NO20062050L - Terapeutiske kombinasjoner av antihypertensive og antiangiogene midler - Google Patents

Terapeutiske kombinasjoner av antihypertensive og antiangiogene midler

Info

Publication number
NO20062050L
NO20062050L NO20062050A NO20062050A NO20062050L NO 20062050 L NO20062050 L NO 20062050L NO 20062050 A NO20062050 A NO 20062050A NO 20062050 A NO20062050 A NO 20062050A NO 20062050 L NO20062050 L NO 20062050L
Authority
NO
Norway
Prior art keywords
antihypertensive
agent
therapeutic combinations
antiangiogenic agents
angiogenesis
Prior art date
Application number
NO20062050A
Other languages
English (en)
Other versions
NO326277B1 (no
Inventor
Jon Owen Curwen
Donald James Ogilvie
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Publication of NO20062050L publication Critical patent/NO20062050L/no
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of NO326277B1 publication Critical patent/NO326277B1/no

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55Protease inhibitors
    • A61K38/556Angiotensin converting enzyme inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/48Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
NO20062050A 2000-04-05 2006-05-08 Anvendelse av terapeutiske kombinasjoner av et vaskulaert malmiddel og et anti-hypertensivt middel for fremstilling av medikament for behandling av sykdom samt et farmasoytisk preparat omfattende disse NO326277B1 (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0008269.3A GB0008269D0 (en) 2000-04-05 2000-04-05 Combination chemotherapy

Publications (2)

Publication Number Publication Date
NO20062050L true NO20062050L (no) 2001-10-08
NO326277B1 NO326277B1 (no) 2008-10-27

Family

ID=9889176

Family Applications (2)

Application Number Title Priority Date Filing Date
NO20024814A NO323467B1 (no) 2000-04-05 2002-10-04 Farmasoytisk sammensetning som omfatter antihypertensivt middel og en VEGF-reseptortyrosinkinaseinhibitor, et testsett som omfatter middelet og inhibitorene og anvendelse av dem for fremstilling av et medikament
NO20062050A NO326277B1 (no) 2000-04-05 2006-05-08 Anvendelse av terapeutiske kombinasjoner av et vaskulaert malmiddel og et anti-hypertensivt middel for fremstilling av medikament for behandling av sykdom samt et farmasoytisk preparat omfattende disse

Family Applications Before (1)

Application Number Title Priority Date Filing Date
NO20024814A NO323467B1 (no) 2000-04-05 2002-10-04 Farmasoytisk sammensetning som omfatter antihypertensivt middel og en VEGF-reseptortyrosinkinaseinhibitor, et testsett som omfatter middelet og inhibitorene og anvendelse av dem for fremstilling av et medikament

Country Status (29)

Country Link
US (1) US7829573B2 (no)
EP (3) EP1272186B1 (no)
JP (1) JP2003528917A (no)
KR (2) KR100849149B1 (no)
CN (1) CN1431902A (no)
AT (1) ATE355065T1 (no)
AU (2) AU4438601A (no)
BR (1) BR0109729A (no)
CA (1) CA2401854A1 (no)
CY (1) CY1107615T1 (no)
CZ (1) CZ299410B6 (no)
DE (1) DE60126923T2 (no)
DK (1) DK1272186T3 (no)
EE (1) EE200200578A (no)
ES (1) ES2280349T3 (no)
GB (1) GB0008269D0 (no)
HU (1) HUP0300426A2 (no)
IL (1) IL151503A0 (no)
IS (2) IS2455B (no)
MX (1) MXPA02009743A (no)
NO (2) NO323467B1 (no)
NZ (2) NZ534455A (no)
PL (1) PL357605A1 (no)
PT (1) PT1272186E (no)
RU (1) RU2002129353A (no)
SI (1) SI1272186T1 (no)
SK (1) SK14302002A3 (no)
WO (1) WO2001074360A1 (no)
ZA (1) ZA200206959B (no)

Families Citing this family (69)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7381413B1 (en) * 1998-04-17 2008-06-03 University Of Vermont And State Agricultural College Methods and products related to metabolic interactions in disease
US7173038B1 (en) 1999-11-05 2007-02-06 Astrazeneca Ab Quinazoline derivatives as VEGF inhibitors
DE60112268T2 (de) 2000-03-06 2006-05-24 Astrazeneca Ab Verwendung von quinazolinderivate als inhibitoren der angiogenese
AU779695B2 (en) * 2000-04-07 2005-02-10 Astrazeneca Ab Quinazoline compounds
GB0126879D0 (en) * 2001-11-08 2002-01-02 Astrazeneca Ab Combination therapy
CA2473572C (en) * 2002-02-01 2011-05-10 Astrazeneca Ab Quinazoline compounds
CN100352441C (zh) * 2002-04-16 2007-12-05 阿斯特拉曾尼卡有限公司 用于***的zd6126和zd1839的联合药物
US7358236B1 (en) 2002-06-21 2008-04-15 Oxigene, Inc. Control of acute hypertension and cardiotoxicity in patients treated with vascular targeting agents
EP2277867B1 (en) 2002-07-15 2012-12-05 Symphony Evolution, Inc. Compounds, pharmaceutical compositions thereof and their use in treating cancer
US7335362B2 (en) 2002-07-19 2008-02-26 Beth Israel Deaconess Medical Center Methods of treating pre-eclampsia or eclampsia
ES2534926T3 (es) * 2002-07-19 2015-04-30 Beth Israel Deaconess Medical Center Métodos para tratar la preeclampsia
US7435419B2 (en) * 2002-07-19 2008-10-14 Beth Israel Deaconess Medical Center Methods of diagnosing and treating pre-eclampsia or eclampsia
GB0218526D0 (en) * 2002-08-09 2002-09-18 Astrazeneca Ab Combination therapy
GB0223380D0 (en) * 2002-10-09 2002-11-13 Astrazeneca Ab Combination therapy
KR101089462B1 (ko) 2002-11-04 2011-12-07 아스트라제네카 아베 Src 티로신 키나제 억제제로서의 퀴나졸린 유도체
SI1592423T1 (sl) * 2003-02-13 2011-07-29 Astrazeneca Ab Kombinacijska terapija ZD6474 s 5-FU in/ali CPT-11
GB0307333D0 (en) * 2003-03-29 2003-05-07 Astrazeneca Ab Therapeutic agent
GB0310401D0 (en) * 2003-05-07 2003-06-11 Astrazeneca Ab Therapeutic agent
KR20060036058A (ko) * 2003-06-18 2006-04-27 앤지오젠 파마슈티칼스 리미티드 결장직장암의 치료를 위한 혈관 손상 활성을 갖는 5fu,cpt-11 또는 5-fu 및 cpt-11과 함께 zd6126을포함하는 조성물
GB0316127D0 (en) * 2003-07-10 2003-08-13 Astrazeneca Ab Combination therapy
EP1648465B1 (en) * 2003-07-10 2010-08-25 AstraZeneca AB Use of the quinazoline derivative zd6474 combined with platinum compounds and optionally ionising radiation in the treatment of diseases associated with angiogenesis and/or increased vascular permeability
GB0316123D0 (en) * 2003-07-10 2003-08-13 Astrazeneca Ab Combination therapy
GB0318422D0 (en) * 2003-08-06 2003-09-10 Astrazeneca Ab Chemical compounds
BRPI0413876A (pt) 2003-08-29 2006-10-24 Pfizer tienopiridin-fenilacetamidas e seus derivados úteis como agentes antiangiogênicos
BRPI0418102A (pt) * 2003-12-23 2007-04-27 Pfizer derivados de quinolina
GB0330002D0 (en) * 2003-12-24 2004-01-28 Astrazeneca Ab Quinazoline derivatives
GB0406445D0 (en) * 2004-03-23 2004-04-28 Astrazeneca Ab Combination therapy
AU2005225192B2 (en) * 2004-03-23 2008-10-09 Astrazeneca Ab Combination therapy
US20070142308A1 (en) * 2005-04-06 2007-06-21 Helmut Augustin Angiogenesis-affecting compounds and methods for use thereof
US20070142433A1 (en) * 2004-04-06 2007-06-21 Helmut Augustin Angiogenesis-affecting compounds and methods of use thereof
JP2007532536A (ja) * 2004-04-06 2007-11-15 アンジオジェネティクス・スウェーデン・アクチボラゲット 血管新生に作用する化合物およびその使用方法
US8273383B2 (en) * 2004-05-04 2012-09-25 Children's Medical Center Corporation Methods and compositions for treatment of preeclampsia
ATE493973T1 (de) 2004-06-04 2011-01-15 Teva Pharma Irbesartan enthaltende pharmazeutische zusammensetzung
US7740849B2 (en) * 2004-09-24 2010-06-22 Beth Israel Deaconess Medical Center Use of compounds that bind soluble endoglin and SFLT-1 for the treatment of pregnancy related hypertensive disorders
KR20130119506A (ko) 2004-09-24 2013-10-31 베스 이스라엘 데코니스 메디칼 센터 임신성 합병증의 진단 및 치료 방법
AU2005288737B2 (en) * 2004-09-27 2008-08-14 Astrazeneca Ab Combination comprising ZD6474 and imatinib
GB0424339D0 (en) * 2004-11-03 2004-12-08 Astrazeneca Ab Combination therapy
AU2005314133B2 (en) * 2004-12-06 2012-03-08 Medicinova, Inc. Ibudilast for treating neuropathic pain and associated syndromes
WO2007053161A2 (en) * 2004-12-15 2007-05-10 Beth Israel Deaconess Medical Center Nucleic acids and polypeptides useful for diagnosing and treating complications of pregnancy
WO2006086544A2 (en) 2005-02-11 2006-08-17 Regeneron Pharmaceuticals, Inc. Therapeutic combination of a vegf antagonist (vegf trap) and an anti-hypertensive agent
KR20070110081A (ko) * 2005-03-09 2007-11-15 머크 앤드 캄파니 인코포레이티드 퀴나졸린온 t-형 칼슘 채널 길항제
NZ564189A (en) * 2005-07-06 2011-04-29 Astrazeneca Ab Combination therapy of cancer with AZD2171 and gemcitabine
BRPI0614115A2 (pt) 2005-08-08 2011-03-09 Pfizer sais e polimofos de um inibidor de vergf-r, composição farmacêutica e cápsula contendo os mesmos, bem como seu uso
RU2414924C2 (ru) 2005-08-12 2011-03-27 Ридженерон Фармасьютикалз, Инк. Способы лечения заболеваний антагонистами vegf
NZ568812A (en) * 2005-12-22 2011-09-30 Astrazeneca Ab Combination of AZD2171 and pemetrexed
JP5167144B2 (ja) * 2005-12-22 2013-03-21 アストラゼネカ アクチボラグ 併用療法
US20090286271A1 (en) * 2006-05-31 2009-11-19 Karumanchi Ananth S Methods of Diagnosing and Treating Complications of Pregnancy
EP2066353B1 (en) * 2006-09-29 2013-01-02 AstraZeneca AB Combination of zd6474 and bevacizumab for cancer therapy
WO2008080110A1 (en) * 2006-12-21 2008-07-03 Alcon, Inc. Methods for treating macular edema and pathologic ocular angiogenesis using a neuroprotective agent and a receptor tyrosine kinase inhibitor
US20080181876A1 (en) * 2007-01-30 2008-07-31 Johnson Kirk W Methods for treating acute and subchronic pain
US20080190689A1 (en) * 2007-02-12 2008-08-14 Ballard Ebbin C Inserts for engine exhaust systems
WO2008137107A1 (en) * 2007-05-02 2008-11-13 Krouse Andrew J Dihydropyridine derivative for treating cancer or a pre-cancerous condition and other conditions
WO2008137012A1 (en) * 2007-05-03 2008-11-13 Avigen, Inc. Use of a glial attenuator to prevent amplified pain responses caused by glial priming
EP2175725A1 (en) * 2007-07-10 2010-04-21 Merck Sharp & Dohme Corp. Quinazolinone t-type calcium channel antagonists
US9073985B2 (en) 2008-07-14 2015-07-07 The Regents Of The University Of Colorado, A Body Corporate Methods and products for treating proliferative diseases
MX360640B (es) 2010-03-01 2018-11-09 Tau Therapeutics Llc Star Diagnosis e imagenologia de cancer.
JO3283B1 (ar) 2011-04-26 2018-09-16 Sanofi Sa تركيب يتضمن أفليبيرسيبت, حمض فولينيك, 5- فلورويوراسيل (5- Fu) وإرينوسيتان (FOLFIRI)
CN103110614B (zh) * 2013-01-18 2015-02-18 杭州雷索药业有限公司 舒洛地尔在制备抗血管生成类药物中的应用
AU2014219024B2 (en) 2013-02-20 2018-04-05 KALA BIO, Inc. Therapeutic compounds and uses thereof
CN106572988B (zh) 2014-04-08 2022-04-08 卫理公会医院 Inos抑制性组合物及其作为乳腺癌治疗剂的用途
TR201909951T4 (tr) 2014-07-18 2019-07-22 Sanofi Sa Kanser olduğundan şüphelenilen bir hastanın aflibersept ile tedavisinin sonucunun öngörülmesine yönelik yöntem.
US10265111B2 (en) 2016-04-26 2019-04-23 Medtronic Holding Company Sárl Inflatable bone tamp with flow control and methods of use
US10799138B2 (en) 2018-04-05 2020-10-13 University Of Maryland, Baltimore Method of administering sotalol IV/switch
WO2020028007A1 (en) * 2018-07-31 2020-02-06 Colorado State University Research Foundation Compositions, methods and uses for modulating the tumor microenvironment to enhance antitumor immunity
US11344518B2 (en) 2018-08-14 2022-05-31 AltaThera Pharmaceuticals LLC Method of converting atrial fibrillation to normal sinus rhythm and loading oral sotalol in a shortened time frame
US11696902B2 (en) 2018-08-14 2023-07-11 AltaThera Pharmaceuticals, LLC Method of initiating and escalating sotalol hydrochloride dosing
US11610660B1 (en) 2021-08-20 2023-03-21 AltaThera Pharmaceuticals LLC Antiarrhythmic drug dosing methods, medical devices, and systems
US10512620B1 (en) 2018-08-14 2019-12-24 AltaThera Pharmaceuticals, LLC Method of initiating and escalating sotalol hydrochloride dosing
US11484355B2 (en) 2020-03-02 2022-11-01 Medtronic Holding Company Sàrl Inflatable bone tamp and method for use of inflatable bone tamp

Family Cites Families (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4010797A1 (de) 1990-04-04 1991-10-10 Hoechst Ag Substituierte azole, verfahren zu deren herstellung, diese enthaltende mittel und deren verwendung
US5646136A (en) 1994-01-04 1997-07-08 Duke University Methods of inhibiting angiogenesis and tumor growth, and treating ophthalmologic conditions with angiostatic and therapeutic steroids
GB9624482D0 (en) * 1995-12-18 1997-01-15 Zeneca Phaema S A Chemical compounds
IL125686A (en) * 1996-02-13 2002-11-10 Zeneca Ltd Quinazoline derivatives, processes for their preparation, pharmaceutical preparations containing them and their use in the manufacture of a drug with an anti-angiogenic effect and / or an effect of reducing vascular permeability
DE69709319T2 (de) * 1996-03-05 2002-08-14 Astrazeneca Ab 4-anilinochinazolin derivate
WO1997034876A1 (en) * 1996-03-15 1997-09-25 Zeneca Limited Cinnoline derivatives and use as medicine
GB9707800D0 (en) * 1996-05-06 1997-06-04 Zeneca Ltd Chemical compounds
JP2001500890A (ja) * 1996-09-25 2001-01-23 ゼネカ リミテッド Vegfのような成長因子の作用を阻害するキノリン誘導体
GB9718972D0 (en) * 1996-09-25 1997-11-12 Zeneca Ltd Chemical compounds
EP0951298A1 (en) 1996-12-23 1999-10-27 Cambridge University Technical Services Limited Diagnosis and treatment of pathological pregnancies
DE69838172T2 (de) * 1997-08-22 2008-04-10 Astrazeneca Ab Oxindolylchinazolinderivate als angiogenesehemmer
ES2389387T3 (es) * 1998-03-17 2012-10-25 Genentech, Inc. Polipéptidos homólogos de VEGF y de BMP1
US6191144B1 (en) * 1998-08-17 2001-02-20 Warner-Lambert Company Method of using angiotensin converting enzyme inhibitor to stimulate angiogenesis
DK1112083T3 (da) 1998-09-09 2004-03-08 Univ Washington Behandling af mikrovaskulære angiopatier
US20030191055A1 (en) * 1999-01-15 2003-10-09 Epstein Stephen E. Inhibiting development of microvessels withins coronary or peripheral vessel walls for restenosis/atherosclerosis prevention or therapy
KR20080015482A (ko) * 1999-02-10 2008-02-19 아스트라제네카 아베 혈관형성 억제제로서의 퀴나졸린 유도체
US7173038B1 (en) * 1999-11-05 2007-02-06 Astrazeneca Ab Quinazoline derivatives as VEGF inhibitors
ATE304849T1 (de) * 2000-07-13 2005-10-15 Alteon Inc Cyanomethyl-substituierte thiazolium- und imidazolium-verbindungen und behandlung von erkrankungen im zusammenhang mit proteinalterung
GB0126879D0 (en) 2001-11-08 2002-01-02 Astrazeneca Ab Combination therapy
EP1534287A1 (en) 2002-08-09 2005-06-01 Astrazeneca AB Combination of zd6474, an inhibitor of the vascular endothelial growth factor receptor, with radiotherapy in the treatment of cancer
GB0218526D0 (en) 2002-08-09 2002-09-18 Astrazeneca Ab Combination therapy
GB0223380D0 (en) 2002-10-09 2002-11-13 Astrazeneca Ab Combination therapy
SI1592423T1 (sl) 2003-02-13 2011-07-29 Astrazeneca Ab Kombinacijska terapija ZD6474 s 5-FU in/ali CPT-11
GB0310401D0 (en) 2003-05-07 2003-06-11 Astrazeneca Ab Therapeutic agent
GB0316127D0 (en) 2003-07-10 2003-08-13 Astrazeneca Ab Combination therapy
GB0316123D0 (en) 2003-07-10 2003-08-13 Astrazeneca Ab Combination therapy
EP1648465B1 (en) 2003-07-10 2010-08-25 AstraZeneca AB Use of the quinazoline derivative zd6474 combined with platinum compounds and optionally ionising radiation in the treatment of diseases associated with angiogenesis and/or increased vascular permeability
AU2005225192B2 (en) 2004-03-23 2008-10-09 Astrazeneca Ab Combination therapy
GB0406446D0 (en) 2004-03-23 2004-04-28 Astrazeneca Ab Combination therapy
GB0406445D0 (en) 2004-03-23 2004-04-28 Astrazeneca Ab Combination therapy
AU2005288736B2 (en) 2004-09-27 2008-08-14 Astrazeneca Ab Cancer combination therapy comprising AZD2171 and imatinib
AU2005288737B2 (en) 2004-09-27 2008-08-14 Astrazeneca Ab Combination comprising ZD6474 and imatinib
GB0424339D0 (en) 2004-11-03 2004-12-08 Astrazeneca Ab Combination therapy
NZ564189A (en) 2005-07-06 2011-04-29 Astrazeneca Ab Combination therapy of cancer with AZD2171 and gemcitabine
WO2007068895A1 (en) 2005-12-15 2007-06-21 Astrazeneca Ab Combination of angiopoietin-2 antagonist and of vegf-a, kdr and/or flt1 antagonist for treating cancer
NZ568812A (en) 2005-12-22 2011-09-30 Astrazeneca Ab Combination of AZD2171 and pemetrexed
JP5167144B2 (ja) 2005-12-22 2013-03-21 アストラゼネカ アクチボラグ 併用療法
EP2066353B1 (en) 2006-09-29 2013-01-02 AstraZeneca AB Combination of zd6474 and bevacizumab for cancer therapy
WO2008125820A1 (en) 2007-04-13 2008-10-23 Astrazeneca Ab Combination therapy comprising azd2171 and azd6244 or mek-inhibitor ii

Also Published As

Publication number Publication date
AU4438601A (en) 2001-10-15
BR0109729A (pt) 2003-02-04
NO326277B1 (no) 2008-10-27
SK14302002A3 (sk) 2003-05-02
EP1790340A2 (en) 2007-05-30
EP1272186B1 (en) 2007-02-28
RU2002129353A (ru) 2004-03-20
NZ534455A (en) 2007-01-26
DE60126923D1 (de) 2007-04-12
CA2401854A1 (en) 2001-10-11
JP2003528917A (ja) 2003-09-30
HUP0300426A2 (hu) 2003-06-28
WO2001074360A1 (en) 2001-10-11
ZA200206959B (en) 2003-12-01
NO20024814D0 (no) 2002-10-04
GB0008269D0 (en) 2000-05-24
SI1272186T1 (sl) 2007-06-30
MXPA02009743A (es) 2003-03-27
CZ299410B6 (cs) 2008-07-16
EP1790340A3 (en) 2009-03-18
EE200200578A (et) 2004-06-15
IS6557A (is) 2002-09-20
EP1658849A2 (en) 2006-05-24
KR20030007491A (ko) 2003-01-23
KR100849149B1 (ko) 2008-07-31
NO20024814L (no) 2002-11-12
IS2455B (is) 2008-11-15
DK1272186T3 (da) 2007-05-21
ATE355065T1 (de) 2006-03-15
IS8726A (is) 2008-04-16
CN1431902A (zh) 2003-07-23
CY1107615T1 (el) 2013-03-13
DE60126923T2 (de) 2007-10-31
US20030144298A1 (en) 2003-07-31
IL151503A0 (en) 2003-04-10
ES2280349T3 (es) 2007-09-16
US7829573B2 (en) 2010-11-09
AU2001244386B2 (en) 2005-01-27
KR20080034523A (ko) 2008-04-21
NZ520938A (en) 2005-08-26
NO323467B1 (no) 2007-05-21
PL357605A1 (en) 2004-07-26
EP1272186A1 (en) 2003-01-08
EP1658849A3 (en) 2009-02-18
PT1272186E (pt) 2007-04-30

Similar Documents

Publication Publication Date Title
NO20062050L (no) Terapeutiske kombinasjoner av antihypertensive og antiangiogene midler
DK1346041T3 (da) Terapeutiske midler og fremgangsmåder til anvendelse deraf til behandling af en amyloidogen sygdom
EP1558220A4 (en) ORAL COMPOSITIONS FOR THE TREATMENT OF DISEASES
BR0114799A (pt) Compostos de ácido cianofenoxi carboxìlico e composições para liberar agentes ativos
NO20031019D0 (no) Vedvarende frigivelsesformuleringer av oksymorfon
ATE297723T1 (de) Pharmazeutische zusammensetzung enthaltend ein 5- aminolaevulinsäure-ester als photochemotherapeutikum und ein mucoadhäsivum
MXPA03010085A (es) Composiciones y su uso en la hiperplasia.
WO2005011655A3 (en) Pyridazine derivatives and their use as therapeutic agents
MXPA03009772A (es) Metodos y composiciones para tratar lesiones orales y del esofago.
ATE302616T1 (de) Oral anzuwendende arzneizusammensetzungen mit gesteuerter wirkstoffabgabe
ATE413187T1 (de) Pharmazeutische zusammensetzungen mit interferon- tau
DK1147105T3 (da) Optisk aktivt pyridyl-4H-1,2,4-oxadiazinderivat og anvendelse af dette til behandling af karsygdomme
SE0000303D0 (sv) Novel compounds
IT1320192B1 (it) Composizione terapeutica per la cura della psoriasi.
WO2002053099A3 (en) Methods and compositions for treating periodontal disease
BR0005319A (pt) Tratamento combinado para depressão e ansiedade
DE60031385D1 (de) Pharmazeutische Zusammensetzungen von Antibiotika und Fruktan-Gemische
DE60126504D1 (de) Verwendung von gegen candida wirksamen mitteln zur behandlung von störungen der oralen und intestinalen mucosa

Legal Events

Date Code Title Description
MM1K Lapsed by not paying the annual fees