NO20063810L - Hydroisoindolintakykininreseptorantagonister - Google Patents

Hydroisoindolintakykininreseptorantagonister

Info

Publication number
NO20063810L
NO20063810L NO20063810A NO20063810A NO20063810L NO 20063810 L NO20063810 L NO 20063810L NO 20063810 A NO20063810 A NO 20063810A NO 20063810 A NO20063810 A NO 20063810A NO 20063810 L NO20063810 L NO 20063810L
Authority
NO
Norway
Prior art keywords
compounds
certain
hydroisoindolintakykininreseptorantagonister
tachykinin
neurokinin
Prior art date
Application number
NO20063810A
Other languages
English (en)
Other versions
NO339041B1 (no
Inventor
Sander G Mills
Jaime Lynn Bunda
Robert J Devita
Jinlong Jiang
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of NO20063810L publication Critical patent/NO20063810L/no
Publication of NO339041B1 publication Critical patent/NO339041B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/4035—Isoindoles, e.g. phthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)

Abstract

Den foreliggende oppfinnelse er rettet mot bestemte hydroisoindolinforbindelser med formel I som er anvendbare som reseptorantagonister for neurokinin-1 (NK-1), og inhibitorer for takykinin og særlig substans P. Oppfinnelsen vedrører også farmasøytiske preparater som omfatter disse forbindelsene som aktive bestanddeler, og anvendelsen av forbindelsene og deres formuleringer ved behandlingen av bestemte forstyrrelser, inkludert emese, urininkontinens, depresjon og angst.
NO20063810A 2004-01-27 2006-08-25 Hydroisoindolintakykininreseptorantagonister, farmasøytiske preparater derav, og deres anvendelse ved fremstilling av et medikament NO339041B1 (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US53991304P 2004-01-27 2004-01-27
US56122704P 2004-04-09 2004-04-09
PCT/US2005/002149 WO2005073191A1 (en) 2004-01-27 2005-01-26 Hydroisoindoline tachykinin receptor antagonists

Publications (2)

Publication Number Publication Date
NO20063810L true NO20063810L (no) 2006-10-26
NO339041B1 NO339041B1 (no) 2016-11-07

Family

ID=34830494

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20063810A NO339041B1 (no) 2004-01-27 2006-08-25 Hydroisoindolintakykininreseptorantagonister, farmasøytiske preparater derav, og deres anvendelse ved fremstilling av et medikament

Country Status (31)

Country Link
US (3) US7217731B2 (no)
EP (1) EP1711465B1 (no)
JP (1) JP3987100B2 (no)
KR (1) KR20060127927A (no)
AR (1) AR047439A1 (no)
AT (1) ATE382034T1 (no)
AU (1) AU2005207934B2 (no)
BR (1) BRPI0507050A (no)
CA (1) CA2554550C (no)
CO (1) CO5700771A2 (no)
CR (1) CR8522A (no)
CY (1) CY1107167T1 (no)
DE (1) DE602005004011T2 (no)
DK (1) DK1711465T3 (no)
EA (1) EA010598B1 (no)
EC (1) ECSP066716A (no)
ES (1) ES2297687T3 (no)
GE (1) GEP20094691B (no)
HK (1) HK1100937A1 (no)
HR (1) HRP20080100T3 (no)
IL (1) IL176879A0 (no)
MA (1) MA28359A1 (no)
NI (1) NI200600164A (no)
NO (1) NO339041B1 (no)
NZ (1) NZ548415A (no)
PE (1) PE20050687A1 (no)
PL (1) PL1711465T3 (no)
PT (1) PT1711465E (no)
TW (1) TWI341198B (no)
UA (1) UA84192C2 (no)
WO (1) WO2005073191A1 (no)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR047439A1 (es) * 2004-01-27 2006-01-18 Merck & Co Inc Antagonistas del receptor hidroisoindolina taquiquinina
CA2590039A1 (en) 2004-12-14 2006-06-22 Merck & Co., Inc. Octahydropyrano[3,4-c]pyrrole tachykinin receptor antagonists
CA2611550A1 (en) * 2005-06-27 2007-01-04 Merck & Co., Inc. Hydroisoindoline tachykinin receptor antagonists
JP2009500452A (ja) 2005-07-11 2009-01-08 メルク エンド カムパニー インコーポレーテッド ヒドロイソインドリンタキキニン受容体アンタゴニストの製造方法
CA2624440A1 (en) 2005-10-04 2007-04-19 Merck & Co., Inc. Combination therapy for the treatment of urinary frequency, urinary urgency and urinary incontinence
WO2007075528A2 (en) * 2005-12-22 2007-07-05 Merck & Co., Inc. Octahydropyrano[3,4-c]pyrrole tachykinin receptor antagonists
US20090042854A1 (en) * 2006-01-24 2009-02-12 Jianming Bao Hexahydro-3H-Pyrrolizin-3-Ones Useful as Tachykinin Receptor Antagonists
US20100209496A1 (en) * 2006-09-06 2010-08-19 Eleni Dokou Liquid and semi-solid pharmaceutical formulations for oral administration of a substituted amide
WO2008054690A2 (en) * 2006-11-02 2008-05-08 Merck & Co., Inc. Polymorphs of a hydroisoindoline tachykinin receptor antagonist
US20100113469A1 (en) * 2007-03-29 2010-05-06 Merck & Co., Inc. Combination therapy for the treatment-of lower urinary tract symptoms
CA2683584C (en) * 2007-04-10 2015-07-07 Merck & Co., Inc. Hydroxymethyl ether hydroisoindoline tachykinin receptor antagonists
JP5812500B2 (ja) 2010-04-30 2015-11-17 メルク・シャープ・エンド・ドーム・コーポレイション 新規なβ３アドレナリン作動性受容体アゴニスト
US8627816B2 (en) 2011-02-28 2014-01-14 Intelliject, Inc. Medicament delivery device for administration of opioid antagonists including formulations for naloxone
NO2729147T3 (no) 2011-07-04 2018-02-03
US9198898B2 (en) 2013-06-24 2015-12-01 Tigercat Pharma, Inc. Use of NK-1 receptor antagonists in pruritus
MX366728B (es) * 2013-06-24 2019-07-22 Menlo Therapeutics Inc Uso de serlopitant como antagonistas del receptor nk-1 en prurito.
US8906951B1 (en) 2013-06-24 2014-12-09 Tigercat Pharma, Inc. Use of NK-1 receptor antagonists in pruritus
EA201992414A1 (ru) 2017-04-10 2020-03-16 Чейс Терапьютикс Корпорейшн Комбинация nk1-антагониста и способ лечения синуклеинопатий
MA49524A (fr) 2017-06-30 2021-05-26 Chase Therapeutics Corp Compositions d'antagoniste de nk-1 et méthodes destinées à être utilisées dans le traitement de la dépression
WO2019162519A1 (en) 2018-02-26 2019-08-29 Ospedale San Raffaele S.R.L. Nk-1 antagonists for use in the treatment of ocular pain
EP4117673A1 (en) 2020-03-11 2023-01-18 Ospedale San Raffaele S.r.l. Treatment of stem cell deficiency
KR20220165251A (ko) 2020-04-03 2022-12-14 네르 쎄라퓨틱스 리미티드 패혈증, 패혈성 쇼크, 급성 호흡 곤란 증후군 (ards) 또는 다발성 기관 기능장애 증후군 (mods)으로부터 선택된 질환을 치료하기 위한 nk-1 수용체 길항제
US11872222B2 (en) 2020-06-02 2024-01-16 Nerre Therapeutics Limited Uses

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5650142A (en) * 1995-09-27 1997-07-22 Church & Dwight Co., Inc. Bicarbonate-containing deodorant cosmetic stick compositions
JP2002534955A (ja) * 1995-10-18 2002-10-15 メルク エンド カンパニー インコーポレーテッド シクロペンチルタキキニン受容体アンタゴニスト
CN1859914A (zh) 2003-09-30 2006-11-08 默克公司 苯基吡咯烷醚速激肽受体拮抗剂
AR047439A1 (es) * 2004-01-27 2006-01-18 Merck & Co Inc Antagonistas del receptor hidroisoindolina taquiquinina

Also Published As

Publication number Publication date
AR047439A1 (es) 2006-01-18
CR8522A (es) 2007-06-06
JP2007519728A (ja) 2007-07-19
PE20050687A1 (es) 2005-09-27
HRP20080100T3 (en) 2008-04-30
PL1711465T3 (pl) 2008-05-30
EP1711465A1 (en) 2006-10-18
IL176879A0 (en) 2006-10-31
AU2005207934A1 (en) 2005-08-11
ECSP066716A (es) 2006-10-31
DK1711465T3 (da) 2008-03-31
EA200601378A1 (ru) 2007-02-27
ES2297687T3 (es) 2008-05-01
JP3987100B2 (ja) 2007-10-03
US20070161695A1 (en) 2007-07-12
CA2554550A1 (en) 2005-08-11
US7645790B2 (en) 2010-01-12
NZ548415A (en) 2009-11-27
EP1711465B1 (en) 2007-12-26
NI200600164A (es) 2007-05-29
US20050165083A1 (en) 2005-07-28
DE602005004011T2 (de) 2008-12-11
AU2005207934B2 (en) 2010-11-25
CA2554550C (en) 2011-05-03
EA010598B1 (ru) 2008-10-30
HK1100937A1 (en) 2007-10-05
BRPI0507050A (pt) 2007-06-12
TWI341198B (en) 2011-05-01
ATE382034T1 (de) 2008-01-15
US7217731B2 (en) 2007-05-15
US7345083B2 (en) 2008-03-18
WO2005073191A1 (en) 2005-08-11
PT1711465E (pt) 2008-02-25
CO5700771A2 (es) 2006-11-30
KR20060127927A (ko) 2006-12-13
US20080280966A1 (en) 2008-11-13
CY1107167T1 (el) 2012-10-24
DE602005004011D1 (de) 2008-02-07
MA28359A1 (fr) 2006-12-01
GEP20094691B (en) 2009-05-25
UA84192C2 (en) 2008-09-25
TW200534850A (en) 2005-11-01
NO339041B1 (no) 2016-11-07

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