NO20090233L - Ny sammensetning som har affinitet for amyloid - Google Patents
Ny sammensetning som har affinitet for amyloidInfo
- Publication number
- NO20090233L NO20090233L NO20090233A NO20090233A NO20090233L NO 20090233 L NO20090233 L NO 20090233L NO 20090233 A NO20090233 A NO 20090233A NO 20090233 A NO20090233 A NO 20090233A NO 20090233 L NO20090233 L NO 20090233L
- Authority
- NO
- Norway
- Prior art keywords
- amyloid
- affinity
- salt
- carbon atoms
- substituent
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/041—Heterocyclic compounds
- A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
- A61K51/0455—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Optics & Photonics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Det beskrives en forbindelse som har affinitet mot amyloid, som viser tilstrekkelig hurtig klaring fra normal vev, og som har lav toksisitet som mutagenisitet, og som har den generelle formel (1): eller et salt derav, der R1 er en gruppe valgt fra hydrogen, hydroksyl, karboksyl, sulfat, amino, nitro, cyano, en alkylsubstituent med ett til 4 karbonatomer eller en alkoksysubstituent med ett til 4 karbonatomer; R2 er en radioaktiv halogensubstituent; og m er et helt tall 0 til 2, og et lav-toksisk diagnostisk middel for Alzheimers sykdom omfattende en forbindelse representert ved formelen ovenfor eller et salt derav.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US80535606P | 2006-06-21 | 2006-06-21 | |
JP2006188034 | 2006-07-07 | ||
PCT/JP2007/062503 WO2007148755A1 (ja) | 2006-06-21 | 2007-06-21 | 新規アミロイド親和性化合物 |
Publications (1)
Publication Number | Publication Date |
---|---|
NO20090233L true NO20090233L (no) | 2009-02-11 |
Family
ID=38833493
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20090233A NO20090233L (no) | 2006-06-21 | 2009-01-14 | Ny sammensetning som har affinitet for amyloid |
Country Status (10)
Country | Link |
---|---|
US (1) | US8277777B2 (no) |
EP (1) | EP2042501B1 (no) |
KR (1) | KR20090025282A (no) |
CN (1) | CN101501033B (no) |
AU (1) | AU2007261985B2 (no) |
CA (1) | CA2655826A1 (no) |
HK (1) | HK1133254A1 (no) |
IL (1) | IL196046A0 (no) |
NO (1) | NO20090233L (no) |
WO (1) | WO2007148755A1 (no) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TW200803903A (en) * | 2006-04-28 | 2008-01-16 | Nihon Mediphysics Co Ltd | Novel compound having affinity to amyloid |
AU2007252658B2 (en) * | 2006-05-19 | 2012-03-29 | Nihon Medi-Physics Co., Ltd. | Novel compound having affinity for amyloid |
TW200823211A (en) * | 2006-11-30 | 2008-06-01 | Nihon Mediphysics Co Ltd | Novel compound having affinity for amyloid |
CA2703649A1 (en) * | 2007-10-24 | 2009-04-30 | Shigeyuki Tanifuji | Novel compound having affinity for amyloid |
EP2213671A4 (en) * | 2007-10-26 | 2012-02-22 | Nihon Mediphysics Co Ltd | NOVEL COMPOUND HAVING AFFINITY FOR AMYLOID |
EP2218464A1 (en) * | 2009-02-11 | 2010-08-18 | Technische Universität München | Compounds for non-invasive measurement of aggregates of amyloid peptides |
KR101123178B1 (ko) * | 2009-04-09 | 2012-06-13 | (주)에스메디 | 2-아릴벤조싸이오펜 유도체 또는 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 함유하는 퇴행성 뇌질환의 진단 또는 치료용 약학적 조성물 |
IN2014DN00185A (no) | 2011-06-24 | 2015-07-10 | Nihon Mediphysics Co Ltd | |
RU2015147450A (ru) | 2013-04-29 | 2017-06-05 | Ф. Хоффманн-Ля Рош Аг | ПРОИЗВОДНЫЕ 2-ФЕНИЛ ИЛИ 2-ГЕТЕРОАРИЛ ИМИДАЗОЛ[1,2-a]ПИРИДИНА |
CN103724207B (zh) * | 2013-12-20 | 2016-07-06 | 北京智博高科生物技术有限公司 | 苯基苄基醚类衍生物及其制备方法和应用 |
EA039923B1 (ru) * | 2014-08-29 | 2022-03-28 | Сиэйчдиай Фаундэйшн, Инк. | Зонды для визуализации белка хантингтина |
US9926316B2 (en) * | 2016-03-03 | 2018-03-27 | The Cleveland Clinic Foundation | Antitumor derivatives for differentiation therapy |
CN108822105A (zh) * | 2018-08-14 | 2018-11-16 | 河南师范大学 | 一种由乙苯类化合物合成2-芳基咪唑并[1,2-a]吡啶类化合物的方法 |
Family Cites Families (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4833149A (en) * | 1986-09-22 | 1989-05-23 | Ortho Pharmaceutical Corporation | 2- or 3-aryl substituted imidazo[1,2-a]pyridines |
US4791117A (en) * | 1986-09-22 | 1988-12-13 | Ortho Pharmaceutical Corporation | 2- or 3-aryl substituted imidazo[1,2-a]pyridines and their use as calcium channel blockers |
US4727145A (en) * | 1986-09-22 | 1988-02-23 | Ortho Pharmaceutical Corporation | 2- Or 3- aryl substituted imidazo [1,2-a]pyridines |
US4871745A (en) * | 1986-09-22 | 1989-10-03 | Ortho Pharmaceutical Corporation | 2- or 3-aryl substituted imidazo(1,2-A)pyridines and their use as antisecretory agents |
BR9611047A (pt) * | 1995-10-17 | 2000-03-08 | Searle & Co | Processo de deteção de ciclo oxigenase-2 |
US6812327B1 (en) * | 1996-10-25 | 2004-11-02 | Human Genome Sciences, Inc. | Neutrokine-alpha polypeptides |
EP1105163A4 (en) | 1998-08-20 | 2003-05-02 | Univ California | METHOD FOR MARKING AMYLOID PLAQUES AND NEUROFIBRILLIC GIFTS |
JP4025468B2 (ja) | 1999-07-29 | 2007-12-19 | 三井化学株式会社 | 有機電界発光素子 |
US6489337B1 (en) | 2000-03-31 | 2002-12-03 | Ortho-Mcneil Pharmaceutical, Inc. | Method for treating histamine H3 receptor-mediated disorders with 2- or 3-aryl substituted imidazo[1,2-a] pyridines |
US20010051632A1 (en) * | 2000-03-31 | 2001-12-13 | Wenying Chai | Phenyl-substituted indolizines and tetrahydroindolizines |
ATE361297T1 (de) * | 2000-03-31 | 2007-05-15 | Ortho Mcneil Pharm Inc | Phenyl-substituierte imidazopyridine |
DE10040016A1 (de) | 2000-08-16 | 2002-02-28 | Boehringer Ingelheim Pharma | Neue beta-Amyloid Inhibitoren, Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel |
US6514969B2 (en) * | 2000-08-16 | 2003-02-04 | Boehringer Ingelheim Pharma Kg | β-amyloid inhibitors, processes for preparing them, and their use in pharmaceutical compositions |
ES2536449T3 (es) | 2000-08-24 | 2015-05-25 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Derivados de tioflavina para uso en diagnosis de la enfermedad de Alzheimer |
JP2004529884A (ja) * | 2001-02-26 | 2004-09-30 | ブリストル−マイヤーズ・スクイブ・ファーマ・カンパニー | 金属放射性医薬のためのアスコルビン酸類似体 |
US6596731B2 (en) | 2001-03-27 | 2003-07-22 | Hoffmann-La Roche Inc. | Substituted imidazo[1,2-A] pyridine derivatives |
DE60217090T2 (de) * | 2001-04-23 | 2007-07-12 | The Trustees Of The University Of Pennsylvania | Amyloid plaque aggregationshemmer und diagnostische bilderzeugungsmittel |
DK1432453T3 (da) | 2001-08-27 | 2013-11-18 | Univ Pennsylvania | Stilbenderivater og anvendelse heraf til binding og billeddannelse af amyloid-plaques |
GB0205281D0 (en) * | 2002-03-06 | 2002-04-17 | Novartis Ag | Organic compounds |
EP1356827A1 (en) * | 2002-04-24 | 2003-10-29 | Mallinckrodt Inc. | Method for obtaining a 2-18F-fluor-2-deoxy-D-glucose (18F-FDG)-solution |
WO2003106439A1 (ja) | 2002-06-12 | 2003-12-24 | 株式会社ビーエフ研究所 | アミロイド蓄積性疾患の画像診断プローブ化合物、老人斑/びまん性老人斑染色用化合物、ならびにアミロイド蓄積性疾患の治療薬 |
EP2229957A3 (en) | 2002-11-05 | 2010-10-06 | Ion Beam Applications S.A. | Stabilization of aqueous compositions of 18f-isotope labelled 2-fluoro-2-deoxy-d-glucose with ethanol |
GB0229695D0 (en) * | 2002-12-20 | 2003-01-29 | Amersham Plc | Solid-phase preparation of 18F-labelled amino acids |
NZ548098A (en) | 2003-12-31 | 2010-05-28 | Schering Plough Ltd | Control of parasites in animals by the use of imidazo[1,2-b]pyridazine derivatives |
AU2006261917A1 (en) * | 2005-06-24 | 2007-01-04 | The Trustees Of The University Of Pennsylvania | Radiolabeled-pegylation of ligands for use as imaging agents |
US20080219922A1 (en) * | 2005-09-12 | 2008-09-11 | Goodman Mark M | Alzheimer's Disease Imaging Agents |
AU2007252658B2 (en) * | 2006-05-19 | 2012-03-29 | Nihon Medi-Physics Co., Ltd. | Novel compound having affinity for amyloid |
CA2703649A1 (en) * | 2007-10-24 | 2009-04-30 | Shigeyuki Tanifuji | Novel compound having affinity for amyloid |
EP2213671A4 (en) * | 2007-10-26 | 2012-02-22 | Nihon Mediphysics Co Ltd | NOVEL COMPOUND HAVING AFFINITY FOR AMYLOID |
CA2704139A1 (en) * | 2007-10-30 | 2009-05-07 | Nihon Medi-Physics Co., Ltd. | Utilization of novel compounds with amyloid affinity and method of producing the same |
-
2007
- 2007-06-21 AU AU2007261985A patent/AU2007261985B2/en not_active Expired - Fee Related
- 2007-06-21 US US12/308,715 patent/US8277777B2/en active Active
- 2007-06-21 CA CA002655826A patent/CA2655826A1/en not_active Abandoned
- 2007-06-21 KR KR1020087031662A patent/KR20090025282A/ko not_active Application Discontinuation
- 2007-06-21 CN CN2007800298930A patent/CN101501033B/zh active Active
- 2007-06-21 WO PCT/JP2007/062503 patent/WO2007148755A1/ja active Application Filing
- 2007-06-21 EP EP07767329.1A patent/EP2042501B1/en active Active
-
2008
- 2008-12-18 IL IL196046A patent/IL196046A0/en unknown
-
2009
- 2009-01-14 NO NO20090233A patent/NO20090233L/no not_active Application Discontinuation
- 2009-12-03 HK HK09111320.9A patent/HK1133254A1/xx unknown
Also Published As
Publication number | Publication date |
---|---|
CA2655826A1 (en) | 2007-12-27 |
AU2007261985A1 (en) | 2007-12-27 |
HK1133254A1 (en) | 2010-03-19 |
EP2042501A1 (en) | 2009-04-01 |
EP2042501B1 (en) | 2017-04-12 |
AU2007261985B2 (en) | 2012-04-19 |
WO2007148755A1 (ja) | 2007-12-27 |
US20100092387A1 (en) | 2010-04-15 |
CN101501033B (zh) | 2012-08-01 |
EP2042501A4 (en) | 2012-11-21 |
KR20090025282A (ko) | 2009-03-10 |
US8277777B2 (en) | 2012-10-02 |
CN101501033A (zh) | 2009-08-05 |
IL196046A0 (en) | 2009-09-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FC2A | Withdrawal, rejection or dismissal of laid open patent application |