NO20061060L - Antagonistiske analoger av GH-RH (2003) - Google Patents
Antagonistiske analoger av GH-RH (2003)Info
- Publication number
- NO20061060L NO20061060L NO20061060A NO20061060A NO20061060L NO 20061060 L NO20061060 L NO 20061060L NO 20061060 A NO20061060 A NO 20061060A NO 20061060 A NO20061060 A NO 20061060A NO 20061060 L NO20061060 L NO 20061060L
- Authority
- NO
- Norway
- Prior art keywords
- analogs
- inhibit
- hgh
- antagonistic analogs
- antagonistic
- Prior art date
Links
- 230000003042 antagnostic effect Effects 0.000 title abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 2
- 230000000694 effects Effects 0.000 abstract 2
- 102000018997 Growth Hormone Human genes 0.000 abstract 1
- 108010051696 Growth Hormone Proteins 0.000 abstract 1
- 101710198286 Growth hormone-releasing hormone receptor Proteins 0.000 abstract 1
- 102100033365 Growth hormone-releasing hormone receptor Human genes 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 239000000122 growth hormone Substances 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 230000001817 pituitary effect Effects 0.000 abstract 1
- 230000036515 potency Effects 0.000 abstract 1
- 230000035755 proliferation Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/60—Growth hormone-releasing factor [GH-RF], i.e. somatoliberin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Endocrinology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Zoology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Toxicology (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Analytical Chemistry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
Det blir tilveiebrakt en ny serie med syntetiske antagonistiske analoger av hGH-RH(1-29)NH2. Disse analoger hemmer aktiviteten av endogen hGH-RH på hypofyse-GHRH-reseptorer, og hindrer derfor frigjøringen av veksthormon. Analogene hemmer også prolifereringen av humane cancere gjennom en direkte effekt på cancercellen. De høyere hemmende potensene til de nye analogene sammenlignet med de som tidligere er beskrevet, er et resultat fra erstatning av forskjellige aminosyrer.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US49270603P | 2003-08-05 | 2003-08-05 | |
PCT/US2004/024183 WO2005016953A2 (en) | 2003-08-05 | 2004-07-26 | Antagonistic analogs of gh-rh (2003) |
Publications (1)
Publication Number | Publication Date |
---|---|
NO20061060L true NO20061060L (no) | 2006-05-03 |
Family
ID=34193144
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20061060A NO20061060L (no) | 2003-08-05 | 2006-03-03 | Antagonistiske analoger av GH-RH (2003) |
Country Status (19)
Country | Link |
---|---|
US (1) | US7452865B2 (no) |
EP (1) | EP1651662A4 (no) |
JP (1) | JP2007526900A (no) |
KR (1) | KR20060088875A (no) |
CN (1) | CN1871020A (no) |
AR (1) | AR049149A1 (no) |
AU (1) | AU2004265280A1 (no) |
BR (1) | BRPI0413257A (no) |
CA (1) | CA2534436A1 (no) |
IL (1) | IL173201A0 (no) |
MX (1) | MXPA06001369A (no) |
NO (1) | NO20061060L (no) |
PL (1) | PL380437A1 (no) |
RS (1) | RS20060086A (no) |
RU (1) | RU2335506C2 (no) |
SG (1) | SG136958A1 (no) |
TW (1) | TW200517400A (no) |
WO (1) | WO2005016953A2 (no) |
ZA (1) | ZA200600966B (no) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2009108364A2 (en) * | 2008-02-27 | 2009-09-03 | Ipsen Pharma S.A.S. | Antagonistic analogues of ghrh |
AU2009228244A1 (en) * | 2008-03-28 | 2009-10-01 | The United States Of America Represented By The United States Department Of Veteran's Affairs | Novel N-and C-terminal substituted -antagonistic analogs of human GH-RH |
US8691942B2 (en) | 2008-03-28 | 2014-04-08 | University Of Miami | N- and C- terminal substituted antagonistic analogs of GH-RH |
EP2310028B1 (en) * | 2008-06-12 | 2016-11-16 | Ipsen Bioinnovation Limited | Fusion proteins for use in the treatment of acromegaly |
US8796216B2 (en) | 2008-06-12 | 2014-08-05 | Syntaxin Limited | Suppression of neuroendocrine diseases |
CN107446053A (zh) | 2008-06-12 | 2017-12-08 | 益普生生物创新有限公司 | 癌症的抑制 |
US8227421B2 (en) * | 2009-09-17 | 2012-07-24 | University Of Miami | Fluorinated GHRH antagonists |
WO2011153491A2 (en) | 2010-06-03 | 2011-12-08 | University Of Miami | Agonists of growth hormone releasing hormone as effectors for survival and proliferation of pancreatic islets |
US8361964B2 (en) | 2011-04-21 | 2013-01-29 | Theratechnologies Inc. | Growth hormone releasing factor (GRF) analogs and uses thereof |
US9079974B2 (en) * | 2011-12-21 | 2015-07-14 | The University Of Miami | GH-RH analogs with potent agonistic effects |
US20150166617A1 (en) * | 2012-06-27 | 2015-06-18 | University Of Miami | Compositions and methods of treating alzheimer's disease |
WO2014100816A2 (en) | 2012-12-21 | 2014-06-26 | University Of Miami | Ghrh agonists for islet cell transplantation and function and the treatment of diabetes |
US9855312B2 (en) | 2012-12-21 | 2018-01-02 | University Of Miami | GHRH agonists for the treatment of ischemic disorders |
EP3920961A4 (en) | 2019-02-08 | 2022-12-14 | United States Government as represented by the Department of Veterans Affairs | GROWTH HORMONE RELEASING HORMONE ANTAGONISTS AND THEIR USES |
CA3178840A1 (en) | 2020-04-27 | 2021-11-04 | The University Of Miami | Method of treating an inflammatory disorder |
CN114195881B (zh) * | 2021-12-16 | 2022-09-16 | 浙江湃肽生物股份有限公司 | 一种制备醋酸舍莫瑞林的方法 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5942489A (en) * | 1996-05-03 | 1999-08-24 | The Administrators Of The Tulane Educational Fund | HGH-RH(1-29)NH2 analogues having antagonistic activity |
US6057422A (en) * | 1998-11-25 | 2000-05-02 | The Administrators Of The Tulane Educational Fund | Antagonistic analogs of GH-RH inhibiting IGF-I and -II |
-
2004
- 2004-07-23 TW TW093121985A patent/TW200517400A/zh unknown
- 2004-07-26 RS YUP-2006/0086A patent/RS20060086A/sr unknown
- 2004-07-26 BR BRPI0413257-2A patent/BRPI0413257A/pt not_active IP Right Cessation
- 2004-07-26 SG SG200716961-8A patent/SG136958A1/en unknown
- 2004-07-26 KR KR1020067002465A patent/KR20060088875A/ko active IP Right Grant
- 2004-07-26 PL PL380437A patent/PL380437A1/pl unknown
- 2004-07-26 CA CA002534436A patent/CA2534436A1/en not_active Abandoned
- 2004-07-26 WO PCT/US2004/024183 patent/WO2005016953A2/en active Application Filing
- 2004-07-26 EP EP04757325A patent/EP1651662A4/en not_active Withdrawn
- 2004-07-26 CN CNA2004800222868A patent/CN1871020A/zh active Pending
- 2004-07-26 AU AU2004265280A patent/AU2004265280A1/en not_active Abandoned
- 2004-07-26 MX MXPA06001369A patent/MXPA06001369A/es unknown
- 2004-07-26 US US10/566,776 patent/US7452865B2/en not_active Expired - Fee Related
- 2004-07-26 RU RU2006106701/04A patent/RU2335506C2/ru not_active IP Right Cessation
- 2004-07-26 JP JP2006522602A patent/JP2007526900A/ja active Pending
- 2004-08-03 AR ARP040102755A patent/AR049149A1/es unknown
-
2006
- 2006-01-17 IL IL173201A patent/IL173201A0/en unknown
- 2006-02-02 ZA ZA200600966A patent/ZA200600966B/en unknown
- 2006-03-03 NO NO20061060A patent/NO20061060L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
KR20060088875A (ko) | 2006-08-07 |
IL173201A0 (en) | 2006-06-11 |
EP1651662A4 (en) | 2009-07-01 |
JP2007526900A (ja) | 2007-09-20 |
US20070042950A1 (en) | 2007-02-22 |
US7452865B2 (en) | 2008-11-18 |
SG136958A1 (en) | 2007-11-29 |
WO2005016953A3 (en) | 2006-02-09 |
ZA200600966B (en) | 2007-05-30 |
RU2335506C2 (ru) | 2008-10-10 |
RS20060086A (en) | 2008-08-07 |
BRPI0413257A (pt) | 2006-10-03 |
AR049149A1 (es) | 2006-07-05 |
MXPA06001369A (es) | 2007-02-19 |
EP1651662A2 (en) | 2006-05-03 |
RU2006106701A (ru) | 2007-09-20 |
TW200517400A (en) | 2005-06-01 |
PL380437A1 (pl) | 2007-01-22 |
AU2004265280A1 (en) | 2005-02-24 |
WO2005016953A2 (en) | 2005-02-24 |
CN1871020A (zh) | 2006-11-29 |
CA2534436A1 (en) | 2005-02-24 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
NO20061060L (no) | Antagonistiske analoger av GH-RH (2003) | |
CR8188A (es) | Compuestos novedosos que poseen actividad inhibitoria contra transportador de glucosa dependiente de sodio | |
ATE480252T1 (de) | Peptidantagonist von zonulin und dessen verwendung | |
DE60309481D1 (de) | Cyclische n-aroylamine als orexinrezeptorantagonisten | |
AP9801312A0 (en) | 4-aminopyrrole (3,2-d) pyrimidines as neuropeptide y receptor anatagonist. | |
PE20040636A1 (es) | Ester de 2'-c-metil-3'-o-l-valina de ribofuranosilcitidina | |
EA200101177A1 (ru) | Производные индола в качестве антагонистов прогестерона | |
EA200500520A1 (ru) | Пуриновые соединения и их применение в качестве лигандов каннабиноидных рецепторов | |
MXPA04009435A (es) | Derivados de quinolina y quinolinona radiomarcados y su uso como ligandos de receptor de glutamato metabotropico. | |
GEP20074231B (en) | Calcitonin gene related peptide receptor antagonists | |
ATE284413T1 (de) | Therapeutische peptid derivate | |
EA200400816A1 (ru) | Замещенные аналоги хиназолин-4-иламина в качестве модуляторов капсаицина | |
IL140622A0 (en) | Biphenyl sufonamide derivatives, pharmaceutical compositions containing the same and methods for the preparation thereof | |
DE60325024D1 (de) | Selektiv tragbare und entfernbare elektroden/sensoren | |
IL160872A0 (en) | Pyrimidinones as melanin concentrating hormone receptor 1 | |
EA200500388A1 (ru) | Способ получения сухих порошковых композиций для ингаляции | |
TR200002542T2 (tr) | Meta-azasiklik amino benzoik asit bileşikleri ve bunların integrin antagonistleri olan türevleri | |
RU94045881A (ru) | Производные пептидов, способ получения, фармацевтическая композиция, способ лечения | |
MX9801890A (es) | Nuevos compuestos antagonistas selectivos del receptor nk3 humano, procedimiento para su obtencion y composiciones farmaceuticas que los contienen. | |
TR199902848T2 (xx) | Ergolin t�revleri ve bunlar�n somatostatin resept�r antagonist olarak kullan�mlar� | |
BRPI0413676A (pt) | composto, e, composição farmacêutica | |
TR200101492T2 (tr) | IGF-I ve II 'yi engelleyen GH-RH'nın antagonistik analogları | |
BRPI0417943A (pt) | antagonistas de receptor de crf e métodos relacionados para essa finalidade | |
EA200500830A1 (ru) | Производные имидазохинолина в качестве лигандов аденозиновых a3 рецепторов | |
NO20033911L (no) | Somatostatin antagonister |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FC2A | Withdrawal, rejection or dismissal of laid open patent application |