NO20054311L - HIV-repliksjonsinhiberende pyrimidiner og triaziner - Google Patents

HIV-repliksjonsinhiberende pyrimidiner og triaziner

Info

Publication number
NO20054311L
NO20054311L NO20054311A NO20054311A NO20054311L NO 20054311 L NO20054311 L NO 20054311L NO 20054311 A NO20054311 A NO 20054311A NO 20054311 A NO20054311 A NO 20054311A NO 20054311 L NO20054311 L NO 20054311L
Authority
NO
Norway
Prior art keywords
triazines
hiv replication
replication inhibitory
pyrimidines
inhibitory pyrimidines
Prior art date
Application number
NO20054311A
Other languages
English (en)
Other versions
NO20054311D0 (no
Inventor
Jan Heeres
Kurt Hertogs
Marc Rene De Jonge
Lucien Maria Henricus Koymans
Eva Bettens
Jerome Emile George Guillemont
Elisabeth Therese Jea Pasquier
Paulus Joannes Lewi
Frederik Frans Desire Daeyaert
Hendrik Maarten Vinkers
Original Assignee
Tibotec Pharm Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tibotec Pharm Ltd filed Critical Tibotec Pharm Ltd
Publication of NO20054311D0 publication Critical patent/NO20054311D0/no
Publication of NO20054311L publication Critical patent/NO20054311L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

Denne oppfinnelse vedrører HTV-reproduksjonsinhibitorer med formel. N-oksidene, de farmasøytisk akseptable addisjonssalter, de kvaternære aminer og de stereokjemisk isomere former derav, deres anvendelse som medisin, fremgangsmåter ved deres fremstilling og farmasøytiske sammensetninger inneholdende dem.
NO20054311A 2003-02-20 2005-09-19 HIV-repliksjonsinhiberende pyrimidiner og triaziner NO20054311L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP03100411 2003-02-20
US47501203P 2003-06-02 2003-06-02
PCT/EP2004/050175 WO2004074261A1 (en) 2003-02-20 2004-02-20 Hiv replication inhibiting pyrimidines and triazines

Publications (2)

Publication Number Publication Date
NO20054311D0 NO20054311D0 (no) 2005-09-19
NO20054311L true NO20054311L (no) 2005-10-27

Family

ID=32910137

Family Applications (2)

Application Number Title Priority Date Filing Date
NO20054311A NO20054311L (no) 2003-02-20 2005-09-19 HIV-repliksjonsinhiberende pyrimidiner og triaziner
NO20054312A NO20054312L (no) 2003-02-20 2005-09-19 HIV-replikasjonsinhiberende pyrimidiner og triaziner

Family Applications After (1)

Application Number Title Priority Date Filing Date
NO20054312A NO20054312L (no) 2003-02-20 2005-09-19 HIV-replikasjonsinhiberende pyrimidiner og triaziner

Country Status (27)

Country Link
US (2) US7585870B2 (no)
EP (2) EP1603887B1 (no)
JP (2) JP4586013B2 (no)
KR (2) KR20050099994A (no)
CN (2) CN1751031B (no)
AP (1) AP2005003373A0 (no)
AR (2) AR044500A1 (no)
AT (2) ATE361915T1 (no)
AU (2) AU2004213186B2 (no)
BR (2) BRPI0407732A (no)
CA (2) CA2516699C (no)
CL (2) CL2004000303A1 (no)
CY (1) CY1106788T1 (no)
DE (2) DE602004032321D1 (no)
DK (1) DK1597238T3 (no)
EA (2) EA010423B1 (no)
ES (1) ES2287734T3 (no)
HR (2) HRP20050820A2 (no)
IL (2) IL169596A (no)
MX (2) MXPA05008866A (no)
MY (1) MY138308A (no)
NO (2) NO20054311L (no)
NZ (2) NZ542428A (no)
PL (2) PL226954B1 (no)
PT (1) PT1597238E (no)
TW (2) TW200500346A (no)
WO (2) WO2004074261A1 (no)

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CL2004000303A1 (es) * 2003-02-20 2005-04-08 Tibotec Pharm Ltd Compuestos derivados de pirimidinas y triazinas; proceso de preparacion; composicion farmaceutica; y su uso para inhibir la replicacion del vih.
CN102358738A (zh) 2003-07-30 2012-02-22 里格尔药品股份有限公司 2,4-嘧啶二胺化合物及其预防和治疗自体免疫疾病的用途
AU2005231507B2 (en) 2004-04-08 2012-03-01 Targegen, Inc. Benzotriazine inhibitors of kinases
JP5275628B2 (ja) 2004-08-25 2013-08-28 ターゲジェン インコーポレーティッド 複素環式化合物および使用方法
CA2584295C (en) 2004-11-24 2014-08-26 Rigel Pharmaceuticals, Inc. Spiro-2, 4-pyrimidinediamine compounds and their uses
DE602006010979D1 (de) 2005-01-19 2010-01-21 Rigel Pharmaceuticals Inc Prodrugs aus 2,4-pyrimidindiamin-verbindungen und ihre verwendungen
WO2006133426A2 (en) 2005-06-08 2006-12-14 Rigel Pharmaceuticals, Inc. Compositions and methods for inhibition of the jak pathway
US20070203161A1 (en) 2006-02-24 2007-08-30 Rigel Pharmaceuticals, Inc. Compositions and methods for inhibition of the jak pathway
US8604042B2 (en) 2005-11-01 2013-12-10 Targegen, Inc. Bi-aryl meta-pyrimidine inhibitors of kinases
DK1951684T3 (en) 2005-11-01 2016-10-24 Targegen Inc BIARYLMETAPYRIMIDIN kinase inhibitors
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TWI491605B (zh) 2008-11-24 2015-07-11 Boehringer Ingelheim Int 新穎化合物
EP2406253B1 (en) 2009-03-11 2013-07-03 Pfizer Inc. Benzofuranyl derivatives used as glucokinase inhibitors
WO2012060847A1 (en) 2010-11-07 2012-05-10 Targegen, Inc. Compositions and methods for treating myelofibrosis
US9249124B2 (en) 2011-03-30 2016-02-02 H. Lee Moffitt Cancer Center And Research Institute, Inc. Aurora kinase inhibitors and methods of making and using thereof
CN103501612B (zh) 2011-05-04 2017-03-29 阿里亚德医药股份有限公司 抑制表皮生长因子受体导致的癌症中细胞增殖的化合物
GB201119358D0 (en) 2011-11-10 2011-12-21 Lewi Paulus J Disubstituted triazine dimers for treatment and/or prevention of infectious diseases
GB201204756D0 (en) 2012-03-19 2012-05-02 Lewi Paulus J Triazines with suitable spacers for treatment and/or prevention of HIV infections
WO2013169401A1 (en) 2012-05-05 2013-11-14 Ariad Pharmaceuticals, Inc. Compounds for inhibiting cell proliferation in egfr-driven cancers
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US9611283B1 (en) 2013-04-10 2017-04-04 Ariad Pharmaceuticals, Inc. Methods for inhibiting cell proliferation in ALK-driven cancers
WO2018019204A1 (zh) * 2016-07-26 2018-02-01 深圳市塔吉瑞生物医药有限公司 用于抑制蛋白酪氨酸激酶活性的氨基嘧啶类化合物
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JP2022531801A (ja) 2019-05-10 2022-07-11 デシフェラ・ファーマシューティカルズ，エルエルシー フェニルアミノピリミジンアミドオートファジー阻害剤およびその使用方法
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Also Published As

Publication number Publication date
NO20054312D0 (no) 2005-09-19
AU2004213186B2 (en) 2009-10-01
EA011256B1 (ru) 2009-02-27
DK1597238T3 (da) 2007-09-10
IL169647A0 (en) 2007-07-04
TW200510339A (en) 2005-03-16
AU2004213187A1 (en) 2004-09-02
US7442705B2 (en) 2008-10-28
KR20050094896A (ko) 2005-09-28
US20060194804A1 (en) 2006-08-31
ATE506353T1 (de) 2011-05-15
CL2004000306A1 (es) 2005-04-08
CN1751030A (zh) 2006-03-22
HRP20050820A2 (en) 2006-11-30
EA200501326A1 (ru) 2006-02-24
IL169596A (en) 2017-02-28
PL226954B1 (pl) 2017-10-31
AU2004213186A1 (en) 2004-09-02
ATE361915T1 (de) 2007-06-15
KR20050099994A (ko) 2005-10-17
WO2004074261A1 (en) 2004-09-02
AU2004213187B2 (en) 2009-11-05
DE602004006383T2 (de) 2008-01-10
IL169596A0 (en) 2007-07-04
EP1603887B1 (en) 2011-04-20
CA2516699A1 (en) 2004-09-02
MXPA05008867A (es) 2005-10-05
BRPI0407741A (pt) 2006-02-14
JP2006518357A (ja) 2006-08-10
NZ542428A (en) 2007-11-30
CN100572364C (zh) 2009-12-23
ES2287734T3 (es) 2007-12-16
JP4586014B2 (ja) 2010-11-24
EP1597238A1 (en) 2005-11-23
EP1603887A1 (en) 2005-12-14
US20060142571A1 (en) 2006-06-29
BRPI0407741B8 (pt) 2021-05-25
MY138308A (en) 2009-05-29
PL378136A1 (pl) 2006-03-06
IL169647A (en) 2013-05-30
NO20054312L (no) 2005-11-16
CA2516589A1 (en) 2004-09-02
BRPI0407741B1 (pt) 2018-05-29
PL227295B1 (pl) 2017-11-30
CA2516589C (en) 2012-04-17
HRP20050821A2 (en) 2006-11-30
PL378064A1 (pl) 2006-02-20
MXPA05008866A (es) 2005-10-05
JP4586013B2 (ja) 2010-11-24
AR044499A1 (es) 2005-09-14
BRPI0407732A (pt) 2006-02-14
TW200500346A (en) 2005-01-01
AR044500A1 (es) 2005-09-14
CY1106788T1 (el) 2012-05-23
DE602004006383D1 (de) 2007-06-21
CN1751031B (zh) 2010-07-21
PT1597238E (pt) 2007-08-08
DE602004032321D1 (de) 2011-06-01
NO20054311D0 (no) 2005-09-19
EP1597238B1 (en) 2007-05-09
JP2006518356A (ja) 2006-08-10
US7585870B2 (en) 2009-09-08
CN1751031A (zh) 2006-03-22
AP2005003373A0 (en) 2005-09-30
EA010423B1 (ru) 2008-08-29
CL2004000303A1 (es) 2005-04-08
WO2004074262A1 (en) 2004-09-02
EA200501327A1 (ru) 2006-02-24
CA2516699C (en) 2011-07-12
NZ541601A (en) 2007-09-28

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