NO301284B1 - Fremgangsmåte for fremstilling av et ikke naturlig forekommende pseudorabiesvirus, samt fremgangsmåte for in vitro bestemmelse av hvorvidt et vaksinert dyr er blitt smittet med et virulent pseudorabiesvirus av villtype - Google Patents

Fremgangsmåte for fremstilling av et ikke naturlig forekommende pseudorabiesvirus, samt fremgangsmåte for in vitro bestemmelse av hvorvidt et vaksinert dyr er blitt smittet med et virulent pseudorabiesvirus av villtype Download PDF

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Publication number
NO301284B1
NO301284B1 NO871313A NO871313A NO301284B1 NO 301284 B1 NO301284 B1 NO 301284B1 NO 871313 A NO871313 A NO 871313A NO 871313 A NO871313 A NO 871313A NO 301284 B1 NO301284 B1 NO 301284B1
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Norway
Prior art keywords
virus
prv
gene
fragment
plasmid
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NO871313A
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English (en)
Norwegian (no)
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NO871313L (no
NO871313D0 (no
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Leonard E Post
Darrell R Thomsen
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Upjohn Co
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Publication of NO871313L publication Critical patent/NO871313L/no
Publication of NO871313D0 publication Critical patent/NO871313D0/no
Publication of NO301284B1 publication Critical patent/NO301284B1/no

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/12Viral antigens
    • A61K39/245Herpetoviridae, e.g. herpes simplex virus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/12Viral antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/20Antivirals for DNA viruses
    • A61P31/22Antivirals for DNA viruses for herpes viruses
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    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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    • GPHYSICS
    • G01MEASURING; TESTING
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    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56983Viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525Virus
    • A61K2039/5252Virus inactivated (killed)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
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    • A61K2039/552Veterinary vaccine
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K2039/70Multivalent vaccine
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C12N2710/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011Details
    • C12N2710/16011Herpesviridae
    • C12N2710/16711Varicellovirus, e.g. human herpesvirus 3, Varicella Zoster, pseudorabies
    • C12N2710/16721Viruses as such, e.g. new isolates, mutants or their genomic sequences
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    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2710/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011Details
    • C12N2710/16011Herpesviridae
    • C12N2710/16711Varicellovirus, e.g. human herpesvirus 3, Varicella Zoster, pseudorabies
    • C12N2710/16722New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • CCHEMISTRY; METALLURGY
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    • C12N2710/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011Details
    • C12N2710/16011Herpesviridae
    • C12N2710/16711Varicellovirus, e.g. human herpesvirus 3, Varicella Zoster, pseudorabies
    • C12N2710/16734Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/82Proteins from microorganisms
    • Y10S530/826Viruses

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  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
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  • Tropical Medicine & Parasitology (AREA)
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NO871313A 1985-07-29 1987-03-27 Fremgangsmåte for fremstilling av et ikke naturlig forekommende pseudorabiesvirus, samt fremgangsmåte for in vitro bestemmelse av hvorvidt et vaksinert dyr er blitt smittet med et virulent pseudorabiesvirus av villtype NO301284B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US76013085A 1985-07-29 1985-07-29
PCT/US1986/001322 WO1987000862A1 (en) 1985-07-29 1986-06-17 Virus vaccine

Publications (3)

Publication Number Publication Date
NO871313L NO871313L (no) 1987-03-27
NO871313D0 NO871313D0 (no) 1987-03-27
NO301284B1 true NO301284B1 (no) 1997-10-06

Family

ID=25058182

Family Applications (1)

Application Number Title Priority Date Filing Date
NO871313A NO301284B1 (no) 1985-07-29 1987-03-27 Fremgangsmåte for fremstilling av et ikke naturlig forekommende pseudorabiesvirus, samt fremgangsmåte for in vitro bestemmelse av hvorvidt et vaksinert dyr er blitt smittet med et virulent pseudorabiesvirus av villtype

Country Status (18)

Country Link
US (1) US4810634A (de)
EP (1) EP0231209B1 (de)
JP (2) JP2559384B2 (de)
KR (1) KR950000887B1 (de)
CN (1) CN1018845B (de)
AT (1) ATE60799T1 (de)
AU (1) AU591145B2 (de)
CA (1) CA1275625C (de)
DE (1) DE3677494D1 (de)
DK (1) DK170948B1 (de)
ES (1) ES2001752A6 (de)
FI (1) FI871362A0 (de)
HK (1) HK32696A (de)
IE (1) IE59087B1 (de)
NO (1) NO301284B1 (de)
PH (1) PH25776A (de)
WO (1) WO1987000862A1 (de)
ZA (1) ZA865277B (de)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5041536A (en) * 1984-05-02 1991-08-20 The Upjohn Company Pseudorabies virus (PRV) gene
US5128128A (en) * 1985-07-29 1992-07-07 The Upjohn Company Virus vaccine
US5275934A (en) * 1985-07-29 1994-01-04 The Upjohn Company Method of detecting viral infection in vaccinated animals
EP0263207B1 (de) * 1986-10-08 1991-11-27 The Upjohn Company Virus-Vakzin
US5047237A (en) * 1985-09-06 1991-09-10 Prutech Research And Development Partnership Attenuated pseudorabies virus having a deletion of at least a portion of a gene encoding an antigenic, nonessential protein, vaccine containing same and methods of identifying animals vaccinated with the vaccine
US5068192A (en) * 1986-01-27 1991-11-26 Prutech Research And Development Partnership Attenuated pseudorabies virus which includes foreign DNA encoding an amino acid sequence
US5763269A (en) * 1985-09-06 1998-06-09 Syntro Corporation Recombinant infectious bovine rhinotrocheitis virus
AU601378B2 (en) * 1985-10-04 1990-09-13 Pharmacia & Upjohn Company Pseudorabies virus protein
US5352575A (en) * 1985-10-04 1994-10-04 The Upjohn Company Pseudorabies virus protein
WO1987004463A1 (en) * 1986-01-27 1987-07-30 Syntro Corporation Attenuated herpesviruses, herpesviruses which include foreign dna encoding an amino acid sequence and vaccine containing same
US5593873A (en) * 1986-01-27 1997-01-14 Syntro Corporation Recombinant infectious bovine rhinotracheitis virus
US6172186B1 (en) 1986-03-26 2001-01-09 Pharmacia & Upjohn Company Pseudorabies virus protein
FR2601689B1 (fr) * 1986-07-17 1992-10-16 Syntro Corp Herpes virus attenues, herpes virus qui renferment de l'adn etranger codant pour une sequence d'amino-acides, et vaccins les contenant
US5037742A (en) * 1986-07-18 1991-08-06 E. I. Du Pont De Nemours And Company Pseudorabies virus recombinants and their use in the production of proteins
US5004693A (en) * 1986-07-18 1991-04-02 E. I. Du Pont De Nemours And Company Pseudorabies virus recombinants and their use in the production of proteins
WO1988007088A1 (en) * 1987-03-19 1988-09-22 Synergen, Inc. Viral vector system for the introduction of foreign dna expression products into gallinaceous birds
US5273876A (en) * 1987-06-26 1993-12-28 Syntro Corporation Recombinant human cytomegalovirus containing foreign gene
US5783195A (en) * 1991-07-18 1998-07-21 Syntro Corporation Recombinant infectious bovine rhinotracheitis virus S-IBR-052 and uses thereof
WO1989001040A1 (en) * 1987-07-27 1989-02-09 Syntro Corporation Attenuated herpes viruses, herpes viruses which include foreign dna encoding an amino acid sequence and vaccines containing same
US4992051A (en) * 1987-11-03 1991-02-12 Novagene, Inc. Infectious bovine rhinotracheitis virus mutants, methods for the production of same and methods for the use of same
US5128129A (en) * 1987-11-03 1992-07-07 Novagene Inc. Infectious bovine rhinotrachetis virus mutants, vaccines containing same, methods for the production of same and methods for the use of same
US5069901A (en) * 1988-02-03 1991-12-03 Jones Elaine V Preparation of a recombinant subunit vaccine against pseudorabies infection
JP2779447B2 (ja) * 1988-03-20 1998-07-23 財団法人阪大微生物病研究会 弱毒マレック病ウイルス・ベクターを用いる組換え遺伝子作成法、及び該ウイルスの組換え体
JP2583115B2 (ja) * 1988-09-10 1997-02-19 財団法人化学及血清療法研究所 組換えマレック病ウイルスおよびその製法
US5122447A (en) * 1989-01-23 1992-06-16 Iowa State University Research Foundation, Inc. Method of detecting pseudorabies virus specific serum antibody by use of a universal diagnostic antigen
US5240703A (en) * 1991-03-01 1993-08-31 Syntro Corporation Attenuated, genetically-engineered pseudorabies virus s-prv-155 and uses thereof
US5874279A (en) * 1991-07-18 1999-02-23 Syntro Corporation Recombinant infectious bovine rhinotracheitis virus
CA2113641A1 (en) * 1991-07-18 1993-02-04 Mark D. Cochran Recombinant infectious bovine rhinotracheitis virus
WO1993024147A1 (en) * 1992-05-29 1993-12-09 Smithkline Beecham Corporation Lecithin adjuvanted modified live virus vaccines
TW289731B (de) * 1992-07-09 1996-11-01 Akzo Nv
EP0606452B1 (de) * 1992-07-30 2002-11-13 Akzo Nobel N.V. Impfstoff-vektoren von rekombinantem katzen-herpesvirus
WO1994008000A1 (en) * 1992-10-06 1994-04-14 Akzo Nobel N.V. Pseudorabies virus vaccine
US5738854A (en) * 1992-10-06 1998-04-14 Akzo Nobel N.V. Pseudorabies virus vaccine
ES2074965B1 (es) * 1994-01-31 1996-05-01 Hipra Lab Sa Virus mutante recombinante de rinotraqueitis infecciosa bovina y vacunas que lo contienen.
WO1995035380A1 (en) * 1994-06-17 1995-12-28 Instituut Voor Dierhouderij En Diergezondheid Nucleotide sequences of pestivirus strains, polypeptides encoded by these sequences and use thereof for diagnosis and prevention of pestivirus infections
US6284251B1 (en) 1996-02-26 2001-09-04 Kansas State University Research Foundation BHV-1 gene-deleted virus vaccine
GB0126047D0 (en) * 2001-10-30 2001-12-19 Univ Cambridge Tech Therapeutic molecules
CN106456805B (zh) 2014-03-03 2020-01-10 阿尔伯特爱因斯坦医学院公司 重组单纯疱疹病毒2(hsv-2)疫苗载体
US10918712B2 (en) 2014-03-03 2021-02-16 Albert Einstein College Of Medicine Passive transfer of immunity using recombinant herpes simplex virus 2 (HSV-2) vaccine vectors
WO2017106736A1 (en) * 2015-12-18 2017-06-22 Louisiana State University Research & Technology Foundation Pseudorabies virus (prv) vector expressing heterologous polypeptides
KR20210088655A (ko) * 2018-11-06 2021-07-14 베링거잉겔하임베트메디카게엠베하 조류 인플루엔자 바이러스 h5 서브타입에 대한 면역원성 조성물

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4603112A (en) * 1981-12-24 1986-07-29 Health Research, Incorporated Modified vaccinia virus
NL8303501A (nl) * 1983-10-12 1985-05-01 Centraal Diergeneeskundig Inst Deletiemutant van een herpesvirus en vaccin, dat dit virus bevat.
US4514497B1 (en) * 1983-12-30 1998-02-24 Novagene Inc Modified live pseudorabies viruses
US4703011A (en) * 1985-11-12 1987-10-27 Novagene, Inc. Thymidine kinase deletion mutants of bovine herpesvirus-1
US4711850A (en) * 1986-01-28 1987-12-08 Novagene, Inc. Pseudorabies virus mutants, vaccines containing same, methods for the production of same and methods for the use of same

Also Published As

Publication number Publication date
AU5994886A (en) 1987-03-05
US4810634A (en) 1989-03-07
ATE60799T1 (de) 1991-02-15
HK32696A (en) 1996-03-01
NO871313L (no) 1987-03-27
CA1275625C (en) 1990-10-30
ES2001752A6 (es) 1988-06-16
DK170948B1 (da) 1996-03-25
EP0231209B1 (de) 1991-02-06
DK157087D0 (da) 1987-03-27
DE3677494D1 (de) 1991-03-14
CN1018845B (zh) 1992-10-28
JPH08333279A (ja) 1996-12-17
FI871362A (fi) 1987-03-27
AU591145B2 (en) 1989-11-30
WO1987000862A1 (en) 1987-02-12
JP2559384B2 (ja) 1996-12-04
PH25776A (en) 1991-10-18
JP2738524B2 (ja) 1998-04-08
KR950000887B1 (ko) 1995-02-03
IE861996L (en) 1987-01-29
KR880700070A (ko) 1988-02-15
DK157087A (da) 1987-03-27
EP0231209A1 (de) 1987-08-12
CN86105450A (zh) 1987-03-04
FI871362A0 (fi) 1987-03-27
IE59087B1 (en) 1994-01-12
NO871313D0 (no) 1987-03-27
ZA865277B (en) 1987-03-25
JPS63500449A (ja) 1988-02-18

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