ATE382034T1 - Hydroisoindolin-tachykininrezeptorantagonisten - Google Patents

Hydroisoindolin-tachykininrezeptorantagonisten

Info

Publication number: ATE382034T1
Authority: AT; Austria
Prior art keywords: tachykine; hydroisoindoline; receptor antagonists; antagonists; receptor
Prior art date: 2004-01-27

Application number

AT05726323T

Other languages

English (en)

Inventor

Jaime Bunda

Robert Devita

Jinlong Jiang

Sander Mills

Original Assignee

Merck & Co Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-01-27

Filing date

2005-01-26

Publication date

2008-01-15

2005-01-26 Application filed by Merck & Co Inc filed Critical Merck & Co Inc

2008-01-15 Application granted granted Critical

2008-01-15 Publication of ATE382034T1 publication Critical patent/ATE382034T1/de

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/4035—Isoindoles, e.g. phthalimide
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Epidemiology (AREA)
Urology & Nephrology (AREA)
Pain & Pain Management (AREA)
Psychiatry (AREA)
Pulmonology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Indole Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

AT05726323T 2004-01-27 2005-01-26 Hydroisoindolin-tachykininrezeptorantagonisten ATE382034T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US53991304P	2004-01-27	2004-01-27
US56122704P	2004-04-09	2004-04-09

Publications (1)

Publication Number	Publication Date
ATE382034T1 true ATE382034T1 (de)	2008-01-15

Family

ID=34830494

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT05726323T ATE382034T1 (de)	2004-01-27	2005-01-26	Hydroisoindolin-tachykininrezeptorantagonisten

Country Status (31)

Country	Link
US (3)	US7217731B2 (de)
EP (1)	EP1711465B1 (de)
JP (1)	JP3987100B2 (de)
KR (1)	KR20060127927A (de)
AR (1)	AR047439A1 (de)
AT (1)	ATE382034T1 (de)
AU (1)	AU2005207934B2 (de)
BR (1)	BRPI0507050A (de)
CA (1)	CA2554550C (de)
CO (1)	CO5700771A2 (de)
CR (1)	CR8522A (de)
CY (1)	CY1107167T1 (de)
DE (1)	DE602005004011T2 (de)
DK (1)	DK1711465T3 (de)
EA (1)	EA010598B1 (de)
EC (1)	ECSP066716A (de)
ES (1)	ES2297687T3 (de)
GE (1)	GEP20094691B (de)
HK (1)	HK1100937A1 (de)
HR (1)	HRP20080100T3 (de)
IL (1)	IL176879A0 (de)
MA (1)	MA28359A1 (de)
NI (1)	NI200600164A (de)
NO (1)	NO339041B1 (de)
NZ (1)	NZ548415A (de)
PE (1)	PE20050687A1 (de)
PL (1)	PL1711465T3 (de)
PT (1)	PT1711465E (de)
TW (1)	TWI341198B (de)
UA (1)	UA84192C2 (de)
WO (1)	WO2005073191A1 (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AR047439A1 (es)	2004-01-27	2006-01-18	Merck & Co Inc	Antagonistas del receptor hidroisoindolina taquiquinina
JP2008523147A (ja) *	2004-12-14	2008-07-03	メルクエンドカムパニーインコーポレーテッド	オクタヒドロピラノ［３，４−ｃ］ピロールタキキニン受容体拮抗薬
WO2007002457A2 (en) *	2005-06-27	2007-01-04	Merck & Co., Inc.	Hydroisoindoline tachykinin receptor antagonists
DE602006020450D1 (de) *	2005-07-11	2011-04-14	Merck Sharp & Dohme	Ykinin-rezeptorantagonisten
AU2006302562A1 (en) *	2005-10-04	2007-04-19	Merck Sharp & Dohme Corp.	Combination therapy for the treatment of urinary frequency, urinary urgency and urinary incontinence
EP1965794A4 (de) *	2005-12-22	2009-10-21	Merck & Co Inc	Octahydropyrano[3,4-c]pyrrol-tachykinin-rezeptorantagonisten
US20090042854A1 (en) *	2006-01-24	2009-02-12	Jianming Bao	Hexahydro-3H-Pyrrolizin-3-Ones Useful as Tachykinin Receptor Antagonists
JP2010502703A (ja) *	2006-09-06	2010-01-28	メルクエンドカムパニーインコーポレーテッド	置換アミドの経口投与のための液体及び半固体の医薬製剤
EP2089019A4 (de) *	2006-11-02	2011-05-04	Merck Sharp & Dohme	Polymorphe eines hydroisoindolin-tachykinin-rezeptorantagonisten
US20100113469A1 (en) *	2007-03-29	2010-05-06	Merck & Co., Inc.	Combination therapy for the treatment-of lower urinary tract symptoms
EP2144503B9 (de) *	2007-04-10	2013-09-04	Merck Sharp & Dohme Corp.	4-(octahydro-2H-isoindol-2-yl)-1,3-oxazol-4-one-Verbindungen als TACHYKININ-REZEPTOR-ANTAGONISTEN
AU2011245499B2 (en)	2010-04-30	2014-09-25	Merck Sharp & Dohme Corp.	Novel beta 3 adrenergic receptor agonists
US8627816B2 (en)	2011-02-28	2014-01-14	Intelliject, Inc.	Medicament delivery device for administration of opioid antagonists including formulations for naloxone
EP2729147B1 (de)	2011-07-04	2017-09-06	IRBM - Science Park S.p.A.	Nk-1 rezeptorantagonisten zur behandlung der hornhautrevaskularisierung
EP3013336A1 (de)	2013-06-24	2016-05-04	Tigercat Pharma Inc.	Verwendung des nk-1 rezeptor-antagonisten serlopitant bei pruritus
US9198898B2 (en)	2013-06-24	2015-12-01	Tigercat Pharma, Inc.	Use of NK-1 receptor antagonists in pruritus
US8906951B1 (en)	2013-06-24	2014-12-09	Tigercat Pharma, Inc.	Use of NK-1 receptor antagonists in pruritus
KR20200002899A (ko)	2017-04-10	2020-01-08	체이스 테라퓨틱스 코포레이션	시누클레인병변을 치료하기 위한 nk1-길항제 배합물 및 방법
JP7158425B2 (ja)	2017-06-30	2022-10-21	チェイスセラピューティクスコーポレイション	Ｎｋ－１アンタゴニスト組成物およびうつ病の処置における使用法
WO2019162519A1 (en)	2018-02-26	2019-08-29	Ospedale San Raffaele S.R.L.	Nk-1 antagonists for use in the treatment of ocular pain
EP4117673A1 (de)	2020-03-11	2023-01-18	Ospedale San Raffaele S.r.l.	Behandlung von stammzellenmangel
BR112022018876A2 (pt)	2020-04-03	2022-11-22	Nerre Therapeutics Ltd	Antagonista de receptor de nk-1 para tratar uma doença selecionada a partir de sepse, choque séptico, síndrome de desconforto respiratório agudo (ards) ou síndrome de disfunção múltipla dos órgãos
WO2021245512A1 (en)	2020-06-02	2021-12-09	Nerre Therapeutics Limited	Neurokinin (nk)-1 receptor antagonists for use in the treatment of pulmonary fibrosis conditions promoted by mechanical injury to the lungs

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5650142A (en) *	1995-09-27	1997-07-22	Church & Dwight Co., Inc.	Bicarbonate-containing deodorant cosmetic stick compositions
AU722883B2 (en) *	1995-10-18	2000-08-10	Merck & Co., Inc.	Cyclopentyl tachykinin receptor antagonists
WO2005032464A2 (en)	2003-09-30	2005-04-14	Merck & Co., Inc.	Phenyl pyrrolidine ether tachykinin receptor antagonists
AR047439A1 (es) *	2004-01-27	2006-01-18	Merck & Co Inc	Antagonistas del receptor hidroisoindolina taquiquinina

2005
- 2005-01-20 AR ARP050100203A patent/AR047439A1/es active IP Right Grant
- 2005-01-20 TW TW094101721A patent/TWI341198B/zh not_active IP Right Cessation
- 2005-01-24 PE PE2005000090A patent/PE20050687A1/es not_active Application Discontinuation
- 2005-01-26 EP EP05726323A patent/EP1711465B1/de active Active
- 2005-01-26 AT AT05726323T patent/ATE382034T1/de active
- 2005-01-26 UA UAA200609315A patent/UA84192C2/ru unknown
- 2005-01-26 GE GEAP20059594A patent/GEP20094691B/en unknown
- 2005-01-26 ES ES05726323T patent/ES2297687T3/es active Active
- 2005-01-26 WO PCT/US2005/002149 patent/WO2005073191A1/en active IP Right Grant
- 2005-01-26 KR KR1020067015184A patent/KR20060127927A/ko not_active Application Discontinuation
- 2005-01-26 BR BRPI0507050-3A patent/BRPI0507050A/pt not_active IP Right Cessation
- 2005-01-26 JP JP2006551356A patent/JP3987100B2/ja not_active Expired - Fee Related
- 2005-01-26 US US11/043,213 patent/US7217731B2/en active Active
- 2005-01-26 PT PT05726323T patent/PT1711465E/pt unknown
- 2005-01-26 US US10/586,727 patent/US7645790B2/en active Active
- 2005-01-26 DE DE602005004011T patent/DE602005004011T2/de active Active
- 2005-01-26 PL PL05726323T patent/PL1711465T3/pl unknown
- 2005-01-26 EA EA200601378A patent/EA010598B1/ru not_active IP Right Cessation
- 2005-01-26 NZ NZ548415A patent/NZ548415A/en not_active IP Right Cessation
- 2005-01-26 CA CA2554550A patent/CA2554550C/en not_active Expired - Fee Related
- 2005-01-26 DK DK05726323T patent/DK1711465T3/da active
- 2005-01-26 AU AU2005207934A patent/AU2005207934B2/en not_active Ceased
2006
- 2006-07-16 IL IL176879A patent/IL176879A0/en unknown
- 2006-07-19 CR CR8522A patent/CR8522A/es not_active Application Discontinuation
- 2006-07-21 EC EC2006006716A patent/ECSP066716A/es unknown
- 2006-07-26 NI NI200600164A patent/NI200600164A/es unknown
- 2006-07-27 CO CO06073837A patent/CO5700771A2/es active IP Right Grant
- 2006-08-11 MA MA29265A patent/MA28359A1/fr unknown
- 2006-08-25 NO NO20063810A patent/NO339041B1/no not_active IP Right Cessation
2007
- 2007-03-06 US US11/714,352 patent/US7345083B2/en active Active
- 2007-08-09 HK HK07108650.7A patent/HK1100937A1/xx not_active IP Right Cessation
2008
- 2008-01-31 CY CY20081100113T patent/CY1107167T1/el unknown
- 2008-03-06 HR HR20080100T patent/HRP20080100T3/xx unknown

Also Published As

Publication number	Publication date
AR047439A1 (es)	2006-01-18
EP1711465B1 (de)	2007-12-26
EA200601378A1 (ru)	2007-02-27
US20070161695A1 (en)	2007-07-12
WO2005073191A1 (en)	2005-08-11
JP3987100B2 (ja)	2007-10-03
UA84192C2 (en)	2008-09-25
HK1100937A1 (en)	2007-10-05
CA2554550C (en)	2011-05-03
ECSP066716A (es)	2006-10-31
US20050165083A1 (en)	2005-07-28
EA010598B1 (ru)	2008-10-30
DK1711465T3 (da)	2008-03-31
AU2005207934B2 (en)	2010-11-25
IL176879A0 (en)	2006-10-31
US7345083B2 (en)	2008-03-18
PT1711465E (pt)	2008-02-25
KR20060127927A (ko)	2006-12-13
CO5700771A2 (es)	2006-11-30
CA2554550A1 (en)	2005-08-11
EP1711465A1 (de)	2006-10-18
NZ548415A (en)	2009-11-27
NO20063810L (no)	2006-10-26
BRPI0507050A (pt)	2007-06-12
ES2297687T3 (es)	2008-05-01
CY1107167T1 (el)	2012-10-24
AU2005207934A1 (en)	2005-08-11
PE20050687A1 (es)	2005-09-27
DE602005004011D1 (de)	2008-02-07
NO339041B1 (no)	2016-11-07
NI200600164A (es)	2007-05-29
US7645790B2 (en)	2010-01-12
HRP20080100T3 (en)	2008-04-30
DE602005004011T2 (de)	2008-12-11
CR8522A (es)	2007-06-06
JP2007519728A (ja)	2007-07-19
PL1711465T3 (pl)	2008-05-30
US7217731B2 (en)	2007-05-15
TWI341198B (en)	2011-05-01
MA28359A1 (fr)	2006-12-01
GEP20094691B (en)	2009-05-25
US20080280966A1 (en)	2008-11-13
TW200534850A (en)	2005-11-01

Legal Events

Date

Code

Title

Description

2008-05-15

UEP

Publication of translation of european patent specification

Ref document number: 1711465

Country of ref document: EP

2010-11-15

EEFA

Change of the company name

Publication	Publication Date	Title
ATE382034T1 (de)	2008-01-15	Hydroisoindolin-tachykininrezeptorantagonisten
ATE452886T1 (de)	2010-01-15	Chemokinrezeptorantagonisten
DK1973886T3 (da)	2013-03-18	Prokineticin-1-receptor-antagonister
DK1951660T3 (da)	2014-01-27	Histamin-3-receptorantagonister
ATE413400T1 (de)	2008-11-15	Cgrp-rezeptorantagonisten
DK1682142T3 (da)	2012-10-15	M3-muscarin-acetylcholin-receptor-antagonister
DE602004030930D1 (de)	2011-02-17	Muscarinische acetylcholin-rezeptor-antagonisten
DK1740177T3 (da)	2012-10-29	Antagonister til muskarinfølsomme acetylcholinreceptorer
DK2653465T3 (da)	2016-08-22	Opioid-receptormodulatorer
DK1963369T3 (da)	2013-06-03	Il-21-antagonister
EP1765805A4 (de)	2009-08-26	Cgrp-rezeptorantagonisten
NO20051871D0 (no)	2005-04-18	Opioid reseptorantagonister
FI20050610A0 (fi)	2005-06-08	Vertikaalinen värähtelijä
DK2081951T3 (da)	2010-08-09	Progesteron-receptorantagonister
IL182355A0 (en)	2007-07-24	Thrombin receptor antagonists
ATE549350T1 (de)	2012-03-15	Neuropeptid-2-rezeptor-agonisten
DK2009992T3 (da)	2012-08-13	Il-8 receptor-antagonister
EP1799672A4 (de)	2011-01-19	Cgrp-rezeptorantagonisten
DK2094709T3 (da)	2010-12-06	Thiazol-pyrazolopyrimidiner som CRF1-receptorantagonister
DE602005009355D1 (de)	2008-10-09	Gehinderte himbacinanaloga als thrombinrezeptorantagonisten
ATE534628T1 (de)	2011-12-15	Urotensin ii-rezeptorantagonisten
EP1812008A4 (de)	2008-10-29	Il-8-rezeptorantagonisten
DE602006018334D1 (de)	2010-12-30	Indol-3-ylcarbonylazaspiroderivate als vasopressinrezeptorantagonisten
GB0525029D0 (en)	2006-01-18	Receptor Antagonist
DK1735330T3 (da)	2008-03-31	Progesteronreceptormodulatorer