabilisateurs/modulateurs des récepteurs de la dopamine affichant des profils d'effets secondaires cardiovasculaires améliorés |
WO2008127727A1 (fr) * | 2007-04-13 | 2008-10-23 | Kinex Pharmaceuticals, Llc | Compositions de biaryle et procédés de modulation d'une cascade de kinases |
WO2009009041A2 (fr) * | 2007-07-06 | 2009-01-15 | Kinex Pharmaceuticals, Llc | Compositions et procédés permettant de moduler une cascade de kinases |
JP5946604B2 (ja) * | 2007-10-20 | 2016-07-06 | アテネックス, インコーポレイテッド | キナーゼカスケードをモジュレートするための医薬組成物およびその使用の方法 |
JP2011505341A (ja) * | 2007-11-21 | 2011-02-24 | デコード ジェネティクス イーエイチエフ | 炎症性、心血管およびcns障害を治療するビアリールpde4抑制剤 |
EP2674417A3 (fr) | 2007-11-21 | 2014-04-09 | Decode Genetics EHF | Inhibiteurs de pde4 biaryle pour le traitement de l'inflammation |
DE102008049675A1 (de) | 2008-09-30 | 2010-04-01 | Markus Dr. Heinrich | Verfahren zur Herstellung von 3-Aminobiphenylen |
CA2796419C (fr) | 2010-04-16 | 2018-11-06 | Kinex Pharmaceuticals, Llc | Compositions et procedes pour la prevention et le traitement du cancer |
EP2571870B1 (fr) | 2010-05-17 | 2015-01-21 | Boehringer Ingelheim International GmbH | Antagonistes de ccr2 et leurs utilisations |
WO2012059432A1 (fr) * | 2010-11-01 | 2012-05-10 | Abbott Gmbh & Co. Kg | Composés de type n-phényl-(homo)pipérazinyl-benzènesulfonyle ou benzènesulfonamide appropriés pour le traitement de troubles qui répondent à la modulation du récepteur 5-ht6 |
US9586928B2 (en) | 2011-05-16 | 2017-03-07 | The Scripps Research Institute | Modulators of the nuclear hormone receptor ROR |
US8921533B2 (en) | 2011-07-25 | 2014-12-30 | Chromatin Technologies | Glycosylated valproic acid analogs and uses thereof |
GB201113538D0 (en) | 2011-08-04 | 2011-09-21 | Karobio Ab | Novel estrogen receptor ligands |
US9012476B2 (en) | 2011-12-08 | 2015-04-21 | IVAX International GmbH | Hydrobromide salt of pridopidine |
EA027748B1 (ru) | 2012-04-04 | 2017-08-31 | Тева Фармасьютикалз Интернэшнл Гмбх | Применение придопидина в комбинации с тетрабеназином для лечения двигательных нарушений и ожирения |
CN109999040A (zh) | 2012-08-30 | 2019-07-12 | 阿西纳斯公司 | 蛋白质酪氨酸激酶调节剂 |
WO2017127602A1 (fr) * | 2016-01-22 | 2017-07-27 | Rush University Medical Center | Identification de nouvelles petites molécules agonistes de l'intégrine bêta 2 |
EP3999490A4 (fr) * | 2019-07-12 | 2023-03-08 | Canopy Growth Corporation | Dérivés cannabinoïdes |
Family Cites Families (13)
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IT1066857B (it) * | 1965-12-15 | 1985-03-12 | Acraf | Derivati della s ipiazolo 4.3 a piridina e processi per la loro preparazione |
US3558629A (en) * | 1967-08-31 | 1971-01-26 | Sterling Drug Inc | 2-halo-4-(1-piperazinyl)-benzaldehydes and related compounds |
US3692821A (en) * | 1970-09-09 | 1972-09-19 | Lewis H Sarett | Derivatives of 2-alkanoyloxy and 2-hydroxy-3-phenylbenzoic acid |
US4125612A (en) * | 1977-06-20 | 1978-11-14 | Schering Corporation | N-1-(p-Biphenylalkyl)piperazines and their use as anti-inflammatory agents |
JPS54128588A (en) * | 1978-03-29 | 1979-10-05 | Dainippon Pharmaceut Co Ltd | Antidepressive drugs consisting mainly of 2-(1-piperazinyl)- 4-phenylquinoline |
FR2530236B1 (fr) * | 1982-07-16 | 1985-08-02 | Delalande Sa | Nouveaux derives aminoalkyl naphtaleniques, leurs sels d'addition d'acide et le procede de preparation ainsi que l'application en therapeutique de ces derives et sels |
US4804663A (en) * | 1985-03-27 | 1989-02-14 | Janssen Pharmaceutica N.V. | 3-piperidinyl-substituted 1,2-benzisoxazoles and 1,2-benzisothiazoles |
FR2602771B1 (fr) * | 1986-08-12 | 1988-11-04 | Rhone Poulenc Sante | Nouveaux derives de la benzyl-4 piperazine, leur preparation et les compositions pharmaceutiques qui les contiennent |
DK0385237T3 (da) * | 1989-03-03 | 1994-07-25 | Dainippon Pharmaceutical Co | 2-(1-Piperazinyl)-4-phenylcycloalkanopyridinderivater, fremgangsmåde til fremstilling deraf og farmaceutisk præparat indeholdende dem |
FR2675802B1 (fr) * | 1991-04-26 | 1993-12-24 | Rhone Poulenc Rorer Sa | Antiserotonines, leur preparation et les medicaments les contenant. |
US5332743A (en) * | 1992-06-12 | 1994-07-26 | Mcneilab, Inc. | Benzyl and benzhydryl alcohols |
US5428037A (en) * | 1993-04-09 | 1995-06-27 | Syntex Pharmaceuticals, Ltd. | Heterocyclic derivatives in the treatment of Ischaemia and related diseases |
CA2144669A1 (fr) * | 1994-03-29 | 1995-09-30 | Kozo Akasaka | Derives du biphenyle |
-
1995
- 1995-03-17 CA CA002144669A patent/CA2144669A1/fr not_active Abandoned
- 1995-03-22 ES ES95104208T patent/ES2184772T3/es not_active Expired - Lifetime
- 1995-03-22 DE DE69528485T patent/DE69528485T2/de not_active Expired - Fee Related
- 1995-03-22 AT AT95104208T patent/ATE225780T1/de not_active IP Right Cessation
- 1995-03-22 EP EP95104208A patent/EP0675118B1/fr not_active Expired - Lifetime
- 1995-03-24 AU AU15058/95A patent/AU691561B2/en not_active Ceased
- 1995-03-24 FI FI951417A patent/FI113172B/fi not_active IP Right Cessation
- 1995-03-27 TW TW084102945A patent/TW434229B/zh not_active IP Right Cessation
- 1995-03-27 NO NO951160A patent/NO305986B1/no unknown
- 1995-03-28 HU HU9500896A patent/HUT72492A/hu unknown
- 1995-03-28 RU RU95104322A patent/RU2125051C1/ru not_active IP Right Cessation
- 1995-03-28 NZ NZ270816A patent/NZ270816A/en unknown
- 1995-03-29 CN CN95103617A patent/CN1114596C/zh not_active Expired - Fee Related
- 1995-03-29 BR BR9500996-5A patent/BR9500996A/pt not_active IP Right Cessation
- 1995-03-29 KR KR1019950006910A patent/KR100199638B1/ko not_active IP Right Cessation
-
1997
- 1997-05-12 US US08/855,790 patent/US5849912A/en not_active Expired - Fee Related
-
1998
- 1998-10-05 US US09/166,229 patent/US6281214B1/en not_active Expired - Fee Related
-
2000
- 2000-03-10 CN CN00103862A patent/CN1290700A/zh active Pending
Also Published As
Publication number | Publication date |
---|---|
KR100199638B1 (ko) | 1999-06-15 |
FI113172B (fi) | 2004-03-15 |
CN1114596C (zh) | 2003-07-16 |
US5849912A (en) | 1998-12-15 |
US6281214B1 (en) | 2001-08-28 |
EP0675118A2 (fr) | 1995-10-04 |
RU2125051C1 (ru) | 1999-01-20 |
AU1505895A (en) | 1995-10-05 |
HUT72492A (en) | 1996-05-28 |
FI951417A (fi) | 1995-09-30 |
CA2144669A1 (fr) | 1995-09-30 |
BR9500996A (pt) | 1995-10-24 |
FI951417A0 (fi) | 1995-03-24 |
DE69528485T2 (de) | 2003-08-14 |
ATE225780T1 (de) | 2002-10-15 |
TW434229B (en) | 2001-05-16 |
EP0675118B1 (fr) | 2002-10-09 |
HU9500896D0 (en) | 1995-05-29 |
ES2184772T3 (es) | 2003-04-16 |
CN1290700A (zh) | 2001-04-11 |
NZ270816A (en) | 1996-08-27 |
CN1117966A (zh) | 1996-03-06 |
NO951160L (no) | 1995-10-02 |
RU95104322A (ru) | 1997-04-27 |
AU691561B2 (en) | 1998-05-21 |
KR950026866A (ko) | 1995-10-16 |
NO951160D0 (no) | 1995-03-27 |
EP0675118A3 (fr) | 1997-09-03 |
DE69528485D1 (de) | 2002-11-14 |
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